Microtubule Associated

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Microtubule Associated Signaling Pathway Map

Microtubule Associated Signaling Pathways

Microtubule Associated Products

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  • Microtubule Associated Inhibitors (47)
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Catalog No. Product Name Information Product Use Citations Product Validations
S0328 MMAF MMAF (Monomethylauristatin F) is a synthetic antineoplastic agent and a potent inhibitor of tubulin polymerization. MMAF (Monomethylauristatin F) is applied as a cytotoxic component of antibody-drug conjugates (ADCs) such as vorsetuzumab mafodotin, ABT-414 and SGN-CD19A.
Cancer Cell, 2021, S1535-6108(21)00659-0
S0444 Indibulin Indibulin (ZIO 301, D 24851, Zybulin) is an orally applied inhibitor of tubulin assembly with potent anticancer activity. Indibulin induces mitotic arrest and apoptosis.
Bioorg Med Chem, 2020, 28(20):115712
S1148 Docetaxel (RP56976) Docetaxel (RP56976, NSC 628503), an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.
Cancers (Basel), 2022, 14(4)949
Cancers (Basel), 2022, 14(4)928
Sci Rep, 2022, 12(1):1442
S1150 Paclitaxel (NSC 125973) Paclitaxel (NSC 125973, PTX, Taxol, Onxal, Abraxane) is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.
Cell Res, 2022, 10.1038/s41422-022-00651-9
Nat Chem Biol, 2022, 10.1038/s41589-022-00996-7
Mol Cell, 2022, 82(1):75-89.e9
S1165 ABT-751 (E7010) ABT-751 (E7010) binds to the colchicine site on β-tubulin and inhibits polymerization of microtubules, not a substrate for the MDR transporter and is active against cell lines resistant to vincristine, doxorubicin, and cisplatin. Phase 1/2.
J Clin Invest, 2020, 10.1172/JCI122462
Fitoterapia, 2017, 116:106-115
PLoS Genet, 2016, 12(9):e1006279
S1241 Vincristine (NSC-67574) sulfate Vincristine sulfate (NSC-67574, Leurocristine, Oncovin, 22-Oxovincaleukoblastine) is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay. Vincristine sulfate induces apoptosis.
Nat Cell Biol, 2022, 10.1038/s41556-021-00814-7
Mol Cell, 2022, 82(1):75-89.e9
Haematologica, 2022, 10.3324/haematol.2021.279957
S1297 Epothilone A Epothilone A is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 2 μM.
Environ Mol Mutagen, 2022, 63(3):151-161
Cancers (Basel), 2020, 12(12)E3816
Sci Rep, 2020, 10(1):13124
S1364 Patupilone (Epothilone B) Patupilone (EPO906, Epothilone B) is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 1.8 μM. Phase 2.
Brain, 2022, awac079
J Cell Biol, 2021, 220(12)e202010155
Biochem Pharmacol, 2021, 193:114789
S1640 Albendazole (SKF-62979) Albendazole (SKF-62979) is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.
Sci Rep, 2022, 12(1):5706
Mol Cell, 2021, 81(19):4041-4058.e15
Cancer Lett, 2021, 520:307-320
S1836 Albendazole Oxide Albendazole Oxide (Ricobendazole) is a tubulin polymerization or assembly inhibitor, used for the treatment of a variety of parasitic worm infestations.
S2195 Lexibulin (CYT997) Lexibulin (CYT997, SRI-32007) is a potent microtubule polymerization inhibitor with IC50 of 10-100 nM in cancer cell lines. Phase 2.
Cell, 2021, 184(2):334-351.e20
Adv Virol, 2020, 2020:8844061
J Exp Clin Cancer Res, 2019, 38(1):44
S2254 4-Demethylepipodophyllotoxin(NSC-122819,VM-26) 4-Demethylepipodophyllotoxin (NSC-122819, VM-26, DMEP) is an antimitotic agent which binds to monomeric tubulin, preventing micro-tubule polymerization. It is a potent inhibitor of microtubule assembly.
Front Pharmacol, 2019, 10:381
S2284 Colchicine (NSC 757) Colchicine (NSC 757, Colchineos, Colchisol, Colcin) is a microtubule polymerization inhibitor with an IC50 of 3 nM.
Transl Stroke Res, 2022, 10.1007/s12975-022-01022-7
Eur J Pharmacol, 2022, 919:174802
Biochem Biophys Res Commun, 2022, 594:161-167
S2440 Vindesine sulfate Vindesine sulfate (Eldesine, Eldisine, Desacetyl Vinblastine amide, Desacetylvinblastine amide, DAVA, DVA, VDS), a vinca alkaloid derived from Catharanthus roseus, is a potent inhibitor of mitosis with antineoplastic activities. Vindesine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death.
