Beta Amyloid

Neuronal Signaling

DPP Aminopeptidase Procollagen C Proteinase P450 (e.g. CYP17) Phospholipase (e.g. PLA) Factor Xa PDE DHFR Carbonic Anhydrase Hydroxylase Liver X Receptor FAAH Acyltransferase Dehydrogenase Phosphorylase PPAR CYP17 CETP FXR HMG-CoA Reductase Transferase IDO/TDO Retinoid Receptor Casein Kinase NAMPT phosphatase Lipase Lipoxygenase Thioredoxin Decarboxylase Vitamin Serine/threonin kinase LDL Fatty Acid Synthase FOX Glycogen synthesis PKM Glycolysis HDL Carbohydrate Metabolism ATP-citrate lyase Acetyl-CoA carboxylase CYP450 PCSK9 Leukotriene PDHK PGC-1α ROR FABP Peroxidases Aldose Reductase Xanthine Oxidase THR Epoxide Hydrolase PEP GTPCH FAO PAI-1 LDH SCD PREP CPSase Mannosidase Thioredoxin Reductase SGK FTase γGCS SREBP Mitochondrial Metabolism PARG Glucosylceramide Synthase Catalase 3-MST Serine hydrolase CAR glucocerebrosidase Mitochondrial pyruvate carrier GOT SHIP SOD LCN Endogenous Metabolite ATGL NMT Aconitase AGEs Amino Acids and Derivatives Amylase Drug Metabolite Glucokinase Glucosidase glycosidase GSNOR GST Hexokinase Isocitrate Dehydrogenase (IDH) Lipid Liposome LPL Receptor MAGL NEDD4-1 NPC1L1 PGK1 Reductase stilbene oxidase UGT

