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TRP Channel

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Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S6657 2-APB (2-Aminoethyl Diphenylborinate) 2-Aminoethyl Diphenylborinate (2-APB) is an IP3 receptor inhibitor and regulates IP3-induced calcium release. It also inhibits the SOC channel activity and, at higher concentrations, inhibits TRP channel.
J Virol, 2026, 100(5):e0212525
Cell Prolif, 2025, e70120.
PLoS Pathog, 2025, 21(1):e1012872
S1990 Capsaicin(Vanilloid) Capsaicin(Vanilloid) is an active component of chili peppers, which are plants belonging to the genus Capsicum. It is a TRPV1 agonist with an EC50 of 0.29 μM in HEK293 cells. This compound is a mixture of Capsaicin and Dihydrocapsaicin.
J Biomed Sci, 2025, 32(1):47
Int J Mol Sci, 2025, 26(1)380
Biol Pharm Bull, 2025, 48(6):769-781
S7999 SKF96365 SKF96365, originally identified as a blocker of receptor-mediated calcium entry, is widely used diagnostically, as a blocker of transient receptor potential canonical type (TRPC) channels.
Exp Lung Res, 2025, 51(1):23-37
J Vis Exp, 2025, (224)
Research Square, 2024, 10.21203/rs.3.rs-3863076/v1
S7115 AMG-517 AMG 517 is a potent and selective TRPV1 antagonist, and antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM， respectively.
Mucosal Immunol, 2024, S1933-0219(24)00006-0
Frontiers in Immunology, 2024, 1477072
Mucosal Immunology, 2024, 211-225
S8137 Capsazepine Capsazepine acts as a competitive antagonist of capsaicin and a transient receptor potential vanilloid type 1(TRPV1) antagonist. If you want to do cell experiments, please select batch 01.
ImmunoTargets and Therapy, 2026 Mar 4, 571037
Immunotargets Ther, 2026, 15:571037
Biological and Pharmaceutical Bulletin, 2025, 769-781
S8367 GSK2193874 GSK2193874 is an orally active, potent, and selective blocker of transient receptor potential vanilloid 4 (TRPV4) with IC50 values of 0.04 and 0.002 μM for hTRPV4 and rTRPV4, respectively.
Brain Stimul, 2025, 18(5):1455-1469
Int J Oral Sci, 2024, 16(1):3
iScience, 2023, 26(5):106749
S2918 HC-030031 HC-030031 (TOSLAB 829227) is a selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx with IC50 of 6.2 μM and 5.3 μM respectively.
Int J Mol Sci, 2025, 26(3)1385
Lipids Health Dis, 2023, 22(1):6
Lipids in Health and Disease, 2023, 6
S8107 GSK1016790A GSK1016790A (GSK101) is a novel, potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34nM in choroid plexus epithelial cells.
Brain Stimul, 2025, 18(5):1455-1469
Am J Physiol Lung Cell Mol Physiol, 2024, 326(3):L252-L265
iScience, 2023, 26(5):106749
S9849 EIPA (L593754) EIPA (L593754; MH 12-43) acts as an inhibitor of macropinocytosis and sodium-hydrogen exchangers(NHE) (IC50=0.033μg/mL). EIPA blocks the activity of Na(+)/H(+) exchanger, which are plasma membrane proteins implicated in all forms of macropinocytosis.
MedComm (2020), 2026, 7(3):e70657
J Adv Res, 2025, S2090-1232(25)00267-X
J Nanobiotechnology, 2025, 23(1):173
S4022 Probenecid Probenecid (Benemid) is a classical competitive inhibitor of organic anion transport, which is also a TRPV2 agonist and an inhibitor of TAS2R16. This compound is also a clinically used broad-spectrum Pannexin1 (Panx1) blocker.
bioRxiv, September 28, 2025, nan
Frontiers in Immunology, September 21, 2022, 992505
Molecular Biology of the Cell, January 1, 2024, ar5