MT Receptor

Signaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S1259 Ramelteon <1 mg/mL 52 mg/mL 52 mg/mL
S1204 Melatonin <1 mg/mL 47 mg/mL 47 mg/mL
S4281 Tasimelteon -1 mg/mL 49 mg/mL -1 mg/mL

Isoform-specific Inhibitors

Catalog No. Information Product Use Citations Product Validations
S1259

Ramelteon

Ramelteon is a novel melatonin receptor agonist for human MT1 and MT2 receptors and chick forebrain melatonin receptors with Ki of 14 pM, 112 pM and 23.1 pM, respectively.

S1204

Melatonin

Melatonin is a MT receptor agonist, used as a dietary supplement.

S4281New

Tasimelteon

Tasimelteon is a selective dual melatonin receptor (MT1/MT2) agonist with 2.1-4.4 times greater affinity for the MT2 receptor believed to mediate circadian rhythm phase-shifting (Ki = 0.0692 nM and Ki = 0.17 nM in NIH-3T3 and CHOeK1 cells, respectively), than for the MT1 receptor (Ki = 0.304 nM and Ki = 0.35 nM, respectively).