Sci Rep, 2020, 10(1):13124
S2441 Estramustine phosphate sodium Estramustine phosphate sodium (EMP, Emcyt, Estracyt) is an antitumour drug with a unique dual mode of action. Estrone and estradiol, products of the metabolism of estramustine phosphate sodium, have shown antigonadotrophic activity resulting in reduced testosterone levels. Estramustine(the cytotoxic metabolite produced by dephosphorylation of estramustine phosphate sodium) is an antiprostatic tumor drug with antimicrotubule effects.
S2444 Parbendazole Parbendazole (SKF 29044) is an extremely potent inhibitor of microtubule assembly with IC50 of 3 µM for the assembly of brain microtubules.
S2447 Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222) Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222, Antibiotic C 15003P3) is a potent inhibitor of tubulin polymerization with IC50 of 3.4 μM.
S2775 Nocodazole (R17934) Nocodazole (R17934, Oncodazole, NSC238159) is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM in cell-free assays, respectively. Nocodazole induces apoptosis.
Signal Transduct Target Ther, 2022, 7(1):97
Front Cell Dev Biol, 2022, 10:817831
J Biol Chem, 2022, S0021-9258(22)00072-2
S3022 Cabazitaxel (XRP6258) Cabazitaxel (RPR-116258A, XRP6258, TXD 258, Taxoid XRP6258) is a semi-synthetic derivative of a natural taxoid that kills cancer cells by inhibiting cell division and growth. Cabazitaxel exerts its effects by inhibiting microtubule growth and assembly, processes that are essential for cells to divide. Cabazitaxel induces autophagy via the PI3K/Akt/mTOR pathway.
Mol Cancer Ther, 2021, molcanther.0983.2020
Prostate, 2021, 10.1002/pros.24138
Prostate, 2021, 10.1002/pros.24200
S3206 5a-Pregnane-3,20-dione 5a-Pregnane-3,20-dione (5alphaP, 5-a-dihydroprogesterone, 3,20-allopregnanedione, 5-Alpha-Dihydro Progesterone) is the endogenous progesterone metabolite. 5a-Pregnane-3,20-dione depolymerizes actin and decreases expression of actin and vinculin. 5a-Pregnane-3,20-dione is involved in promoting breast neoplasia and metastasis by affecting adhesion and cytoskeletal molecules.
S3220 Trigonelline Trigonelline (Trigenolline) is a plant alkaloid and a major component of coffee and fenugreek with anti-degranulation, anti-diabetic, antioxidant, anti-inflammatory, and neuroprotective effects. Trigonelline inhibits FcεRI-mediated intracellular signaling pathways, such as phosphorylation of PLCγ1, PI3K, and Akt. Trigonelline (Trigenolline) also inhibits the microtubule formation in RBL-2H3 cells.
Biomed Pharmacother, 2021, 143:112204
S3725 ELR-510444 ELR-510444 is a novel microtubule disruptor with potential antivascular effects and in vivo antitumor efficacy, causing a loss of cellular microtubules and the formation of aberrant mitotic spindles and leading to mitotic arrest and apoptosis of cancer cells.
S3970 Vindoline Vindoline is a chemical precursor to vinblastine and exhibits antimitotic activity by inhibiting microtubule assembly.
Nat Commun, 2020, 11(1):941
S4071 Griseofulvin Griseofulvin, a production from some strains of the mold Penicillium griseofulvumam, is able to inhibit cell mitosis by interfering with microtubule function.
S4114 Triclabendazole Triclabendazole (CGA-89317) is a benzimidazole, it binds to tubulin impairing intracellular transport mechanisms and interferes with protein synthesis.
S4269 Vinorelbine ditartrate (KW-2307) Vinorelbine Tartrate (KW-2307, Nor-5'-anhydrovinblastine ditartrate) is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin. Vinorelbine Tartrate exhibits anti-tumor activities via inducing the mitotic apoptosis, autophagy and inflammation.
Transl Lung Cancer Res, 2022, 11(4):543-559
Cancer Res, 2021, canres.0955.2021
Br J Cancer, 2021, 10.1038/s41416-021-01420-y
S4505 Vinblastine (NSC-49842) sulfate Vinblastine sulfate (NSC49842, Vincaleukoblastine sulfate salt, 29060-LE, Exal, Velban, Velbe) inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer. Vinblastine sulfate induces autophagy and apoptosis.
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Nat Chem Biol, 2021, 10.1038/s41589-021-00751-4
Cancer Res, 2021, canres.0955.2021
S4535 Methylene Blue Methylene Blue (Basic Blue 9, Tetramethylthionine chloride, methylthioninium chloride, CI-52015) is used as a dye in chromoendoscopy. It Inhibits tau filament formation with IC50 of 1.9μM. Also it inhibits soluble guanylyl cyclase.
bioRxiv, 2020, 2020/9/20.4.7.30734
S5256 Benproperine phosphate Benproperine phosphate (Blascorid, Pirexyl), a cough suppressant, is an orally active, potent actin-related protein 2/3 complex subunit 2 (ARPC2) inhibitor. Benproperine phosphate attenuates the actin polymerization rate of action polymerization nucleation by impairing Arp2/3 function. Benproperine phosphate suppresses cancer cell migration and tumor metastasis.
