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Catalog No. Product Name Information Product Use Citations Product Validations
S1528 LY2811376 LY2811376 is the first orally available non-peptidic β-secretase(BACE1) inhibitor with IC50 of 239 nM-249 nM, that act to decrease Aβ secretion with EC50 of 300 nM, demonstrated to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin. Phase 1.
J Agric Food Chem, 2022, 70(5):1536-1546
Analyst, 2022, 10.1039/d2an00031h
Sci Rep, 2022, 12(1):7
S2156 LY2886721 LY2886721 is a BACE inhibitor used for the treatment of Alzheimer's Disease. Phase 1/2.
Cell Rep, 2021, 37(10):110102
Front Immunol, 2021, 12:693149
Neurotoxicology, 2021, 86:19-25
S3245 Nodakenetin Nodakenetin (NANI), a plant-derived coumarin isolated from Angelica decursiva, inhibits α-glucosidase, PTP1B, rat lens aldose reductase (RLAR), AChE, BChE, and β-site amyloid precursor protein cleaving enzyme 1 (BACE1). Nodakenetin alters the protein expression of Bax and Bcl-2, and prompts mitochondrial apoptosis. Nodakenetin exhibits anti-tumor activity.
S3326 Phytic acid dipotassium salt

Phytic acid dipotassium salt (Phytic acid potassium, IP6 (PS)), an endogenous metabolite in rice grain extract and digest, inhibits β-secretase 1 (BACE1) with IC50 of approximately 0.25 μM.

Analyst, 2022, 10.1039/d2an00031h
S3835 Loganin Loganin (Loganoside) is an iridoid glycoside first isolated from the seeds of Strychnos nux-vomica, a member of the Loganiaceae family. It is a non-competitive inhibitor of BACE1 with IC50 of 47.97 μM an also inhibits AChE and BChE with IC50 values of 3.95 μM and 33.02 μM, respectively.
S4657 Eslicarbazepine Acetate Eslicarbazepine Acetate (BIA 2093, Zebinix, Exalief, Stedesa, Aptiom), an antiepileptic drug, is a dual a dual Inhibitor of β-Secretase and voltage-gated sodium channel.
S6503 LX2343 LX2343 is a multi-target agent that exhibits a high capability for ameliorating multi-abnormalities of AD pathogenesis. It is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM.
S7731 AZD3839 AZD3839 is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1.
Analyst, 2022, 10.1039/d2an00031h
Genome Med, 2021, 13(1):168
Alzheimers Dement, 2019, 15(9):1183-1194
S8173 Verubecestat (MK-8931) Trifluoroacetate Verubecestat (MK-8931) Trifluoroacetate is a potent and selective beta-secretase inhibitor and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor.
Analyst, 2022, 10.1039/d2an00031h
Alzheimers Dement (N Y), 2020, 6(1):e12038
Alzheimer's Association, 2020, 16-S2
S8193 Lanabecestat (AZD3293) Lanabecestat (AZD3293, LY3314814) is an oral beta-secretase 1 cleaving enzyme (BACE) inhibitor with an inhibitory constant Ki  of 0.4 nM.
Analyst, 2022, 10.1039/d2an00031h
Alzheimers Res Ther, 2020, 26;12(1):63
Commun Biol, 2020, 3(1):728
S8564 Verubecestat (MK-8931) Verubecestat (MK-8931) is a potent and selective beta-secretase (also known as Beta-site APP-cleaving enzyme 1) inhibitor.
Analyst, 2022, 10.1039/d2an00031h
bioRxiv, 2021, 10.1101/2021.09.10.459826
Alzheimers Dement, 2019, 15(9):1183-1194
S8600 Elenbecestat Elenbecestat (E2609) is a novel BACE1 inhibitor, demonstrating prolonged reductions in plasma beta-amyloid levels after single dosing.
S1528 LY2811376 LY2811376 is the first orally available non-peptidic β-secretase(BACE1) inhibitor with IC50 of 239 nM-249 nM, that act to decrease Aβ secretion with EC50 of 300 nM, demonstrated to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin. Phase 1.
J Agric Food Chem, 2022, 70(5):1536-1546
Analyst, 2022, 10.1039/d2an00031h
Sci Rep, 2022, 12(1):7
S2156 LY2886721 LY2886721 is a BACE inhibitor used for the treatment of Alzheimer's Disease. Phase 1/2.
Cell Rep, 2021, 37(10):110102
Front Immunol, 2021, 12:693149
Neurotoxicology, 2021, 86:19-25
S3245 Nodakenetin Nodakenetin (NANI), a plant-derived coumarin isolated from Angelica decursiva, inhibits α-glucosidase, PTP1B, rat lens aldose reductase (RLAR), AChE, BChE, and β-site amyloid precursor protein cleaving enzyme 1 (BACE1). Nodakenetin alters the protein expression of Bax and Bcl-2, and prompts mitochondrial apoptosis. Nodakenetin exhibits anti-tumor activity.
S3326 Phytic acid dipotassium salt

Phytic acid dipotassium salt (Phytic acid potassium, IP6 (PS)), an endogenous metabolite in rice grain extract and digest, inhibits β-secretase 1 (BACE1) with IC50 of approximately 0.25 μM.

Analyst, 2022, 10.1039/d2an00031h
S3835 Loganin Loganin (Loganoside) is an iridoid glycoside first isolated from the seeds of Strychnos nux-vomica, a member of the Loganiaceae family. It is a non-competitive inhibitor of BACE1 with IC50 of 47.97 μM an also inhibits AChE and BChE with IC50 values of 3.95 μM and 33.02 μM, respectively.
S4657 Eslicarbazepine Acetate Eslicarbazepine Acetate (BIA 2093, Zebinix, Exalief, Stedesa, Aptiom), an antiepileptic drug, is a dual a dual Inhibitor of β-Secretase and voltage-gated sodium channel.
S6503 LX2343 LX2343 is a multi-target agent that exhibits a high capability for ameliorating multi-abnormalities of AD pathogenesis. It is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM.
S7731 AZD3839 AZD3839 is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1.
Analyst, 2022, 10.1039/d2an00031h
Genome Med, 2021, 13(1):168
Alzheimers Dement, 2019, 15(9):1183-1194
S8173 Verubecestat (MK-8931) Trifluoroacetate Verubecestat (MK-8931) Trifluoroacetate is a potent and selective beta-secretase inhibitor and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor.
Analyst, 2022, 10.1039/d2an00031h
Alzheimers Dement (N Y), 2020, 6(1):e12038
Alzheimer's Association, 2020, 16-S2
S8193 Lanabecestat (AZD3293) Lanabecestat (AZD3293, LY3314814) is an oral beta-secretase 1 cleaving enzyme (BACE) inhibitor with an inhibitory constant Ki  of 0.4 nM.
Analyst, 2022, 10.1039/d2an00031h
Alzheimers Res Ther, 2020, 26;12(1):63
Commun Biol, 2020, 3(1):728
S8564 Verubecestat (MK-8931) Verubecestat (MK-8931) is a potent and selective beta-secretase (also known as Beta-site APP-cleaving enzyme 1) inhibitor.
Analyst, 2022, 10.1039/d2an00031h
bioRxiv, 2021, 10.1101/2021.09.10.459826
Alzheimers Dement, 2019, 15(9):1183-1194
S8600 Elenbecestat Elenbecestat (E2609) is a novel BACE1 inhibitor, demonstrating prolonged reductions in plasma beta-amyloid levels after single dosing.
Tags: BACE inhibitor|BACE agonist|BACE activator|BACE inducer|BACE antagonist|BACE signaling pathway|BACE assay kit