GSH (Glutathione)

Synonyms: Isethion, Glutathion, Tathion, L-Glutathione reduced, γ-L-Glutamyl-L-cysteinyl-glycine

GSH (Glutathione) acts as an antioxidant, a free radical scavenger and a detoxifying agent. It is a tripeptide comprised of three amino acids (cysteine, glutamic acid, and glycine) present in most mammalian tissue.

GSH (Glutathione) Chemical Structure

GSH (Glutathione) Chemical Structure

CAS No. 70-18-8

Purity & Quality Control

GSH (Glutathione) Related Products

Biological Activity

Description GSH (Glutathione) acts as an antioxidant, a free radical scavenger and a detoxifying agent. It is a tripeptide comprised of three amino acids (cysteine, glutamic acid, and glycine) present in most mammalian tissue.
In vitro
In vitro

Glutathione (GSH) is able to recover the meiotic failure induced by heavy metal cadmium (Cd) exposure through suppressing the excessive ROS level, DNA damage accumulation and apoptotic incidence in porcine oocytes.[2]

Cell Research Cell lines porcine oocytes
Concentrations 1, 2 and 4 mM
Incubation Time --
Method

Cadmium chloride is dissolved in PBS and diluted in TCM-199 medium to a final concentration of 0.4, 2, 10 and 50 μM, respectively. GSH is dissolved in PBS and diluted in TCM-199 medium to a final concentration of 1, 2 and 4 mM, respectively. Both cadmium chloride and GSH are supplemented to TCM-199 medium immediately before culture.

In Vivo
In vivo

Oral GSH can increase GSH concentrations in several tissues following GSH depletion.[1]

Animal Research Animal Models Mice (outbred albino ICR, 30-40 g)
Dosages 100 mg/kg
Administration oral administration
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06205030 Not yet recruiting
Diabetes Mellitus Type 2|Insulin Resistance
Kerman Medical University|Afzalipour Hospital
June 14 2024 Phase 4

Chemical Information & Solubility

Molecular Weight 307.32 Formula

C10H17N3O6S

CAS No. 70-18-8 SDF Download GSH (Glutathione) SDF
Smiles C(CC(=O)NC(CS)C(=O)NCC(=O)O)C(C(=O)O)N
Storage (From the date of receipt) 3 years -20°C(in the dark) powder

In vitro
Batch:

Water : 61 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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