Mol Oncol, 2020, 10.1002/1878-0261.12854
S5919 KHS101 hydrochloride KHS101 is a small-molecule inhibitor of TACC3, which is a key component of centrosome-microtubule dynamic networks.
S6661 VcMMAE VcMMAE (mc-vc-PAB-MMAE), a MMAE derivative with valine-citrulline (Vc) linker,is an Drug-linker Conjugate for antibody-drug conjugate (ADC) with potent antitumor activity. MMAE is a synthetic antineoplastic agent and can be efficiently released from VcMMAE in vitro and exert cytotoxic activity.
S6773New Mertansine Mertansine (DM1, Maytansinoid DM1), an antibody-conjugatable maytansinoid, is a selective microtubule inhibitor that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC). Solutions are best fresh-prepared.
S6954New CK-869 CK-869 (CK 0157869) is a small molecule inhibitor of actin-related protein 2/3 (Arp2/3) complex with an IC50 of 7 μM. CK-869 can directly suppresses microtubule assembly both in vitro and in vivo.
S7204 Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium Fosbretabulin (Combretastatin A4 Phosphate, CA4P, CA 4DP) Disodium is the water-soluble prodrug of Combretastatin A4 (CA4), which is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM in a cell-free assay. Fosbretabulin Disodium inhibits the polymerization of tubulin with IC50 of 2.4 μM, and also disrupts tumor vasculature. Fosbretabulin disodium induces mitotic arrest and apoptosis in endothelial cells. Phase 3.
Cell, 2020, 182(3):685-712.e19
Cell, 2020, 182(3):685-712.e19
J Drug Target, 2020, 10.1080/1061186X.2020.1818759
S7336 CW069 CW069 is an allosteric, and selective inhibitor of microtubule motor protein HSET with IC50 of 75 μM, significant selectivity over KSP.
EMBO Rep, 2020, 9:e49234
Mol Syst Biol, 2018, 14(8):e8238
Anticancer Res, 2018, 38(6):3393-3400
S7493 INH1 INH1 (IBT 13131) is a cell-permeable Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction.
J Clin Invest, 2018, 128(7):2877-2893
S7494 INH6 INH6 is a potent Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction and causes chromosome mis-alignment.
S7495 TAI-1 TAI-1 is a potent and specific Hec1 inhibitor, which disrupts Hec1-Nek2 protein interaction.
J Exp Clin Cancer Res, 2019, 18;38(1):316
Curr Biol, 2019, 29(18):3072-3080.e5
Curr Biol, 2019, 29(18):3072-3080
S7497 CK-636 CK-636 (CK-0944636) is an Arp2/3 complex inhibitor with IC50 of 4 μM, 24 μM and 32 μM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively.
Elife, 2021, 10e65910
Theranostics, 2019, 9(25):7628-7647
Front Cell Infect Microbiol, 2017, 7:400
S7721 Monomethyl auristatin E (MMAE) Monomethyl auristatin E (MMAE, SGD-1010) is a synthetic antineoplastic agent, which is linked to a monoclonal antibody (MAB). It is also a microtubule-disrupting agent .
Cancer Cell, 2021, S1535-6108(21)00659-0
Oncol Lett, 2021, 21(5):397
PaDUA, 2019, N/A
S7762 TRx0237 (LMTX) mesylate TRx 0237 mesylate (LMTX, Hydromethylthionine) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.
S7783 Combretastatin A4 Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM.Phase 3.
Mol Cancer Ther, 2020, molcanther.0525.2020
Mol Pharmacol, 2019, 96(6):711-719
Drug Des Devel Ther, 2017, 11:1335-1351
S7787 Docetaxel Trihydrate Docetaxel (RP56976, NSC 628503), an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.
Sci Rep, 2022, 12(1):1442
Anal Cell Pathol (Amst), 2022, 2022:8708202
Bioengineered, 2022, 13(4):11310-11320
S7930 Ixabepilone (BMS-247550) Ixabepilone (BMS-247550, Azaepothilone B, BMS 247550-1, Ixempra, Aza-epothilone B) is an orally bioavailable microtubule inhibitor. It binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis.
Environ Mol Mutagen, 2022, 63(3):151-161
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Genome Med, 2021, 13(1):103
S8789 SSE15206 SSE15206 is a tubulin polymerization inhibitor that has potent antiproliferative activities in cancer cell lines of different origins and overcomes resistance to microtubule-targeting agents.
