Dantrolene sodium

Catalog No.S5478

Dantrolene sodium Chemical Structure

Molecular Weight(MW): 336.23

Dantrolene sodium acts as a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.

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USD 107 In stock
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Biological Activity

Description Dantrolene sodium acts as a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.

Protocol

References

Solubility (25°C)

In vitro DMSO 67 mg/mL (199.26 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 336.23
Formula

C14H9N4NaO5

CAS No. 14663-23-1
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03189433 Active not recruiting Drug Toxicity Psychotropic Agents Psychostimulants Eagle Pharmaceuticals Inc. August 12 2017 Phase 2
NCT03189433 Active not recruiting Drug Toxicity Psychotropic Agents Psychostimulants Eagle Pharmaceuticals Inc. August 12 2017 Phase 2
NCT02829268 Recruiting Wolfram Syndrome|Diabetes Mellitus|Optic Nerve Atrophy|Ataxia Washington University School of Medicine|National Institutes of Health (NIH) January 2017 Phase 1|Phase 2
NCT02829268 Recruiting Wolfram Syndrome|Diabetes Mellitus|Optic Nerve Atrophy|Ataxia Washington University School of Medicine|National Institutes of Health (NIH) January 2017 Phase 1|Phase 2
NCT02513095 Completed Heat Stroke Eagle Pharmaceuticals Inc.|Quintiles Inc. September 2015 Phase 2
NCT02513095 Completed Heat Stroke Eagle Pharmaceuticals Inc.|Quintiles Inc. September 2015 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Calcium Channel Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID