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MT Receptor

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MT Receptor Signaling Pathways

Isoform-selective Inhibitors

MT Receptor Products

All (4)
MT Receptor Antagonist (1)
MT Receptor Agonists (3)
New MT Receptor Products

Catalog No.	Product Name	Information	Product Use Citations	Product Validations
S3584	Luzindole	Luzindole (N-0774, N-acetyl-2-benzyltryptamine) is a selective melatonin receptor antagonist with Kis of 179 nM for MT1 and 7.3 nM for MT2, respectively.	Aging Cell, 2021, e13375 Int Immunopharmacol, 2021, 96:107787
S1204	Melatonin (NSC 113928)	Melatonin (NSC 113928, NSC 56423, N-Acetyl-5-methoxytryptamine) is a MT receptor agonist, used as a dietary supplement. Melatonin is a selective ATF-6 inhibitor and downregulates COX-2. Melatonin enhances mitophagy and regulates the homeostasis of apoptosis and autophagy.	Ecotoxicol Environ Saf, 2022, 241:113754 Cell Chem Biol, 2021, S2451-9456(21)00442-6 Int J Mol Sci, 2021, 22(11)5649
S1259	Ramelteon	Ramelteon (TAK-375) is a novel melatonin receptor agonist for human MT1 and MT2 receptors and chick forebrain melatonin receptors with K_i of 14 pM, 112 pM and 23.1 pM, respectively.	Aging Cell, 2021, e13375 Cell Cycle, 2021, 20(12):1195-1208 Plant Cell Physiol, 2020, 10.1093/pcp/pcaa018
S4281	Tasimelteon	Tasimelteon (BMS 214778, VEC 162) is a selective dual melatonin receptor (MT1/MT2) agonist with 2.1-4.4 times greater affinity for the MT2 receptor believed to mediate circadian rhythm phase-shifting (Ki = 0.0692 nM and Ki = 0.17 nM in NIH-3T3 and CHOeK1 cells, respectively), than for the MT1 receptor (Ki = 0.304 nM and Ki = 0.35 nM, respectively).
S3584	Luzindole	Luzindole (N-0774, N-acetyl-2-benzyltryptamine) is a selective melatonin receptor antagonist with Kis of 179 nM for MT1 and 7.3 nM for MT2, respectively.	Aging Cell, 2021, e13375 Int Immunopharmacol, 2021, 96:107787
S1204	Melatonin (NSC 113928)	Melatonin (NSC 113928, NSC 56423, N-Acetyl-5-methoxytryptamine) is a MT receptor agonist, used as a dietary supplement. Melatonin is a selective ATF-6 inhibitor and downregulates COX-2. Melatonin enhances mitophagy and regulates the homeostasis of apoptosis and autophagy.	Ecotoxicol Environ Saf, 2022, 241:113754 Cell Chem Biol, 2021, S2451-9456(21)00442-6 Int J Mol Sci, 2021, 22(11)5649
S1259	Ramelteon	Ramelteon (TAK-375) is a novel melatonin receptor agonist for human MT1 and MT2 receptors and chick forebrain melatonin receptors with K_i of 14 pM, 112 pM and 23.1 pM, respectively.	Aging Cell, 2021, e13375 Cell Cycle, 2021, 20(12):1195-1208 Plant Cell Physiol, 2020, 10.1093/pcp/pcaa018
S4281	Tasimelteon	Tasimelteon (BMS 214778, VEC 162) is a selective dual melatonin receptor (MT1/MT2) agonist with 2.1-4.4 times greater affinity for the MT2 receptor believed to mediate circadian rhythm phase-shifting (Ki = 0.0692 nM and Ki = 0.17 nM in NIH-3T3 and CHOeK1 cells, respectively), than for the MT1 receptor (Ki = 0.304 nM and Ki = 0.35 nM, respectively).

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