S8912New Eribulin Mesylate (E7389)

Eribulin Mesylate (E7389, B-1939, ER-086526), an analogue of the marine natural product halichondrin B, is a nontaxane completely synthetic microtubule inhibitor.

S9555 Vincristine Vincristine (Leurocristine, NSC-67574, 22-Oxovincaleukoblastine) is a natural alkaloid isolated from the plant Vinca rosea Linn. with anti-tumor activity. Vincristine inhibits microtubule formation in mitotic spindle and binds to microtubule with Ki of 85 nM.
Haematologica, 2022, 10.3324/haematol.2021.279957
Dis Model Mech, 2022, dmm.049109
J Gastroenterol Hepatol, 2022, 10.1111/jgh.15775
A5106 Lamin B1 Rabbit Recombinant mAb Lamin B1 Rabbit Recombinant mAb detects endogenous levels of total Lamin B1.
A5107 beta Tubulin III Rabbit Recombinant mAb beta Tubulin III Rabbit Recombinant mAb detects endogenous levels of total beta Tubulin III.
A5167 Beta Tubulin Rabbit Recombinant mAb (HRP conjugated) Beta Tubulin Rabbit Recombinant mAb (HRP conjugated) detects endogenous level of total beta tubulin.
A5204 67kDa Laminin Receptor Rabbit Recombinant mAb 67kDa Laminin Receptor Rabbit Recombinant mAb detects endogenous level of total 67kDa Laminin Receptor.
A5228 Filamin A Rabbit Recombinant mAb Filamin A Rabbit Recombinant mAb detects endogenous level of Filamin A.
A5230 Cytokeratin 19 Rabbit Recombinant mAb Cytokeratin 19 Rabbit Recombinant mAb detects endogenous level of total cytokeration 19.
A5234 Stathmin 1 Rabbit Recombinant mAb Stathmin 1 Rabbit Recombinant mAb detects endogenous level of total Stathmin 1.
A5249 Cytokeratin 7 Rabbit Recombinant mAb Cytokeratin 7 Rabbit Recombinant mAb detects endogenous level of total Cytokeratin 7.
A5253 Desmin Rabbit Recombinant mAb Desmin Rabbit Recombinant mAb detects endogenous level of total desmin.
A5266 Cytokeratin 10 Rabbit Recombinant mAb Cytokeratin 10 Rabbit Recombinant mAb detects endogenous level of total Cytokeratin 10.
Bioact Mater, 2022, 9:523-540
A5280 Radixin Rabbit Recombinant mAb Radixin Rabbit Recombinant mAb detects endogenous level of total Radixin.
A5281 Ezrin Rabbit Recombinant mAb Ezrin Rabbit Recombinant mAb detects endogenous level of total Ezrin.
A5295 NEFM Rabbit Recombinant mAb NEFM Rabbit Recombinant mAb detects endogenous level of total NEFM.
A5309 Drebrin Rabbit Recombinant mAb Drebrin Rabbit Recombinant mAb detects endogenous level of total Drebrin.
S0360 EGFR Inhibitor EGFR inhibitor, a cell permeable, 4,6-disubstituted pyrimidine compound, is a highly selevtive inhibitor of EGFR kinase with IC50 of 21 nM. EGFR inhibitor directly depolymerizes microtubules and is used as a chemical probe to investigate both the EGFR pathway and microtubule dynamics.
S1176 Plinabulin (NPI-2358) Plinabulin (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing with IC50 of 9.8~18 nM in tumor cells. Phase 1/2.
J Biol Chem, 2019, 294(20):8161-8170
Mol Pharmacol, 2019, 96(6):711-719
Curr Protoc Chem Biol, 2013, 5(3):195-212
S1233 2-Methoxyestradiol (2-MeOE2) 2-Methoxyestradiol (2-MeOE2, NSC 659853, 2-ME2) depolymerizes microtubules and blocks HIF-1α nuclear accumulation and HIF-transcriptional activity. 2-Methoxyestradiol induces both autophagy and apoptosis in various carcinogenic cell lines. Phase 2.
Biochim Biophys Acta Mol Basis Dis, 2022, 1868(5):166356
Mol Cancer Res, 2022, 20(1):161-175
Cell Transplant, 2022, 31:9636897211073127
S3374 Verubulin hydrochloride Verubulin hydrochloride(MPC 6827 hydrochloride) is a microtubule destabilizer and vascular disrupting agent that achieve high brain concentration relative to plasma in animals.
S0328 MMAF MMAF (Monomethylauristatin F) is a synthetic antineoplastic agent and a potent inhibitor of tubulin polymerization. MMAF (Monomethylauristatin F) is applied as a cytotoxic component of antibody-drug conjugates (ADCs) such as vorsetuzumab mafodotin, ABT-414 and SGN-CD19A.
