Calcium Channel

Signaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S1356 Levetiracetam 34 mg/mL 34 mg/mL 34 mg/mL
S1813 Amlodipine Besylate <1 mg/mL 113 mg/mL 14 mg/mL
S1293 Cilnidipine <1 mg/mL 99 mg/mL 15 mg/mL
S1811 Amiloride HCl 6 mg/mL 53 mg/mL 5 mg/mL
S1425 Ranolazine 2HCl 100 mg/mL 100 mg/mL <1 mg/mL
S9566 Bepridil hydrochloride -1 mg/mL 41 mg/mL -1 mg/mL
S5255 Nicardipine 30 mg/mL 95 mg/mL 95 mg/mL
S9400 Rhynchophylline -1 mg/mL 76 mg/mL -1 mg/mL
S5514 Lanthanum(III) chloride heptahydrate -1 mg/mL 50 mg/mL -1 mg/mL
S5279 Fendiline hydrochloride -1 mg/mL 70 mg/mL -1 mg/mL
S4977 Efonidipine -1 mg/mL 100 mg/mL 40 mg/mL
S8691 ML204 <1 mg/mL 45 mg/mL 45 mg/mL
S3867 (E)-Cardamoni -1 mg/mL 54 mg/mL -1 mg/mL
S3845 Panaxadiol <1 mg/mL <1 mg/mL 22 mg/mL
S3883 Protopine -1 mg/mL 30 mg/mL -1 mg/mL
S4202 Verapamil HCl 50 mg/mL 98 mg/mL 12 mg/mL
S2482 Manidipine 2HCl <1 mg/mL 21 mg/mL <1 mg/mL
S1799 Ranolazine <1 mg/mL 86 mg/mL 20 mg/mL
S1662 Isradipine <1 mg/mL 74 mg/mL 74 mg/mL
S1905 Amlodipine <1 mg/mL 82 mg/mL 82 mg/mL
S1885 Felodipine <1 mg/mL 77 mg/mL 72 mg/mL
S2481 Manidipine <1 mg/mL 122 mg/mL 3 mg/mL
S1748 Nisoldipine <1 mg/mL 77 mg/mL 60 mg/mL
S1747 Nimodipine <1 mg/mL 84 mg/mL 84 mg/mL
S2721 Nilvadipine <1 mg/mL 77 mg/mL 33 mg/mL
S1994 Lacidipine <1 mg/mL 91 mg/mL 22 mg/mL
S2114 Dronedarone HCl <1 mg/mL 80 mg/mL 40 mg/mL
S4181 Nicardipine HCl <1 mg/mL 100 mg/mL <1 mg/mL
S1808 Nifedipine <1 mg/mL 69 mg/mL 15 mg/mL
S2080 Clevidipine Butyrate <1 mg/mL 91 mg/mL 3 mg/mL
S2017 Benidipine HCl <1 mg/mL 8 mg/mL <1 mg/mL
S2918 HC-030031 <1 mg/mL 32 mg/mL <1 mg/mL
S2030 Flunarizine 2HCl <1 mg/mL 5 mg/mL 3 mg/mL
S2491 Nitrendipine <1 mg/mL 72 mg/mL <1 mg/mL
S3053 Azelnidipine <1 mg/mL 117 mg/mL 7 mg/mL
S2573 Tetracaine HCl 60 mg/mL 60 mg/mL 30 mg/mL
S1865 Diltiazem HCl 90 mg/mL 90 mg/mL 4 mg/mL
S7999 SKF96365 80 mg/mL 80 mg/mL 80 mg/mL
S3045 Cinepazide maleate 107 mg/mL 107 mg/mL <1 mg/mL
S8380 YM-58483 (BTP2) <1 mg/mL 84 mg/mL 84 mg/mL
S4626 Ethosuximide 28 mg/mL 28 mg/mL 28 mg/mL
S4597 Lercanidipine hydrochloride <1 mg/mL 66 mg/mL 1 mg/mL
S3700 DHBP dibromide 100 mg/mL 100 mg/mL 100 mg/mL
S2403 Tetrandrine <1 mg/mL 1 mg/mL 2 mg/mL
S4084 Lomerizine 2HCl <1 mg/mL 100 mg/mL 52 mg/mL
S4648 Dantrolene sodium hemiheptahydrate <1 mg/mL 14 mg/mL <1 mg/mL
S3682 Ethyl 3-Aminobenzoate methanesulfonate 52 mg/mL 52 mg/mL 52 mg/mL
S3674 Levamlodipine 81 mg/mL 81 mg/mL 81 mg/mL
S4727 Cinnarizine <1 mg/mL 73 mg/mL <1 mg/mL
S2050 Strontium Ranelate <1 mg/mL <1 mg/mL <1 mg/mL
S8073 Optovin <1 mg/mL 63 mg/mL <1 mg/mL
S7924 Bay K 8644 <1 mg/mL 71 mg/mL 71 mg/mL
S4209 Chlorocresol <1 mg/mL 29 mg/mL 29 mg/mL
S3809 Imperatorin -1 mg/mL 54 mg/mL -1 mg/mL
S3942 Cardamonin <1 mg/mL 54 mg/mL 54 mg/mL
S9151 Praeruptorin E -1 mg/mL 34.6 mg/mL -1 mg/mL
S4787 Methyl syringate -1 mg/mL 42 mg/mL -1 mg/mL
S2535 Econazole nitrate <1 mg/mL 89 mg/mL 5 mg/mL
S2415 Astragaloside A <1 mg/mL 100 mg/mL <1 mg/mL
S5478 Dantrolene sodium -1 mg/mL 67 mg/mL -1 mg/mL
S2446 Levosimendan <1 mg/mL 56 mg/mL <1 mg/mL
S1911 Disodium Cromoglycate 2 mg/mL <1 mg/mL <1 mg/mL
Catalog No. Information Product Use Citations Product Validations


