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2,6-Dihydroxypurine

Cat.No.S3693

2,6-Dihydroxypurine (Xanthine, Isoxanthine) is a purine base found in most body tissues and fluids, certain plants, and some urinary calculi. It is a product on the pathway of purine degradation.
2,6-Dihydroxypurine Chemical Structure

Chemical Structure

Molecular Weight: 152.11

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: S369301 DMSO]2 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.22%
99.22

Chemical Information, Storage & Stability

Molecular Weight 152.11 Formula

C5H4N4O2

 Storage (From the date of receipt)
CAS No. 69-89-6 Download SDF Storage of Stock Solutions

Synonyms Xanthine, Isoxanthine Smiles C1=NC2=C(N1)C(=O)NC(=O)N2

Solubility

In vitro
Batch:

DMSO : 2 mg/mL (13.14 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05888233 Recruiting
Heart Failure Preserved Ejection Fraction|Resistant Hypertension
VA Office of Research and Development
 August 2 2023 Phase 2
NCT05361044 Recruiting
Liver Transplant Failure
Hospices Civils de Lyon
 August 22 2022 Not Applicable
NCT05351333 Recruiting
Spinal Cord Injuries|Polytrauma|Burns
Spaulding Rehabilitation Hospital|National Institute on Drug Abuse (NIDA)
 August 3 2022 Not Applicable
NCT05256810 Terminated
Gout
Alnylam Pharmaceuticals
 February 25 2022 Phase 1|Phase 2
NCT04676009 Completed
Carcinoma Non-Small-Cell Lung
Centre Leon Berard|Claude Bernard University|Lyon Cancer Research Centre|Hospices Civils de Lyon|Inter-university Laboratory of Human Movement Biology
 January 21 2021 Not Applicable

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