Home Cell Cycle RUNX

RUNX

Other Cell Cycle Related Inhibitors

CDK ROCK Wee1 Aurora Kinase Chk PLK APC MPS1 Rho Myc

Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S9709 Muramyl dipeptide (MDP) Muramyl dipeptide (MDP), a shared structural unit of peptidoglycans, is an inducer of bone formation through the induction of Runx2.
Oxid Med Cell Longev, 2021, 2021:2353504
Front Cell Dev Biol, 2021, 9:707959
S0790 CADD522 CADD522 is a potent inhibitor of RUNX2(runt-related transcription factor 2)-DNA binding with IC50 of 10 nM. This compound exhibits anticancer activity.
Sci Rep, 2025, 15(1):6832
bioRxiv, 2025, 2025.07.21.665972
E2909 L-Ascorbic acid 2-phosphate sesquimagnesium salt hydrate L-Ascorbic acid 2-phosphate sesquimagnesium salt hydrate is a vitamin C derivative. This compound increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation.
S8756 XRK3F2 XRK3F2 is an inhibitor of the p62-ZZ domain that blunts MM-induced Runx2 suppression in vitro, and this compound induces new bone formation and remodeling in the presence of tumor in vivo.
S3223 L-Quebrachitol L-Quebrachitol (L-QCT), a natural product isolated from many plants, promotes proliferation and cell DNA synthesis. This compound upregulates bone morphogenetic protein-2 (BMP-2) and runt-related transcription factor-2 (Runx2) and regulatory genes associated with mitogen-activated protein kinase (MAPK) and Wnt/β-catenin signaling pathway, while down-regulating the receptor activator of the nuclear factor-κB(NF-κB) ligand (RANKL) mRNA level.
E2692 L-Ascorbic acid 2-phosphate sesquimagnesium salt L-Ascorbic acid 2-phosphate sesquimagnesium salt (2-Phospho-L-ascorbic acid magnesium), a long-acting vitamin C derivative that can stimulate collagen formation and expression, can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs), which increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation.
J Funct Biomater, 2024, 15(12)385