GABA Receptor
Signaling Pathway Map
Research Area
- Inhibitory Selectivity
- Solubility
| Catalog No. | Product Name | Solubility(25°C) | ||
|---|---|---|---|---|
| Water | DMSO | Alcohol | ||
| S1168 | Valproic acid sodium salt (Sodium valproate) | 33 mg/mL | 33 mg/mL | 33 mg/mL |
| S3018 | Niflumic acid | <1 mg/mL | 56 mg/mL | <1 mg/mL |
| S4661 | Tiagabine hydrochloride | 11 mg/mL | 82 mg/mL | 82 mg/mL |
| S1969 | Nefiracetam | 5 mg/mL | 49 mg/mL | 49 mg/mL |
| S1332 | Flumazenil | <1 mg/mL | 5 mg/mL | <1 mg/mL |
| S9249 | Securinine | -1 mg/mL | 44 mg/mL | -1 mg/mL |
| S9176 | Pimpinellin | -1 mg/mL | 49 mg/mL | -1 mg/mL |
| s9065 | Songorine | -1 mg/mL | 71 mg/mL | -1 mg/mL |
| S5049 | Thiocolchicoside | 100 mg/mL | 100 mg/mL | 2 mg/mL |
| S7071 | (+)-Bicuculline | <1 mg/mL | 21 mg/mL | <1 mg/mL |
| S2026 | Ginkgolide A | <1 mg/mL | 81 mg/mL | 2 mg/mL |
| S4587 | Pentylenetetrazol | 27 mg/mL | 27 mg/mL | 27 mg/mL |
| S4197 | Bemegride | <1 mg/mL | 31 mg/mL | 31 mg/mL |
| S1338 | Gabapentin HCl | 42 mg/mL | <1 mg/mL | <1 mg/mL |
| S1329 | Etomidate | <1 mg/mL | 49 mg/mL | 49 mg/mL |
| S2133 | Gabapentin | 34 mg/mL | <1 mg/mL | <1 mg/mL |
| S4840 | Baclofen | 0.1 mg/mL | <1 mg/mL | <1 mg/mL |
| S4892 | Phenibut | -1 mg/mL | 35 mg/mL | -1 mg/mL |
| S3072 | (R)-baclofen | 8 mg/mL | <1 mg/mL | <1 mg/mL |
| S4574 | Piperazine | 17 mg/mL | 8 mg/mL | 17 mg/mL |
| S3634 | 6-Hydroxyflavone (6-HF) | <1 mg/mL | 47 mg/mL | <1 mg/mL |
| S2269 | Baicalin | <1 mg/mL | 89 mg/mL | <1 mg/mL |
| S3786 | Glabridin | -1 mg/mL | 64 mg/mL | -1 mg/mL |
| S2399 | Dihydromyricetin | <1 mg/mL | 64 mg/mL | 64 mg/mL |
| S3663 | Afloqualone | <1 mg/mL | 56 mg/mL | 28 mg/mL |
| S4270 | Oxiracetam | 31 mg/mL | 31 mg/mL | <1 mg/mL |
| S4700 | 4-Aminobutyric acid (GABA) | 20 mg/mL | <1 mg/mL | <1 mg/mL |
| S3748 | Acamprosate Calcium | 40 mg/mL | <1 mg/mL | <1 mg/mL |
| S5805 | Allopregnanolone | <1 mg/mL | 64 mg/mL | 31 mg/mL |
Isoform-specific Inhibitors
- GABA Receptor Inhibitors (31)
- New GABA Receptor Products
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S1168 |
Valproic acid sodium salt (Sodium valproate)Valproic acid sodium salt (Sodium valproate) is a HDAC inhibitor by selectively inducing proteasomal degradation of HDAC2, used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. |
(A,B) Wild-type C57BL/6 male mice were treated with vehicle (saline) or 10 mg/kg of paraquat (PQ) for 3 days, and mice received VPA (3.5 mg/kg) or anacardic acid (5 mg/kg) starting 24 and 1 h before PQ injection. IL-6 mRNA expression was determined by real-time PCR.
