Wee1
Signaling Pathway Map
Research Area
- Inhibitory Selectivity
- Solubility
| Catalog No. | Product Name | Solubility(25°C) | ||
|---|---|---|---|---|
| Water | DMSO | Alcohol | ||
| S1525 | Adavosertib （MK-1775） | 0.0001 mg/mL | 80 mg/mL | 10 mg/mL |
| S8148 | PD0166285 | <1 mg/mL | 100 mg/mL | 100 mg/mL |
- Wee1 Inhibitors (2)
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S1525 |
Adavosertib （MK-1775）MK-1775 is a potent and selective Wee1 inhibitor with IC50 of 5.2 nM in a cell-free assay; hinders G2 DNA damage checkpoint. Phase 2. |
Panobinostat enhances the antitumor activity of MK-1775 in a BxPC-3 xenograft model. Tumor specimens were fixed in 10% formalin, embedded in paraffin, and cut into 4 μM-thick slides for H&E staining.
|
|
| S8148 |
PD0166285PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations (IC50=24 nM for Wee1 and 72 nM for Myt1). PD0166285 is also a novel G2 checkpoint abrogator. |
