S1336 |
Fluvoxamine (DU-23000) maleate
|
Fluvoxamine maleate (DU-23000, MK-264) is a selective serotonin (5-HT) reuptake inhibitor (SSRI), used in the treatment of obsessive-compulsive disorder. |
-
mBio, 2022, 13(1):e0337721
-
J Neurotrauma, 2022, 10.1089/neu.2021.0355
-
Research Square, 2021, 10.21203/rs.3.rs-916525/v1
|
|
S1441 |
Venlafaxine HCl
|
Venlafaxine HCl is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia. |
-
Nat Commun, 2020, 14;11(1):1825
-
Drug Metab Dispos, 2020, 48(10):1044-1052
|
|
S1627 |
Nitazoxanide (NSC 697855)
|
Nitazoxanide (NTZ, NSC 697855) is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent(IC50 for canine influenza virus ranges from 0.17 to 0.21 μM). Nitazoxanide modulates autophagy and inhibits mTORC1 signaling. |
-
Biochem Pharmacol, 2022, 197:114913
-
Oncol Lett, 2022, 23(4):123
-
Front Pharmacol, 2021, 12:781640
|
|
S1869 |
Dapoxetine HCl
|
Dapoxetine HCl (LY-210448) is a short-acting novel selective serotonin reuptake inhibitor, used for the treatment of premature ejaculation. |
|
|
S2084 |
Duloxetine HCl
|
Duloxetine HCl (LY-248686) is a serotonin-norepinephrine reuptake inhibitor with Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD). |
-
Drug Metab Dispos, 2015, 44(3):378-88
-
J Pharmacol Exp Ther, 2014, 349(3):402-7
-
Am J Physiol Renal Physiol, 2013, 305(12):F1663-8
|
|
S2282 |
Cinchonidine
|
Cinchonidine is an alkaloid used in asymmetric synthesis in organic chemistry. |
-
J Med Virol, 2019, 91(8):1440-1447
|
|
S2541 |
Clomipramine HCl
|
Clomipramine HCl is a hydrochloride salt of clomipramine which is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively. |
-
bioRxiv, 2020, 2020/9/20.4.7.30734
|
|
S3005 |
Paroxetine HCl
|
Paroxetine HCl (BRL-29060A, FG-7051) is an antidepressant drug of the SSRI type. |
-
Nat Commun, 2022, 13(1):3034
-
Am J Cancer Res, 2022, 12(4):1465-1483
-
Anal Methods, 2021, 10.1039/d0ay02027c
|
|
S3140 |
Milnacipran HCl
|
Milnacipran inhibits both norepinephrine transporter (NET) and norepinephrine transporter (SERT) with IC50 of 77 nM and 420 nM, respectively. |
|
|
S3183 |
Amitriptyline HCl
|
Amitriptyline HCl is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. Amitriptyline HCl also inhibits histamine receptor H1, histamine receptor H4, 5-HT2 and sigma 1 receptor with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. Amitriptyline is a tricyclic antidepressant (TCA). |
-
Environ Toxicol Chem, 2021, 10.1002/etc.5018
-
PLoS Pathog, 2020, 16;16(3):e1008341
-
Sci Rep, 2018, 8(1):15753
|
|
S4053 |
Sertraline HCl
|
Sertraline HCl (CP-51974-1) is a 5-HT antagonist with Ki of 13 nM. |
-
Antimicrob Agents Chemother, 2021, AAC.01146-20
-
Sci Rep, 2021, 11(1):1250
-
J Glob Antimicrob Resist, 2021, 27:167-171
|
|
S4064 |
Escitalopram Oxalate
|
Escitalopram Oxalate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM. |
|
|
S4112 |
Desvenlafaxine Succinate
|
Desvenlafaxine Succinate (WY 45233) is a new serotonin (5-HT) transporter and norepinephrine (NE) transporter reuptake inhibitor with Ki of 40.2 nM and 558.4 nM respectively. |
-
Drug Metab Dispos, 2020, 48(10):1044-1052
|
|
S4113 |
Desvenlafaxine
|
Desvenlafaxine (WY 45233 Succinate) is a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor with Ki of 40.2 nM and 558.4 nM, respectively. |
-
Drug Metab Dispos, 2020, 48(10):1044-1052
|
|
S4259 |
Vilazodone HCl
|
Vilazodone HCl is a selective serotonin reuptake inhibitor (SSRI) and a partial agonist of 5-HT1A receptors, used for the treatment of major depressive disorder. |
