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CAS No. 141505-33-1
Levosimendan is a calcium sensitizer acting through calcium-dependent binding to cardiac troponin C (cTnC), provides treatment for heart failure.
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(B-E) The % of GFP-positive cells upon compound treatment were determined for the indicated HIV-1 latency cell lines (B. J-LAT 6.3; C. JLAT 10.6; D. CA5; E. EF7). Results were normalized to DMSO control. Values represent the mean ± s.d. (n = 4-6). * p < 0.05, one-way ANOVA followed by Tukey’s multiplecomparison test
Antiviral Res, 2017, 146:76-85. Levosimendan purchased from Selleck.
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|Description||Levosimendan is a calcium sensitizer acting through calcium-dependent binding to cardiac troponin C (cTnC), provides treatment for heart failure.|
Levosimendan is a calcium sensitizer acting through calcium-dependent binding to cardiac troponin C (cTnC). Levosimendan at 3 μM decreases the value of Ca50 from 2.73μM to 1.19 μM. levosimendan exhibits its calcium sensitizing effect through calcium-dependent binding to the N-terminal domain of cTnC.  Levosimendan significantly hyperpolarizes resting potential of rat mesenteric arterial myocytes with an EC50 of 2.9 μM and maximal effect (19.5 mV) at 10 μM, probably through activation of a glibenclamide-sensitive K+ channel.  Levosimendan has inotropic and lusitropic actions in failing human myocardium, with average maximum increase in twitch tension of 47% at a levosimendan concentration of 0.8 μM.  Levosimendan causes rapid dose-dependent improvement in hemodynamic function in patients with decompensated heart failure. 
|In vivo||Levosimendan at low concentrations (0.03 to 0.1 μM) acts preferably as a Ca2+ sensitizer, whereas at higher concentrations (0.1 to 0.3 μmol/L) its action as a phosphodiesterase inhibitor contributes to the positive inotropic effect. |
|In vitro||DMSO||56 mg/mL (199.8 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04252404||Not yet recruiting||--||Acute Heart Failure||Arcothova||January 28 2020||--|
|NCT04323709||Completed||Other: Data collection|Other: Data analysis||Cardiogenic Shock|Refractory Shock||Hospices Civils de Lyon||January 1 2019||--|
|NCT03681379||Not yet recruiting||--||Acute Heart Failure||Nantes University Hospital||October 1 2018||--|
|NCT03764722||Recruiting||Drug: Levosimendan||Systolic Heart Failure||Collegium Medicum w Bydgoszczy||August 1 2018||Phase 4|
|NCT03346824||Unknown status||--||Cardiogenic Shock||University Hospital Strasbourg France||November 15 2017||--|
|NCT03189901||Enrolling by invitation||Drug: Regular management+Levosimendan||Early Management|Acute Heart Failure|NSTEMI - Non-ST Segment Elevation MI||Qilu Hospital of Shandong University||July 1 2017||Phase 4|
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