Signaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S1472 Safinamide Mesylate 80 mg/mL 80 mg/mL 13 mg/mL
S2102 Rasagiline Mesylate 53 mg/mL 53 mg/mL 53 mg/mL
S4246 Tranylcypromine (2-PCPA) HCl 33 mg/mL 33 mg/mL 33 mg/mL
S3212 Moclobemide (Ro 111163) <1 mg/mL 53 mg/mL 10 mg/mL
S4856 Iproniazid 35 mg/mL 35 mg/mL 35 mg/mL
S5795 Rasagiline 4 mg/mL 34 mg/mL 34 mg/mL
S9464 Tranylcypromine Sulfate -1 mg/mL 2 mg/mL -1 mg/mL
S5663 Minaprine dihydrochloride 74 mg/mL 74 mg/mL 4 mg/mL
S5357 Safinamide -1 mg/mL 60 mg/mL -1 mg/mL
S4033 Sennoside A <1 mg/mL 100 mg/mL <1 mg/mL
S2302 Glycyrrhizin (Glycyrrhizic Acid) <1 mg/mL 100 mg/mL 100 mg/mL
S3690 Pargyline hydrochloride 39 mg/mL 39 mg/mL 39 mg/mL
S2339 Paeonol <1 mg/mL 33 mg/mL 33 mg/mL
S4717 Isatin <1 mg/mL 29 mg/mL 10 mg/mL
S3868 Harmine -1 mg/mL 42 mg/mL -1 mg/mL

Isoform-specific Inhibitors

Catalog No. Information Product Use Citations Product Validations

Safinamide Mesylate

Safinamide Mesylate is mesylate salt of Safinamide, selectively and reversibly inhibits MAO-B with IC50 of 98 nM, exhibits 5918-fold selectivity against MAO-A. Phase 3.


Rasagiline Mesylate

Rasagiline Mesylate is a new MAO-B inhibitor for the treatment of idiopathic Parkinson's disease.


Tranylcypromine (2-PCPA) HCl

Tranylcypromine is a monoamine oxidase inhibitor, which inhibits CYP2A6 with Ki of 0.08 μM and 0.2 μM in cDNA-expressing microsomes and Human Liver Microsomes, respectively.


Moclobemide (Ro 111163)

Moclobemide is a MAO-A (5-HT) inhibitor with IC50 of 6.1 μM.



Iproniazid is a non-selective, irreversible monoamine oxidase (MAO) inhibitor (MAOI) that is used as an antidepressive agent.



Rasagiline is a novel selective and irreversible MAO-B propargylamine inhibitor with in vitro IC50s of 4.43 nM and 412 nM for MAO-B and MAO-A, respectively.


Tranylcypromine Sulfate

Tranylcypromine is an irreversible inhibitor of monoamine oxidase (MAO) with a rapid onset of activity.


Minaprine dihydrochloride

Minaprine dihydrochloride is hydrochloride salt form of Minaprine, which acts as a reversible inhibitor of MAO-A in rats and weakly inhibit acetylcholinesterase in rat brain (striatum) homogenates.



Safinamide is an orally active, selective, reversible monoamine oxidase-B inhibitor with both dopaminergic and non-dopaminergic (glutamatergic) properties. The IC50 value of safinamide for MAO-B is 98 nM.


Sennoside A

Sennoside A, a kind of irritant laxative isolated from rhei rhizome, causes purgative actions in the intestine.


Glycyrrhizin (Glycyrrhizic Acid)

Glycyrrhizin (Glycyrrhizic Acid) is a direct HMGB1(high mobility group box 1) inhibitor that inhibits HMGB1-dependent inflammatory molecule expression and oxidative stress; modulates P38 and P-JNK but not p-ERK signalling; Also inhibits 11 beta-hydroxysteroid dehydrogenase and monoamine oxidase (MAO).


Pargyline hydrochloride

Pargyline is an irreversible inhibitor of monoamine oxidase (MAO)-B with Ki values of 13 and 0.5 μM for time-dependent inhibition of the activity of MAO-A and -B, respectivey.



Paeonol (Peonol), a phenolic compound extracted from Chinese herbs Paeonia suffruticosa (moutan cortex) and Cynanchum paniculatum, inhibits MAO with an IC50 of about 50 μM.



Isatin is an endogenous MAO inhibitor with an IC50 of 15 μM and more active against MAO-B than MAO-A.



Harmine is an alkaloid of the β-carboline family that regulates PPARγ expression through inhibition of the Wnt signaling pathway. It also selectively binds to MAO-A and reversibly inhibits monoamine oxidase A (MAO-A) but not the variant MAO-B.