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TRP Channel

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Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S1990 Capsaicin(Vanilloid) Capsaicin(Vanilloid) is an active component of chili peppers, which are plants belonging to the genus Capsicum. It is a TRPV1 agonist with an EC50 of 0.29 μM in HEK293 cells. This compound is a mixture of Capsaicin and Dihydrocapsaicin.
J Biomed Sci, 2025, 32(1):47
Int J Mol Sci, 2025, 26(1)380
Biol Pharm Bull, 2025, 48(6):769-781
S6657 2-APB (2-Aminoethyl Diphenylborinate) 2-Aminoethyl Diphenylborinate (2-APB) is an IP3 receptor inhibitor and regulates IP3-induced calcium release. It also inhibits the SOC channel activity and, at higher concentrations, inhibits TRP channel.
Cell Prolif, 2025, e70120.
PLoS Pathog, 2025, 21(1):e1012872
Liver Int, 2025, 45(10):e70341
S7999 SKF96365 SKF96365, originally identified as a blocker of receptor-mediated calcium entry, is widely used diagnostically, as a blocker of transient receptor potential canonical type (TRPC) channels.
Exp Lung Res, 2025, 51(1):23-37
J Vis Exp, 2025, (224)
Research Square, 2024, 10.21203/rs.3.rs-3863076/v1
S7115 AMG-517 AMG 517 is a potent and selective TRPV1 antagonist, and antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM， respectively.
Mucosal Immunol, 2024, S1933-0219(24)00006-0
Front Immunol, 2024, 15:1477072
iScience, 2023, 26(5):106749
S8367 GSK2193874 GSK2193874 is an orally active, potent, and selective blocker of transient receptor potential vanilloid 4 (TRPV4) with IC50 values of 0.04 and 0.002 μM for hTRPV4 and rTRPV4, respectively.
Brain Stimul, 2025, 18(5):1455-1469
Int J Oral Sci, 2024, 16(1):3
iScience, 2023, 26(5):106749
S8107 GSK1016790A GSK1016790A (GSK101) is a novel, potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34nM in choroid plexus epithelial cells.
Brain Stimul, 2025, 18(5):1455-1469
Am J Physiol Lung Cell Mol Physiol, 2024, 326(3):L252-L265
iScience, 2023, 26(5):106749
S2918 HC-030031 HC-030031 (TOSLAB 829227) is a selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx with IC50 of 6.2 μM and 5.3 μM respectively.
Int J Mol Sci, 2025, 26(3)1385
Lipids Health Dis, 2023, 22(1):6
Mol Pain, 2023, 19:17448069231158290
S8137 Capsazepine Capsazepine acts as a competitive antagonist of capsaicin and a transient receptor potential vanilloid type 1(TRPV1) antagonist. If you want to do cell experiments, please select batch 01.
Biol Pharm Bull, 2025, 48(6):769-781
J Ethnopharmacol, 2024, 337(Pt 2):118882
Sci Adv, 2023, 9(27):eadg9593
S9849 EIPA (L593754) EIPA (L593754; MH 12-43) acts as an inhibitor of macropinocytosis and sodium-hydrogen exchangers(NHE) (IC50=0.033μg/mL). EIPA blocks the activity of Na(+)/H(+) exchanger, which are plasma membrane proteins implicated in all forms of macropinocytosis.
J Adv Res, 2025, S2090-1232(25)00267-X
J Nanobiotechnology, 2025, 23(1):173
iScience, 2025, 28(2):111830
S2773 SB705498 SB705498 is a TRPV1 antagonist for hTRPV1, antagonizes capsaicin, acid, and heat activation of TRPV1 with IC50 of 3 nM, 0.1 nM and 6 nM, shows a degree of voltage dependence, exhibits >100-fold selectivity for TRPV1 over TRPM8. Phase 2.
Oxid Med Cell Longev, 2022, 2022:8096009
IUBMB Life, 2022, 10.1002/iub.2605
Biogerontology, 2016, 17(5-6):907-920
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