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| S3018 |
Niflumic acidNiflumic acid is an inhibitor of cyclooxygenase-2 used for joint and muscular pain. |
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| S4661 |
Tiagabine hydrochlorideTiagabine Hydrochloride is the hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. A selective gamma-aminobutyric acid (GABA) reuptake inhibitor. |
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| S4675 |
TiagabineTiagabine is an anti-convulsive medication and a selective gamma-aminobutyric acid (GABA) reuptake inhibitor. |
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| S1969 |
NefiracetamNefiracetam is a GABAergic, cholinergic, and monoaminergic neuronal system enhancer for Ro 5-4864-induced convulsions. Phase 2. |
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| S1332 |
FlumazenilFlumazenil is a competitive GABAA receptor antagonist, used in the treatment of benzodiazepine overdoses. |
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| S9249New |
SecurinineSecurinine, a major natural alkaloid product from the root of the plant Securinega suffruticosa, acts as a γ-amino butyric acid (GABA) receptor antagonist. |
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| S9176New |
PimpinellinPimpinellin is a furocoumarin that acts as antagonist of proteins with GABA receptor activity. |
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| s9065New |
SongorineSongorine, a ubiquitous alkaloid in the genus Aconitum, is a novel antagonist of the GABAA receptor in rat brain and has antiarrhythmic, antinociceptive, anti-inflammatory, regenerative and CNS-modulating properties. |
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| S5049New |
ThiocolchicosideThiocolchicoside is a natural occuring glycoside originated from the flower seeds of superba gloriosa with anti-inflammatory and analgesic properties as well as pronounced convulsant activity. It is also an antagonist of GABAA receptor. |
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| S7071 |
(+)-Bicuculline(+)-Bicuculline is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels. |
-Bicuculline-S707101X0320161109.gif)
-Bicuculline-S707101X0320161109.gif)
Effects of antagonists on the anti-hyperalgesic effects of sinomenine in CCI rats. * P<0.05 as compared to vehicle control group (N=8 per group). The GABAA receptor antagonist bicuculline but not the opioid receptor antagonist naltrexone nor the 5-HT1A receptor antagonist WAY100635 blocked the antinociceptive effects of 40 mg/kg sinomenine. |
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| S2026 |
Ginkgolide AGinkgolide A is an extract from in Ginkgo biloba and a g-aminobutyric acid (GABA) antagonist with a Ki of 14.5 μM. |
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| S4587 |
PentylenetetrazolPentylenetetrazol displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GABA(A) receptor antagonist. |
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| S4197 |
BemegrideBemegride is a central nervous system stimulant and antidote for barbiturate poisoning. |
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| S1338 |
Gabapentin HClGabapentin HCl is a GABA analogue, used to treat seizures and neuropathic pain. |
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| S1329 |
EtomidateEtomidate is a GABAA receptor agonist, used as a short-acting anaesthetic agent or sedative. |
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| S2133 |
GabapentinGabapentin is a GABA analogue, used to treat seizures and neuropathic pain. |
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| S4840New |
BaclofenBaclofen is a gamma-amino-butyric acid (GABA) derivative used as a skeletal muscle relaxant and central nervous system depressant. It activates GABA receptors, specifically the GABAB receptors. |
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| S4892New |
PhenibutPhenibut, a GABA analogue, is a central nervous system depressant with anxiolytic and sedative effects. |
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| S3072 |
(R)-baclofen(R)-baclofen is a derivative of gamma-aminobutyric acid primarily used to treat spasticity. |
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| S4574 |
PiperazinePiperazine, GABA receptor agonist, is an anthelmintic used in the treatment of the intestinal nematodes Ascaris lumbricoides and Enterobius vermicularis. |
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| S3634 |
6-Hydroxyflavone (6-HF)6-Hydroxyflavone, a naturally occurring flavonoid, binds to GABAA receptors with moderate affinity and acts as a partial agonist of GABAA receptors. |
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| S2269 |
BaicalinBaicalin is a known prolyl endopeptidase inhibitor and affects the GABA receptors. |
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| S3786 |
GlabridinGlabridin, one of the active phytochemicals in licorice extract, binds to and activates the ligand binding domain of PPARγ, as well as the full length receptor. It is also a GABAA receptor positive modulator promoting fatty acid oxidation and improving learning and memory. |
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| S2399 |
DihydromyricetinDihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata. |
A. Cal27 cells transfected with GFP-LC3 plasmid were treated with different concentration of DHM for 24 h. The formation of GFP-LC3 puncta were examined using immunofluorescence and quantified. Scale bar 50 μm. |
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| S3663 |
AfloqualoneAfloqualone (AFQ) is a quinazolinone family GABAergic drug with muscle-relaxant and sedative effects, showing the agonist activity at the β subtype of the GABAa receptor. |
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| S4270 |
OxiracetamOxiracetam, a cyclic derivative of gamma-aminobutyric acid (GABA), is used as a nootropic drug to improve memory and learning. |
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| S4700 |
4-Aminobutyric acid (GABA)Gamma-Aminobutyric Acid is a naturally occurring neurotransmitter with central nervous system (CNS) inhibitory activity. |
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| S3748 |
Acamprosate CalciumAcamprosate, calcium acetylhomotaurinate, is a synthetic compound with a chemical structure similar to the amino acid neurotransmitter gamma-aminobutyric acid (GABA) and the amino acid neuromodulator taurine. |
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| S5805New |
AllopregnanoloneAllopregnanolone, a neurosteroid synthesized from progesterone in brain, acts as a highly potent positive allosteric modulator of the GABAA receptor. |
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| S5131New |
HomotaurineHomotaurine is a synthetic organic compound that has GABAergic activity by mimicking GABA. It is a GABAA partial agonist as well as a GABAB receptor partial agonist with low efficacy. |