-
J Pain, 2019, 20(1):16.e1-16.e16
-
Acta Pol Pharm, 2017, 74(3):765-775
|
|
S4377 |
Imipramine HCl
|
Imipramine (Melipramine) is a tricyclic antidepressant (TCA) of the dibenzazepine group, mainly used in the treatment of major depression and enuresis (inability to control urination). |
-
Antioxidants (Basel), 2021, 10(6)956
|
|
S4749 |
Citalopram HBr
|
Citalopram HBr (Nitalapram HBr, Prepram HBr, Bonitrile HBr, Lu 10-171 HBr), an antidepressant, is an orally administered selective serotonin reuptake inhibitor (SSRI) with IC50 of 1.8 nM. |
-
Aging (Albany NY), 2021, 13(11):14729-14744
-
Sci Rep, 2021, 11(1):1250
-
Viruses, 2021, 13(8)1533
|
|
S5071 |
Duloxetine
|
Duloxetine (LY-248686) is a potent inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline (NE) uptake in vitro and in vivo and is 3- to 5-times more effective at inhibiting 5-HT uptake. |
|
|
S5239 |
Paroxetine mesylate
|
Paroxetine Mesylate is the mesylate salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties. |
-
Am J Cancer Res, 2022, 12(4):1465-1483
-
Anal Methods, 2021, 10.1039/d0ay02027c
|
|
S5485 |
Desipramine Hydrochloride
|
Desipramine hydrochloride (Desmethylimipramine, Norimipramine, EX-4355, G-35020, JB-8181, NSC-114901) is a dibenzazepine-derivative tricyclic antidepressant that acts as a selective norepinephrine reuptake inhibitor. It also shows weak serotonin reuptake inhibitory, α1-blocking, antihistamine, and anticholinergic effects. |
|
|
S5506 |
Vortioxetine
|
Vortioxetine, a novel antidepressant for the treatment of major depressive disorder, is a 5-HT3, 5-HT7 and 5-HT1D receptor antagonist, 5-HT1B receptor partial agonist, 5-HT1A receptor agonist and serotonin (5-HT) transporter (SERT) inhibitor. |
|
|
S5655 |
Venlafaxine
|
Venlafaxine (Wy 45030) is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia. |
|
|
S5693 |
Levomilnacipran Hydrochloride
|
Levomilnacipran Hydrochloride is a selective serotonin and norepinephrine reuptake inhibitor with antidepressant activity. |
|
|
S5858 |
Vilazodone
|
Vilazodone (EMD-68843, SB-659746A) is a novel antidepressant having a selective serotonin (5-HT) reuptake inhibitory and 5-HT1A receptor partial agonist activity. The affinity of vilazodone is much higher in the 5-HT reuptake site (Ki=0.1 nM) than in norepinephrine (Ki=56 nM) and dopamine (Ki=37 nM) sites. |
-
J Pain, 2019, 20(1):16.e1-16.e16
|
|
S5947 |
Amitriptyline
|
Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant (TCA) with analgesic properties, widely used to treat depression and neuropathic pain. Amitriptyline is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. Amitriptyline also inhibits histamine receptor H1, histamine receptor H4, 5-HT2 and sigma 1 receptor with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. This product is a waxy solid. |
-
Cancers (Basel), 2019, 11(12)
|
|
S8021 |
Vortioxetine (Lu AA21004) HBr
|
Vortioxetine (Lu AA21004), a multimodal serotonergic agent, is an antagonist of human (h) serotonin (5-HT)3A receptor and h5-HT7 receptor with Ki of 3.7 nM and 19 nM, respectively. Vortioxetine (Lu AA21004) is also a h5-HT1B receptor partial agonist with Ki of 33 nM and h5-HT1A receptor agonist with Ki of 15 nM, and a human 5-HT transporter (SERT) inhibitor with Ki of 1.6 nM. |
|
|
S6301 |
MPP+ iodide
|
