Home Transmembrane Transporters Calcium Channel inhibitor - Ras inhibitor Fendiline hydrochloride

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Fendiline hydrochloride Calcium Channel inhibitor

Cat.No.S5279

Fendiline hydrochloride is the hydrochloride salt form of Fendiline, which is an L-type calcium channel blocker and also a specific inhibitor of K-Ras plasma membrane targeting with no detectable effect on the localization of H- and N-Ras.
Fendiline hydrochloride Calcium Channel inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 351.91

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Quality Control

Batch: S527901 DMSO]70 mg/mL]false]]]false]]]false Purity: 99.86%
99.86

Chemical Information, Storage & Stability

Molecular Weight 351.91 Formula

C23H25N.HCl

 Storage (From the date of receipt)
CAS No. 13636-18-5 -- Storage of Stock Solutions

Synonyms N/A Smiles CC(C1=CC=CC=C1)NCCC(C2=CC=CC=C2)C3=CC=CC=C3.Cl

Solubility

In vitro
Batch:

DMSO : 70 mg/mL (198.91 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
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In vivo Formulation Calculator (Clear solution)

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Mechanism of Action

Targets/IC50/Ki
K-ras [1]
L-type calcium channel [1]
In vitro
Fendiline, an L-type calcium channel blocker, is a specific inhibitor of K-Ras plasma membrane targeting with no detectable effect on the localization of H- and N-Ras. Fendiline does not inhibit K-Ras posttranslational processing but significantly reduced nanoclustering of K-Ras and redistributed K-Ras from the plasma membrane to the endoplasmic reticulum (ER), Golgi apparatus, endosomes, and cytosol. Fendiline significantly inhibited signaling downstream of constitutively active K-Ras and endogenous K-Ras signaling in cells transformed by oncogenic H-Ras. Consistent with these effects, fendiline blocked the proliferation of pancreatic, colon, lung, and endometrial cancer cell lines expressing oncogenic mutant K-Ras[1].
References

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