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Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S8031 NSC 23766 Trihydrochloride NSC 23766 trihydrochloride is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of ~50 μM in a cell-free assay; does not inhibit the closely related targets, Cdc42 or RhoA.
J Orthop Translat, 2025, 54:152-166
Microbiol Spectr, 2025, 13(2):e0222124
Nat Commun, 2024, 15(1):8159
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S7719 CCG-1423 CCG-1423 is a specific RhoA pathway inhibitor, which inhibits SRF-mediated transcription.
Journal of Clinical Medicine, June 25, 2021, 2790
Cancer Biology & Therapy, December 9, 2025, Vol 26, No 1
OncoTargets and Therapy, December 27, 2019, 11507-11516
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S7686 ML141 (CID-2950007) ML141 (CID-2950007) is demonstrated to be a potent, selective and reversible non-competitive inhibitor of Cdc42 GTPase suitable for in vitro assays, with IC50 of 200 nM and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7). ML141 is associated with an increase in p38 activation and may induce p38-dependent apoptosis/senescence. ML141 also protects neuroblastoma cells from metformin-induced apoptosis.
bioRxiv, 2026, 2026.03.07.583866
Cell Rep, 2025, 44(8):116025
Cell Mol Life Sci, 2025, 82(1):127
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S7319 EHop-016 EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 μM for Rac1 in MDA-MB-435 and MDA-MB-231 cells, equally potent inhibition for Rac3.
Microbiol Spectr, 2025, 13(2):e0222124
Biochem Biophys Res Commun, 2025, 766:151846
bioRxiv, 2025, 2025.07.31.668026
Verified customer review of EHop-016
S7482 EHT 1864 2HCl EHT 1864 2HCl is a potent Rac family GTPase inhibitor with Kd of 40 nM, 50 nM, 60 nM and 250 nM for Rac1, Rac1b, Rac2 and Rac3, respectively.
Cell Mol Life Sci, 2025, 82(1):127
Cancer Metab, 2025, 13(1):39
Sci Adv, 2025, 11(31):eads2310
Verified customer review of EHT 1864 2HCl
S7293 ZCL278 ZCL278 is a selective Cdc42 GTPase inhibitor with Kd of 11.4 μM.
Journal of Clinical Medicine, June 25, 2021, 2790
Frontiers in Oncology, June 18, 2021, 656608
Journal of Experimental & Clinical Cancer Research, July 22, 2022, 230
Verified customer review of ZCL278
S1721 Azathioprine Azathioprine(BW 57-322) is an immunosuppressive drug, inhibiting purine synthesis and GTP-binding protein Rac1 activation, used in the treatment of organ transplantation and autoimmune diseases.
JCI Insight, May 30, 2024, e174329
Scientific Reports, March 13, 2019, 4360
Microbiology Spectrum, January 11, 2024, e0239123
S8749 MBQ-167 MBQ-167 is a potent and dual inhibitor of Rac and Cdc42 with IC50s of 103 nM and 78 nM respectively, in metastatic breast cancer cells.
Cancer Discovery, 2025, Online ahead of print
iScience, 2024, 27(6):110139
Nat Genet, 2022, 10.1038/s41588-022-01191-z
S8988 Rhosin hydrochloride Rhosin (G04) hydrochloride (HCl) is a potent, specific inhibitor of RhoA subfamily Rho GTPases with Kd of ~ 0.4 uM. Rhosin hydrochloride induces cell apoptosis.
The American Journal of Pathology, 2026, 598-617
J Biol Chem, 2023, 299(6):104749
Communications Biology, 2022, 407
S8469 CCG-203971 CCG-203971 is a novel small-molecule inhibitor of the Rho/MRTF/SRF pathway with the IC50 value of 0.64 μM for SRE.L. It inhibits Rho-mediated gene transcription.
Small GTPases, February 17, 2020, 273-281
Biomedicines, August 23, 2023, 2351
Biomedicines, 2023, 11(9)2351

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