Catalog No.S1704

Emtricitabine  Chemical Structure

Molecular Weight(MW): 247.25

Emtricitabine (FTC) is a new nucleoside agent that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus. It is a reverse transcriptase inhibitor. Intracellular half-life is 39 h.

Size Price Stock Quantity  
In DMSO USD 160 In stock
USD 120 In stock
USD 370 In stock
USD 747 In stock
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Biological Activity

Description Emtricitabine (FTC) is a new nucleoside agent that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus. It is a reverse transcriptase inhibitor. Intracellular half-life is 39 h.
Reverse transcriptase [1]
In vitro

Emtricitabine moderately reduces hepatocyte proliferation independent of effects on mtDNA in HepG2 human hepatoma cells. Emtricitabine plus tenofovir slightly reduced cell proliferation without affecting mitochondrial parameters. [1] Emtricitabine efficiently converts to their active metabolites in PBMCs and CEM cells. Emtricitabine combined with Tenofovir displays additive to synergistic activity against HIV replication in PBMCs and results in strongly synergistic anti-HIV activity in MT-2 cells against both wild-type and mutant virus. [2] Emtricitabine demonstrates antiviral activity against laboratory adapted strains of HIV-1 and HIV-2 in various cell system. Emtricitabine also exhibits antiviral activity in cell culture against feline and simian immuno-deficiency viruses (SIVs). Emtricitabine consistently exhibits up to 10-fold greater activity than lamivudine against all viruses tested in all T-cell lines. Emtricitabine generally demonstrates greater potency in vitro in human PBMCs than in MT-4 lines. [3] Emtricitabine also exhibits anti-HBV activity in vitro (EC50, 0.01–0.04 µM) that is comparable to the anti-HBV activity of 3TC. [4] Emtricitabine is approximately fourfold more active than 3TC in assays in the transformed T-cell line MT-4 infected with HIV-(1IIIB), whereas Zidovudine is more active than Emtricitabine. Emtricitabine, Lamivudine and Zidovudine are equally active against a panel of eight primary HIV-1 isolates from antiretroviral-naive subjects in PBMCs. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HepAD38 cell NWrsSW13TnWwY4Tpc44h[XO|YYm= NVnjb|U1UW6qaXLpeIlwdiCxZjDo[ZBifGm2aYOgRkB3cXK3czDy[ZBtcWOjdHnvckBqdiC2aHWgTIVxSUR|ODDj[YxtKGyrbnWsJGVFPTB;MD6wN{DPxE1? Mnq2NVEyOjh4NUK=
MT2 cells NUToVlFiTnWwY4Tpc44h[XO|YYm= MljqRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXOSCrbn\lZ5Rm\CCrbjDoeY1idiCPVEKgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYLhcEBz\XCuaXPheIlwdixiSVO1NF0xNjB2NDFOwG0> M33UVFE6PTl4OEi1
HeLa P4/R5 cells M3fEeWZ2dmO2aX;uJIF{e2G7 M3XuNWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhKXjFiaX7m[YN1\WRiaX6gbJVu[W5iSHXMZUBRPC:UNTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcnHsJJJmeGyrY3H0bY9vNCCLQ{WwQVAvOTdizszN NFnUNIEyQTV7Nki4OS=>
HepG2 cells NX[zbXR2S3m2b4TvfIlkcXS7IHHzd4F6 NVjlNXNxQSCmYYnz MlrzR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgPUBl[Xm|IHL5JG1VXCCjc4PhfUwhUUN3ME2yO{44KM7:TR?= NGjUbpcyPzh6OE[2Ni=>
MDCK2 cells NEDo[HpHfW6ldHnvckBie3OjeR?= NHnobmMyOCEQvF2= Ml\5TY5pcWKrdHnvckBw\iCqdX3hckBOWlB|IHX4dJJme3OnZDDpckBOTEONMjDj[YxteyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBqdnS{YXPlcIx2dGG{IFPNSkBndHWxcnXzZ4Vv[2ViYYSgNVAhfU1iYomgR21HTEFiYYPzZZk> MWKxO|E4OjNzMR?=

... Click to View More Cell Line Experimental Data


Solubility (25°C)

In vitro DMSO 49 mg/mL (198.17 mM)
Water 49 mg/mL (198.17 mM)
Ethanol 9 mg/mL (36.4 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 247.25


CAS No. 143491-57-0
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03789968 Enrolling by invitation Drug: bictegravir/emtricitabine/tenofovir alafenamide HIV/AIDS Thomas Jefferson University|University of Maryland College Park|Indiana University Health|The Brooklyn Hospital Center|University of Illinois at Chicago|Nova Southeastern University|University of California San Francisco September 1 2019 --
NCT03960645 Recruiting Drug: B/F/TAF HIV-1-infection Gilead Sciences June 28 2019 Phase 1
NCT03917420 Completed Drug: Tenofovir 300Mg Oral Tablet|Drug: Emtricitabine 200 MG HIV/AIDS University of North Carolina Chapel Hill|National Institute of Allergy and Infectious Diseases (NIAID) March 26 2019 Phase 4

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Reverse Transcriptase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID