Home Metabolism Antioxidant inhibitor GSH (L-Glutathione reduced)

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GSH (L-Glutathione reduced) Antioxidant

Cat.No.S4606

GSH (Glutathione) acts as an antioxidant, a free radical scavenger and a detoxifying agent. It is a tripeptide comprised of three amino acids (cysteine, glutamic acid, and glycine) present in most mammalian tissue.
GSH (L-Glutathione reduced) Antioxidant inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 307.32

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Quality Control

Batch: Purity: 99.97%
99.97

Solubility

In vitro
Batch:

Water : 61 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 307.32 Formula

C10H17N3O6S

 Storage (From the date of receipt) 3 years -20°C(in the dark) powder
CAS No. 70-18-8 Download SDF Storage of Stock Solutions Solutions are unstable. Prepare fresh or purchase small, pre-packaged sizes. Repackage upon receipt.
Synonyms Isethion, Glutathion, Tathion, L-Glutathione reduced, γ-L-Glutamyl-L-cysteinyl-glycine SMILES C(CC(=O)NC(CS)C(=O)NCC(=O)O)C(C(=O)O)N

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Mechanism of Action

In vitro

Glutathione (GSH) is able to recover the meiotic failure induced by heavy metal cadmium (Cd) exposure through suppressing the excessive ROS level, DNA damage accumulation and apoptotic incidence in porcine oocytes.
In vivo

Following GSH depletion, oral administration of this compound can increase its concentrations in several tissues.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-08-21)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07304440 RECRUITING
Autism Spectrum Disorder; Autism; ASD; Autism Spectrum Disorder (ASD)
Adia Med of Winter Park LLC
 2026-05-01 PHASE1; PHASE2
NCT07572890 RECRUITING
Chronic Kidney Disease; Kidney Disease; Kidney Disease, Chronic; Chronic Kidney Disease (CKD); CKD
Adia Med of Winter Park LLC
 2026-05-18 PHASE1
NCT02971046 ACTIVE_NOT_RECRUITING
Healthy
The Hospital for Sick Children
 2020-10-01
NCT05266417 RECRUITING
Parkinson Disease
Gateway Institute for Brain Research
 2022-02-07 PHASE2
NCT07064005 RECRUITING
Parkinsons Disease (PD)
Pravat Mandal
 2026-03-23 PHASE1
NCT06620523 RECRUITING
Renal Failure; Coronary Artery Disease; Surgery; Surgery-Complications
George Washington University
 2024-07-18 PHASE2

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