Adenosine Deaminase

Inhibitory Selectivity

Adenosine Deaminase Products

Catalog No. Information Product Use Citations Product Validations
S1199

Cladribine (RWJ 26251)

Cladribine (RWJ 26251, Leustatin, 2-CdA, 2-chlorodeoxyadenosine, 2-Chloro-2′-deoxyadenosine, CldAdo, Jk 6251, NSC 105014) is an adenosine deaminase inhibitor for U266, RPMI8226, and MM1.S cells with IC50 of approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectively.
Hum Cell, 2021, 10.1007/s13577-021-00579-z
Nat Commun, 2021, 12(1):1275
Nat Commun, 2020, 29;11(1):2086
S9521

Pentostatin

Pentostatin is a potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.
Nat Metab, 2020, 10.1038/s42255-020-0227-4
S0950New

Hibifolin

Hibifolin, a flavonol glycoside, prevents beta-amyloid-induced neurotoxicity in vitro.
Catalog No. Information Product Use Citations Product Validations
S1199

Cladribine (RWJ 26251)

Cladribine (RWJ 26251, Leustatin, 2-CdA, 2-chlorodeoxyadenosine, 2-Chloro-2′-deoxyadenosine, CldAdo, Jk 6251, NSC 105014) is an adenosine deaminase inhibitor for U266, RPMI8226, and MM1.S cells with IC50 of approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectively.
Hum Cell, 2021, 10.1007/s13577-021-00579-z
Nat Commun, 2021, 12(1):1275
Nat Commun, 2020, 29;11(1):2086
S9521

Pentostatin

Pentostatin is a potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.
Nat Metab, 2020, 10.1038/s42255-020-0227-4
S0950New

Hibifolin

Hibifolin, a flavonol glycoside, prevents beta-amyloid-induced neurotoxicity in vitro.