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Neurokinin Receptor

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NK1R Selective

Neurokinin Receptor Products

All (6)
Neurokinin Receptor Antagonists (6)
New Neurokinin Receptor Products

Catalog No.	Product Name	Information	Product Use Citations	Product Validations
E0192^New	Maropitant citrate	Maropitant citrate is a novel neurokinin type-1 (NK1) receptor antagonist with anti-inflammatory and analgesic properties.
S0772	L-732138	L-732138 (L-732,138) is a selective, potent and competitive antagonist of neurokinin-1 (NK-1) receptor/substance P (SP) receptor. L-732138 inhibits the binding of ¹²⁵I-SP to the human NK-1 receptor stably expressed in CHO cells with IC50 of 2.3 nM.
S1189	Aprepitant (MK-0869)	Aprepitant (MK-0869, L-754030) is a potent and selective neurokinin-1 receptor antagonist with IC50 of 0.1 nM. Aprepitant reduces levels of pro-inflammatory cytokines including G-CSF, IL-6, IL-8 and TNFα. Aprepitant inhibits HIV infection of human macrophages.	Cancers (Basel), 2021, 13(15)3871 Phytomedicine, 2021, 95:153864 Nat Commun, 2020, 29;11(1):2673
S3038	Fosaprepitant dimeglumine salt	Fosaprepitant dimeglumine salt (MK-0517) is a water-soluble phosphoryl prodrug for Aprepitant which is a NK1 antagonist.
S4654	Netupitant	Netupitant (CID6451149) is a selective neurokinin 1 (NK1) receptor antagonist with potential antiemetic activity.	Nat Commun, 2019, 10(1):17
S5476	Rolapitant	Rolapitant (SCH-619734) is a selective and competitive antagonist of human substance P/NK1 receptors with antiemetic activity. It has a high affinity for the human NK1 receptor of 0.66 nM and high selectivity over the human NK2 and NK3 subtypes of >1000-fold, as well as preferential affinity for human, guinea pig, gerbil and monkey NK1 receptors over rat, mouse and rabbit.
E0192^New	Maropitant citrate	Maropitant citrate is a novel neurokinin type-1 (NK1) receptor antagonist with anti-inflammatory and analgesic properties.
S0772	L-732138	L-732138 (L-732,138) is a selective, potent and competitive antagonist of neurokinin-1 (NK-1) receptor/substance P (SP) receptor. L-732138 inhibits the binding of ¹²⁵I-SP to the human NK-1 receptor stably expressed in CHO cells with IC50 of 2.3 nM.
S1189	Aprepitant (MK-0869)	Aprepitant (MK-0869, L-754030) is a potent and selective neurokinin-1 receptor antagonist with IC50 of 0.1 nM. Aprepitant reduces levels of pro-inflammatory cytokines including G-CSF, IL-6, IL-8 and TNFα. Aprepitant inhibits HIV infection of human macrophages.	Cancers (Basel), 2021, 13(15)3871 Phytomedicine, 2021, 95:153864 Nat Commun, 2020, 29;11(1):2673
S3038	Fosaprepitant dimeglumine salt	Fosaprepitant dimeglumine salt (MK-0517) is a water-soluble phosphoryl prodrug for Aprepitant which is a NK1 antagonist.
S4654	Netupitant	Netupitant (CID6451149) is a selective neurokinin 1 (NK1) receptor antagonist with potential antiemetic activity.	Nat Commun, 2019, 10(1):17
S5476	Rolapitant	Rolapitant (SCH-619734) is a selective and competitive antagonist of human substance P/NK1 receptors with antiemetic activity. It has a high affinity for the human NK1 receptor of 0.66 nM and high selectivity over the human NK2 and NK3 subtypes of >1000-fold, as well as preferential affinity for human, guinea pig, gerbil and monkey NK1 receptors over rat, mouse and rabbit.
E0192^New	Maropitant citrate	Maropitant citrate is a novel neurokinin type-1 (NK1) receptor antagonist with anti-inflammatory and analgesic properties.