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Tenofovir
Catalog No.S1401 Synonyms: GS-1278
For research use only.
Tenofovir (GS-1278) blocks reverse transcriptase and hepatitis B virus infections.
CAS No. 147127-20-6
Selleck's Tenofovir has been cited by 22 publications
Purity & Quality Control
Choose Selective Reverse Transcriptase Inhibitors
Related Compound Libraries
Other Reverse Transcriptase Products
Biological Activity
| Description | Tenofovir (GS-1278) blocks reverse transcriptase and hepatitis B virus infections. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Features | Tenofovir disoproxil fumarate is the prodrug form of tenofovir. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| In vitro |
Tenofovir reduces the viral cytopathic effect of HIV-1(IIIB), HIV-2(ROD) and HIV(EHO) with EC50 of 1.15 μg/mL, 1.12 μg/mL and 1.05 μg/mL in MT-4 cells. Tenofovir also reduces the viral cytopathic effect of SIV(mac251) , SIV(B670) ,SHIV(89.6) and SHIV(RTSHIV). [1] Tenofovir is uniquely active against multinucleoside-resistant HIV expressing the Q151M mutation, but shows reduced susceptibility to the T69S insertion mutations. [2] Tenofovir inhibits hepatitis B virus (HBV) activity in HepG2 2.2.15, HepAD38 and HepAD79 cells. [3] Tenofovir (4 μM) completely inhibits the growth of HIVIIIB in MT-2 cells. Tenofovir inhibits synthesis of negative strand strong-stop DNA with IC50 of 9 µM for wild-type RT, 6 µM for M184V RT and 50 µM for K65R RT. [4] |
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| Cell Data |
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| In vivo | Tenofovir (30 mg/kg) completely prevents SIV infection in all macaques without toxicity. Tenofovir treatment reduces plasma viral RNA levels to undetectable, with parallel decreases in the infectivity of plasma and infectious cells in peripheral blood mononuclear cells and cerebrospinal fluid (CSF) and stabilization of CD4+ T-cell numbers. Tenofovir (30 mg/kg, s.c.) completely abrogates HIV infection via intravaginal exposure in pig-tailed macaques. [5] |
Protocol (from reference)
| Animal Research:[1] |
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| References |
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Solubility (25°C)
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In vitro |
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In vivo |
Add solvents to the product individually and in order |
30 mg/mL |
Chemical Information
| Molecular Weight | 287.21 | ||
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| Formula | C9H14N5O4P |
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| CAS No. | 147127-20-6 | ||
| Storage | 3 years | -20°C | powder |
| 2 years | -80°C | in solvent | |
| Smiles | CC(CN1C=NC2=C(N=CN=C21)N)OCP(=O)(O)O | ||
In vivo Formulation Calculator (Clear solution)
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Clinical Trial Information
| NCT Number | Recruitment | Interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|---|
| NCT05140954 | Not yet recruiting | Drug: co-formulated 25mg TAF/ 200mg FTC | HIV Infections | University of Washington|Kenya Medical Research Institute|University of Colorado Denver|Gilead Sciences | September 2022 | Phase 2|Phase 3 |
| NCT05057858 | Enrolling by invitation | Drug: co-formulated 300 mg TDF/ 200mg FTC | HIV Infections | University of Washington|University of Colorado Denver|Kenya Medical Research Institute|National Institute of Allergy and Infectious Diseases (NIAID) | April 25 2022 | Phase 2 |
(data from https://clinicaltrials.gov, updated on 2022-08-01)
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