Dantrolene sodium hemiheptahydrate

Catalog No.S4648 Synonyms: Dantrolene sodium salt, Dantrium, Sodium dantrolene

Dantrolene sodium hemiheptahydrate Chemical Structure

Molecular Weight(MW): 399.29

Dantrolene sodium hemiheptahydrate ia a skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber.

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Biological Activity

Description Dantrolene sodium hemiheptahydrate ia a skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber.
In vitro

Dantrolene sodium is a skeletal muscle relaxant, which inhibits intracellular Ca2+ release from the sarcoplasmic reticulum. Dantrolene sodium shows strong antioxidant activity in the linoleic acid emulsion system[2].

In vivo Dantrolene sodium (5 mg/kg) has a greater depressant action on the twitch contraction of the fast extensor digitorum longus (EDL) muscle than on the slow soleus (SOL) muscle[1].

Protocol

Animal Research:[1]
+ Expand
  • Animal Models: Sprague Dawley rats
  • Formulation: 5% mannitol taken to pH 10 with NaOH.
  • Dosages: 5 mg/kg
  • Administration: i.v.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 14 mg/mL (35.06 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 399.29
Formula

C14H9N4O5.7/2H2O.Na

CAS No. 24868-20-0
Storage powder
in solvent
Synonyms Dantrolene sodium salt, Dantrium, Sodium dantrolene

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID