APC

Anaphase-Promoting Complex (APC) which is also called cyclosome, a highly conserved protein, plays a key role in both cell cycle and Ubq degradation pathway. The APC can results in degradation of specific proteins which are involved in cell cycle by tagging those proteins during the transition from metaphase to anaphase. When spindle checkpoint is silenced, APC can easily bind to Cdc20 after phosphorylated by M-Cdks. Then APC targets cyclin A and cyclin B for degradation.

Cell Cycle

CFTR Calcium Channel Proton Pump P-gp Sodium Channel ATPase Potassium Channel CD markers TRPV CRM1 Cell Penetrating Peptide GLUT Amino acid transporter Chloride Channel MCT TRP Channel BCRP OAT GlyR VMAT MTP EAAT Aquaporin OATP NCX NBC NKCC Mechanosensitive Channel VRAC

All (2)
APC Inhibitors (2)
New APC Products

Cat.No.	Product Name	Information	Product Use Citations
S2225	TAME	Tosyl-L-Arginine Methyl Ester (TAME) is an APC inhibitor.	Dev Cell, 2023, 58(3):192-210.e11 J Pers Med, 2022, 12(2)258 Hum Cell, 2022, 10.1007/s13577-022-00671-y
S9605	Apcin	Apcin (APC inhibitor) is an inhibitor of the E3 ligase activity of the mitotic anaphase-promoting complex/cyclosome (APC/C) that binds to Cdc20 and competitively inhibits the ubiquitylation of D-box-containing substrates.	Nature, 2025, 647(8091):952-961 Theranostics, 2025, 15(8):3439-3461 Cell Mol Biol Lett, 2025, 30(1):29
S2225	TAME	Tosyl-L-Arginine Methyl Ester (TAME) is an APC inhibitor.	Dev Cell, 2023, 58(3):192-210.e11 J Pers Med, 2022, 12(2)258 Hum Cell, 2022, 10.1007/s13577-022-00671-y
S9605	Apcin	Apcin (APC inhibitor) is an inhibitor of the E3 ligase activity of the mitotic anaphase-promoting complex/cyclosome (APC/C) that binds to Cdc20 and competitively inhibits the ubiquitylation of D-box-containing substrates.	Nature, 2025, 647(8091):952-961 Theranostics, 2025, 15(8):3439-3461 Cell Mol Biol Lett, 2025, 30(1):29

APC

Cell Cycle

Signaling Pathway Map