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Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S0790 CADD522 CADD522 is a potent inhibitor of RUNX2(runt-related transcription factor 2)-DNA binding with IC50 of 10 nM. This compound exhibits anticancer activity.
Sci Rep, 2025, 15(1):6832
bioRxiv, 2025, 2025.07.21.665972
S9709 Muramyl dipeptide (MDP) Muramyl dipeptide (MDP), a shared structural unit of peptidoglycans, is an inducer of bone formation through the induction of Runx2.
Frontiers in Cell and Developmental Biology, August 20, 2021, 707959
Oxid Med Cell Longev, 2021, 2021:2353504
Frontiers in Cell and Developmental Biology, 2021, 707959
E2909 L-Ascorbic acid 2-phosphate sesquimagnesium salt hydrate L-Ascorbic acid 2-phosphate sesquimagnesium salt hydrate is a vitamin C derivative. This compound increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation.
S8756 XRK3F2 XRK3F2 is an inhibitor of the p62-ZZ domain that blunts MM-induced Runx2 suppression in vitro, and this compound induces new bone formation and remodeling in the presence of tumor in vivo.
E2692 L-Ascorbic acid 2-phosphate sesquimagnesium salt L-Ascorbic acid 2-phosphate sesquimagnesium salt (2-Phospho-L-ascorbic acid magnesium), a long-acting vitamin C derivative that can stimulate collagen formation and expression, can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs), which increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation.
J Funct Biomater, 2024, 15(12)385
S3223 L-Quebrachitol L-Quebrachitol (L-QCT), a natural product isolated from many plants, promotes proliferation and cell DNA synthesis. This compound upregulates bone morphogenetic protein-2 (BMP-2) and runt-related transcription factor-2 (Runx2) and regulatory genes associated with mitogen-activated protein kinase (MAPK) and Wnt/β-catenin signaling pathway, while down-regulating the receptor activator of the nuclear factor-κB(NF-κB) ligand (RANKL) mRNA level.
E8328New Ro24-7429 Ro24-7429 is a benzodiazepine derivative that acts as a potent, orally active antagonist of HIV-1's Tat transactivator protein, disrupting viral replication by inhibiting Tat-mediated transactivation of the HIV-1 long terminal repeat (LTR) promoter. It also inhibits RUNX1 (runt-related transcription factor 1), contributing to antifibrotic effects by reducing fibrosis markers in models like bleomycin-induced pulmonary fibrosis, alongside anti-inflammatory properties.