Econazole nitrate

Catalog No.S2535 Synonyms: NSC 243115

Econazole nitrate  Chemical Structure

Molecular Weight(MW): 444.7

Econazole Nitrate is a Ca2+ channel blocker, used as an antifungal medicine that fights infections caused by fungus.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
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Biological Activity

Description Econazole Nitrate is a Ca2+ channel blocker, used as an antifungal medicine that fights infections caused by fungus.
Targets
Calcium channel [1]
In vitro

Econazole nitrate is an effective inducer of micronuclei over a narrow dose range in cell lines V79, XEM2 and XEMd-MZ (expresses CYP1A2). [1] Econazole nitrate inhibits the proliferation of MCF-7 cells in a time- and dose-dependent manner by MTT method and colony forming assay. Econazole nitrate results in typical characteristics of apoptosis including the morphological changes and DNA fragmentation in MCF-7 cells. Econazole nitrate results in the decrease expression of procaspase-3, procaspase-9 and bcl-2. [2] Econazole inhibits ADP-ribose-activated currents in HEK-293 cells expressing recombinant human TRPM2 (hTRPM2). Econazole produces an essentially complete inhibition of the TRPM2-mediated current. [3] Econazole (25-50 mM) partially inhibits capacitative Ca2+ entry induced by cyclopiazonic acid, another endoplasmic reticulum Ca2+ pump inhibitor. Econazole induces Ca2+ influx via two separate pathways: one is sensitive to La3+, the other is not. [4] Econazole reversibly inhibits (Bu)(2)cAMP-stimulated progesterone production in a dose- and time-dependent manner in MA-10 cells without affecting total protein synthesis or P450(scc) and 3beta-hydroxysteroid dehydrogenase (3beta-HSD) enzyme expression or activity. [5] Econazole is a store-operated Ca2+ channel antagonist which induces cytotoxic cell death of leukemia. Econazole (5-20 mM) arrests human colon cancer cells at the G0/G1 phase of the cell cycle. Econazole induces COLO 205 cells apoptosis evidenced by ladder formation in DNA fragmentation assay and sub-G1 peak. [6]

Protocol

Solubility (25°C)

In vitro DMSO 89 mg/mL (200.13 mM)
Ethanol 5 mg/mL (11.24 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 444.7
Formula

C18H15Cl3N2O.HNO3

CAS No. 24169-02-6
Storage powder
in solvent
Synonyms NSC 243115

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02720783 Completed Healthy Women Aziende Chimiche Riunite Angelini Francesco S.p.A|Cross Research S.A. March 4 2016 Phase 1
NCT02720783 Completed Healthy Women Aziende Chimiche Riunite Angelini Francesco S.p.A|Cross Research S.A. March 4 2016 Phase 1
NCT03129321 Completed Tinea Pedis Mylan Inc.|DPT Laboratories Ltd. March 15 2016 Phase 3
NCT03129321 Completed Tinea Pedis Mylan Inc.|DPT Laboratories Ltd. March 15 2016 Phase 3
NCT02713893 Completed Healthy Aziende Chimiche Riunite Angelini Francesco S.p.A|Cross Research S.A. September 2015 Phase 1
NCT02713893 Completed Healthy Aziende Chimiche Riunite Angelini Francesco S.p.A|Cross Research S.A. September 2015 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID