P-gp

Signaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S8028 Tariquidar <1 mg/mL 52 mg/mL <1 mg/mL
S7772 Elacridar (GF120918) <1 mg/mL 8 mg/mL <1 mg/mL
S3600 Schisandrin B (Sch B) <1 mg/mL 80 mg/mL 10 mg/mL
S7124 SC144 <1 mg/mL 28 mg/mL <1 mg/mL
S1481 Zosuquidar (LY335979) 3HCl 23 mg/mL 100 mg/mL <1 mg/mL
S9201 Levistilide A -1 mg/mL 76 mg/mL -1 mg/mL
Catalog No. Information Product Use Citations Product Validations
S8028

Tariquidar

Tariquidar is a potent and selective noncompetitive inhibitor of P-glycoprotein with Kd of 5.1 nM in CHrB30 cell line, reverses drug resistance in MDR cell Lines. Phase 3.

S7772

Elacridar (GF120918)

Elacridar (GF120918) is a potent P-gp (MDR-1) and BCRP inhibitor.

S3600

Schisandrin B (Sch B)

Schisandrin B is the most abundant dibenzocyclooctadiene lignan present in the traditional Chinese medicinal herb Schisandra chinensis (Turcz.) Baill. It is a kind of ATR and P-gp inhibitor with high safety.

S9145New

Solamargine

Solamargine, a bioactive steroidal alkaloid isolated from Solanum aculeastrum, induces potent, non-selective cytotoxicity and P-gp inhibition.

S7124

SC144

SC144 is the first-in-class orally active small-molecule gp130 inhibitor that induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes.

S1481

Zosuquidar (LY335979) 3HCl

Zosuquidar (LY335979) 3HCl is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM in a cell-free assay. Phase 3.

S9201New

Levistilide A

Levistilide A, a natural compound isolated from the traditional Chinese herb Ligusticum chuanxiong Hort, is a potential P-gp modulator and used for treating cancer.