All (25)
Beta Amyloid Inhibitors (21)
New Beta Amyloid Products

Cat.No.	Product Name	Information	Product Use Citations
S8185	FPS-ZM1	FPS-ZM1 is a blood-brain-barrier permeant, non-toxic, tertiary amide compound which is a high affinity RAGE-specific inhibitor, blocking Aβ binding to the V domain of RAGE.	Circ J, 2025, 10.1253/circj.CJ-24-0878 Clin Immunol, 2024, 262:110178 Pharmacol Res, 2023, 192:106791
S4261	EUK 134	EUK 134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.	Signal Transduct Target Ther, 2025, 10(1):171 Front Aging Neurosci, 2022, 14:1013943 Chem Biol Interact, 2021, 351:109756
S3922	(-)-epigallocatechin	(-)-Epigallocatechin, widespread in plants, has been shown to exhibit anti-tumor, anti-cancer and anti-inflammatory functions.	Front Pharmacol, 2024, 15:1403424 J Inflamm Res, 2023, 16:2007-2020 Eur J Pharmacol, 2020, 173323
S3923	Ginsenoside Rg1	Ginsenoside Rg1 (Ginsenoside A2, Panaxoside A, Panaxoside Rg1, Sanchinoside C1, Sanchinoside Rg1), one of the major active components of ginseng, is identified as a protopanaxatriol-type and has pharmacological actions such as neuroprotective and anti-tumor effects on various cancer types. This compound reduces cerebral Aβ levels and NF-κB nuclear translocation.	Kaohsiung J Med Sci, 2025, e70078. iScience, 2024, 27(10):110862 Waste Biomass Valori, 2024, 10.1007/s12649-023-02147-y
S3811	Ginsenoside Re	Ginsenoside Re (Ginsenoside B2, Panaxoside Re, Sanchinoside Re, Chikusetsusaponin Ivc), an extract from Panax notoginseng, is a major ginsenoside in ginseng and belongs to 20(S)-protopanaxatriol group. It has diverse in vitro and in vivo effects, including vasorelaxant, antioxidant, antihyperlipidemic, and angiogenic actions. This compound decreases the β-amyloid protein (Aβ). It plays a role in antiinflammation through inhibition of JNK and NF-κB.	J Ethnopharmacol, 2021, S0378-8741(21)00169-0
S0486	Hoechst 34580	Hoechst 34580 (HOE 34580) is a cell-permeable blue fluorescent dye to stain DNA and nuclei. This compound is also a good candidate for treating the Alzheimer's disease by inhibiting amyloid beta (Aβ) formation with IC50 of 0.86 μM.	Front Nutr, 2022, 9:961182
E2948	β-Amyloid (25-35)	β-Amyloid (25-35) (Amyloid beta-peptide (25-35), Aβ25-35, β-Amyloid peptide (25-35)) is a highly toxic synthetic derivative of Amyloid beta-peptide (Aβ-peptides) which forms fibrillary aggregates. This compound, with the sequence GSNKGAIIGLM, is involved in the pathogenesis of Alzheimer's disease.
E3560	Incised notopterygium rhizome Extract	Incised Notopterygium Rhizome Extract is extracted from Notopterygium incisum, which rescues cognitive deficits in APP/PS1 Alzheimer's disease mice by attenuating amyloid-beta, tau, and neuroinflammation pathology.
S0529	PBD-150	PBD-150 is a potent human glutaminyl cyclase (hQC) Y115E-Y117E variant inhibitor with Ki of 60 nM.
S5101	Tabersonine hydrochloride	Tabersonine, an ingredient extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1−42) aggregation and toxicity.
E0077	Simufilam	Simufilam(PTI-125) is a potent, orally active small drug against AD, which interacts to filamin and controls the actin cytoskeleton. This compound reduces tau hyperphosphorylation, amyloid and tau formation by preventing and reversing the binding of Aβ42 to α7 nAChR.
S9087	Tenuifolin	Tenuifolin, a secondary saponin isolated from hydrolysates of polygalasaponins, inhibits beta-amyloid synthesis in vitro and has nootropic activity in vivo via acetylcholine esterase inhibition and increases norepinephrine and dopamine production.	CNS Neurosci Ther, 2025, 31(8):e70588
S6733	Edonerpic maleate	Edonerpic maleate (T-817) is a novel neurotrophic agent which can inhibit amyloid-β peptides (Aβ).
S9428	Brazilin	Brazilin (Natural Red 24) is a red pigment obtained from the wood of the brazilwood family. It is used to dye fabric and has diverse biological activities, including neuroprotective, anti-inflammatory, antibacterial, and antioxidant properties.	J Cell Mol Med, 2025, 29(13):e70688
S2418	Frentizole	Frentizole (Frentizol) is a novel inhibitor of amyloid beta peptide (Abeta) binding alcohol dehydrogenase (ABAD) interaction with IC50 of 200 μM. This compound is a nontoxic antiviral and immunosuppressive agent used clinically in rheumatoid arthritis and systemic lupus erythematosus.
S3405	CRANAD-2	CRANAD-2, a near-infrared (NIR) Amyloid-beta (Aβ) plaque-specific fluorescent probe, penetrates the blood brain barrier and has a high affinity for Aβ aggregates with a Kd of 38 nM.
S2215	DAPT	DAPT is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells. DAPT enhances the apoptosis of human tongue carcinoma cells and regulates autophagy.	Signal Transduct Target Ther, 2025, 10(1):334 Cell Host Microbe, 2025, 33(3):408-419.e8 Nat Commun, 2025, 16(1):8693
