NMDAR

Inhibitory Selectivity

Isoform-specific Inhibitors

NMDAR Products

New NMDAR Products
Catalog No. Information Product Use Citations Product Validations
S4023

Procaine HCl

Procaine is an inhibitor of sodium channel, NMDA receptor and nAChR with IC50 of 60 μM, 0.296 mM and 45.5 μM, which is also an inhibitor of 5-HT3 with KD of 1.7 μM.

S2857

(-)-MK 801 maleate

(-)-MK-801 (Dizocilpine) is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM.

S2876

(+)-MK 801 maleate

(+)-MK-801 is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.

S4091

Ifenprodil Tartrate

Ifenprodil is an atypical noncompetitive antagonist at the NMDA receptor, it interacts with high affinity at a homogeneous population of NMDA receptors in neonatal rat forebrain with IC50 of 0.3 μM.

S5664New

Orphenadrine Hydrochloride

Orphenadrine Hydrochloride is an uncompetitive NMDAR antagonist, H1 receptor antagonist and nonselective mAChR antagonist with muscle relaxant activity.

S2043

Memantine HCl

Memantine HCl is an antagonist of NMDAR. It is also a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively.

S1330

Felbamate

Felbamate (Felbatol) is an anticonvulsant drug used in the treatment of epilepsy; NMDAR antagonist.

S4957

Linalool

Linalool, a monoterpene compound commonly found as major component of essential oils of several aromatic species, is a competitive antagonist of NMDA receptors.

S5287

Tiletamine Hydrochloride

Tiletamine is a lipophilc and potent vetrinary anesthetic. It is also a NMDA receptor antagonist.

S3653

Spermidine trihydrochloride

Spermidine, a natural polyamine produced from putrescine and decarboxylated S-adenosylmethionine (dcSAM) by spermidine synthase, is a novel autophagy inducer and negatively modulates N-methyl-d-aspartate (NMDA).

S5032

Mephenesin

Mephenesin is centrally acting muscle relaxant, a topical analgesic and may be an NMDA receptor antagonist.

S4719

Kynurenic acid

Kynurenic acid, a natural metabolite of tryptophan via the kynurenine pathway, is a broad-spectrum excitatory amino acid antagonist; It proved to be an antagonist at NMDA, kainate and AMPA receptors.

S7072

NMDA (N-Methyl-D-aspartic acid)

NMDA(N-Methyl-D-aspartic acid)is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Phase 4.

S3624

Quinolinic acid

Quinolinic Acid, a neuroactive metabolite of the kynurenine pathway, is an agonist of N-methyl-D-aspartate (NMDA) receptor.

S4702

Sarcosine

Sarcosine is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.

S9271New

Pulchinenoside A

Pulchinenoside A, a natural triterpenoid saponin, is a AMPARs and NMDAR modulator.

S5129

D-Aspartic acid

D-Aspartic acid (D-Asp) is an endogenous amino acid occurring in several tissues and cells of both invertebrates and vertebrates. It can regulate testosterone synthesis and may act on a stimulatory receptor (NMDA).

S5302

6-Methoxy-2-naphthoic acid

6-Methoxy-2-naphthoic acid is an modulator of NMDAR.

Catalog No. Information Product Use Citations Product Validations
S4023

Procaine HCl

Procaine is an inhibitor of sodium channel, NMDA receptor and nAChR with IC50 of 60 μM, 0.296 mM and 45.5 μM, which is also an inhibitor of 5-HT3 with KD of 1.7 μM.

Catalog No. Information Product Use Citations Product Validations
S2857

(-)-MK 801 maleate

(-)-MK-801 (Dizocilpine) is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM.

S2876

(+)-MK 801 maleate

(+)-MK-801 is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.

S4091

Ifenprodil Tartrate

Ifenprodil is an atypical noncompetitive antagonist at the NMDA receptor, it interacts with high affinity at a homogeneous population of NMDA receptors in neonatal rat forebrain with IC50 of 0.3 μM.

S5664New

Orphenadrine Hydrochloride

Orphenadrine Hydrochloride is an uncompetitive NMDAR antagonist, H1 receptor antagonist and nonselective mAChR antagonist with muscle relaxant activity.

S2043

Memantine HCl

Memantine HCl is an antagonist of NMDAR. It is also a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively.

S1330

Felbamate

Felbamate (Felbatol) is an anticonvulsant drug used in the treatment of epilepsy; NMDAR antagonist.

S4957

Linalool

Linalool, a monoterpene compound commonly found as major component of essential oils of several aromatic species, is a competitive antagonist of NMDA receptors.

S5287

Tiletamine Hydrochloride

Tiletamine is a lipophilc and potent vetrinary anesthetic. It is also a NMDA receptor antagonist.

S3653

Spermidine trihydrochloride

Spermidine, a natural polyamine produced from putrescine and decarboxylated S-adenosylmethionine (dcSAM) by spermidine synthase, is a novel autophagy inducer and negatively modulates N-methyl-d-aspartate (NMDA).

S5032

Mephenesin

Mephenesin is centrally acting muscle relaxant, a topical analgesic and may be an NMDA receptor antagonist.

S4719

Kynurenic acid

Kynurenic acid, a natural metabolite of tryptophan via the kynurenine pathway, is a broad-spectrum excitatory amino acid antagonist; It proved to be an antagonist at NMDA, kainate and AMPA receptors.

Catalog No. Information Product Use Citations Product Validations
S7072

NMDA (N-Methyl-D-aspartic acid)

NMDA(N-Methyl-D-aspartic acid)is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Phase 4.

S3624

Quinolinic acid

Quinolinic Acid, a neuroactive metabolite of the kynurenine pathway, is an agonist of N-methyl-D-aspartate (NMDA) receptor.

S4702

Sarcosine

Sarcosine is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.

Catalog No. Information Product Use Citations Product Validations
S9271New

Pulchinenoside A

Pulchinenoside A, a natural triterpenoid saponin, is a AMPARs and NMDAR modulator.

S5129

D-Aspartic acid

D-Aspartic acid (D-Asp) is an endogenous amino acid occurring in several tissues and cells of both invertebrates and vertebrates. It can regulate testosterone synthesis and may act on a stimulatory receptor (NMDA).

S5302

6-Methoxy-2-naphthoic acid

6-Methoxy-2-naphthoic acid is an modulator of NMDAR.