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Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S1421 Staurosporine (STS) Staurosporine (STS) is a potent PKC inhibitor for PKCα, PKCγ and PKCη with IC50 of 2 nM, 5 nM and 4 nM, less potent to PKCδ (20 nM), PKCε (73 nM) and little active to PKCζ (1086 nM) in cell-free assays. This compound also shows inhibitory activities on other kinases, such as PKA, PKG, S6K, CaMKII, etc. Phase 3.
Cell Metab, 2025, S1550-4131(25)00149-4
Mol Cell, 2025, 85(19):3711-3728.e11
EMBO J, 2025, 10.1038/s44318-025-00526-w
Verified customer review of Staurosporine (STS)
S7423 KN-93 Phosphate KN-93 Phosphate is a potent and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with Ki of 0.37 μM, no remarkable inhibitory effects on APK, PKC, MLCK or Ca2+-PDE activities. KN-93 attenuates CaMKII-induced autophagy.This product is not soluble in saline. Please do not dissolve it in saline for administration.
Stem Cell Res Ther, 2025, 16(1):208
bioRxiv, 2025, 2025.03.20.644192
Eye Vis (Lond), 2024, 11(1):37
Verified customer review of KN-93 Phosphate
S6787 KN-93 KN-93 is a cell-permeable, reversible and competitive inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMK-II) with Ki of 2.58 μM at rabbit myocardial CaM kinase activity.
Acta Neuropathol Commun, 2025, 13(1):70
Int J Mol Med, 2025, 56(5)196
Nat Commun, 2024, 15(1):840
S8274 STO-609 STO-609 is a specific inhibitor of the Ca2+/Calmodulin-dependent protein kinase kinase(CaM-KK) that inhibits the activities of recombinant CaM-KKα and CaM-KKβ isoforms, with Ki values of 80 and 15 ng/ml, respectively, and also inhibits their autophosphorylation activities. This compound inhibits AMPKK activity and inhibits autophagy.
Redox Rep, 2025, 30(1):2447721
PLoS One, 2025, 20(8):e0330282
Cell Genom, 2025, 5(3):100782
S7422 KN-62 KN-62 is a potent and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with Ki of 0.9 μM; also a non-competitive antagonist of the purinergic receptor P2RX7 (IC50 = 15 nM). It is selective for CaMKII relative to PKA, PKC and MLCK, but inhibits CaMKI and CaMKIV equally well, The Ki value of this compound for CaMK V is 0.8 μM.
J Extracell Vesicles, 2025, 14(8):e70149
Cell Rep, 2025, 44(6):115839
Redox Biol, 2024, 75:103249
Verified customer review of KN-62
S7436 NH125 NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor.
Acta Pharmacol Sin, 2018, 10.1038/s41401-018-0165-9
Drug Des Devel Ther, 2018, Drug Des Devel Ther
BMC Cancer, 2016, 16(1):813
Verified customer review of NH125
S6507 KN-92 phosphate KN-92 is an inactive derivative of KN-93, the selective inhibitor of Ca2+/calmodulin-dependent kinase type II (CaMKII).
Sci Rep, 2023, 13(1):5827
Elife, 2022, 11e74519
Front Physiol, 2021, 12:736920
E5833New KN-93 hydrochloride KN-93 hydrochloride is a methoxybenzenesulfonamide derivative that inhibits Ca2+/calmodulin-dependent protein kinase II (CaMKII) with a Ki of 0.37 µM. It reduces dopamine (DA) production by influencing the reaction rate of tyrosine hydroxylase (TH), leading to decreased Ca(2+)-mediated phosphorylation of the TH protein.
S7188 CID755673 CID755673 is a cell-active pan-PKD1/2/3 inhibitor with IC50 of 180 nM, 280nM, and 227 nM, respectively, about 200-fold selectivity over other CAMKs.
World Allergy Organ J, 2025, 18(8):101089
J Thromb Haemost, 2024, S1538-7836(24)00618-4
Nat Commun, 2023, 14(1):3543
S9141 Berbamine Berbamine (BA), a traditional Chinese medicine extracted from Berberis amurensis (xiaoboan), is a novel inhibitor of bcr/abl fusion gene with potent anti-leukemia activity and also an inhibitor of NF-κB. This compound induces apoptosis in human myeloma cells and inhibits the growth of cancer cells by targeting Ca²⁺/calmodulin-dependent protein kinase II (CaMKII).
Vet Res, 2025, 56(1):37
Vet Microbiol, 2025, 301:110356
iScience, 2024, 27(10):110862