Levetiracetam is an anticonvulsant medication used to treat epilepsy.


Amlodipine Besylate

Amlodipine Besylate is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.



Cilnidipine is a unique L-type and N-type calcium channel blocker, used for high blood pressure treatment.


Amiloride HCl

Amiloride is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA)(Ki=7 μM).


Ranolazine 2HCl

Ranolazine 2HCl is a calcium uptake inhibitor via the sodium/calcium channal, used to treat chronic angina.


Bepridil hydrochloride

Bepridil hydrochloride is an anti-anginal drug classified as a calcium channel blocker. It also blocks multiple other ion channels, including sodium and potassium channels.



Nicardipine is a potent calcium channel blockader with marked vasodilator action.



Rhynchophylline, an active component isolated from species of the genus Uncaria, acts as a calcium channel blocker and is widely used in traditional Chinese medicine mainly for treating ailments of central nervous and cardiovascular systems, such as lightheadedness, convulsions, numbness, and hypertension.


Lanthanum(III) chloride heptahydrate

Lanthanum(III) chloride is the inorganic compound used in biochemical research to block the activity of divalent cation channels, mainly calcium channels.


Fendiline hydrochloride

Fendiline hydrochloride is the hydrochloride salt form of Fendiline, which is an L-type calcium channel blocker and also a specific inhibitor of K-Ras plasma membrane targeting with no detectable effect on the localization of H- and N-Ras.



Efonidipine is an L- and T-type calcium channel blocker leading to vasodilation and decreased automaticity of the heart. It also suppresses aldosterone secretion from the adrenal.



ML204 is a novel, potent, and selective TRPC4 channel inhibitor with apparent IC50 values of about 1 μM in fluorescent intracellular Ca2+ assays and about 3 μM in whole-cell voltage clamp experiments. It exhibits some selectivity within the TRPC subfamily of channels and higher selectivity against other TRP channels and non-TRP channels.



Cardamonin is a naturally occurring chalcone with strong anti-inflammatory activity. It is a novel TRPA1 antagonist with IC50 of 454 nM and also a NF-kB inhibitor.



Panaxadiol is a triterpene sapogenin originally found in species of Panax (ginseng) and exhibits anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities. It inhibits Ca2+ channels, decreasing channel open time and open state probability in vitro and displaying anti-arrhythmic potential.



Protopine, an alkaloid present in different plants, has been shown to exhibit a number of activities, such as inhibition of calcium influx through both voltage and receptor-operated channels and inhibition of rabbit blood platelet aggregation. It also possesses anti-cholinergic and anti-histaminic as well as anti-bacterial activities.


Verapamil HCl

Verapamil HCl is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent.


Manidipine 2HCl

Manidipine 2HCl is a HCl salt form of Manidipine, which is a calcium channel blocker with IC50 of 2.6 nM, used clinically as an antihypertensive. Phase 4.



Ranolazine is a calcium uptake inhibitor via the sodium/calcium channel, used to treat chronic angina.



Isradipine is a potent and selective L-type voltage-gated calcium channel blocker, used to treat high blood pressure.



Amlodipine is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.



Felodipine is a selective L-type Ca2+ channel blocker with IC50 of 0.15 nM.



Manidipine is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive.



Nisoldipine (Sular) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM.



Nimodipine is a dihydropyridine calcium channel blocker and an autophagy inhibitor, used in the treatment of high blood pressure.



Nilvadipine is a potent calcium channel blocker with an IC50 of 0.03 nM.



Lacidipine is a L-type calcium channel blocker, used for treating high blood pressure.


