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OX Receptor

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Isoform-selective Inhibitors

OX Receptor Products

All (6)
OX Receptor Antagonists (6)
New OX Receptor Products

Catalog No.	Product Name	Information	Product Use Citations	Product Validations
E0107^New	EMPA	EMPA is a selective OX2 receptor antagonist and binds to human and rat OX2-HEK293 membranes with Kd values of 1.1 and 1.4 nM respectively.	Oxid Med Cell Longev, 2022, 2022:1122494
S1545	SB408124	SB408124 is a non-peptide antagonist for OX1 receptor with K_i of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor.	Nat Chem Biol, 2017, 13(2):235-242
S2160	Almorexant HCl	Almorexant HCl (ACT-078573) is an orally active, dual orexin receptor antagonist with IC50 of 6.6 nM and 3.4 nM for OX1 and OX2 receptor, respectively. Phase 3.	Cell Rep, 2020, 31(11):107779 Am J Physiol Heart Circ Physiol, 2017, 312(4):H808-H817 J Pharmacol Exp Ther, 2016, 358(3):492-501
S6717	TCS-OX2-29	TCX-OX2-29 is a OX2R antagonist (pKi = 7.5) that exhibits >250-fold selectivity for hOX2R compared with hOX1R (IC50s = 40 nM and >10,000 nM, respectively).
S6726	MK1064	MK1064 is a selective orexin 2 receptor antagonist (2-SORA) with an IC50 of 18 nM.
S7585	SB-334867	SB-334867 is a selective orexin-1 (OX1) receptor antagonist.	J Neuroinflammation, 2020, 17(1):187 Med Sci Monit, 2019, 25:2886-2895
E0107^New	EMPA	EMPA is a selective OX2 receptor antagonist and binds to human and rat OX2-HEK293 membranes with Kd values of 1.1 and 1.4 nM respectively.	Oxid Med Cell Longev, 2022, 2022:1122494
S1545	SB408124	SB408124 is a non-peptide antagonist for OX1 receptor with K_i of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor.	Nat Chem Biol, 2017, 13(2):235-242
S2160	Almorexant HCl	Almorexant HCl (ACT-078573) is an orally active, dual orexin receptor antagonist with IC50 of 6.6 nM and 3.4 nM for OX1 and OX2 receptor, respectively. Phase 3.	Cell Rep, 2020, 31(11):107779 Am J Physiol Heart Circ Physiol, 2017, 312(4):H808-H817 J Pharmacol Exp Ther, 2016, 358(3):492-501
S6717	TCS-OX2-29	TCX-OX2-29 is a OX2R antagonist (pKi = 7.5) that exhibits >250-fold selectivity for hOX2R compared with hOX1R (IC50s = 40 nM and >10,000 nM, respectively).
S6726	MK1064	MK1064 is a selective orexin 2 receptor antagonist (2-SORA) with an IC50 of 18 nM.
S7585	SB-334867	SB-334867 is a selective orexin-1 (OX1) receptor antagonist.	J Neuroinflammation, 2020, 17(1):187 Med Sci Monit, 2019, 25:2886-2895
E0107^New	EMPA	EMPA is a selective OX2 receptor antagonist and binds to human and rat OX2-HEK293 membranes with Kd values of 1.1 and 1.4 nM respectively.	Oxid Med Cell Longev, 2022, 2022:1122494

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