Tenofovir

For research use only.

Catalog No.S1401 Synonyms: GS-1278

19 publications

Tenofovir  Chemical Structure

CAS No. 147127-20-6

Tenofovir (GS-1278) blocks reverse transcriptase and hepatitis B virus infections.

Size Price Stock Quantity  
10mM (1mL in DMSO) USD 110 In stock
USD 97 In stock
USD 270 In stock
USD 570 In stock
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Selleck's Tenofovir has been cited by 19 publications

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Biological Activity

Description Tenofovir (GS-1278) blocks reverse transcriptase and hepatitis B virus infections.
Features Tenofovir disoproxil fumarate is the prodrug form of tenofovir.
Targets
Reverse transcriptase [1]
In vitro

Tenofovir reduces the viral cytopathic effect of HIV-1(IIIB), HIV-2(ROD) and HIV(EHO) with EC50 of 1.15 μg/mL, 1.12 μg/mL and 1.05 μg/mL in MT-4 cells. Tenofovir also reduces the viral cytopathic effect of SIV(mac251) , SIV(B670) ,SHIV(89.6) and SHIV(RTSHIV). [1] Tenofovir is uniquely active against multinucleoside-resistant HIV expressing the Q151M mutation, but shows reduced susceptibility to the T69S insertion mutations. [2] Tenofovir inhibits hepatitis B virus (HBV) activity in HepG2 2.2.15, HepAD38 and HepAD79 cells. [3] Tenofovir (4 μM) completely inhibits the growth of HIVIIIB in MT-2 cells. Tenofovir inhibits synthesis of negative strand strong-stop DNA with IC50 of 9 µM for wild-type RT, 6 µM for M184V RT and 50 µM for K65R RT. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human MT2 cells Mmj6SpVv[3Srb36gZZN{[Xl? M3f2dVUh\GG7cx?= NWXkdlF1SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEmYMTCzRkBqdm[nY4Tl[EBqdiCqdX3hckBOXDJiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXOg[YZn\WO2IHHmeIVzKDViZHH5d{BjgSC[VGSgZZN{[XluIFXDOVA:OC5yMUOg{txO M{DD[FIxPDB7N{Kx
human H9 cells MUHGeY5kfGmxbjDhd5NigQ>? MY\BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDITXYyKGOuYXTlJGYhcXOxbHH0[UAzOzN6IHnu[oVkfGWmIHnuJIh2dWGwIFi5JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwhemWybHnjZZRqd25uIFXDOVA:OC5yNDFOwG0> NYTIZXhIOjF6MEO0OlI>
C3H/3T3 cells NYTt[GRzTnWwY4Tpc44h[XO|YYm= MXq2JIRigXN? MUPJcohq[mm2aX;uJI9nKG23cnnu[UB{[XKlb33hJJZqenW|LXnu[JVk\WRidILhcpNnd3KvYYTpc44hd2ZibX;1d4Uh\W2kconvJIZq[nKxYnzhd5QhSzOKL{PUN{Bk\WyuczDh[pRmeiB4IHThfZMtKEWFNUC9NE4zOyEQvF2= MmXjNVg2PTZ{MEm=
CEM (human leukemia) cells M3LjOmZ2dmO2aX;uJIF{e2G7 NEjh[GhCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJUVZvMTCoTWlKSiliaX6gR2VOKCiqdX3hckBt\XWtZX3pZUkh[2WubIOsJGVEPTB;MT6yJO69VQ>? M3LJ[lE1PTh2OUW2
MT-4 cells MnLOSpVv[3Srb36gZZN{[Xl? NHjocWxKdiC4aYTyc{BidnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJUVZvMjDpckBOXC12IHPlcIx{NCCHQ{WwQVEvPCEQvF2= MmKyNVE{Ojd3OEe=
human bone marrow cells M4\icWN6fG:2b4jpZ4l1gSCjc4PhfS=> NX7VcW0zOjRiaB?= M{nJOmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJIJwdmVibXHydo94KGOnbHzzJIFnfGW{IEK0JIhzeyCkeTDCSnUuTSCjc4PhfUwhS0N3ME2zMlUh|ryP Mof5NlA1Ozl4MEm=
C8166 cells MXXGeY5kfGmxbjDhd5NigQ>? MnyzOEBl[Xm| MYnBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDCxNFAhXEOLREWwJJdqdGRvdInw[UBJfW2jbjDpcY12dm:mZX\pZ4lmdmO7II\pdpV{KHS7cHWgNkBTV0RiaX7m[YN1\WRiaX6gR|gyPjZiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB{gW6leYTpZUBnd3KvYYTpc44h[W[2ZYKgOEBl[Xm|IHL5JI1q[3Kxc3PvdIlkKGGwYXz5d4l{NCCHQ{WwQVcvOSEQvF2= MnXMNlE5ODN2NkK=
mouse L1210 cells MXHDfZRwfG:6aXPpeJkh[XO|YYm= M3rLN|Q5KGh? NYixZ284S3m2b4P0ZZRq[yCjY4Tpeol1gSCjZ3HpcpN1KG2xdYPlJGwyOjFyIHPlcIx{KGGodHXyJFQ5KGi{czDifUBkd3WudHXyJINwfW62aX7nJIFv[Wy7c3nzMEBKSzVyPUGxJO69VQ>? MWmyOFY5PjBzMh?=
human HepG2 cells NXL1WG9QTnWwY4Tpc44h[XO|YYm= M2DBRVkh\GG7cx?= M2S0RmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmeGG2aYTpd{BDKH[rcoXzJIlv\mWldHXkJIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IEmg[IF6eyCkeTDNWHQh[XO|YYmsJGlEPTB;MUKuN{DPxE1? MUmxO|g5QDZ4Mh?=
human HeLa cells NVe5SJJQS3m2b4TvfIlkcXS7IHHzd4F6 MYC3NkBp NGXwUmlEgXSxc4TheIlkKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gTIVN[SClZXzsd{Bi\nSncjC3NkBpenNiYomgZ492dHSncjDjc5VvfGmwZzDhcoFtgXOrczygTWM2OD1zNzFOwG0> M1j3SVI1Pjh4MEGy
CHO cells NH[zTpREgXSxdH;4bYNqfHliYYPzZZk> MlHtNVIxKGh? NXHucW5wS3m2b4TvfIlkcXS7IHHnZYlve3RiQ1jPJINmdGy|IHHmeIVzKDF{MDDodpMh[nliQ3XscE1VcXSncjDHcI8h[XO|YYmsJGNEPTB;MkGg{txO MXqxPVAxOTFyOB?=
MDCK2 cells NH\xWlZHfW6ldHnvckBie3OjeR?= MmPINVAh|ryP NVH5NolFUW6qaXLpeIlwdiCxZjDoeY1idiCPUmCzJIV5eHKnc4Pl[EBqdiCPRFPLNkBk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCrboTyZYNmdGy3bHHyJGNOTiCobIXvdoV{[2WwY3WgZZQhOTBidV2gZpkhS02IRFGgZZN{[Xl? M2[2XVE4OTd{M{Gx
human HepG2 cells MXjDfZRwfG:6aXPpeJkh[XO|YYm= NX3OcIxLOTRiZHH5dy=> MkXGR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyudXzhdkBFVkFicnXwcIlk[XSrb36gZYZ1\XJiMUSg[IF6ew>? NUTie29OOjB2MEm3NlE>

