Signaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S1452 Ispinesib (SB-715992) <1 mg/mL 103 mg/mL 103 mg/mL
S2182 SB743921 HCl 22 mg/mL 111 mg/mL 111 mg/mL
S2731 AZ 3146 <1 mg/mL 28 mg/mL 91 mg/mL
S7090 GSK923295 <1 mg/mL 100 mg/mL 100 mg/mL
S7355 ARQ 621 <1 mg/mL 100 mg/mL 100 mg/mL
S5933 K 858 <1 mg/mL 55 mg/mL 4 mg/mL
S5522 H-Cys(Trt)-OH -1 mg/mL 5 mg/mL -1 mg/mL
S8439 Monastrol <1 mg/mL 58 mg/mL 58 mg/mL
S8215 BAY 1217389 <1 mg/mL 100 mg/mL 3 mg/mL
S7488 MPI-0479605 <1 mg/mL 62 mg/mL 2 mg/mL
Catalog No. Information Product Use Citations Product Validations

Ispinesib (SB-715992)

Ispinesib (SB-715992) is a potent, specific and reversible inhibitor of kinesin spindle protein (KSP) with Ki app of 1.7 nM in a cell-free assay, no inhibition to CENP-E, RabK6, MCAK, MKLP1, KHC or Kif1A. Phase 2.


SB743921 HCl

SB743921 is a kinesin spindle protein (KSP) inhibitor with Ki of 0.1 nM, almost no affinity to MKLP1, Kin2, Kif1A, Kif15, KHC, Kif4 and CENP-E. Phase 1/2.


AZ 3146

AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM, contributes to recruitment of CENP-E (kinesin-related motor protein), less potent to FAK, JNK1, JNK2, and Kit.



GSK923295 is a first-in-class, specific allosteric inhibitor of CENP-E kinesin motor ATPase with Ki of 3.2 nM, and less potent to mutant I182 and T183. Phase 1.


ARQ 621

ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.


K 858

K858 is a novel and potent inhibitor of Eg5 with an IC50 of 1.3 μM for inhibiting the ATPase activity of Eg5, showing at least 150-fold more selective for Eg5 than other members of the kinesin superfamily.



H-Cys(Trt)-OH is a specific inhibitor of Eg5 that inhibits Eg5-driven microtubule sliding velocity in a reversible fashion with an IC50 of 500 nM.



Monastrol is a cell-permeable small molecule inhibitor of kinesin-5(KIF11) which is essential for maintaining separation of the half-spindles.


BAY 1217389

BAY 1217389 is an orally bioavailable, selective inhibitor of the serine/threonine kinase monopolar spindle 1 (Mps1) with IC50 values below 10 nmol/L while showing an excellent selectivity profile.



MPI-0479605 is an ATP competitive and selective inhibitor of mitotic kinase Mps1 with IC50 of 1.8 nM, >40-fold selectivity over other kinases.

Tags: KSP inhibition | Kinesin inhibition | Kinesin assay | Kinesin phosphorylation | Kinesin cancer | KSP inhibitors cancer | KSP inhibitor clinical trial | Kinesin inhibitors list | Kinesin inhibitor review