Emtricitabine

Catalog No.S1704

Emtricitabine  Chemical Structure

Molecular Weight(MW): 247.25

Emtricitabine (FTC) is a new nucleoside agent that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus. It is a reverse transcriptase inhibitor. Intracellular half-life is 39 h.

Size Price Stock Quantity  
In DMSO USD 160 In stock
USD 120 In stock
USD 370 In stock
USD 747 In stock
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Purity & Quality Control

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Biological Activity

Description Emtricitabine (FTC) is a new nucleoside agent that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus. It is a reverse transcriptase inhibitor. Intracellular half-life is 39 h.
Targets
Reverse transcriptase [1]
In vitro

Emtricitabine moderately reduces hepatocyte proliferation independent of effects on mtDNA in HepG2 human hepatoma cells. Emtricitabine plus tenofovir slightly reduced cell proliferation without affecting mitochondrial parameters. [1] Emtricitabine efficiently converts to their active metabolites in PBMCs and CEM cells. Emtricitabine combined with Tenofovir displays additive to synergistic activity against HIV replication in PBMCs and results in strongly synergistic anti-HIV activity in MT-2 cells against both wild-type and mutant virus. [2] Emtricitabine demonstrates antiviral activity against laboratory adapted strains of HIV-1 and HIV-2 in various cell system. Emtricitabine also exhibits antiviral activity in cell culture against feline and simian immuno-deficiency viruses (SIVs). Emtricitabine consistently exhibits up to 10-fold greater activity than lamivudine against all viruses tested in all T-cell lines. Emtricitabine generally demonstrates greater potency in vitro in human PBMCs than in MT-4 lines. [3] Emtricitabine also exhibits anti-HBV activity in vitro (EC50, 0.01–0.04 µM) that is comparable to the anti-HBV activity of 3TC. [4] Emtricitabine is approximately fourfold more active than 3TC in assays in the transformed T-cell line MT-4 infected with HIV-(1IIIB), whereas Zidovudine is more active than Emtricitabine. Emtricitabine, Lamivudine and Zidovudine are equally active against a panel of eight primary HIV-1 isolates from antiretroviral-naive subjects in PBMCs. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HepAD38 cell NYC2NZBRTnWwY4Tpc44h[XO|YYm= Ml7nTY5pcWKrdHnvckBw\iCqZYDheIl1cXNiQjD2bZJ2eyC{ZYDsbYNifGmxbjDpckB1cGViSHXwRWQ{QCClZXzsJIxqdmVuIFXEOVA:OC5yMzFOwG0> NV\mW2lCOTFzMki2OVI>
MT2 cells M2POdWZ2dmO2aX;uJIF{e2G7 M4jmVmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhKXjFiaX7m[YN1\WRiaX6gbJVu[W5iTWSyJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwhemWybHnjZZRqd25uIFnDOVA:OC5yNESg{txO NYP4[lVzOTl3OU[4PFU>
HeLa P4/R5 cells MV7GeY5kfGmxbjDhd5NigQ>? MV3BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDITXYyKGmwZnXjeIVlKGmwIHj1cYFvKEinTHGgVFQwWjViY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXKjbDDy[ZBtcWOjdHnvckwhUUN3ME2wMlE4KM7:TR?= NFflNGsyQTV7Nki4OS=>
HepG2 cells NHewSolEgXSxdH;4bYNqfHliYYPzZZk> NI\4U286KGSjeYO= MmTSR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgPUBl[Xm|IHL5JG1VXCCjc4PhfUwhUUN3ME2yO{44KM7:TR?= NFr1TZEyPzh6OE[2Ni=>
MDCK2 cells MVnGeY5kfGmxbjDhd5NigQ>? NHXD[owyOCEQvF2= NXexOoRjUW6qaXLpeIlwdiCxZjDoeY1idiCPUmCzJIV5eHKnc4Pl[EBqdiCPRFPLNkBk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCrboTyZYNmdGy3bHHyJGNOTiCobIXvdoV{[2WwY3WgZZQhOTBidV2gZpkhS02IRFGgZZN{[Xl? NFjWeYQyPzF5MkOxNS=>

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 49 mg/mL (198.17 mM)
Water 49 mg/mL (198.17 mM)
Ethanol 9 mg/mL (36.4 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 247.25
Formula

C8H10FN3O3S

CAS No. 143491-57-0
Storage powder
in solvent
Synonyms N/A

Bio Calculators

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03067285 Recruiting HIV Infections Fundacion SEIMC-GESIDA September 8 2017 Phase 4
NCT03060785 Completed HIV Prevention Johns Hopkins University March 8 2016 Phase 1
NCT03425994 Recruiting Chronic Hepatitis B in HIV Patient|Kidney Injury|Bone Diseases National Taiwan University Hospital|National Taiwan University Hospital Hsin-Chu Branch|National Taiwan University Hospital Yun-Lin Branch|Far Eastern Memorial Hospital|Taoyuan General Hospital|Mackay Memorial Hospital|Chung Shan Medical University|Taichung Veterans General Hospital|National Cheng-Kung University Hospital|Changhua Christian Hospital|Chi Mei Medical Hospital|Kaohsiung Veterans General Hospital.|Kaohsiung Medical University Chung-Ho Memorial Hospital|Chang Gung Memorial Hospital|E-DA Hospital|Lotung Poh-Ai Hospital February 6 2018 --
NCT02431247 Active not recruiting Immunodeficiency Virus Type 1 Human Janssen Sciences Ireland UC July 6 2015 Phase 3
NCT02198443 Completed HIV Fundacion Clinic per a la Recerca Biomédica June 6 2015 Phase 4
NCT01854775 Active not recruiting Acquired Immune Deficiency Syndrome (AIDS)|HIV Infections Gilead Sciences May 6 2013 Phase 2|Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Reverse Transcriptase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID