Ranolazine 2HCl

For research use only.

Catalog No.S1425 Synonyms: RS-43285

1 publication

Ranolazine 2HCl Chemical Structure

CAS No. 95635-56-6

Ranolazine 2HCl (RS-43285) is a calcium uptake inhibitor via the sodium/calcium channal, used to treat chronic angina.

Selleck's Ranolazine 2HCl has been cited by 1 publication

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Biological Activity

Description Ranolazine 2HCl (RS-43285) is a calcium uptake inhibitor via the sodium/calcium channal, used to treat chronic angina.
Calcium channel [1]
In vitro

Ranolazine selectively inhibits late I(Na), reduces [Na(+)](i)-dependent calcium overload and attenuates the abnormalities of ventricular repolarisation and contractility that are associated with ischaemia/reperfusion and heart failure in myocardial cells. [1] Ranolazine significantly and reversibly shortens the action potential duration (APD) of myocytes stimulated at either 0.5 Hz or 0.25 Hz in a concentration-dependent manner in left ventricular myocytes of dogs. Ranolazine at 5 and 10 mM reversibly shortens the duration of twitch contractions (TC) and abolished the after contraction. Ranolazine is found to bind more tightly to the inactivated state than the resting state of the sodium channel underlying I(NaL). [2]

In vivo Ranolazine (10 mM) significantly increases glucose oxidation 1.5-fold to 3-fold under conditions in which the contribution of glucoseto overall ATP production is low (low Ca, high FA, with insulin), high (high Ca, low Fa, with pacing), or intermediate in working hearts. Ranolazine similarly increases glucose oxidation in normoxic Langendorff hearts (high Ca, low FA; 15 mL/min). Ranolazine also significantly increases it during flow reduction to 7 mL/min, 3 mL/min, and 0.5 mL/min. Ranolazine significantly improves functional outcome, which is associated with significant increases in glucoseoxidation, a reversal of the increased FA oxidation seen in control reperfusions (versus preischemic), and a smaller but significant increase in glycolysis in reperfuse dischemic working hearts. [3]


Solubility (25°C)

In vitro DMSO 100 mg/mL (199.81 mM)
Water 100 mg/mL (199.81 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 500.46


CAS No. 95635-56-6
Storage powder
in solvent
Synonyms RS-43285

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03486561 Unknown status Drug: Ranolazine Chronic Stable Angina OBS Pakistan April 1 2018 Phase 4
NCT03044964 Unknown status Drug: Ranolazine|Drug: Placebo Angina Amit Malhotra MD|Gilead Sciences|Stern Cardiovascular Foundation Inc. January 10 2017 Phase 4
NCT02252406 Completed Drug: Ranolazine|Other: Placebo Stable Angina|Metabolic Syndrome University of Florida September 2015 Phase 4
NCT02360397 Completed Drug: ranolazine Ventricular Premature Complexes|Myocardial Ischemia Kent Hospital Rhode Island|Gilead Sciences December 2014 Phase 2
NCT02156336 Terminated Drug: Ranolazine|Drug: Placebo Diabetic Peripheral Neuropathic Pain Horizons International Peripheral Group|Gilead Sciences May 2014 Phase 4

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