Ethosuximide

For research use only.

Catalog No.S4626

1 publication

Ethosuximide Chemical Structure

CAS No. 77-67-8

Ethosuximide is a succinimide anticonvulsant, used mainly in absence seizures; A calcium channel blocker.

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Selleck's Ethosuximide has been cited by 1 publication

1 Customer Review

  • Antidepressant effects caused by systemic ethosuximide injection (200 mg kg−1, i.p.; c, d) in the FST(forced swim test) and SPT (sucrose preference test) 1 h after treatment.

    Nature, 2018, 554(7692):317-322. Ethosuximide purchased from Selleck.

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Biological Activity

Description Ethosuximide is a succinimide anticonvulsant, used mainly in absence seizures; A calcium channel blocker.
In vitro

Ethosuximide(ETH) enhances hippocampal derived NSC proliferation and neurospheres formation in vitro. Low concentration of ETH induces proliferation of NSC, while higher concentrations of ETH are cytotoxic. Also, ETH activates the PI3K/Akt signal transduction pathway in adult hippocampal NSC in vitro. Blockade of the PI3K/Akt pathway inhibits ETH induced hippocampal NSC neuronal differentiation[3].

In vivo Anti-epileptic drug ethosuximide rescues the short lifespan and chemosensory defects exhibited by C. elegans null mutants of dnj-14, the worm orthologue of the DNAJC5 gene mutated in autosomal-dominant adult-onset neuronal ceroid lipofuscinosis. It also ameliorates the locomotion impairment and short lifespan of worms expressing a human Tau mutant that causes frontotemporal dementia[1]. Ethosuximide extends lifespan by inhibiting the function of specific chemosensory neurons[2]. It increases neurogenesis, reduces neurodegeneration, and reverses cognitive impairments in rat model of AD like phenotypes[3].

Protocol

Cell Research:

[1]

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  • Cell lines: Mouse neuroblastoma cell line (N2A)
  • Concentrations: 0.1, 0.56, 1 mg/ml
  • Incubation Time: 5 h
  • Method:

    Mouse Neuro2A (N2A) neuroblastoma cells are cultured on 6-well plates and treated with retinoic acid to induce neuronal differentiation. After 24 h, N2A cells are treated with vehicle control (PBS) or increasing concentrations of ethosuximide for 5 h. Total RNA is then isolated, DNase-treated and reverse transcribed to cDNA. qRT-PCR is run above normalising to the reference genes glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and β-actin (ACTB).


    (Only for Reference)
Animal Research:

[3]

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  • Animal Models: Adult Wistar rats
  • Dosages: 125 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 28 mg/mL (198.34 mM)
Water 28 mg/mL (198.34 mM)
Ethanol 28 mg/mL (198.34 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 141.17
Formula

C7H11NO2

CAS No. 77-67-8
Storage powder
in solvent
Synonyms N/A
Smiles CCC1(CC(=O)NC1=O)C

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02973542 Unknown status Drug: Ethosuximide|Other: Placebo Irritable Bowel Syndrome University Hospital Clermont-Ferrand|SFETD (Socièté Française d''Etude et de Traitement de la Douleur) April 30 2018 Phase 2
NCT02100046 Completed Drug: Zarontin® (ethosuximide) and Stodal® Neuropathic Traumatic Pain|Pain NRS ≥ 4|Peripheral Neuropathic Pain|Neuropathic Pain Diagnostic Questionnaire (DN4) ≥ 4 University Hospital Clermont-Ferrand|Fondation Apicil March 2014 Phase 2

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID