P2 Receptor

Signaling Pathway Map

Research Area

Inhibitory Selectivity

Isoform-specific Inhibitors

P2 Receptor Products

Catalog No. Information Product Use Citations Product Validations
S2855

MRS 2578

MRS2578 is a potent P2Y6 receptor antagonist with IC50 of 37 nM, exhibits insignificant activity at P2Y1, P2Y2, P2Y4,and P2Y11 receptors.

S1984

Ticlopidine HCl

Ticlopidine HCl is an P2 receptor inhibitor against ADP-induced platelet aggregation with IC50 of ~2 μM.

S4637

Prasugrel Hydrochloride

Prasugrel hydrochloride is a piperazine derivative and pletelet aggregation inhibitor that is used to prevent thrombosis in patients with acute coronary syndrome.

S3737

Cangrelor Tetrasodium

Cangrelor is a potent, competitive P2Y12 receptor inhibitor that is administered by intravenous infusion and rapidly achieves near complete inhibition of ADP-induced platelet aggregation.

S1258

Prasugrel

Prasugrel is a thienopyridine ADP receptor (P2Y12) antagonist, used for the reduction of thrombotic cardiovascular events.

S4079

Ticagrelor

Ticagrelor is the first reversibly binding oral P2Y12 receptor antagonist with Ki of 2 nM.

S6664New

Gefapixant

Gefapixant is an orally active small molecule antagonist of human P2X3 receptor with IC50 of about 30 nM, 100–250 nM for recombinant hP2X3 homotrimers and hP2X2/3 heterotrimeric receptors, respectively. Gefapixant has shown promise for the treatment of refractory and unexplained chronic cough.

S8725

A-804598

A-804598 is a selective P2X7R antagonist with high affinity at rat (IC50 = 10 nM), mouse (IC50 = 9 nM) and human (IC50 = 11 nM) P2X7 receptors.

S8519

A-317491

A-317491 is a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors with Ki values of 22 nM and 9 nM for human P2X3 and P2X2/3 receptors.

S7705

A-438079 HCl

A-438079 HCl is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9.

S5057

Minodronic acid

Minodronic acid (YM529) is a third-generation nitrogen-cotaining bisphosphonate that is used for the treatment of osteoporosis. Minodronic acid is an aminobisphosphonate that is a selective antagonist of purinergic P2X2/3 receptors involved in pain.

S6592New

Diquafosol Tetrasodium

Diquafosol Tetrasodium, a P2Y2 receptor agonist, is a pharmaceutical drug for the treatment of dry eye disease.

S1415

Clopidogrel Bisulfate

Clopidogrel is an oral, thienopyridine class antiplatelet agent.

Catalog No. Information Product Use Citations Product Validations
S2855

MRS 2578

MRS2578 is a potent P2Y6 receptor antagonist with IC50 of 37 nM, exhibits insignificant activity at P2Y1, P2Y2, P2Y4,and P2Y11 receptors.

S1984

Ticlopidine HCl

Ticlopidine HCl is an P2 receptor inhibitor against ADP-induced platelet aggregation with IC50 of ~2 μM.

S4637

Prasugrel Hydrochloride

Prasugrel hydrochloride is a piperazine derivative and pletelet aggregation inhibitor that is used to prevent thrombosis in patients with acute coronary syndrome.

S3737

Cangrelor Tetrasodium

Cangrelor is a potent, competitive P2Y12 receptor inhibitor that is administered by intravenous infusion and rapidly achieves near complete inhibition of ADP-induced platelet aggregation.

Catalog No. Information Product Use Citations Product Validations
S1258

Prasugrel

Prasugrel is a thienopyridine ADP receptor (P2Y12) antagonist, used for the reduction of thrombotic cardiovascular events.

S4079

Ticagrelor

Ticagrelor is the first reversibly binding oral P2Y12 receptor antagonist with Ki of 2 nM.

S6664New

Gefapixant

Gefapixant is an orally active small molecule antagonist of human P2X3 receptor with IC50 of about 30 nM, 100–250 nM for recombinant hP2X3 homotrimers and hP2X2/3 heterotrimeric receptors, respectively. Gefapixant has shown promise for the treatment of refractory and unexplained chronic cough.

S8725

A-804598

A-804598 is a selective P2X7R antagonist with high affinity at rat (IC50 = 10 nM), mouse (IC50 = 9 nM) and human (IC50 = 11 nM) P2X7 receptors.

S8519

A-317491

A-317491 is a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors with Ki values of 22 nM and 9 nM for human P2X3 and P2X2/3 receptors.

S7705

A-438079 HCl

A-438079 HCl is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9.

S5057

Minodronic acid

Minodronic acid (YM529) is a third-generation nitrogen-cotaining bisphosphonate that is used for the treatment of osteoporosis. Minodronic acid is an aminobisphosphonate that is a selective antagonist of purinergic P2X2/3 receptors involved in pain.

Catalog No. Information Product Use Citations Product Validations
S6592New

Diquafosol Tetrasodium

Diquafosol Tetrasodium, a P2Y2 receptor agonist, is a pharmaceutical drug for the treatment of dry eye disease.

Catalog No. Information Product Use Citations Product Validations
S1415

Clopidogrel Bisulfate

Clopidogrel is an oral, thienopyridine class antiplatelet agent.