MPS1

Choose Selective MPS1 Inhibitors

MPS1 Products

  • All (7)
  • MPS1 Inhibitors (7)
  • New MPS1 Products
Catalog No. Product Name Information Product Use Citations Product Validations
S0426 Pim1/AKK1-IN-1 Pim1/AKK1-IN-1 (LKB1/AAK1 dual inhibitor, MDK-2275) is a potent multi-kinase inhibitor with Kd of 35 nM, 53 nM, 75 nM and 380 nM for Pim1, AKK1, MST2 and LKB1, respectively. Pim1/AKK1-IN-1 also inhibits MPSK1 and TNIK.
S2731 AZ 3146 AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM, contributes to recruitment of CENP-E (kinesin-related motor protein), less potent to FAK, JNK1, JNK2, and Kit.
Oncogene, 2021, 10.1038/s41388-021-02106-8
Nat Cell Biol, 2020, 22(7):856-867
Oncogene, 2020, 39(13):2819-2834
S6768 CC-671 CC-671 is a selectively dual inhibitor of TTK (human protein kinase monopolar spindle 1 [hMps1]) and CDC like kinase 2 (CLK2) with IC50s of 5 nM and 3 nM for TTK and CLK2, respectively.
S7488 MPI-0479605 MPI-0479605 is an ATP competitive and selective inhibitor of mitotic kinase Mps1 with IC50 of 1.8 nM, >40-fold selectivity over other kinases.
J Ovarian Res, 2021, 14(1):128
Front Pharmacol, 2020, 30;11:543
Curr Biol, 2019, 29(18):3072-3080.e5
S8214 Empesertib (BAY1161909) Empesertib (BAY1161909, Mps1-IN-5), a derivative of triazolopyridine, is an orally bioavailable, selective inhibitor of the serine/threonine monopolar spindle 1 (Mps1) kinase with IC50 of <1 nM. Empesertib has potential antineoplastic activity.
S8215 BAY 1217389 BAY 1217389 is an orally bioavailable, selective inhibitor of the serine/threonine kinase monopolar spindle 1 (Mps1) with IC50 values below 10 nmol/L while showing an excellent selectivity profile.
Cell Death Dis, 2021, 12(12):1135
Dev Cell, 2020, 52(4):413-428
Nature, 2019, 575(7781):203-209
S8911New BOS172722 BOS172722 is a monopolar spindle 1 (MPS1) checkpoint inhibitor with IC50 of 11 nM, Ki of 0.11 nM.
S0426 Pim1/AKK1-IN-1 Pim1/AKK1-IN-1 (LKB1/AAK1 dual inhibitor, MDK-2275) is a potent multi-kinase inhibitor with Kd of 35 nM, 53 nM, 75 nM and 380 nM for Pim1, AKK1, MST2 and LKB1, respectively. Pim1/AKK1-IN-1 also inhibits MPSK1 and TNIK.
S2731 AZ 3146 AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM, contributes to recruitment of CENP-E (kinesin-related motor protein), less potent to FAK, JNK1, JNK2, and Kit.
Oncogene, 2021, 10.1038/s41388-021-02106-8
Nat Cell Biol, 2020, 22(7):856-867
Oncogene, 2020, 39(13):2819-2834
S6768 CC-671 CC-671 is a selectively dual inhibitor of TTK (human protein kinase monopolar spindle 1 [hMps1]) and CDC like kinase 2 (CLK2) with IC50s of 5 nM and 3 nM for TTK and CLK2, respectively.
S7488 MPI-0479605 MPI-0479605 is an ATP competitive and selective inhibitor of mitotic kinase Mps1 with IC50 of 1.8 nM, >40-fold selectivity over other kinases.
J Ovarian Res, 2021, 14(1):128
Front Pharmacol, 2020, 30;11:543
Curr Biol, 2019, 29(18):3072-3080.e5
S8214 Empesertib (BAY1161909) Empesertib (BAY1161909, Mps1-IN-5), a derivative of triazolopyridine, is an orally bioavailable, selective inhibitor of the serine/threonine monopolar spindle 1 (Mps1) kinase with IC50 of <1 nM. Empesertib has potential antineoplastic activity.
S8215 BAY 1217389 BAY 1217389 is an orally bioavailable, selective inhibitor of the serine/threonine kinase monopolar spindle 1 (Mps1) with IC50 values below 10 nmol/L while showing an excellent selectivity profile.
Cell Death Dis, 2021, 12(12):1135
Dev Cell, 2020, 52(4):413-428
Nature, 2019, 575(7781):203-209
S8911New BOS172722 BOS172722 is a monopolar spindle 1 (MPS1) checkpoint inhibitor with IC50 of 11 nM, Ki of 0.11 nM.
S8911New BOS172722 BOS172722 is a monopolar spindle 1 (MPS1) checkpoint inhibitor with IC50 of 11 nM, Ki of 0.11 nM.
Tags: MPS1 inhibitor|MPS1 agonist|MPS1 activator|MPS1 inducer|MPS1 antagonist|MPS1 signaling pathway|MPS1 assay kit