Wee1

Signaling Pathway Map

Research Area

Inhibitory Selectivity
Solubility

Catalog No.	Product Name	Solubility(25°C)
Catalog No.	Product Name	Water	DMSO	Alcohol
S1525	Adavosertib （MK-1775）	0.0001 mg/mL	80 mg/mL	10 mg/mL
S8148	PD0166285	<1 mg/mL	100 mg/mL	100 mg/mL

Wee1 Inhibitors (2)

Catalog No.	Information	Product Use Citations	Product Validations
S1525	Adavosertib （MK-1775） MK-1775 is a potent and selective Wee1 inhibitor with IC50 of 5.2 nM in a cell-free assay; hinders G2 DNA damage checkpoint. Phase 2.	Cell, 2018, 173(1):104-116 Blood, 2017, 130(24):2631-2641 J Hematol Oncol, 2014, 7(1):53	Panobinostat enhances the antitumor activity of MK-1775 in a BxPC-3 xenograft model. Tumor specimens were fixed in 10% formalin, embedded in paraffin, and cut into 4 μM-thick slides for H&E staining.
S8148	PD0166285 PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations (IC50=24 nM for Wee1 and 72 nM for Myt1). PD0166285 is also a novel G2 checkpoint abrogator.

Catalog No.

Information

Product Use Citations

Product Validations

S1525

Adavosertib （MK-1775）

MK-1775 is a potent and selective Wee1 inhibitor with IC50 of 5.2 nM in a cell-free assay; hinders G2 DNA damage checkpoint. Phase 2.

Cell, 2018, 173(1):104-116

Blood, 2017, 130(24):2631-2641

J Hematol Oncol, 2014, 7(1):53

S8148

PD0166285

PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations (IC50=24 nM for Wee1 and 72 nM for Myt1). PD0166285 is also a novel G2 checkpoint abrogator.