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Cat.No. Product Name Information Product Use Citations Product Validations
S2215 DAPT DAPT is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells. DAPT enhances the apoptosis of human tongue carcinoma cells and regulates autophagy.
Signal Transduct Target Ther, 2025, 10(1):334
Cell Host Microbe, 2025, 33(3):408-419.e8
Nat Commun, 2025, 16(1):8693
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S1575 RO4929097 (RG-4733) RO4929097 (RG-4733) is a γ secretase inhibitor with IC50 of 4 nM in a cell-free assay, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respectively. Phase 2.
Nat Commun, 2025, 16(1):10435
Cell Rep Med, 2025, S2666-3791(25)00102-8
Cell Death Dis, 2025, 16(1):150
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S2714 LY411575 LY411575 is a potent γ-secretase inhibitor with IC50 of 0.078 nM/0.082 nM (membrane/cell-based), also inhibits Notch cleavage with IC50 of 0.39 nM in APP or NΔE expressing HEK293 cells. LY411575 induces apoptosis.
Nat Commun, 2025, 16(1):5913
Dev Cell, 2025, S1534-5807(25)00468-X
Cell Rep, 2025, 44(4):115508
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S7169 Crenigacestat (LY3039478) Crenigacestat (LY3039478) is an oral Notch and gamma-secretase inhibitor with IC50 of 0.41 nM for Notch.
Cancer Commun (Lond), 2025, 10.1002/cac2.70021
J Exp Clin Cancer Res, 2024, 43(1):286
Cell Death Dis, 2024, 15(1):53
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S7399 FLI-06 FLI-06 is a novel inhibitor of Notch signaling with EC50 of 2.3 μM.
Cell Rep Med, 2025, S2666-3791(25)00231-9
Dev Cell, 2022, 57(2):260-276.e9
Autophagy, 2020, 16:1-24
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S8280 IMR-1 IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 26 μM.
Oncogene, 2024,
Cell Death Dis, 2022, 13(11):945
Cell Biosci, 2021, 11(1):87
S3376 RIN1 (RBPJ Inhibitor-1) RIN1 (RBPJ Inhibitor-1) is a potent inhibitor of the transcription factor RBPJ that disrupts the interaction between NOTCH and RBPJ.
Cell Commun Signal, 2024, 22(1):608
bioRxiv, 2024, 2024.12.02.626505
Nat Cardiovasc Res, 2024, 3(9):1035-1048
S9719 Limantrafin (CB-103)

An orally active inhibitor of the Notch transcription activation complex, Limantrafin (CB-103) produces Notch loss-of-function phenotypes in flies and mice and inhibits the growth of human breast cancer and leukemia xenografts.
Sci Rep, 2024, 14(1):21912
Stem Cell Reports, 2023, 18(7):1516-1533
Sci Rep, 2023, 13(1):13700
S6668 NVS-ZP7-4 NVS-ZP7-4,a Zinc transporter SLC39A7 (ZIP7) inhibitor,is the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel druggable node in the Notch pathway.
P1255New Jagged-1 (188-204) (TFA) Jagged-1 (188-204) (TFA) is a peptide fragment of the Jagged-1 (JAG-1) protein with Notch agonist activity. JAG-1 is highly expressed in cultured and primary multiple myeloma (MM) cells. JAG-1 also induces the maturation of monocyte-derived human dendritic cells.