MT Receptor
Signaling Pathway Map
Research Area
- Inhibitory Selectivity
- Solubility
| Catalog No. | Product Name | Solubility(25°C) | ||
|---|---|---|---|---|
| Water | DMSO | Alcohol | ||
| S1259 | Ramelteon | <1 mg/mL | 52 mg/mL | 52 mg/mL |
| S1204 | Melatonin | <1 mg/mL | 47 mg/mL | 47 mg/mL |
| S4281 | Tasimelteon | -1 mg/mL | 49 mg/mL | -1 mg/mL |
Isoform-specific Inhibitors
- MT Receptor Inhibitors (3)
- New MT Receptor Products
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S1259 |
RamelteonRamelteon is a novel melatonin receptor agonist for human MT1 and MT2 receptors and chick forebrain melatonin receptors with Ki of 14 pM, 112 pM and 23.1 pM, respectively. |
(A) CLSM images of Porphyromonas gingivalis biofilm formed in the presence of melatonin and ramelteon at sub-MIC concentrations. Biofilm-forming cells were stained using the Live/Dead Bacterial Viability Kit. Dead cells were stained red, whereas live bacteria were stained green. In the presence of 50 μg/mL or 25 μg/mL ramelteon, the areas of biofilm formation were narrower than that of vehicle controls. Bars = 50 μm.
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| S1204 |
MelatoninMelatonin is a MT receptor agonist, used as a dietary supplement. |
TUNEL staining of treated adipocytes and flow cytometry analysis of positive TUNEL cells (n=3). |
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| S4281New |
TasimelteonTasimelteon is a selective dual melatonin receptor (MT1/MT2) agonist with 2.1-4.4 times greater affinity for the MT2 receptor believed to mediate circadian rhythm phase-shifting (Ki = 0.0692 nM and Ki = 0.17 nM in NIH-3T3 and CHOeK1 cells, respectively), than for the MT1 receptor (Ki = 0.304 nM and Ki = 0.35 nM, respectively). |
