Emtricitabine

Catalog No.S1704

Emtricitabine  Chemical Structure

Molecular Weight(MW): 247.25

Emtricitabine (FTC) is a new nucleoside agent that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus. It is a reverse transcriptase inhibitor. Intracellular half-life is 39 h.

Size Price Stock Quantity  
In DMSO USD 160 In stock
USD 120 In stock
USD 370 In stock
USD 747 In stock
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Purity & Quality Control

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Biological Activity

Description Emtricitabine (FTC) is a new nucleoside agent that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus. It is a reverse transcriptase inhibitor. Intracellular half-life is 39 h.
Targets
Reverse transcriptase [1]
In vitro

Emtricitabine moderately reduces hepatocyte proliferation independent of effects on mtDNA in HepG2 human hepatoma cells. Emtricitabine plus tenofovir slightly reduced cell proliferation without affecting mitochondrial parameters. [1] Emtricitabine efficiently converts to their active metabolites in PBMCs and CEM cells. Emtricitabine combined with Tenofovir displays additive to synergistic activity against HIV replication in PBMCs and results in strongly synergistic anti-HIV activity in MT-2 cells against both wild-type and mutant virus. [2] Emtricitabine demonstrates antiviral activity against laboratory adapted strains of HIV-1 and HIV-2 in various cell system. Emtricitabine also exhibits antiviral activity in cell culture against feline and simian immuno-deficiency viruses (SIVs). Emtricitabine consistently exhibits up to 10-fold greater activity than lamivudine against all viruses tested in all T-cell lines. Emtricitabine generally demonstrates greater potency in vitro in human PBMCs than in MT-4 lines. [3] Emtricitabine also exhibits anti-HBV activity in vitro (EC50, 0.01–0.04 µM) that is comparable to the anti-HBV activity of 3TC. [4] Emtricitabine is approximately fourfold more active than 3TC in assays in the transformed T-cell line MT-4 infected with HIV-(1IIIB), whereas Zidovudine is more active than Emtricitabine. Emtricitabine, Lamivudine and Zidovudine are equally active against a panel of eight primary HIV-1 isolates from antiretroviral-naive subjects in PBMCs. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HepAD38 cell M4L3T2Z2dmO2aX;uJIF{e2G7 MUfJcohq[mm2aX;uJI9nKGincHH0bZRqeyCEII\pdpV{KHKncHzpZ4F1cW:wIHnuJJRp\SCKZYDBSFM5KGOnbHygcIlv\SxiRVS1NF0xNjB|IN88US=> NVvx[5h5OTFzMki2OVI>
MT2 cells NXf3XW1XTnWwY4Tpc44h[XO|YYm= NHnHUmdCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJUVZzIHnu[oVkfGWmIHnuJIh2dWGwIF3UNkBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdoFtKHKncHzpZ4F1cW:wLDDJR|UxRTBwMES0JO69VQ>? M1\OfFE6PTl4OEi1
HeLa P4/R5 cells NGXsboRHfW6ldHnvckBie3OjeR?= MV7BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDITXYyKGmwZnXjeIVlKGmwIHj1cYFvKEinTHGgVFQwWjViY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXKjbDDy[ZBtcWOjdHnvckwhUUN3ME2wMlE4KM7:TR?= MVKxPVU6Pjh6NR?=
HepG2 cells M3XTV2N6fG:2b4jpZ4l1gSCjc4PhfS=> NW[5NVY4QSCmYYnz NF;hS5dEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkA6KGSjeYOgZpkhVVSWIHHzd4F6NCCLQ{WwQVI4NjdizszN NGHVS2IyPzh6OE[2Ni=>
MDCK2 cells NVLuVGR1TnWwY4Tpc44h[XO|YYm= MoL1NVAh|ryP M2C5fmlvcGmkaYTpc44hd2ZiaIXtZY4hVVKSMzDlfJBz\XO|ZXSgbY4hVUSFS{KgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcW62cnHj[YxtfWyjcjDDUWYh\my3b4Lld4NmdmOnIHH0JFExKHWPIHL5JGNOTkSDIHHzd4F6 MUixO|E4OjNzMR?=

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 49 mg/mL (198.17 mM)
Water 49 mg/mL (198.17 mM)
Ethanol 9 mg/mL (36.4 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 247.25
Formula

C8H10FN3O3S

CAS No. 143491-57-0
Storage powder
in solvent
Synonyms N/A

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03789968 Enrolling by invitation Drug: bictegravir/emtricitabine/tenofovir alafenamide HIV/AIDS Thomas Jefferson University|University of Maryland College Park|Indiana University Health|The Brooklyn Hospital Center|University of Illinois at Chicago|Nova Southeastern University|University of California San Francisco September 1 2019 --
NCT03960645 Recruiting Drug: B/F/TAF HIV-1-infection Gilead Sciences June 28 2019 Phase 1
NCT03917420 Completed Drug: Tenofovir 300Mg Oral Tablet|Drug: Emtricitabine 200 MG HIV/AIDS University of North Carolina Chapel Hill|National Institute of Allergy and Infectious Diseases (NIAID) March 26 2019 Phase 4
NCT03706924 Completed Drug: VM-1500FDC|Drug: Elpida®|Drug: Truvada® HIV-1-infection Viriom June 1 2018 Phase 1
NCT03270969 Completed Drug: Tenofovir Disoproxil Fumarate/Emtricitabine HIV Prevention University of Nebraska January 5 2018 Phase 1
NCT03197961 Completed Combination Product: tenofovir/emtricitabine|Drug: DMPA HIV/AIDS|Contraception Jessica Tarleton|University of Pittsburgh November 17 2017 Early Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Reverse Transcriptase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID