OX Receptor

Signaling Pathway Map

Research Area

Inhibitory Selectivity

Isoform-specific Inhibitors

OX Receptor Products

New OX Receptor Products
Catalog No. Information Product Use Citations Product Validations
S7585

SB-334867

SB-334867 is a selective orexin-1 (OX1) receptor antagonist.

S1545

SB408124

SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor.

S2160

Almorexant HCl

Almorexant HCl is an orally active, dual orexin receptor antagonist with IC50 of 6.6 nM and 3.4 nM for OX1 and OX2 receptor, respectively. Phase 3.

S6717New

TCS-OX2-29

TCX-OX2-29 is a OX2R antagonist (pKi = 7.5) that exhibits >250-fold selectivity for hOX2R compared with hOX1R (IC50s = 40 nM and >10,000 nM, respectively).

S3054

Alverine Citrate

Alverine citrate is a drug used for functional gastrointestinal disorders.

S3880

Schisantherin A

Schisantherin A, also known as Gomisin C, is a dibenzocyclooctadiene that exhibits anti-tussive, sedative, anti-inflammatory, anti-osteoporotic, neuroprotective, cognition enhancing, and cardioprotective activities.

Catalog No. Information Product Use Citations Product Validations
S7585

SB-334867

SB-334867 is a selective orexin-1 (OX1) receptor antagonist.

S1545

SB408124

SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor.

S2160

Almorexant HCl

Almorexant HCl is an orally active, dual orexin receptor antagonist with IC50 of 6.6 nM and 3.4 nM for OX1 and OX2 receptor, respectively. Phase 3.

S6717New

TCS-OX2-29

TCX-OX2-29 is a OX2R antagonist (pKi = 7.5) that exhibits >250-fold selectivity for hOX2R compared with hOX1R (IC50s = 40 nM and >10,000 nM, respectively).

Catalog No. Information Product Use Citations Product Validations
S3054

Alverine Citrate

Alverine citrate is a drug used for functional gastrointestinal disorders.

S3880

Schisantherin A

Schisantherin A, also known as Gomisin C, is a dibenzocyclooctadiene that exhibits anti-tussive, sedative, anti-inflammatory, anti-osteoporotic, neuroprotective, cognition enhancing, and cardioprotective activities.