Cancer Cell, 2021, S1535-6108(21)00659-0
S0444 Indibulin Indibulin (ZIO 301, D 24851, Zybulin) is an orally applied inhibitor of tubulin assembly with potent anticancer activity. Indibulin induces mitotic arrest and apoptosis.
Bioorg Med Chem, 2020, 28(20):115712
S1148 Docetaxel (RP56976) Docetaxel (RP56976, NSC 628503), an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.
Cancers (Basel), 2022, 14(4)949
Cancers (Basel), 2022, 14(4)928
Sci Rep, 2022, 12(1):1442
S1150 Paclitaxel (NSC 125973) Paclitaxel (NSC 125973, PTX, Taxol, Onxal, Abraxane) is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.
Cell Res, 2022, 10.1038/s41422-022-00651-9
Nat Chem Biol, 2022, 10.1038/s41589-022-00996-7
Mol Cell, 2022, 82(1):75-89.e9
S1165 ABT-751 (E7010) ABT-751 (E7010) binds to the colchicine site on β-tubulin and inhibits polymerization of microtubules, not a substrate for the MDR transporter and is active against cell lines resistant to vincristine, doxorubicin, and cisplatin. Phase 1/2.
J Clin Invest, 2020, 10.1172/JCI122462
Fitoterapia, 2017, 116:106-115
PLoS Genet, 2016, 12(9):e1006279
S1241 Vincristine (NSC-67574) sulfate Vincristine sulfate (NSC-67574, Leurocristine, Oncovin, 22-Oxovincaleukoblastine) is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay. Vincristine sulfate induces apoptosis.
Nat Cell Biol, 2022, 10.1038/s41556-021-00814-7
Mol Cell, 2022, 82(1):75-89.e9
Haematologica, 2022, 10.3324/haematol.2021.279957
S1297 Epothilone A Epothilone A is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 2 μM.
Environ Mol Mutagen, 2022, 63(3):151-161
Cancers (Basel), 2020, 12(12)E3816
Sci Rep, 2020, 10(1):13124
S1364 Patupilone (Epothilone B) Patupilone (EPO906, Epothilone B) is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 1.8 μM. Phase 2.
Brain, 2022, awac079
J Cell Biol, 2021, 220(12)e202010155
Biochem Pharmacol, 2021, 193:114789
S1640 Albendazole (SKF-62979) Albendazole (SKF-62979) is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.
Sci Rep, 2022, 12(1):5706
Mol Cell, 2021, 81(19):4041-4058.e15
Cancer Lett, 2021, 520:307-320
S1836 Albendazole Oxide Albendazole Oxide (Ricobendazole) is a tubulin polymerization or assembly inhibitor, used for the treatment of a variety of parasitic worm infestations.
S2195 Lexibulin (CYT997) Lexibulin (CYT997, SRI-32007) is a potent microtubule polymerization inhibitor with IC50 of 10-100 nM in cancer cell lines. Phase 2.
Cell, 2021, 184(2):334-351.e20
Adv Virol, 2020, 2020:8844061
J Exp Clin Cancer Res, 2019, 38(1):44
S2254 4-Demethylepipodophyllotoxin(NSC-122819,VM-26) 4-Demethylepipodophyllotoxin (NSC-122819, VM-26, DMEP) is an antimitotic agent which binds to monomeric tubulin, preventing micro-tubule polymerization. It is a potent inhibitor of microtubule assembly.
Front Pharmacol, 2019, 10:381
S2284 Colchicine (NSC 757) Colchicine (NSC 757, Colchineos, Colchisol, Colcin) is a microtubule polymerization inhibitor with an IC50 of 3 nM.
Transl Stroke Res, 2022, 10.1007/s12975-022-01022-7
Eur J Pharmacol, 2022, 919:174802
Biochem Biophys Res Commun, 2022, 594:161-167
S2440 Vindesine sulfate Vindesine sulfate (Eldesine, Eldisine, Desacetyl Vinblastine amide, Desacetylvinblastine amide, DAVA, DVA, VDS), a vinca alkaloid derived from Catharanthus roseus, is a potent inhibitor of mitosis with antineoplastic activities. Vindesine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death.
Sci Rep, 2020, 10(1):13124
S2441 Estramustine phosphate sodium Estramustine phosphate sodium (EMP, Emcyt, Estracyt) is an antitumour drug with a unique dual mode of action. Estrone and estradiol, products of the metabolism of estramustine phosphate sodium, have shown antigonadotrophic activity resulting in reduced testosterone levels. Estramustine(the cytotoxic metabolite produced by dephosphorylation of estramustine phosphate sodium) is an antiprostatic tumor drug with antimicrotubule effects.
S2444 Parbendazole Parbendazole (SKF 29044) is an extremely potent inhibitor of microtubule assembly with IC50 of 3 µM for the assembly of brain microtubules.