Dronedarone HCl

Dronedarone HCl is a multichannel blocker targeting potassium channel, sodium channel and calcium channel, used as an antiarrhythmic drug for treatment of atrial fibrillation (AF).


Nicardipine HCl

Nicardipine is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders.



Nifedipine is a dihydropyridine calcium channel blocker, used to lower hypertension and to treat angina.


Clevidipine Butyrate

Clevidipine Butyrate is a dihydropyridine calcium channel blocker, uses as an agent for the reduction of blood pressure.


Benidipine HCl

Benidipine HCl is a hydrochloride salt form of benidipine which is a dihydropyridine calcium channel blocker.



HC-030031 is a selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx with IC50 of 6.2 μM and 5.3 μM respectively.


Flunarizine 2HCl

Flunarizine 2HCl is a dihydrochloride salt form which is a calcium channel blocker with a Ki of 68 nM.



Nitrendipine is a dihydropyridine calcium channel blocker with an IC50 of 95 nM.



Azelnidipine is a dihydropyridine calcium channel blocker.


Tetracaine HCl

Tetracaine HCl is a hydrochloride salt form of tetracaine which is a potent local anaesthetic and a channel function allosteric inhibitor.


Diltiazem HCl

Diltiazem HCl (Tiazac) is a benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions.



SKF96365, originally identified as a blocker of receptor-mediated calcium entry, is widely used diagnostically, as a blocker of transient receptor potential canonical type (TRPC) channels.


Cinepazide maleate

Cinepazide maleate is a maleate salt form of cinepazide which is a vasodilator.


YM-58483 (BTP2)

YM-58483/BTP2 is a blocker of store-operated Ca2+ entry (SOCE), which regulates the activation of non-excitable cells such as lymphocytes.



Ethosuximide is a succinimide anticonvulsant, used mainly in absence seizures; A calcium channel blocker.


Lercanidipine hydrochloride

Lercanidipine is a calcium channel blocker of the dihydropyridine class.


DHBP dibromide

DHBP, a viologen for electrochromic memory display agent, inhibits the calcium release induced by 2 mM caffeine and 2 μg/ml polylysine with an IC50 value of 5 μg/ml and 4 μg/ml respectively.



Tetrandrine, a bis-benzylisoquinoline alkaloid derived from Stephania tetrandra, is a calcium channel blocker.


Lomerizine 2HCl

Lomerizine dihydrochloride is a relatively new L- and T-type calcium channel blocker used in the treatment of migraine.


Dantrolene sodium hemiheptahydrate

Dantrolene sodium hemiheptahydrate ia a skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber.


Ethyl 3-Aminobenzoate methanesulfonate

Ethyl 3-Aminobenzoate can block the generation of action potentials via voltage-dependent Na+-channels and usually used for anesthesia, sedation, or euthanasia of fish.



Levamlodipine is a pharmacologically active enantiomer of amlodipine which belongs to the dihydropyridine group of calcium channel blocker. It acts on the L-type of calcium channels and its treatment results in vasodilation and a fall in blood pressure.



Cinnarizine is a medication derivative of piperazine, and characterized as an antihistamine and a calcium channel blocker.


Strontium Ranelate

Strontium Ranelate is a strontium(II) salt of ranelic acid for (-)-desmethoxyverapamil binding to calcium channel with IC50 of 0.5 mM.



Optovin is a reversible photoactivated TRPA1 activator.


Bay K 8644

Bay K 8644 is a potent, selective activator of L-type Ca2+ channel with IC50 of 17.3 nM.



Chlorocresol is an activator of ryanodine receptor.



Imperatorin, a naturally occurring psoralen-type furanocoumarin, is a potent myorelaxant agent and acts as a calcium antagonist on vascular smooth muscle.



Cardamonin, isolated from the fruits of Alpinia species, is a chalconoid with anti-inflammatory and anti-tumor activity. It has been shown to be a novel antagonist of hTRPA1 cation channel with IC50 of 454 nM while does not interact with TRPV1 nor TRPV4 channel.


Praeruptorin E

Praeruptorin E, isolated from Peucedanum praeruptorum Dunn., is a cardiotonic agent with selective cardiac calcium channel agonistic effect.


Methyl syringate

Methyl syringate, a plant phenolic compound, is a specific and selective TRPA1 agonist.


Econazole nitrate

Econazole Nitrate is a Ca2+ channel blocker, used as an antifungal medicine that fights infections caused by fungus.


Astragaloside A

Astragaloside A (Astragaloside IV) is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases.


Dantrolene sodium

Dantrolene sodium acts as a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.



Levosimendan is a calcium sensitizer acting through calcium-dependent binding to cardiac troponin C (cTnC), provides treatment for heart failure.


Disodium Cromoglycate

Disodium Cromoglycate is an antiallergic drug with IC50 of 39 μg/mL.