NMDAR

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S4023 Procaine HCl 55 mg/mL 55 mg/mL <1 mg/mL
S2857 (-)-MK 801 maleate <1 mg/mL 67 mg/mL 7 mg/mL
S2876 (+)-MK 801 maleate <1 mg/mL 68 mg/mL <1 mg/mL
S4091 Ifenprodil Tartrate 9 mg/mL 95 mg/mL 62 mg/mL
S5664 Orphenadrine Hydrochloride -1 mg/mL 61 mg/mL -1 mg/mL
S5287 Tiletamine Hydrochloride -1 mg/mL 30 mg/mL -1 mg/mL
S1330 Felbamate <1 mg/mL 48 mg/mL 3 mg/mL
S3653 Spermidine trihydrochloride 50 mg/mL 30 mg/mL <1 mg/mL
S4719 Kynurenic acid <1 mg/mL 10 mg/mL <1 mg/mL
S7072 NMDA (N-Methyl-D-aspartic acid) 30 mg/mL 5 mg/mL <1 mg/mL
S3624 Quinolinic acid 3 mg/mL 25 mg/mL <1 mg/mL
S4702 Sarcosine 17 mg/mL <1 mg/mL <1 mg/mL
S5302 6-Methoxy-2-naphthoic acid <1 mg/mL 40 mg/mL 16 mg/mL
S5129 D-Aspartic acid <1 mg/mL 0.01 mg/mL <1 mg/mL

Isoform-specific Inhibitors

Catalog No. Information Product Use Citations Product Validations
S4023

Procaine HCl

Procaine is an inhibitor of sodium channel, NMDA receptor and nAChR with IC50 of 60 μM, 0.296 mM and 45.5 μM, which is also an inhibitor of 5-HT3 with KD of 1.7 μM.

S2857

(-)-MK 801 maleate

(-)-MK-801 (Dizocilpine) is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM.

S2876

(+)-MK 801 maleate

(+)-MK-801 is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.

S4091

Ifenprodil Tartrate

Ifenprodil is an atypical noncompetitive antagonist at the NMDA receptor, it interacts with high affinity at a homogeneous population of NMDA receptors in neonatal rat forebrain with IC50 of 0.3 μM.

S5664New

Orphenadrine Hydrochloride

Orphenadrine Hydrochloride is an uncompetitive NMDAR antagonist, H1 receptor antagonist and nonselective mAChR antagonist with muscle relaxant activity.

S5287New

Tiletamine Hydrochloride

Tiletamine is a lipophilc and potent vetrinary anesthetic. It is also a NMDA receptor antagonist.

S5032New

Mephenesin

Mephenesin is centrally acting muscle relaxant, a topical analgesic and may be an NMDA receptor antagonist.

S4957New

Linalool

Linalool, a monoterpene compound commonly found as major component of essential oils of several aromatic species, is a competitive antagonist of NMDA receptors.

S1330

Felbamate

Felbamate (Felbatol) is an anticonvulsant drug used in the treatment of epilepsy; NMDAR antagonist.

S3653

Spermidine trihydrochloride

Spermidine, a natural polyamine produced from putrescine and decarboxylated S-adenosylmethionine (dcSAM) by spermidine synthase, is a novel autophagy inducer and negatively modulates N-methyl-d-aspartate (NMDA).

S4719

Kynurenic acid

Kynurenic acid, a natural metabolite of tryptophan via the kynurenine pathway, is a broad-spectrum excitatory amino acid antagonist; It proved to be an antagonist at NMDA, kainate and AMPA receptors.

S7072

NMDA (N-Methyl-D-aspartic acid)

NMDA(N-Methyl-D-aspartic acid)is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Phase 4.

S3624

Quinolinic acid

Quinolinic Acid, a neuroactive metabolite of the kynurenine pathway, is an agonist of N-methyl-D-aspartate (NMDA) receptor.

S4702

Sarcosine

Sarcosine is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.

S9271New

Pulchinenoside A

Pulchinenoside A, a natural triterpenoid saponin, is a AMPARs and NMDAR modulator.

S5302New

6-Methoxy-2-naphthoic acid

6-Methoxy-2-naphthoic acid is an modulator of NMDAR.

S5129New

D-Aspartic acid

D-Aspartic acid (D-Asp) is an endogenous amino acid occurring in several tissues and cells of both invertebrates and vertebrates. It can regulate testosterone synthesis and may act on a stimulatory receptor (NMDA).