Glutathione

Catalog No.S4606 Synonyms: Isethion, Glutathion, Tathion, L-Glutathione reduced, GSH; γ-L-Glutamyl-L-cysteinyl-glycine

For research use only.

Glutathione (Isethion, Tathion, L-Glutathione reduced, GSH; γ-L-Glutamyl-L-cysteinyl-glycine) acts as an antioxidant, a free radical scavenger and a detoxifying agent. It is a tripeptide comprised of three amino acids (cysteine, glutamic acid, and glycine) present in most mammalian tissue.

Glutathione Chemical Structure

CAS No. 70-18-8

Selleck's Glutathione has been cited by 7 Publications

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Biological Activity

Description Glutathione (Isethion, Tathion, L-Glutathione reduced, GSH; γ-L-Glutamyl-L-cysteinyl-glycine) acts as an antioxidant, a free radical scavenger and a detoxifying agent. It is a tripeptide comprised of three amino acids (cysteine, glutamic acid, and glycine) present in most mammalian tissue.
In vitro

Glutathione (GSH) is able to recover the meiotic failure induced by heavy metal cadmium (Cd) exposure through suppressing the excessive ROS level, DNA damage accumulation and apoptotic incidence in porcine oocytes.[2]

In vivo

Oral GSH can increase GSH concentrations in several tissues following GSH depletion.[1]

Protocol (from reference)

Cell Research:

[2]

  • Cell lines: porcine oocytes
  • Concentrations: 1, 2 and 4 mM
  • Incubation Time: --
  • Method:

    Cadmium chloride is dissolved in PBS and diluted in TCM-199 medium to a final concentration of 0.4, 2, 10 and 50 μM, respectively. GSH is dissolved in PBS and diluted in TCM-199 medium to a final concentration of 1, 2 and 4 mM, respectively. Both cadmium chloride and GSH are supplemented to TCM-199 medium immediately before culture.

Animal Research:

[1]

  • Animal Models: Mice (outbred albino ICR, 30-40 g)
  • Dosages: 100 mg/kg
  • Administration: oral administration

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 307.32
Formula

C10H17N3O6S

CAS No. 70-18-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C(CC(=O)NC(CS)C(=O)NCC(=O)O)C(C(=O)O)N

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05449249 Not yet recruiting Procedure: Long-term fasting Healthy|Periodontitis Buchinger Wilhelmi Development & Holding GmbH|Buchinger Wilhelmi Clinic|University of Geneva Switzerland|King''s College London|ETH Zurich (Switzerland) September 1 2022 Not Applicable
NCT05366933 Not yet recruiting Drug: Vitamin B-Complex Supplement Optic Disc Edema|Endothelial Dysfunction National Aeronautics and Space Administration (NASA)|Mayo Clinic|Texas A&M University July 1 2022 Phase 1
NCT05241262 Recruiting Drug: N-Acetylcysteine Mitochondrial Disease Darryl C. De Vivo MD|United States Department of Defense|Columbia University June 2022 Phase 1
NCT04987775 Not yet recruiting Drug: N-Acetyl Cysteine|Drug: Placebo Gulf War Syndrome Nova Southeastern University|RTI International|Miami VA Healthcare System|Boston University|Weill Medical College of Cornell University June 2022 Early Phase 1
NCT05024916 Recruiting Dietary Supplement: Intervention|Dietary Supplement: Control Brain Aging University of Kansas Medical Center|U.S. Highbush Blueberry Council June 1 2022 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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