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p21

Other Cell Cycle Related Inhibitors

CDK ROCK Wee1 Aurora Kinase Chk PLK APC MPS1 Rho Myc
Cat.No. Product Name Information Product Use Citations Product Validations
E0455 Nimbolide Nimbolide inhibits auto-ubiquitination of the E3 ligase RNF114 and p21 ubiquitination in vitro. This compound induces apoptosis through inactivation of NF-κB.
Pharmacol Res Perspect, 2025, 13(3):e70120
E1190 UC2288 UC2288 is a novel, cell-permeable, and orally active p21 attenuator, decreases p21 mRNA expression independently of p53, and attenuates p21 protein levels with minimal effect on p21 protein stability.
Cell Rep, 2025, 44(9):116267
Breast Cancer Res, 2024, 26(1):54
S1095 Dacinostat (LAQ824) Dacinostat (LAQ824, NVP-LAQ824) is a novel HDAC inhibitor with IC50 of 32 nM and is known to activate the p21 promoter.
Int J Mol Sci, 2023, 24(17)13660
Clin Transl Med, 2022, 12(5):e798
Cancers (Basel), 2022, 14(19)4708
Verified customer review of Dacinostat (LAQ824)
S6963 APTO-253

APTO-253 (LOR-253, LT-253) inhibits c-Myc expression and selectively induces CDKN1A (p21), promotes G0-G1 cell-cycle arrest, and triggers apoptosis in acute myeloid leukemia (AML) cells. This compound is also an inducer of KLF4 (Krüppel-like factor 4).
Cell Commun Signal, 2023, 21(1):94
S6885 Ailanthone Ailanthone (AIL, Δ13-Dehydrochaparrinone), a natural anti-hepatocellular carcinoma (HCC) component in Ailanthus altissima, induces G0/G1-phase cell cycle arrest by decreasing expression of cyclins and CDKs and increases expression of p21 and p27. This compound triggers DNA damage characterized by activation of the ATM/ATR pathway. It induces apoptosis which is mitochondrion-mediated and involves the PI3K/AKT signaling pathway in Huh7 cells. This chemical is also a potent inhibitor of both full-length Androgen Receptor (AR-FL) and constitutively active truncated AR splice variants (AR-Vs, AR1-651) with IC50 of 69 nM and 309 nM, respectively.
Theranostics, 2024, 14(4):1371-1389
S2961 GC7 Sulfate GC7 (N1-guanyl-1,7-diaminoheptane) Sulfate is an inhibitor of deoxyhypusine synthase (DHPS). GC7 inhibits Neuroblastoma (NB) cell proliferation in a dose-dependent manner, through induction of the cell cycle inhibitor p21 and reduction of total and phosphorylated Rb proteins.
Exp Mol Med, 2024, 10.1038/s12276-024-01214-1