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Sigma Receptor

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Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S0106 BD-1047 dihydrobromide BD-1047 dihydrobromide (HBr) is a selective functional antagonist of sigma-1 (σ1) receptor, shows antipsychotic activity in animal models predictive of efficacy in schizophrenia.
Brain Res, 2024, 1838:149011
Authorea Preprints, 2023,
Neuropharmacology, 2021, 196:108360
S6981 Glycerol phenylbutyrate Glycerol phenylbutyrate (GT4P, HPN-100M, Ravicti) is a nitrogen-binding agent and acts as a sigma-2 (σ2) receptor ligand with a pKi of 8.02. This compound is a prodrug in which phenylbutyrate (PBA) is released from the glycerol backbone by lipases in the gastrointestinal tract.
S0295 Anavex 2-73 HCl Anavex 2-73 (Blarcamesine, AVex-73, AE-37), an aminotetrahydrofuran derivative, is a mixed muscarinic and sigma-1/σ1 Receptor agonist with IC50 of 0.86 μM.
S0869 Carbetapentane Carbetapentane (Pentoxyverine, CB) is an antitussive anticonvulsant nonselective sigma-1 (σ1) agonist.
S6561 4-IBP 4-IBP is a selective σ1 receptor agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM).
E0388 WQ 1 WQ 1 is a high affinity and selective σ1 receptor antagonist with pKi values of 10.85, 6.53 and 5.80 at σ1, σ2 receptors and dopamine transporter (DAT), displaying σ1/σ2 selectivity ratio of 20893.
E7744 Siramesine Siramesine (Lu 28-179) is a potent agonist of sigma-2 receptor(σ1R) with an IC50 of 0.12 nM, exhibiting 140-fold selectivity over sigma-1 receptors. It shows strong anxiolytic effects and induces cancer cell death, highlighting its potential anticancer activity.
S2917 Cutamesine Dihydrochloride Cutamesine dihydrochloride (SA4503 dihydrochloride,AGY94806 dihydrochloride) is a potent Sigma-1 receptor agonist with an IC50 of 17.4 nM in guinea pig brain membranes.
S0191 BD1063 2HCL BD1063 2HCL (BD1063 dihydrochloride) is a potent and selective sigma-1 receptor (σ1R) antagonist with Ki of 4.43 nM.
S6950 PRE-084 hydrochloride PRE-084 hydrochloride (HCl) is a potent, selective sigma-1 receptor (σ1, S1R) agonist with IC50 of 44 nM in the sigma receptor assay.
Free Radic Biol Med, 2025, 226:96-108