Fingolimod (FTY-720)

Synonyms: FTY-720A

Fingolimod (FTY-720) is a sphingosine 1-phosphate receptor modulator used for the treatment of relapsing-remitting multiple sclerosis.

Fingolimod (FTY-720) Chemical Structure

Fingolimod (FTY-720) Chemical Structure

CAS No. 162359-55-9

Purity & Quality Control

Fingolimod (FTY-720) Related Products

Biological Activity

Description Fingolimod (FTY-720) is a sphingosine 1-phosphate receptor modulator used for the treatment of relapsing-remitting multiple sclerosis.
Targets
S1P receptor [1]
In vitro
In vitro

 It reversibly redistributes T and B cells from the circulation to secondary lymphoid organs like peripheral and mesenteric lymph nodes and Peyer's patches, thereby causing a state of peripheral lymphopenia[1].

Cell Research Cell lines NSCLC cells
Concentrations 10 μM
Incubation Time 72 h
Method

Cells were treated with various concentrations of drug for 72 h.

Experimental Result Images Methods Biomarkers Images PMID
Western blot p-myosin IIA HC / p-histone H3 S10 / Histone H3 / Cleaved TRPM7 PTEN / p53 / p-AKT / p-GSK3β / p-ERK / ERK / p-STAT3 / STAT3 / Mcl-1 / Cyclin D1 29299124
In Vivo
In vivo

 Absorption is food-independent and slow (maximal plasma concentration after 12-16 h), but extensive, and its bioavailability is high (93%). It reaches steady state concentrations after 1-2 months during daily intake.It has a large volume of distribution of approx. 20L/kg and shows slow blood clearance (6.3±2.3 L/h), resulting in a half-life of 6-9 days[1].

 

Animal Research Animal Models C57/B6 mice
Dosages 1 mg/kg
Administration o.g.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05141669 Completed
Multiple Sclerosis
Novartis Pharmaceuticals|Novartis
May 18 2020 --
NCT03345940 Terminated
Relapsing Remitting Multiple Sclerosis
Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta|Patient-Centered Outcomes Research Institute|Universita degli Studi di Genova
April 30 2017 Phase 4
NCT02575365 Terminated
Cognition|Brain Volume Loss
Novartis Pharmaceuticals|Novartis
February 16 2016 Phase 4

Chemical Information & Solubility

Molecular Weight 307.47 Formula

C19H33NO2

CAS No. 162359-55-9 SDF --
Smiles CCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 13 mg/mL ( (42.28 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 5 mg/mL

Water : Insoluble


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In vivo
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