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Kinesin

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Kinesin Signaling Pathway Map

Isoform-selective Inhibitors

Kinesin-12 Selective

Kinesin Products

All (11)
Kinesin Inhibitors (10)
Kinesin Antibodie (1)
New Kinesin Products

Catalog No.	Product Name	Information	Product Use Citations
S0279	Dimethylenastron	Dimethylenastron is a potent, specific and reversible inhibitor of kinesin Eg5 (kinesin-5/kinesin spindle protein, KSP) with IC50 of 200 nM. Dimethylenastron induces mitotic arrest and apoptosis and upregulate Hsp70 in human multiple myeloma cells.
S1452	Ispinesib (SB-715992)	Ispinesib (SB-715992, CK0238273) is a potent, specific and reversible inhibitor of kinesin spindle protein (KSP) with K_{i app} of 1.7 nM in a cell-free assay, no inhibition to CENP-E, RabK6, MCAK, MKLP1, KHC or Kif1A. Ispinesib induces mitotic arrest and apoptotic cell death. Phase 2.	Cell, 2020, 182(3):685-712.e19 Cell, 2020, 182(3):685-712.e19 Sci Transl Med, 2020, 12(562)eaba4434
S2182	SB743921 HCl	SB743921 is a kinesin spindle protein (KSP) inhibitor with K_i of 0.1 nM, almost no affinity to MKLP1, Kin2, Kif1A, Kif15, KHC, Kif4 and CENP-E. Phase 1/2.	Cell, 2020, 182(3):685-712.e19 Cell, 2020, 182(3):685-712.e19 Sci Transl Med, 2020, 12(562)eaba4434
S5522	H-Cys(Trt)-OH	H-Cys(Trt)-OH (L-Cys(Trt)-OH, H-L-Cys(Trt)-OH, S-Tritylcysteine) is a specific inhibitor of Eg5 that inhibits Eg5-driven microtubule sliding velocity in a reversible fashion with an IC50 of 500 nM.
S5933	K 858	K858 is a novel and potent inhibitor of Eg5 with an IC50 of 1.3 μM for inhibiting the ATPase activity of Eg5, showing at least 150-fold more selective for Eg5 than other members of the kinesin superfamily.
S6796	BTB-1	BTB-1 is a novel, selective and reversible inhibitor of the mitotic motor protein Kif18A with IC50 of 1.69 μM.
S6953^New	GW406108X	GW406108X (GW108X) is an inhibitor of Kif15 (Kinesin-12) with an IC50 of 0.82 μM in the ATPase assay. GW406108X inhibits recombinant ULK1 kinase activity with a pIC50 of 6.37 and blocks autophagy in cells, without affecting the upstream signalling kinases mTORC1 and AMPK.
S7090	GSK923295	GSK923295 is a first-in-class, specific allosteric inhibitor of CENP-E kinesin motor ATPase with K_i of 3.2 nM, and less potent to mutant I182 and T183. GSK923295 induces post-mitotic apoptosis. Phase 1.	Dis Model Mech, 2021, dmm.049001 Cancer Res, 2020, canres.1693.2020 Cancer Res, 2020, 20 pii: canres 883 2019
S7355	ARQ 621	ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.	Mol Cell Proteomics, 2017, 16(3):428-437 Assay Drug Dev Technol, 2016, 14(7):395-406 PLoS One, 2014, 9(9):e105919
S8439	Monastrol	Monastrol ((±)-Monastrol) is a cell-permeable small molecule inhibitor of kinesin-5(KIF11) which is essential for maintaining separation of the half-spindles.	Cancer Sci, 2021, 112(11):4641-4654 Elife, 2020, 9 Curr Biol, 2020, S0960-9822(20)31673-0
A5243	MKLP1 Rabbit Recombinant mAb	MKLP1 Rabbit Recombinant mAb detects endogenous level of total MKLP1.
