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Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S8031 NSC 23766 trihydrochloride NSC 23766 trihydrochloride is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of ~50 μM in a cell-free assay; does not inhibit the closely related targets, Cdc42 or RhoA.
J Orthop Translat, 2025, 54:152-166
Microbiol Spectr, 2025, 13(2):e0222124
Nat Commun, 2024, 15(1):8159
Verified customer review of NSC 23766 trihydrochloride
S7319 EHop-016 EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 μM for Rac1 in MDA-MB-435 and MDA-MB-231 cells, equally potent inhibition for Rac3.
Microbiol Spectr, 2025, 13(2):e0222124
Biochem Biophys Res Commun, 2025, 766:151846
bioRxiv, 2025, 2025.07.31.668026
Verified customer review of EHop-016
S7719 CCG-1423 CCG-1423 is a specific RhoA pathway inhibitor, which inhibits SRF-mediated transcription.
FASEB J, 2025, 39(7):e70505
Cell Rep, 2024, 43(4):113989
Bioact Mater, 2023, 26:413-424
Verified customer review of CCG-1423
S7686 ML141 ML141 (CID-2950007) is demonstrated to be a potent, selective and reversible non-competitive inhibitor of Cdc42 GTPase suitable for in vitro assays, with IC50 of 200 nM and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7). This compound is associated with an increase in p38 activation and may induce p38-dependent apoptosis/senescence. It also protects neuroblastoma cells from metformin-induced apoptosis.
Cell Rep, 2025, 44(8):116025
Cell Mol Life Sci, 2025, 82(1):127
EMBO Rep, 2025, 26(21):5239-5269
Verified customer review of ML141
S7482 EHT 1864 2HCl EHT 1864 2HCl is a potent Rac family GTPase inhibitor with Kd of 40 nM, 50 nM, 60 nM and 250 nM for Rac1, Rac1b, Rac2 and Rac3, respectively.
Cell Mol Life Sci, 2025, 82(1):127
Cancer Metab, 2025, 13(1):39
Sci Adv, 2025, 11(31):eads2310
Verified customer review of EHT 1864 2HCl
S7293 ZCL278 ZCL278 is a selective Cdc42 GTPase inhibitor with Kd of 11.4 μM.
Am J Physiol Cell Physiol, 2025, 10.1152/ajpcell.00987.2024
Cell Death Dis, 2024, 15(11):867
Cancer Commun (Lond), 2023, 43(8):909-937
Verified customer review of ZCL278
S8749 MBQ-167 MBQ-167 is a potent and dual inhibitor of Rac and Cdc42 with IC50s of 103 nM and 78 nM respectively, in metastatic breast cancer cells.
iScience, 2024, 27(6):110139
Nat Genet, 2022, 10.1038/s41588-022-01191-z
Osteoarthritis Cartilage, 2022, S1063-4584(22)00035-8
S8469 CCG-203971 CCG-203971 is a novel small-molecule inhibitor of the Rho/MRTF/SRF pathway with the IC50 value of 0.64 μM for SRE.L. It inhibits Rho-mediated gene transcription.
Biomedicines, 2023, 11(9)2351
J Cell Physiol, 2020, 235(5):4790-4803
Small GTPases, 2020, 10.1080/21541248
S1721 Azathioprine Azathioprine(BW 57-322) is an immunosuppressive drug, inhibiting purine synthesis and GTP-binding protein Rac1 activation, used in the treatment of organ transplantation and autoimmune diseases.
Cancer Cell, 2025, 43(4):776-796.e14
J Extracell Vesicles, 2024, 13(4):e12426
J Extracell Vesicles, 2024, 13(4):e12426
S8988 Rhosin hydrochloride Rhosin (G04) hydrochloride (HCl) is a potent, specific inhibitor of RhoA subfamily Rho GTPases with Kd of ~ 0.4 uM. Rhosin hydrochloride induces cell apoptosis.
J Biol Chem, 2023, 299(6):104749
J Biol Chem, 2023, 299(6):104749
Carcinogenesis, 2022, bgac014

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