PP2A

Inhibitory Selectivity

PP2A Products

Catalog No. Information Product Use Citations Product Validations
S0308

AMZ30

AMZ30 (ML136, CS-2122) is a selective and covalent inhibitor of protein phosphatase methylesterase-1(PME-1) with IC50 of 0.60 μM. AMZ30 reduces the demethylated form of PP2A in living cells.
S7537

LB-100

LB-100 is a water soluble protein phosphatase 2A (PP2A) inhibitor with IC50s of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells.
Mol Cell, 2021, S1097-2765(21)00624-9
J Clin Invest, 2021, 144318
Cell Death Dis, 2021, 12(9):849
S8248

IQ-1

IQ-1 enables Wnt/β-catenin-driven expansion of mouse ESCs and prevents spontaneous differentiation, Maintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells and prevents PP2A/Nkd interaction.
Neoplasia, 2020, 23(1):1-11
Cell Mol Life Sci, 2019, 76(14):2817-2832
Front Genet, 2018, 9:746
S9695

iHAP1

iHAP1 is an activator of protein phosphatase 2A (PP2A) enzymes that activates PP2A-B56ε and potently kills malignant cells.
S8774

DT-061 (SMAP)

DT-061 (SMAP) is a bioavailable PP2A activator. It decreases cell viability in HCC827 and HCC3255 cell lines, with IC50 values of 14.3 μM and 12.4 μM respectively.
Development, 2021, dev.198838
Research Square, 2021, 10.21203/rs.3.rs-362391/v1
Catalog No. Information Product Use Citations Product Validations
S0308

AMZ30

AMZ30 (ML136, CS-2122) is a selective and covalent inhibitor of protein phosphatase methylesterase-1(PME-1) with IC50 of 0.60 μM. AMZ30 reduces the demethylated form of PP2A in living cells.
S7537

LB-100

LB-100 is a water soluble protein phosphatase 2A (PP2A) inhibitor with IC50s of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells.
Mol Cell, 2021, S1097-2765(21)00624-9
J Clin Invest, 2021, 144318
Cell Death Dis, 2021, 12(9):849
S8248

IQ-1

IQ-1 enables Wnt/β-catenin-driven expansion of mouse ESCs and prevents spontaneous differentiation, Maintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells and prevents PP2A/Nkd interaction.
Neoplasia, 2020, 23(1):1-11
Cell Mol Life Sci, 2019, 76(14):2817-2832
Front Genet, 2018, 9:746
Catalog No. Information Product Use Citations Product Validations
S9695

iHAP1

iHAP1 is an activator of protein phosphatase 2A (PP2A) enzymes that activates PP2A-B56ε and potently kills malignant cells.
S8774

DT-061 (SMAP)

DT-061 (SMAP) is a bioavailable PP2A activator. It decreases cell viability in HCC827 and HCC3255 cell lines, with IC50 values of 14.3 μM and 12.4 μM respectively.
Development, 2021, dev.198838
Research Square, 2021, 10.21203/rs.3.rs-362391/v1