MPP+ iodide (N-Methyl-4-Phenylpyridinium Iodide), the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces autophagic cell death in SH-SY5Y cells. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons. |
|
|
S1336 |
Fluvoxamine (DU-23000) maleate
|
Fluvoxamine maleate (DU-23000, MK-264) is a selective serotonin (5-HT) reuptake inhibitor (SSRI), used in the treatment of obsessive-compulsive disorder. |
- mBio, 2022, 13(1):e0337721
- J Neurotrauma, 2022, 10.1089/neu.2021.0355
- Research Square, 2021, 10.21203/rs.3.rs-916525/v1
|
|
S1441 |
Venlafaxine HCl
|
Venlafaxine HCl is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia. |
- Nat Commun, 2020, 14;11(1):1825
- Drug Metab Dispos, 2020, 48(10):1044-1052
|
|
S1627 |
Nitazoxanide (NSC 697855)
|
Nitazoxanide (NTZ, NSC 697855) is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent(IC50 for canine influenza virus ranges from 0.17 to 0.21 μM). Nitazoxanide modulates autophagy and inhibits mTORC1 signaling. |
- Biochem Pharmacol, 2022, 197:114913
- Oncol Lett, 2022, 23(4):123
- Front Pharmacol, 2021, 12:781640
|
|
S1869 |
Dapoxetine HCl
|
Dapoxetine HCl (LY-210448) is a short-acting novel selective serotonin reuptake inhibitor, used for the treatment of premature ejaculation. |
|
|
S2084 |
Duloxetine HCl
|
Duloxetine HCl (LY-248686) is a serotonin-norepinephrine reuptake inhibitor with Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD). |
- Drug Metab Dispos, 2015, 44(3):378-88
- J Pharmacol Exp Ther, 2014, 349(3):402-7
- Am J Physiol Renal Physiol, 2013, 305(12):F1663-8
|
|
S2282 |
Cinchonidine
|
Cinchonidine is an alkaloid used in asymmetric synthesis in organic chemistry. |
- J Med Virol, 2019, 91(8):1440-1447
|
|
S2541 |
Clomipramine HCl
|
Clomipramine HCl is a hydrochloride salt of clomipramine which is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively. |
- bioRxiv, 2020, 2020/9/20.4.7.30734
|
|
S3005 |
Paroxetine HCl
|
Paroxetine HCl (BRL-29060A, FG-7051) is an antidepressant drug of the SSRI type. |
- Nat Commun, 2022, 13(1):3034
- Am J Cancer Res, 2022, 12(4):1465-1483
- Anal Methods, 2021, 10.1039/d0ay02027c
|
|
S3140 |
Milnacipran HCl
|
Milnacipran inhibits both norepinephrine transporter (NET) and norepinephrine transporter (SERT) with IC50 of 77 nM and 420 nM, respectively. |
|
|
S3183 |
Amitriptyline HCl
|
Amitriptyline HCl is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. Amitriptyline HCl also inhibits histamine receptor H1, histamine receptor H4, 5-HT2 and sigma 1 receptor with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. Amitriptyline is a tricyclic antidepressant (TCA). |
- Environ Toxicol Chem, 2021, 10.1002/etc.5018
- PLoS Pathog, 2020, 16;16(3):e1008341
- Sci Rep, 2018, 8(1):15753
|
|
S4053 |
Sertraline HCl
|
Sertraline HCl (CP-51974-1) is a 5-HT antagonist with Ki of 13 nM. |
- Antimicrob Agents Chemother, 2021, AAC.01146-20
- Sci Rep, 2021, 11(1):1250
- J Glob Antimicrob Resist, 2021, 27:167-171
|
|
S4064 |
Escitalopram Oxalate
|
Escitalopram Oxalate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM. |
|
|
S4112 |
Desvenlafaxine Succinate
|
Desvenlafaxine Succinate (WY 45233) is a new serotonin (5-HT) transporter and norepinephrine (NE) transporter reuptake inhibitor with Ki of 40.2 nM and 558.4 nM respectively. |
- Drug Metab Dispos, 2020, 48(10):1044-1052
|
|
S4113 |
Desvenlafaxine
|
Desvenlafaxine (WY 45233 Succinate) is a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor with Ki of 40.2 nM and 558.4 nM, respectively. |
- Drug Metab Dispos, 2020, 48(10):1044-1052
|
|
