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BACE

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Cat.No. Product Name Information Product Use Citations Product Validations
S8564 Verubecestat (MK-8931) MK-8931 (Verubecestat) is a potent and selective beta-secretase (also known as Beta-site APP-cleaving enzyme 1) inhibitor.
International Journal of Molecular Sciences, 2025, 3756
Int J Mol Sci, 2025, 26(8)3756
J Cereb Blood Flow Metab, 2023, 43(2_suppl):66-77
S2156 LY2886721 LY2886721 is a BACE inhibitor used for the treatment of Alzheimer's Disease. Phase 1/2.
Acta Neuropathol, 2025, 149(1):10
Foods, 2024, 13(18)2858
Stem Cell Reports, 2023, 18(7):1516-1533
Verified customer review of LY2886721
S1528 LY2811376 LY2811376 is the first orally available non-peptidic β-secretase(BACE1) inhibitor with IC50 of 239 nM-249 nM, that act to decrease Aβ secretion with EC50 of 300 nM, demonstrated to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin. Phase 1.
Glycobiology, 2023, 33(4):325-341
J Agric Food Chem, 2022, 70(5):1536-1546
Sci Rep, 2022, 12(1):7
Verified customer review of LY2811376
S8173 Verubecestat (MK-8931) Trifluoroacetate Verubecestat (MK-8931) Trifluoroacetate is a potent and selective beta-secretase inhibitor and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor.
Journal of Cerebral Blood Flow & Metabolism, 2023, 1235-1250
Analyst, 2022, 10.1039/d2an00031h
Nature Cancer, 2021, 1136-1151
S7731 AZD3839 AZD3839 is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1.
Elife, 2025, 13RP100968
Analyst, 2022, 10.1039/d2an00031h
Genome Med, 2021, 13(1):168
S8193 Lanabecestat (AZD3293) Lanabecestat (AZD3293, LY3314814) is an oral beta-secretase 1 cleaving enzyme (BACE) inhibitor with an inhibitory constant Ki  of 0.4 nM.
Analyst, 2022, 10.1039/d2an00031h
Alzheimers Res Ther, 2020, 26;12(1):63
Commun Biol, 2020, 3(1):728
Verified customer review of Lanabecestat (AZD3293)
S8600 Elenbecestat Elenbecestat (E2609) is a novel BACE1 inhibitor, demonstrating prolonged reductions in plasma beta-amyloid levels after single dosing.
EMBO Rep, 2025, 10.1038/s44319-025-00442-4
EMBO Reports, 2025, 2683-2714
S3326 Phytic acid dipotassium salt

Phytic acid dipotassium salt (Phytic acid potassium, IP6 (PS)), an endogenous metabolite in rice grain extract and digest, inhibits β-secretase 1 (BACE1) with IC50 of approximately 0.25 μM.
Analyst, 2022, 10.1039/d2an00031h
S6503 LX2343 LX2343 is a multi-target agent that exhibits a high capability for ameliorating multi-abnormalities of AD pathogenesis. It is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM.
S3835 Loganin Loganin (Loganoside) is an iridoid glycoside first isolated from the seeds of Strychnos nux-vomica, a member of the Loganiaceae family. This compound is a non-competitive inhibitor of BACE1 with IC50 of 47.97 μM an also inhibits AChE and BChE with IC50 values of 3.95 μM and 33.02 μM, respectively.

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