Glutathione

Catalog No.S4606 Synonyms: Isethion, Glutathion, Tathion, L-Glutathione reduced, GSH; γ-L-Glutamyl-L-cysteinyl-glycine

For research use only.

Glutathione (Isethion, Tathion, L-Glutathione reduced, GSH; γ-L-Glutamyl-L-cysteinyl-glycine) acts as an antioxidant, a free radical scavenger and a detoxifying agent. It is a tripeptide comprised of three amino acids (cysteine, glutamic acid, and glycine) present in most mammalian tissue.

Glutathione Chemical Structure

CAS No. 70-18-8

Selleck's Glutathione has been cited by 5 Publications

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Biological Activity

Description Glutathione (Isethion, Tathion, L-Glutathione reduced, GSH; γ-L-Glutamyl-L-cysteinyl-glycine) acts as an antioxidant, a free radical scavenger and a detoxifying agent. It is a tripeptide comprised of three amino acids (cysteine, glutamic acid, and glycine) present in most mammalian tissue.

Protocol (from reference)

Animal Research:[1]
  • Animal Models: Mice (outbred albino ICR, 30-40 g)
  • Dosages: 100 mg/kg
  • Administration: oral administration

Solubility (25°C)

In vitro

Water 61 mg/mL
(198.49 mM)
DMSO Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 307.32
Formula

C10H17N3O6S

CAS No. 70-18-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C(CC(=O)NC(CS)C(=O)NCC(=O)O)C(C(=O)O)N

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04430517 Recruiting Drug: Nicotinamide riboside Mild Cognitive Impairment|Alzheimer Disease Mclean Hospital|National Institute on Aging (NIA) February 15 2022 Early Phase 1
NCT05146804 Recruiting Other: BroccoCress|Other: Affilla Cress Inflammation Maastricht University Medical Center November 11 2021 Not Applicable
NCT05024916 Not yet recruiting Dietary Supplement: Intervention|Dietary Supplement: Control Brain Aging University of Kansas Medical Center|U.S. Highbush Blueberry Council October 1 2021 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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