S4259 |
Vilazodone HCl
|
Vilazodone HCl is a selective serotonin reuptake inhibitor (SSRI) and a partial agonist of 5-HT1A receptors, used for the treatment of major depressive disorder. |
- J Pain, 2019, 20(1):16.e1-16.e16
- Acta Pol Pharm, 2017, 74(3):765-775
|
|
S4377 |
Imipramine HCl
|
Imipramine (Melipramine) is a tricyclic antidepressant (TCA) of the dibenzazepine group, mainly used in the treatment of major depression and enuresis (inability to control urination). |
- Antioxidants (Basel), 2021, 10(6)956
|
|
S4749 |
Citalopram HBr
|
Citalopram HBr (Nitalapram HBr, Prepram HBr, Bonitrile HBr, Lu 10-171 HBr), an antidepressant, is an orally administered selective serotonin reuptake inhibitor (SSRI) with IC50 of 1.8 nM. |
- Aging (Albany NY), 2021, 13(11):14729-14744
- Sci Rep, 2021, 11(1):1250
- Viruses, 2021, 13(8)1533
|
|
S5071 |
Duloxetine
|
Duloxetine (LY-248686) is a potent inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline (NE) uptake in vitro and in vivo and is 3- to 5-times more effective at inhibiting 5-HT uptake. |
|
|
S5239 |
Paroxetine mesylate
|
Paroxetine Mesylate is the mesylate salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties. |
- Am J Cancer Res, 2022, 12(4):1465-1483
- Anal Methods, 2021, 10.1039/d0ay02027c
|
|
S5485 |
Desipramine Hydrochloride
|
Desipramine hydrochloride (Desmethylimipramine, Norimipramine, EX-4355, G-35020, JB-8181, NSC-114901) is a dibenzazepine-derivative tricyclic antidepressant that acts as a selective norepinephrine reuptake inhibitor. It also shows weak serotonin reuptake inhibitory, α1-blocking, antihistamine, and anticholinergic effects. |
|
|
S5506 |
Vortioxetine
|
Vortioxetine, a novel antidepressant for the treatment of major depressive disorder, is a 5-HT3, 5-HT7 and 5-HT1D receptor antagonist, 5-HT1B receptor partial agonist, 5-HT1A receptor agonist and serotonin (5-HT) transporter (SERT) inhibitor. |
|
|
S5655 |
Venlafaxine
|
Venlafaxine (Wy 45030) is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia. |
|
|
S5693 |
Levomilnacipran Hydrochloride
|
Levomilnacipran Hydrochloride is a selective serotonin and norepinephrine reuptake inhibitor with antidepressant activity. |
|
|
S5858 |
Vilazodone
|
Vilazodone (EMD-68843, SB-659746A) is a novel antidepressant having a selective serotonin (5-HT) reuptake inhibitory and 5-HT1A receptor partial agonist activity. The affinity of vilazodone is much higher in the 5-HT reuptake site (Ki=0.1 nM) than in norepinephrine (Ki=56 nM) and dopamine (Ki=37 nM) sites. |
- J Pain, 2019, 20(1):16.e1-16.e16
|
|
S5947 |
Amitriptyline
|
Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant (TCA) with analgesic properties, widely used to treat depression and neuropathic pain. Amitriptyline is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. Amitriptyline also inhibits histamine receptor H1, histamine receptor H4, 5-HT2 and sigma 1 receptor with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. This product is a waxy solid. |
- Cancers (Basel), 2019, 11(12)
|
|
S8021 |
Vortioxetine (Lu AA21004) HBr
|
Vortioxetine (Lu AA21004), a multimodal serotonergic agent, is an antagonist of human (h) serotonin (5-HT)3A receptor and h5-HT7 receptor with Ki of 3.7 nM and 19 nM, respectively. Vortioxetine (Lu AA21004) is also a h5-HT1B receptor partial agonist with Ki of 33 nM and h5-HT1A receptor agonist with Ki of 15 nM, and a human 5-HT transporter (SERT) inhibitor with Ki of 1.6 nM. |
|
|