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PP2A

Inhibitory Selectivity

PP2A Products

Catalog No. Information Product Use Citations Product Validations
S0308New

AMZ30

AMZ30 (ML136, CS-2122) is a selective and covalent inhibitor of protein phosphatase methylesterase-1(PME-1) with IC50 of 0.60 μM. AMZ30 reduces the demethylated form of PP2A in living cells.
S7537

LB-100

LB-100 is a water soluble protein phosphatase 2A (PP2A) inhibitor with IC50s of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells.
J Cell Biol, 2020, 219(4)
Cancer Res, 2020, 10;canres.57.2020
Int J Mol Sci, 2020, 21(18)E6642
S8248

IQ-1

IQ-1 enables Wnt/β-catenin-driven expansion of mouse ESCs and prevents spontaneous differentiation, Maintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells and prevents PP2A/Nkd interaction.
Neoplasia, 2020, 23(1):1-11
Cell Mol Life Sci, 2019, 76(14):2817-2832
Front Genet, 2018, 9:746
S9695New

iHAP1

iHAP1 is an activator of protein phosphatase 2A (PP2A) enzymes that activates PP2A-B56ε and potently kills malignant cells.
S8774

DT-061 (SMAP)

DT-061 (SMAP) is a bioavailable PP2A activator. It decreases cell viability in HCC827 and HCC3255 cell lines, with IC50 values of 14.3 μM and 12.4 μM respectively.
Catalog No. Information Product Use Citations Product Validations
S0308New

AMZ30

AMZ30 (ML136, CS-2122) is a selective and covalent inhibitor of protein phosphatase methylesterase-1(PME-1) with IC50 of 0.60 μM. AMZ30 reduces the demethylated form of PP2A in living cells.
S7537

LB-100

LB-100 is a water soluble protein phosphatase 2A (PP2A) inhibitor with IC50s of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells.
J Cell Biol, 2020, 219(4)
Cancer Res, 2020, 10;canres.57.2020
Int J Mol Sci, 2020, 21(18)E6642
S8248

IQ-1

IQ-1 enables Wnt/β-catenin-driven expansion of mouse ESCs and prevents spontaneous differentiation, Maintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells and prevents PP2A/Nkd interaction.
Neoplasia, 2020, 23(1):1-11
Cell Mol Life Sci, 2019, 76(14):2817-2832
Front Genet, 2018, 9:746
Catalog No. Information Product Use Citations Product Validations
S9695New

iHAP1

iHAP1 is an activator of protein phosphatase 2A (PP2A) enzymes that activates PP2A-B56ε and potently kills malignant cells.
S8774

DT-061 (SMAP)

DT-061 (SMAP) is a bioavailable PP2A activator. It decreases cell viability in HCC827 and HCC3255 cell lines, with IC50 values of 14.3 μM and 12.4 μM respectively.