Dexamethasone Acetate

Catalog No.S3124 Synonyms: NSC 39471

For research use only.

Dexamethasone (NSC 39471) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.

Dexamethasone Acetate Chemical Structure

CAS No. 1177-87-3

Selleck's Dexamethasone Acetate has been cited by 29 publications

Purity & Quality Control

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Biological Activity

Description Dexamethasone (NSC 39471) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.
Targets
interleukin receptor [1]
In vitro

Dexamethasone inhibits COX-2 mRNA expression induced by IL-1 in human articular chondrocytes. [1] Dexamethasone suppresses the cyclooxygenase-2 induction by tumor necrosis factor α (TNFα) with an IC50 of 1 nM in MC3T3-E1 cells. Dexamethasone binds to the glucocorticoid receptor and then to the glucocorticoid response element. [2]Dexamethasone (10 μM) induces osteoblastic differentiation of rat bone marrow stromal cell cultures with elevated mRNA expression of alkaline phosphatase osteopontin, bone sialoprotein, and osteocalcin. [3] Dexamethasone (5 μM) treatment decreases proliferation of adult hippocampal neural progenitor cells and SRE-driven gene expression. [5]

Assay
Methods Test Index PMID
Western blot p-AKT / AKT ; GRP78 / GRP94 / pIREα / IREα / peIF2α / eIF2α CHOP ; BCRP / P-gp / Mrp2 29436611 24691439 18524938
Immunofluorescence GRP78 24691439
Growth inhibition assay Cell viability 22719835
In vivo Dexamethasone (2 mg/kg) reduces the number of the BrdU-labeled hepatocytes by 80% in male Fischer F344 rats. Dexamethasone (2 mg/kg) pretreatment suppresses the expression of both TNF and IL-6 after partial hepatectomy and significantly reduces the proliferative response of the hepatocytes in male Fischer F344 rats. Dexamethasone also severely diminishes the induction and expansion of oval cells induced by the 2-acetylaminofluorene/partial hepatectomy (AAF/PH) protocol but does not have any effect on the proliferation of the bile duct cells stimulated by bile duct ligation. [4] Dexamethasone (100 μg/kg) produces a significant decrease 59.2% of BrdU(+) hippocampal progenitor cells in Sprague–Dawley rats. Dexamethasone (100 μg/kg) decreases ERK activation in granule cell layer in Sprague–Dawley rats. [5]

Protocol (from reference)

Animal Research:[5]
  • Animal Models: Sprague-Dawley rats
  • Dosages: 100 μg/kg
  • Administration: Intraperitoneal injection

Solubility (25°C)

In vitro

DMSO 87 mg/mL
(200.23 mM)
Water Insoluble
Ethanol '20 mg/mL

Chemical Information

Molecular Weight 434.5
Formula

C24H31FO6

CAS No. 1177-87-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COC(=O)C)O)C)O)F)C

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05142098 Not yet recruiting Drug: Dexamethasone|Drug: Etoricoxib 60 mg Effect of Drug Dow University of Health Sciences January 1 2022 Early Phase 1
NCT05170789 Not yet recruiting Drug: Elotuzumab Selinexor and Dexamethasone (ESd) Relapsed Multiple Myeloma|Refractory Multiple Myeloma Tulane University School of Medicine|Karyopharm Therapeutics Inc|Tulane University January 7 2022 Phase 2
NCT05136781 Recruiting -- Thoracic Surgery|Anesthesiology|Corticosteroids|Respiratory Complication Centre Hospitalier Universitaire Amiens November 16 2021 --

(data from https://clinicaltrials.gov, updated on 2022-01-17)

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