S2447 Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222) Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222, Antibiotic C 15003P3) is a potent inhibitor of tubulin polymerization with IC50 of 3.4 μM.
S2775 Nocodazole (R17934) Nocodazole (R17934, Oncodazole, NSC238159) is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM in cell-free assays, respectively. Nocodazole induces apoptosis.
Signal Transduct Target Ther, 2022, 7(1):97
Front Cell Dev Biol, 2022, 10:817831
J Biol Chem, 2022, S0021-9258(22)00072-2
S3022 Cabazitaxel (XRP6258) Cabazitaxel (RPR-116258A, XRP6258, TXD 258, Taxoid XRP6258) is a semi-synthetic derivative of a natural taxoid that kills cancer cells by inhibiting cell division and growth. Cabazitaxel exerts its effects by inhibiting microtubule growth and assembly, processes that are essential for cells to divide. Cabazitaxel induces autophagy via the PI3K/Akt/mTOR pathway.
Mol Cancer Ther, 2021, molcanther.0983.2020
Prostate, 2021, 10.1002/pros.24138
Prostate, 2021, 10.1002/pros.24200
S3206 5a-Pregnane-3,20-dione 5a-Pregnane-3,20-dione (5alphaP, 5-a-dihydroprogesterone, 3,20-allopregnanedione, 5-Alpha-Dihydro Progesterone) is the endogenous progesterone metabolite. 5a-Pregnane-3,20-dione depolymerizes actin and decreases expression of actin and vinculin. 5a-Pregnane-3,20-dione is involved in promoting breast neoplasia and metastasis by affecting adhesion and cytoskeletal molecules.
S3220 Trigonelline Trigonelline (Trigenolline) is a plant alkaloid and a major component of coffee and fenugreek with anti-degranulation, anti-diabetic, antioxidant, anti-inflammatory, and neuroprotective effects. Trigonelline inhibits FcεRI-mediated intracellular signaling pathways, such as phosphorylation of PLCγ1, PI3K, and Akt. Trigonelline (Trigenolline) also inhibits the microtubule formation in RBL-2H3 cells.
Biomed Pharmacother, 2021, 143:112204
S3725 ELR-510444 ELR-510444 is a novel microtubule disruptor with potential antivascular effects and in vivo antitumor efficacy, causing a loss of cellular microtubules and the formation of aberrant mitotic spindles and leading to mitotic arrest and apoptosis of cancer cells.
S3970 Vindoline Vindoline is a chemical precursor to vinblastine and exhibits antimitotic activity by inhibiting microtubule assembly.
Nat Commun, 2020, 11(1):941
S4071 Griseofulvin Griseofulvin, a production from some strains of the mold Penicillium griseofulvumam, is able to inhibit cell mitosis by interfering with microtubule function.
S4114 Triclabendazole Triclabendazole (CGA-89317) is a benzimidazole, it binds to tubulin impairing intracellular transport mechanisms and interferes with protein synthesis.
S4269 Vinorelbine ditartrate (KW-2307) Vinorelbine Tartrate (KW-2307, Nor-5'-anhydrovinblastine ditartrate) is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin. Vinorelbine Tartrate exhibits anti-tumor activities via inducing the mitotic apoptosis, autophagy and inflammation.
Transl Lung Cancer Res, 2022, 11(4):543-559
Cancer Res, 2021, canres.0955.2021
Br J Cancer, 2021, 10.1038/s41416-021-01420-y
S4505 Vinblastine (NSC-49842) sulfate Vinblastine sulfate (NSC49842, Vincaleukoblastine sulfate salt, 29060-LE, Exal, Velban, Velbe) inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer. Vinblastine sulfate induces autophagy and apoptosis.
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Nat Chem Biol, 2021, 10.1038/s41589-021-00751-4
Cancer Res, 2021, canres.0955.2021
S4535 Methylene Blue Methylene Blue (Basic Blue 9, Tetramethylthionine chloride, methylthioninium chloride, CI-52015) is used as a dye in chromoendoscopy. It Inhibits tau filament formation with IC50 of 1.9μM. Also it inhibits soluble guanylyl cyclase.
bioRxiv, 2020, 2020/9/20.4.7.30734
S5256 Benproperine phosphate Benproperine phosphate (Blascorid, Pirexyl), a cough suppressant, is an orally active, potent actin-related protein 2/3 complex subunit 2 (ARPC2) inhibitor. Benproperine phosphate attenuates the actin polymerization rate of action polymerization nucleation by impairing Arp2/3 function. Benproperine phosphate suppresses cancer cell migration and tumor metastasis.
Mol Oncol, 2020, 10.1002/1878-0261.12854
S5919 KHS101 hydrochloride KHS101 is a small-molecule inhibitor of TACC3, which is a key component of centrosome-microtubule dynamic networks.
