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GSH (Glutathione) Glutathione chemical

Cat.No.S4606

Glutathione (GSH) is a tripeptide comprised of three amino acids (cysteine, glutamic acid, and glycine) present in most mammalian tissue. It acts as an antioxidant, a free radical scavenger, and a detoxifying agent.
GSH (Glutathione) Glutathione chemical Chemical Structure

Chemical Structure

Molecular Weight: 307.32

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Quality Control

Batch: Purity: 99.97%
99.97

Solubility

In vitro
Batch:

Water : 61 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 307.32 Formula

C10H17N3O6S

 Storage (From the date of receipt) 3 years -20°C(in the dark) powder
CAS No. 70-18-8 Download SDF Storage of Stock Solutions

Synonyms Isethion, Glutathion, Tathion, L-Glutathione reduced, γ-L-Glutamyl-L-cysteinyl-glycine Smiles C(CC(=O)NC(CS)C(=O)NCC(=O)O)C(C(=O)O)N

Mechanism of Action

In vitro

Glutathione (GSH) is able to recover the meiotic failure induced by heavy metal cadmium (Cd) exposure through suppressing the excessive ROS level, DNA damage accumulation and apoptotic incidence in porcine oocytes.
In vivo

Following GSH depletion, oral administration of this compound can increase its concentrations in several tissues.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06205030 Not yet recruiting
Diabetes Mellitus Type 2|Insulin Resistance
Kerman Medical University|Afzalipour Hospital
 June 14 2024 Phase 4

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