Emtricitabine
Catalog No.S1704
Molecular Weight(MW): 247.25
Emtricitabine (FTC) is a new nucleoside agent that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus. It is a reverse transcriptase inhibitor. Intracellular half-life is 39 h.
Cited by 1 publication
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Choose Selective Reverse Transcriptase Inhibitors
Biological Activity
| Description | Emtricitabine (FTC) is a new nucleoside agent that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus. It is a reverse transcriptase inhibitor. Intracellular half-life is 39 h. | ||||||||||||||||||||||||||||||||||||||||||||
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| Targets |
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| In vitro |
Emtricitabine moderately reduces hepatocyte proliferation independent of effects on mtDNA in HepG2 human hepatoma cells. Emtricitabine plus tenofovir slightly reduced cell proliferation without affecting mitochondrial parameters. [1] Emtricitabine efficiently converts to their active metabolites in PBMCs and CEM cells. Emtricitabine combined with Tenofovir displays additive to synergistic activity against HIV replication in PBMCs and results in strongly synergistic anti-HIV activity in MT-2 cells against both wild-type and mutant virus. [2] Emtricitabine demonstrates antiviral activity against laboratory adapted strains of HIV-1 and HIV-2 in various cell system. Emtricitabine also exhibits antiviral activity in cell culture against feline and simian immuno-deficiency viruses (SIVs). Emtricitabine consistently exhibits up to 10-fold greater activity than lamivudine against all viruses tested in all T-cell lines. Emtricitabine generally demonstrates greater potency in vitro in human PBMCs than in MT-4 lines. [3] Emtricitabine also exhibits anti-HBV activity in vitro (EC50, 0.01–0.04 µM) that is comparable to the anti-HBV activity of 3TC. [4] Emtricitabine is approximately fourfold more active than 3TC in assays in the transformed T-cell line MT-4 infected with HIV-(1IIIB), whereas Zidovudine is more active than Emtricitabine. Emtricitabine, Lamivudine and Zidovudine are equally active against a panel of eight primary HIV-1 isolates from antiretroviral-naive subjects in PBMCs. [5] |
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| Cell Data |
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Protocol
Solubility (25°C)
| In vitro | DMSO | 49 mg/mL (198.17 mM) |
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| Water | 49 mg/mL (198.17 mM) | |
| Ethanol | 9 mg/mL (36.4 mM) |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 247.25 |
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| Formula | C8H10FN3O3S |
| CAS No. | 143491-57-0 |
| Storage | powder |
| in solvent | |
| Synonyms | N/A |
Bio Calculators
Molarity Calculator
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Molarity Calculator
Clinical Trial Information
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
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| NCT03789968 | Enrolling by invitation | Drug: bictegravir/emtricitabine/tenofovir alafenamide | HIV/AIDS | Thomas Jefferson University|University of Maryland College Park|Indiana University Health|The Brooklyn Hospital Center|University of Illinois at Chicago|Nova Southeastern University|University of California San Francisco | September 1 2019 | -- |
| NCT03960645 | Recruiting | Drug: B/F/TAF | HIV-1-infection | Gilead Sciences | June 28 2019 | Phase 1 |
| NCT03917420 | Completed | Drug: Tenofovir 300Mg Oral Tablet|Drug: Emtricitabine 200 MG | HIV/AIDS | University of North Carolina Chapel Hill|National Institute of Allergy and Infectious Diseases (NIAID) | March 26 2019 | Phase 4 |
| NCT03706924 | Completed | Drug: VM-1500FDC|Drug: Elpida®|Drug: Truvada® | HIV-1-infection | Viriom | June 1 2018 | Phase 1 |
| NCT03270969 | Completed | Drug: Tenofovir Disoproxil Fumarate/Emtricitabine | HIV Prevention | University of Nebraska | January 5 2018 | Phase 1 |
| NCT03197961 | Completed | Combination Product: tenofovir/emtricitabine|Drug: DMPA | HIV/AIDS|Contraception | Jessica Tarleton|University of Pittsburgh | November 17 2017 | Early Phase 1 |
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