S6661 VcMMAE VcMMAE (mc-vc-PAB-MMAE), a MMAE derivative with valine-citrulline (Vc) linker,is an Drug-linker Conjugate for antibody-drug conjugate (ADC) with potent antitumor activity. MMAE is a synthetic antineoplastic agent and can be efficiently released from VcMMAE in vitro and exert cytotoxic activity.
S6773New Mertansine Mertansine (DM1, Maytansinoid DM1), an antibody-conjugatable maytansinoid, is a selective microtubule inhibitor that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC). Solutions are best fresh-prepared.
S6954New CK-869 CK-869 (CK 0157869) is a small molecule inhibitor of actin-related protein 2/3 (Arp2/3) complex with an IC50 of 7 μM. CK-869 can directly suppresses microtubule assembly both in vitro and in vivo.
S7204 Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium Fosbretabulin (Combretastatin A4 Phosphate, CA4P, CA 4DP) Disodium is the water-soluble prodrug of Combretastatin A4 (CA4), which is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM in a cell-free assay. Fosbretabulin Disodium inhibits the polymerization of tubulin with IC50 of 2.4 μM, and also disrupts tumor vasculature. Fosbretabulin disodium induces mitotic arrest and apoptosis in endothelial cells. Phase 3.
Cell, 2020, 182(3):685-712.e19
Cell, 2020, 182(3):685-712.e19
J Drug Target, 2020, 10.1080/1061186X.2020.1818759
S7336 CW069 CW069 is an allosteric, and selective inhibitor of microtubule motor protein HSET with IC50 of 75 μM, significant selectivity over KSP.
EMBO Rep, 2020, 9:e49234
Mol Syst Biol, 2018, 14(8):e8238
Anticancer Res, 2018, 38(6):3393-3400
S7493 INH1 INH1 (IBT 13131) is a cell-permeable Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction.
J Clin Invest, 2018, 128(7):2877-2893
S7494 INH6 INH6 is a potent Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction and causes chromosome mis-alignment.
S7495 TAI-1 TAI-1 is a potent and specific Hec1 inhibitor, which disrupts Hec1-Nek2 protein interaction.
J Exp Clin Cancer Res, 2019, 18;38(1):316
Curr Biol, 2019, 29(18):3072-3080.e5
Curr Biol, 2019, 29(18):3072-3080
S7497 CK-636 CK-636 (CK-0944636) is an Arp2/3 complex inhibitor with IC50 of 4 μM, 24 μM and 32 μM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively.
Elife, 2021, 10e65910
Theranostics, 2019, 9(25):7628-7647
Front Cell Infect Microbiol, 2017, 7:400
S7721 Monomethyl auristatin E (MMAE) Monomethyl auristatin E (MMAE, SGD-1010) is a synthetic antineoplastic agent, which is linked to a monoclonal antibody (MAB). It is also a microtubule-disrupting agent .
Cancer Cell, 2021, S1535-6108(21)00659-0
Oncol Lett, 2021, 21(5):397
PaDUA, 2019, N/A
S7762 TRx0237 (LMTX) mesylate TRx 0237 mesylate (LMTX, Hydromethylthionine) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.
S7783 Combretastatin A4 Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM.Phase 3.
Mol Cancer Ther, 2020, molcanther.0525.2020
Mol Pharmacol, 2019, 96(6):711-719
Drug Des Devel Ther, 2017, 11:1335-1351
S7787 Docetaxel Trihydrate Docetaxel (RP56976, NSC 628503), an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.
Sci Rep, 2022, 12(1):1442
Anal Cell Pathol (Amst), 2022, 2022:8708202
Bioengineered, 2022, 13(4):11310-11320
S7930 Ixabepilone (BMS-247550) Ixabepilone (BMS-247550, Azaepothilone B, BMS 247550-1, Ixempra, Aza-epothilone B) is an orally bioavailable microtubule inhibitor. It binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis.
Environ Mol Mutagen, 2022, 63(3):151-161
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Genome Med, 2021, 13(1):103
S8789 SSE15206 SSE15206 is a tubulin polymerization inhibitor that has potent antiproliferative activities in cancer cell lines of different origins and overcomes resistance to microtubule-targeting agents.
S8912New Eribulin Mesylate (E7389)

Eribulin Mesylate (E7389, B-1939, ER-086526), an analogue of the marine natural product halichondrin B, is a nontaxane completely synthetic microtubule inhibitor.

S9555 Vincristine Vincristine (Leurocristine, NSC-67574, 22-Oxovincaleukoblastine) is a natural alkaloid isolated from the plant Vinca rosea Linn. with anti-tumor activity. Vincristine inhibits microtubule formation in mitotic spindle and binds to microtubule with Ki of 85 nM.