S1575	RO4929097 (RG-4733)	RO4929097 (RG-4733) is a γ secretase inhibitor with IC50 of 4 nM in a cell-free assay, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respectively. Phase 2.	Nat Commun, 2025, 16(1):10435 Cell Rep Med, 2025, S2666-3791(25)00102-8 Cell Death Dis, 2025, 16(1):150
S5742	Deferoxamine mesylate	Deferoxamine mesylate is the mesylate salt of Deferoxamine, which forms iron complexes and is used as a chelating agent. Deferoxamine is a ferroptosis inhibitor that stabilizes HIF-1α expression and improves HIF-1α transactivity in hypoxic and hyperglycemic states in vitro. Deferoxamine decreases beta-amyloid (Aβ) deposition and induces autophagy.Please do not prepare stock solutions with normal saline or PBS, as precipitation may occur.	Cancer Cell, 2025, S1535-6108(25)00132-1 Nat Commun, 2025, 16(1):4919 Nat Commun, 2025, 16(1):6617
S1262	Avagacestat (BMS-708163)	Avagacestat (BMS-708163) is a potent, selective, and orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 values of 0.3 nM and 0.27 nM, respectively. This compound demonstrates a 193-fold selectivity against Notch and has reached Phase 2 clinical trials.	Nat Commun, 2022, 13(1):6345 Sci Rep, 2022, 12(1):7 Cell, 2021, 184(2):521-533.e14
S2660	MK-0752	MK-0752 is a moderately potent γ-secretase inhibitor, which reduces Aβ40 production with IC50 of 5 nM. Phase 1/2.	Nat Cell Biol, 2024, 26(3):353-365 Cancers (Basel), 2023, 15(6)1883 J Cancer Res Clin Oncol, 2023, 149(16):14691-14699
S1594	Semagacestat (LY450139)	Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively. It also inhibits Notch signaling with IC50 of 14.1 nM in H4 human glioma cell. This compound has reached Phase 3 clinical trials.	Cell Rep Med, 2025, S2666-3791(25)00102-8 Biochim Biophys Acta Mol Basis Dis, 2025, 1871(8):167992 Cancers (Basel), 2023, 15(6)1883
S1528	LY2811376	LY2811376 is the first orally available non-peptidic β-secretase(BACE1) inhibitor with IC50 of 239 nM-249 nM, that act to decrease Aβ secretion with EC50 of 300 nM, demonstrated to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin. Phase 1.	Glycobiology, 2023, 33(4):325-341 J Agric Food Chem, 2022, 70(5):1536-1546 Sci Rep, 2022, 12(1):7
S9664	Colivelin	Colivelin (CLN) is a brain-penetrant neuroprotective peptide with potent long-term capacity against Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. Colivelin is an activator of STAT3.	J Clin Invest, 2025, 135(11)e181243 J Adv Res, 2025, S2090-1232(25)00444-8 Stem Cell Res Ther, 2025, 16(1):40
S4760	(2-Hydroxypropyl)-β-cyclodextrin (HP-β-CD)	(2-Hydroxypropyl)-β-cyclodextrin (HP-β-CD, HP-β-cyclodextrin, Hydroxypropyl betadex, Hydroxypropyl-β-cyclodextrin) is a well-known sugar used in drug delivery, genetic vectors, environmental protection, and the treatment of Niemann-Pick disease type C1 (NPC1). It is an inhibitor of amyloid-β aggregation and widely used drug delivery vehicle to improve stability and bioavailability.	bioRxiv , 2023, 10.1101/2023.07.14.548985 Technol Cancer Res Treat, 2021, 20:15330338211027916 Oncotarget, 2015, 6(30):29497-512
S8185	FPS-ZM1	FPS-ZM1 is a blood-brain-barrier permeant, non-toxic, tertiary amide compound which is a high affinity RAGE-specific inhibitor, blocking Aβ binding to the V domain of RAGE.	Circ J, 2025, 10.1253/circj.CJ-24-0878 Clin Immunol, 2024, 262:110178 Pharmacol Res, 2023, 192:106791
S4261	EUK 134	EUK 134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.	Signal Transduct Target Ther, 2025, 10(1):171 Front Aging Neurosci, 2022, 14:1013943 Chem Biol Interact, 2021, 351:109756
S3923	Ginsenoside Rg1	Ginsenoside Rg1 (Ginsenoside A2, Panaxoside A, Panaxoside Rg1, Sanchinoside C1, Sanchinoside Rg1), one of the major active components of ginseng, is identified as a protopanaxatriol-type and has pharmacological actions such as neuroprotective and anti-tumor effects on various cancer types. This compound reduces cerebral Aβ levels and NF-κB nuclear translocation.	Kaohsiung J Med Sci, 2025, e70078. iScience, 2024, 27(10):110862 Waste Biomass Valori, 2024, 10.1007/s12649-023-02147-y
S3811	Ginsenoside Re	Ginsenoside Re (Ginsenoside B2, Panaxoside Re, Sanchinoside Re, Chikusetsusaponin Ivc), an extract from Panax notoginseng, is a major ginsenoside in ginseng and belongs to 20(S)-protopanaxatriol group. It has diverse in vitro and in vivo effects, including vasorelaxant, antioxidant, antihyperlipidemic, and angiogenic actions. This compound decreases the β-amyloid protein (Aβ). It plays a role in antiinflammation through inhibition of JNK and NF-κB.	J Ethnopharmacol, 2021, S0378-8741(21)00169-0
S0486	Hoechst 34580	Hoechst 34580 (HOE 34580) is a cell-permeable blue fluorescent dye to stain DNA and nuclei. This compound is also a good candidate for treating the Alzheimer's disease by inhibiting amyloid beta (Aβ) formation with IC50 of 0.86 μM.	Front Nutr, 2022, 9:961182
