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Histamine Receptor

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Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S1847 Clemastine (HS-592) Fumarate Clemastine fumarate is a selective histamine H1 receptor antagonist with IC50 of 3 nM. Clemastine stimulates autophagy via mTOR pathway.
Journal of Cerebral Blood Flow & Metabolism, March 2026, 786-803
Translational Research, June 2024, 40-50
Neurochemical Research, February 2022, 503-515
Verified customer review of Clemastine (HS-592) Fumarate
S3037 Bepotastine Besilate Bepotastine Besilate (TAU 284) is a non-sedating, selective antagonist of histamine 1 (H1) receptor with pIC50 of 5.7.
iScience, 2024, 27(10):110862
J Pers Med, 2022, 12(2)258
Journal of Cellular Biochemistry, 2022, 673-690
S1358 Loratadine Loratadine is a histamine H1 receptor antagonist, used to treat allergies. This compound also acts as a selective inhibitor of B(0)AT2 with IC50 of 4 μM.
Anticancer Research, July 2019, 3767-3775
Front Cell Infect Microbiol, 2024, 14:1358873
BMC Pharmacol Toxicol, 2024, 25(1):25
S1357 Lidocaine Lidocaine (Alphacaine) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.
ACS Applied Materials & Interfaces, March 09, 2023, 13892-13906
Journal of Inflammation Research, June 17, 2025, 7907-7919
Anticancer Research, July 15, 2019, 3767-3775
S2552 Azelastine HCl Azelastine HCl is a potent, second-generation, selective, histamine receptor antagonist, used in the treatment of rhinitis.
Biomed Pharmacother, 2024, 176:116766
UNIVERSITY OF PÉCS, 2023,
Front Pharmacol, 2022, 13:861295
S2905 JNJ-7777120 JNJ-7777120 is the first potent and selective non-imidazole histamine H4 receptor antagonist with Ki of 4.5 nM, exhibits >1000-fold selectivity over the other histamin receptors.
Front Microbiol, 2022, 13:802409
J Assoc Res Otolaryngol, 2021, 10.1007/s10162-021-00803-5
Neuropharmacology, 2020, 168:108028
S2044 Cyproheptadine HCl Cyproheptadine HCl(Periactin) is a hydrochloride salt form of cyproheptadine which is a histamine receptor antagonist.
Anticancer Research, July 2019, 3767-3775
Frontiers in Pharmacology, April 08 2025, 16:1539032
Front Pharmacol, 2025, 16:1539032
S2078 Famotidine Famotidine (MK208) is a histamine H2–receptor antagonist with IC50 of 0.6 mM, commonly used to treat heartburn, GERD, ulcers, and other digestive conditions.
BMC Pharmacology and Toxicology, October 22, 2021, 62
Anticancer Research, July 2019, 3767-3775
Calcified Tissue International, December 2021, 696-705
S1382 Mianserin HCl Mianserin (Bolvidon, Norval, Tolvon,ORG GB-94 HCl,Mianserin hydrochloride) is an potent antagonist of H1 histamine receptor and 5-HT serotonin receptors, used for the treatment of depression.
Communications Medicine, 2025, 420
Alzheimers Dement, 2023, 10.1002/alz.13090
Proceedings of the National Academy of Sciences, 2021, e2026403118
S1801 Ranitidine Hydrochloride Ranitidine (AH19065) is a histamine H2-receptor antagonist, used to treat stomach or intestinal ulcers.
Anticancer Research, July 2019, 3767-3775
bioRxiv, 2023, Preprint
Calcif Tissue Int, 2021, 109(6):696-705

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