Haematologica, 2022, 10.3324/haematol.2021.279957
Dis Model Mech, 2022, dmm.049109
J Gastroenterol Hepatol, 2022, 10.1111/jgh.15775
A5106 Lamin B1 Rabbit Recombinant mAb Lamin B1 Rabbit Recombinant mAb detects endogenous levels of total Lamin B1.
A5107 beta Tubulin III Rabbit Recombinant mAb beta Tubulin III Rabbit Recombinant mAb detects endogenous levels of total beta Tubulin III.
A5167 Beta Tubulin Rabbit Recombinant mAb (HRP conjugated) Beta Tubulin Rabbit Recombinant mAb (HRP conjugated) detects endogenous level of total beta tubulin.
A5204 67kDa Laminin Receptor Rabbit Recombinant mAb 67kDa Laminin Receptor Rabbit Recombinant mAb detects endogenous level of total 67kDa Laminin Receptor.
A5228 Filamin A Rabbit Recombinant mAb Filamin A Rabbit Recombinant mAb detects endogenous level of Filamin A.
A5230 Cytokeratin 19 Rabbit Recombinant mAb Cytokeratin 19 Rabbit Recombinant mAb detects endogenous level of total cytokeration 19.
A5234 Stathmin 1 Rabbit Recombinant mAb Stathmin 1 Rabbit Recombinant mAb detects endogenous level of total Stathmin 1.
A5249 Cytokeratin 7 Rabbit Recombinant mAb Cytokeratin 7 Rabbit Recombinant mAb detects endogenous level of total Cytokeratin 7.
A5253 Desmin Rabbit Recombinant mAb Desmin Rabbit Recombinant mAb detects endogenous level of total desmin.
A5266 Cytokeratin 10 Rabbit Recombinant mAb Cytokeratin 10 Rabbit Recombinant mAb detects endogenous level of total Cytokeratin 10.
Bioact Mater, 2022, 9:523-540
A5280 Radixin Rabbit Recombinant mAb Radixin Rabbit Recombinant mAb detects endogenous level of total Radixin.
A5281 Ezrin Rabbit Recombinant mAb Ezrin Rabbit Recombinant mAb detects endogenous level of total Ezrin.
A5295 NEFM Rabbit Recombinant mAb NEFM Rabbit Recombinant mAb detects endogenous level of total NEFM.
A5309 Drebrin Rabbit Recombinant mAb Drebrin Rabbit Recombinant mAb detects endogenous level of total Drebrin.
S0360 EGFR Inhibitor EGFR inhibitor, a cell permeable, 4,6-disubstituted pyrimidine compound, is a highly selevtive inhibitor of EGFR kinase with IC50 of 21 nM. EGFR inhibitor directly depolymerizes microtubules and is used as a chemical probe to investigate both the EGFR pathway and microtubule dynamics.
S1176 Plinabulin (NPI-2358) Plinabulin (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing with IC50 of 9.8~18 nM in tumor cells. Phase 1/2.
J Biol Chem, 2019, 294(20):8161-8170
Mol Pharmacol, 2019, 96(6):711-719
Curr Protoc Chem Biol, 2013, 5(3):195-212
S1233 2-Methoxyestradiol (2-MeOE2) 2-Methoxyestradiol (2-MeOE2, NSC 659853, 2-ME2) depolymerizes microtubules and blocks HIF-1α nuclear accumulation and HIF-transcriptional activity. 2-Methoxyestradiol induces both autophagy and apoptosis in various carcinogenic cell lines. Phase 2.
Biochim Biophys Acta Mol Basis Dis, 2022, 1868(5):166356
Mol Cancer Res, 2022, 20(1):161-175
Cell Transplant, 2022, 31:9636897211073127
S3374 Verubulin hydrochloride Verubulin hydrochloride(MPC 6827 hydrochloride) is a microtubule destabilizer and vascular disrupting agent that achieve high brain concentration relative to plasma in animals.
S6773New Mertansine Mertansine (DM1, Maytansinoid DM1), an antibody-conjugatable maytansinoid, is a selective microtubule inhibitor that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC). Solutions are best fresh-prepared.
S6954New CK-869 CK-869 (CK 0157869) is a small molecule inhibitor of actin-related protein 2/3 (Arp2/3) complex with an IC50 of 7 μM. CK-869 can directly suppresses microtubule assembly both in vitro and in vivo.
S8912New Eribulin Mesylate (E7389)

Eribulin Mesylate (E7389, B-1939, ER-086526), an analogue of the marine natural product halichondrin B, is a nontaxane completely synthetic microtubule inhibitor.

Tags: microtubule inhibition | microtubule drugs | microtubule cancer | microtubule assay | microtubule phosphorylation | tubulin pathway | microtubule poison | microtubule inhibitors cancer | microtubule inhibitor drugs | microtubule inhibitor review