S0279	Dimethylenastron	Dimethylenastron is a potent, specific and reversible inhibitor of kinesin Eg5 (kinesin-5/kinesin spindle protein, KSP) with IC50 of 200 nM. Dimethylenastron induces mitotic arrest and apoptosis and upregulate Hsp70 in human multiple myeloma cells.
S1452	Ispinesib (SB-715992)	Ispinesib (SB-715992, CK0238273) is a potent, specific and reversible inhibitor of kinesin spindle protein (KSP) with K_{i app} of 1.7 nM in a cell-free assay, no inhibition to CENP-E, RabK6, MCAK, MKLP1, KHC or Kif1A. Ispinesib induces mitotic arrest and apoptotic cell death. Phase 2.	Cell, 2020, 182(3):685-712.e19 Cell, 2020, 182(3):685-712.e19 Sci Transl Med, 2020, 12(562)eaba4434
S2182	SB743921 HCl	SB743921 is a kinesin spindle protein (KSP) inhibitor with K_i of 0.1 nM, almost no affinity to MKLP1, Kin2, Kif1A, Kif15, KHC, Kif4 and CENP-E. Phase 1/2.	Cell, 2020, 182(3):685-712.e19 Cell, 2020, 182(3):685-712.e19 Sci Transl Med, 2020, 12(562)eaba4434
S5522	H-Cys(Trt)-OH	H-Cys(Trt)-OH (L-Cys(Trt)-OH, H-L-Cys(Trt)-OH, S-Tritylcysteine) is a specific inhibitor of Eg5 that inhibits Eg5-driven microtubule sliding velocity in a reversible fashion with an IC50 of 500 nM.
S5933	K 858	K858 is a novel and potent inhibitor of Eg5 with an IC50 of 1.3 μM for inhibiting the ATPase activity of Eg5, showing at least 150-fold more selective for Eg5 than other members of the kinesin superfamily.
S6796	BTB-1	BTB-1 is a novel, selective and reversible inhibitor of the mitotic motor protein Kif18A with IC50 of 1.69 μM.
S6953^New	GW406108X	GW406108X (GW108X) is an inhibitor of Kif15 (Kinesin-12) with an IC50 of 0.82 μM in the ATPase assay. GW406108X inhibits recombinant ULK1 kinase activity with a pIC50 of 6.37 and blocks autophagy in cells, without affecting the upstream signalling kinases mTORC1 and AMPK.
S7090	GSK923295	GSK923295 is a first-in-class, specific allosteric inhibitor of CENP-E kinesin motor ATPase with K_i of 3.2 nM, and less potent to mutant I182 and T183. GSK923295 induces post-mitotic apoptosis. Phase 1.	Dis Model Mech, 2021, dmm.049001 Cancer Res, 2020, canres.1693.2020 Cancer Res, 2020, 20 pii: canres 883 2019
S7355	ARQ 621	ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.	Mol Cell Proteomics, 2017, 16(3):428-437 Assay Drug Dev Technol, 2016, 14(7):395-406 PLoS One, 2014, 9(9):e105919
S8439	Monastrol	Monastrol ((±)-Monastrol) is a cell-permeable small molecule inhibitor of kinesin-5(KIF11) which is essential for maintaining separation of the half-spindles.	Cancer Sci, 2021, 112(11):4641-4654 Elife, 2020, 9 Curr Biol, 2020, S0960-9822(20)31673-0
A5243	MKLP1 Rabbit Recombinant mAb	MKLP1 Rabbit Recombinant mAb detects endogenous level of total MKLP1.
S6953^New	GW406108X	GW406108X (GW108X) is an inhibitor of Kif15 (Kinesin-12) with an IC50 of 0.82 μM in the ATPase assay. GW406108X inhibits recombinant ULK1 kinase activity with a pIC50 of 6.37 and blocks autophagy in cells, without affecting the upstream signalling kinases mTORC1 and AMPK.