E3560	Incised notopterygium rhizome Extract	Incised Notopterygium Rhizome Extract is extracted from Notopterygium incisum, which rescues cognitive deficits in APP/PS1 Alzheimer's disease mice by attenuating amyloid-beta, tau, and neuroinflammation pathology.
S0529	PBD-150	PBD-150 is a potent human glutaminyl cyclase (hQC) Y115E-Y117E variant inhibitor with Ki of 60 nM.
S5101	Tabersonine hydrochloride	Tabersonine, an ingredient extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1−42) aggregation and toxicity.
E0077	Simufilam	Simufilam(PTI-125) is a potent, orally active small drug against AD, which interacts to filamin and controls the actin cytoskeleton. This compound reduces tau hyperphosphorylation, amyloid and tau formation by preventing and reversing the binding of Aβ42 to α7 nAChR.
S9087	Tenuifolin	Tenuifolin, a secondary saponin isolated from hydrolysates of polygalasaponins, inhibits beta-amyloid synthesis in vitro and has nootropic activity in vivo via acetylcholine esterase inhibition and increases norepinephrine and dopamine production.	CNS Neurosci Ther, 2025, 31(8):e70588
S6733	Edonerpic maleate	Edonerpic maleate (T-817) is a novel neurotrophic agent which can inhibit amyloid-β peptides (Aβ).
S2418	Frentizole	Frentizole (Frentizol) is a novel inhibitor of amyloid beta peptide (Abeta) binding alcohol dehydrogenase (ABAD) interaction with IC50 of 200 μM. This compound is a nontoxic antiviral and immunosuppressive agent used clinically in rheumatoid arthritis and systemic lupus erythematosus.
S2215	DAPT	DAPT is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells. DAPT enhances the apoptosis of human tongue carcinoma cells and regulates autophagy.	Signal Transduct Target Ther, 2025, 10(1):334 Cell Host Microbe, 2025, 33(3):408-419.e8 Nat Commun, 2025, 16(1):8693
S1575	RO4929097 (RG-4733)	RO4929097 (RG-4733) is a γ secretase inhibitor with IC50 of 4 nM in a cell-free assay, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respectively. Phase 2.	Nat Commun, 2025, 16(1):10435 Cell Rep Med, 2025, S2666-3791(25)00102-8 Cell Death Dis, 2025, 16(1):150
S5742	Deferoxamine mesylate	Deferoxamine mesylate is the mesylate salt of Deferoxamine, which forms iron complexes and is used as a chelating agent. Deferoxamine is a ferroptosis inhibitor that stabilizes HIF-1α expression and improves HIF-1α transactivity in hypoxic and hyperglycemic states in vitro. Deferoxamine decreases beta-amyloid (Aβ) deposition and induces autophagy.Please do not prepare stock solutions with normal saline or PBS, as precipitation may occur.	Cancer Cell, 2025, S1535-6108(25)00132-1 Nat Commun, 2025, 16(1):4919 Nat Commun, 2025, 16(1):6617
S1262	Avagacestat (BMS-708163)	Avagacestat (BMS-708163) is a potent, selective, and orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 values of 0.3 nM and 0.27 nM, respectively. This compound demonstrates a 193-fold selectivity against Notch and has reached Phase 2 clinical trials.	Nat Commun, 2022, 13(1):6345 Sci Rep, 2022, 12(1):7 Cell, 2021, 184(2):521-533.e14
S2660	MK-0752	MK-0752 is a moderately potent γ-secretase inhibitor, which reduces Aβ40 production with IC50 of 5 nM. Phase 1/2.	Nat Cell Biol, 2024, 26(3):353-365 Cancers (Basel), 2023, 15(6)1883 J Cancer Res Clin Oncol, 2023, 149(16):14691-14699
S1594	Semagacestat (LY450139)	Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively. It also inhibits Notch signaling with IC50 of 14.1 nM in H4 human glioma cell. This compound has reached Phase 3 clinical trials.	Cell Rep Med, 2025, S2666-3791(25)00102-8 Biochim Biophys Acta Mol Basis Dis, 2025, 1871(8):167992 Cancers (Basel), 2023, 15(6)1883
S1528	LY2811376	LY2811376 is the first orally available non-peptidic β-secretase(BACE1) inhibitor with IC50 of 239 nM-249 nM, that act to decrease Aβ secretion with EC50 of 300 nM, demonstrated to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin. Phase 1.	Glycobiology, 2023, 33(4):325-341 J Agric Food Chem, 2022, 70(5):1536-1546 Sci Rep, 2022, 12(1):7
S9664	Colivelin	Colivelin (CLN) is a brain-penetrant neuroprotective peptide with potent long-term capacity against Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. Colivelin is an activator of STAT3.	J Clin Invest, 2025, 135(11)e181243 J Adv Res, 2025, S2090-1232(25)00444-8 Stem Cell Res Ther, 2025, 16(1):40
S4760	(2-Hydroxypropyl)-β-cyclodextrin (HP-β-CD)	(2-Hydroxypropyl)-β-cyclodextrin (HP-β-CD, HP-β-cyclodextrin, Hydroxypropyl betadex, Hydroxypropyl-β-cyclodextrin) is a well-known sugar used in drug delivery, genetic vectors, environmental protection, and the treatment of Niemann-Pick disease type C1 (NPC1). It is an inhibitor of amyloid-β aggregation and widely used drug delivery vehicle to improve stability and bioavailability.	bioRxiv , 2023, 10.1101/2023.07.14.548985 Technol Cancer Res Treat, 2021, 20:15330338211027916 Oncotarget, 2015, 6(30):29497-512

Beta Amyloid

Neuronal Signaling

Signaling Pathway Map