... Click to View More Cell Line Experimental Data

In vivo Tenofovir (30 mg/kg) completely prevents SIV infection in all macaques without toxicity. Tenofovir treatment reduces plasma viral RNA levels to undetectable, with parallel decreases in the infectivity of plasma and infectious cells in peripheral blood mononuclear cells and cerebrospinal fluid (CSF) and stabilization of CD4+ T-cell numbers. Tenofovir (30 mg/kg, s.c.) completely abrogates HIV infection via intravaginal exposure in pig-tailed macaques. [5]

Protocol

Animal Research:[1]
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  • Animal Models: Macaques
  • Dosages: 30 mg/kg
  • Administration: Subcutaneously
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 4 mg/mL warmed (13.92 mM)
Water 2 mg/mL (6.96 mM)
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% propylene glycol, 5% Tween 80, 65% D5W
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 287.21
Formula

C9H14N5O4P

CAS No. 147127-20-6
Storage powder
in solvent
Synonyms GS-1278
Smiles CC(CN1C=NC2=C(N=CN=C21)N)OCP(=O)(O)O

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04195776 Not yet recruiting Drug: Tenofovir Douche HIV/AIDS|HIV Prevention Johns Hopkins University|National Institute of Allergy and Infectious Diseases (NIAID)|CONRAD June 1 2021 Phase 1
NCT04686279 Not yet recruiting Drug: Tenofovir Douche HIV/AIDS|HIV Prevention University of Pennsylvania|University of North Carolina Chapel Hill|Emory University|Johns Hopkins University|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) April 1 2021 Phase 1

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Reverse Transcriptase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID