P-gp

Choose Selective P-gp Inhibitors

P-gp Signaling Pathway Map

P-gp Signaling Pathways

P-gp Products

  • All (15)
  • P-gp Inhibitors (11)
  • P-gp Agonist (1)
  • P-gp Modulators (3)
  • New P-gp Products
Catalog No. Product Name Information Product Use Citations Product Validations
S0921 Wilforine Wilforine (WR), a sesquiterpene pyridine alkaloid found in T. wilfordii plants, significantly inhibits the efflux activity of P-glycoprotein (P-gp).
S3235 Sinapine Sinapine is an alkaloid isolated from seeds of the cruciferous species with antioxidant, antitumor and radio-protective activities. Sinapine inhibits the proliferation of Caco-2 cells via downregulation of P-glycoprotein.
Gene, 2022, 827:146460
S3431 Encequidar (HM30181) Encequidar (HM30181, HM30181A) is a potent and selective inhibitor of the adenosine triphosphate-binding cassette transporter P-glycoprotein (P-gp).
S3600 Schisandrin B (Sch B) Schisandrin B is the most abundant dibenzocyclooctadiene lignan present in the traditional Chinese medicinal herb Schisandra chinensis (Turcz.) Baill. It is a kind of ATR and P-gp inhibitor with high safety.
Ann Transl Med, 2021, 9(19):1500
Drug Dev Res, 2021, 10.1002/ddr.21905
Pharmacol Res, 2021, 166:105459
S4202 Verapamil (CP-16533-1) HCl Verapamil HCl (CP-16533-1,(±)-Verapamil hydrochloride) is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent. Verapamil inhibits both permeability-glycoprotein (P-gp) and CYP3A4.
EMBO Mol Med, 2022, 14(2):e14903
Cell Rep, 2022, 38(10):110468
ACS Nano, 2021, 10.1021/acsnano.1c03517
S4746 (20S)-Protopanaxadiol 20(S)-Protopanaxadiol (PPD, 20-Epiprotopanaxadiol), the main intestinal metabolite of ginsenosides, is one of the active ingredients in ginseng. 20(S)-Protopanaxadiol inhibits P-glycoprotein in multidrug resistant cancer cells.
S7124 SC144 SC144 is the first-in-class orally active small-molecule gp130 inhibitor that induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes.
Cancers (Basel), 2022, 14(9)2055
Front Pharmacol, 2021, 12:656697
Int J Mol Med, 2021, 48(4)190
S7772 Elacridar (GF120918) Elacridar (GF120918, GW120918, GG918, GW0918) is a potent P-gp (MDR-1) and BCRP inhibitor.
Mol Cancer Ther, 2022, molcanther.0013.2022
Cell Death Dis, 2021, 12(8):742
Nutr Metab (Lond), 2021, 18(1):63
S8028 Tariquidar (XR9576) Tariquidar (XR9576) is a potent and selective noncompetitive inhibitor of P-glycoprotein with Kd of 5.1 nM in CHrB30 cell line, reverses drug resistance in MDR cell Lines. Phase 3.
Cell Death Dis, 2022, 13(5):492
Mol Cancer Ther, 2022, molcanther.0013.2022
BMC Complement Med Ther, 2022, 22(1):13
S9145 Solamargine Solamargine, a bioactive steroidal alkaloid isolated from Solanum aculeastrum, induces potent, non-selective cytotoxicity and P-gp inhibition.
Sci Rep, 2016, 6:36721
S9563 Evodine Evodine, a natural product extracted from Evodiae fructus (EF), is a biomarker for quality assessment of EF in the Chinese Pharmacopoeia. Evodine is a potent P-gp inhibitor.
E0080New UCLA GP130 2 UCLA GP130 2 (GP130 receptor agonist-1) is a potent, brain-penetrant and orally active Glycoprotein 130 (Gp130) receptor agonist, being a humanin mimetic binding to the GP130 D4-D5 domain and reducing NMDA-induced toxicity.
S1481 Zosuquidar (LY335979) 3HCl Zosuquidar 3HCl (LY335979, RS 33295-198, D06387) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM in a cell-free assay. Phase 3.
Mol Cancer Ther, 2022, molcanther.0013.2022
J Neurochem, 2021, 157(6):1861-1875
PLoS One, 2021, 16(3):e0236770
S4662 Atazanavir Atazanavir (Latazanavir, Zrivada, Reyataz, BMS-232632) is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents. Atazanavir is a substrate and inhibitor of cytochrome P450 isozyme 3A (CYP3A4) and an inhibitor and inducer of P-glycoprotein.
Sci Rep, 2021, 11(1):19443
Front Cardiovasc Med, 2021, 8:634774
ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00536
S9201 Levistilide A Levistilide A (Diligustilide), a natural compound isolated from the traditional Chinese herb Ligusticum chuanxiong Hort, is a potential P-gp modulator and used for treating cancer.
S0921 Wilforine Wilforine (WR), a sesquiterpene pyridine alkaloid found in T. wilfordii plants, significantly inhibits the efflux activity of P-glycoprotein (P-gp).
S3235 Sinapine Sinapine is an alkaloid isolated from seeds of the cruciferous species with antioxidant, antitumor and radio-protective activities. Sinapine inhibits the proliferation of Caco-2 cells via downregulation of P-glycoprotein.
Gene, 2022, 827:146460
S3431 Encequidar (HM30181) Encequidar (HM30181, HM30181A) is a potent and selective inhibitor of the adenosine triphosphate-binding cassette transporter P-glycoprotein (P-gp).
S3600 Schisandrin B (Sch B) Schisandrin B is the most abundant dibenzocyclooctadiene lignan present in the traditional Chinese medicinal herb Schisandra chinensis (Turcz.) Baill. It is a kind of ATR and P-gp inhibitor with high safety.
Ann Transl Med, 2021, 9(19):1500
Drug Dev Res, 2021, 10.1002/ddr.21905
Pharmacol Res, 2021, 166:105459
S4202 Verapamil (CP-16533-1) HCl Verapamil HCl (CP-16533-1,(±)-Verapamil hydrochloride) is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent. Verapamil inhibits both permeability-glycoprotein (P-gp) and CYP3A4.
EMBO Mol Med, 2022, 14(2):e14903
Cell Rep, 2022, 38(10):110468
ACS Nano, 2021, 10.1021/acsnano.1c03517
S4746 (20S)-Protopanaxadiol 20(S)-Protopanaxadiol (PPD, 20-Epiprotopanaxadiol), the main intestinal metabolite of ginsenosides, is one of the active ingredients in ginseng. 20(S)-Protopanaxadiol inhibits P-glycoprotein in multidrug resistant cancer cells.
S7124 SC144 SC144 is the first-in-class orally active small-molecule gp130 inhibitor that induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes.
Cancers (Basel), 2022, 14(9)2055
Front Pharmacol, 2021, 12:656697
Int J Mol Med, 2021, 48(4)190
S7772 Elacridar (GF120918) Elacridar (GF120918, GW120918, GG918, GW0918) is a potent P-gp (MDR-1) and BCRP inhibitor.
Mol Cancer Ther, 2022, molcanther.0013.2022
Cell Death Dis, 2021, 12(8):742
Nutr Metab (Lond), 2021, 18(1):63
S8028 Tariquidar (XR9576) Tariquidar (XR9576) is a potent and selective noncompetitive inhibitor of P-glycoprotein with Kd of 5.1 nM in CHrB30 cell line, reverses drug resistance in MDR cell Lines. Phase 3.
Cell Death Dis, 2022, 13(5):492
Mol Cancer Ther, 2022, molcanther.0013.2022
BMC Complement Med Ther, 2022, 22(1):13
S9145 Solamargine Solamargine, a bioactive steroidal alkaloid isolated from Solanum aculeastrum, induces potent, non-selective cytotoxicity and P-gp inhibition.
Sci Rep, 2016, 6:36721
S9563 Evodine Evodine, a natural product extracted from Evodiae fructus (EF), is a biomarker for quality assessment of EF in the Chinese Pharmacopoeia. Evodine is a potent P-gp inhibitor.
E0080New UCLA GP130 2 UCLA GP130 2 (GP130 receptor agonist-1) is a potent, brain-penetrant and orally active Glycoprotein 130 (Gp130) receptor agonist, being a humanin mimetic binding to the GP130 D4-D5 domain and reducing NMDA-induced toxicity.
S1481 Zosuquidar (LY335979) 3HCl Zosuquidar 3HCl (LY335979, RS 33295-198, D06387) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM in a cell-free assay. Phase 3.
Mol Cancer Ther, 2022, molcanther.0013.2022
J Neurochem, 2021, 157(6):1861-1875
PLoS One, 2021, 16(3):e0236770
S4662 Atazanavir Atazanavir (Latazanavir, Zrivada, Reyataz, BMS-232632) is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents. Atazanavir is a substrate and inhibitor of cytochrome P450 isozyme 3A (CYP3A4) and an inhibitor and inducer of P-glycoprotein.
Sci Rep, 2021, 11(1):19443
Front Cardiovasc Med, 2021, 8:634774
ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00536
S9201 Levistilide A Levistilide A (Diligustilide), a natural compound isolated from the traditional Chinese herb Ligusticum chuanxiong Hort, is a potential P-gp modulator and used for treating cancer.
E0080New UCLA GP130 2 UCLA GP130 2 (GP130 receptor agonist-1) is a potent, brain-penetrant and orally active Glycoprotein 130 (Gp130) receptor agonist, being a humanin mimetic binding to the GP130 D4-D5 domain and reducing NMDA-induced toxicity.
Tags: P-gp inhibitor|P-gp agonist|P-gp activator|P-gp inducer|P-gp antagonist|P-gp signaling pathway|P-gp assay kit