DYRK

Inhibitory Selectivity

DYRK Products

Catalog No. Information Product Use Citations Product Validations
S7338

AZ191

AZ191 is a potent and selective DYRK1B inhibitor with IC50 of 17 nM in a cell-free assay, about 5- and 110-fold selectivity over DYRK1A and DYRK2, respectively.

S7327

ID-8

ID-8 is a DYRK inhibitor, and sustains embryonic stem cell self-renewal in long-term culture.

S3817

Harmine hydrochloride

Harmine, a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. It can also inhibit monoamine oxidases (MAOs) and cdc-like kinases (CLKs).

Catalog No. Information Product Use Citations Product Validations
S7338

AZ191

AZ191 is a potent and selective DYRK1B inhibitor with IC50 of 17 nM in a cell-free assay, about 5- and 110-fold selectivity over DYRK1A and DYRK2, respectively.

S7327

ID-8

ID-8 is a DYRK inhibitor, and sustains embryonic stem cell self-renewal in long-term culture.

S3817

Harmine hydrochloride

Harmine, a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. It can also inhibit monoamine oxidases (MAOs) and cdc-like kinases (CLKs).