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Beta Amyloid

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Cat.No. Product Name Information Product Use Citations Product Validations
S2215 DAPT DAPT is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells. DAPT enhances the apoptosis of human tongue carcinoma cells and regulates autophagy.
Signal Transduct Target Ther, 2025, 10(1):334
Cell Host Microbe, 2025, 33(3):408-419.e8
Nat Commun, 2025, 16(1):8693
Verified customer review of DAPT
S1575 RO4929097 (RG-4733) RO4929097 (RG-4733) is a γ secretase inhibitor with IC50 of 4 nM in a cell-free assay, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respectively. Phase 2.
Nat Commun, 2025, 16(1):10435
Cell Rep Med, 2025, S2666-3791(25)00102-8
Cell Death Dis, 2025, 16(1):150
Verified customer review of RO4929097 (RG-4733)
S5742 Deferoxamine mesylate Deferoxamine mesylate is the mesylate salt of Deferoxamine, which forms iron complexes and is used as a chelating agent. Deferoxamine is a ferroptosis inhibitor that stabilizes HIF-1α expression and improves HIF-1α transactivity in hypoxic and hyperglycemic states in vitro. Deferoxamine decreases beta-amyloid (Aβ) deposition and induces autophagy.Please do not prepare stock solutions with normal saline or PBS, as precipitation may occur.
Cancer Cell, 2025, S1535-6108(25)00132-1
Nat Commun, 2025, 16(1):4919
Nat Commun, 2025, 16(1):6617
S8185 FPS-ZM1 FPS-ZM1 is a blood-brain-barrier permeant, non-toxic, tertiary amide compound which is a high affinity RAGE-specific inhibitor, blocking Aβ binding to the V domain of RAGE.
Circ J, 2025, 10.1253/circj.CJ-24-0878
Clin Immunol, 2024, 262:110178
Pharmacol Res, 2023, 192:106791
Verified customer review of FPS-ZM1
S4261 EUK 134 EUK 134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.
Signal Transduct Target Ther, 2025, 10(1):171
Front Aging Neurosci, 2022, 14:1013943
Chem Biol Interact, 2021, 351:109756
S3923 Ginsenoside Rg1 Ginsenoside Rg1 (Ginsenoside A2, Panaxoside A, Panaxoside Rg1, Sanchinoside C1, Sanchinoside Rg1), one of the major active components of ginseng, is identified as a protopanaxatriol-type and has pharmacological actions such as neuroprotective and anti-tumor effects on various cancer types. This compound reduces cerebral Aβ levels and NF-κB nuclear translocation.
Kaohsiung J Med Sci, 2025, e70078.
iScience, 2024, 27(10):110862
Waste Biomass Valori, 2024, 10.1007/s12649-023-02147-y
S3922 (-)-epigallocatechin (-)-Epigallocatechin, widespread in plants, has been shown to exhibit anti-tumor, anti-cancer and anti-inflammatory functions.
Front Pharmacol, 2024, 15:1403424
J Inflamm Res, 2023, 16:2007-2020
Eur J Pharmacol, 2020, 173323
S9087 Tenuifolin Tenuifolin, a secondary saponin isolated from hydrolysates of polygalasaponins, inhibits beta-amyloid synthesis in vitro and has nootropic activity in vivo via acetylcholine esterase inhibition and increases norepinephrine and dopamine production.
CNS Neurosci Ther, 2025, 31(8):e70588
S9428 Brazilin Brazilin (Natural Red 24) is a red pigment obtained from the wood of the brazilwood family. It is used to dye fabric and has diverse biological activities, including neuroprotective, anti-inflammatory, antibacterial, and antioxidant properties.
J Cell Mol Med, 2025, 29(13):e70688
S3811 Ginsenoside Re Ginsenoside Re (Ginsenoside B2, Panaxoside Re, Sanchinoside Re, Chikusetsusaponin Ivc), an extract from Panax notoginseng, is a major ginsenoside in ginseng and belongs to 20(S)-protopanaxatriol group. It has diverse in vitro and in vivo effects, including vasorelaxant, antioxidant, antihyperlipidemic, and angiogenic actions. This compound decreases the β-amyloid protein (Aβ). It plays a role in antiinflammation through inhibition of JNK and NF-κB.
J Ethnopharmacol, 2021, S0378-8741(21)00169-0

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