Home NF-κB AP-1

AP-1

Other NF-κB Related Inhibitors

NF-κB IκB/IKK
Cat.No. Product Name Information Product Use Citations Product Validations
S7468New SR 11302 SR 11302 is a retinoid compound that functions as a selective inhibitor of activator protein-1 (AP-1) transcriptional activity. It exhibits the unique property of suppressing AP-1-mediated transcription without activating retinoic acid response element (RARE)-dependent gene expression.
S8966 T-5224 T-5224 is a selective inhibitor of transcription factor c-Fos/activator protein (AP)-1 with anti-inflammatory effects. T-5224 specifically inhibits the DNA binding activity of c-Fos/c-Jun and the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription.
MedComm (2020), 2025, 6(4):e70154
MedComm (2020), 2025, 6(4):e70154
Cells, 2025, 14(7)474
S9721 Farudodstat

Farudodstat(LAS 186323,ASLAN003) is a potent and orally active inhibitor of DHODH (Dihydroorotate dehydrogenase) with IC50 of 35 nM for human DHODH enzyme activity. ASLAN003 impairs protein synthesis and induces the differentiation and apoptosis transcriptional program in acute myeloid leukemia (AML) cells via activation of AP-1 transcription factors.
Front Cell Dev Biol, 2023, 11:1089945
iScience, 2022, 25(5):104293
bioRxiv, 2021, 10.1101/2021.06.28.450163
S9193 Aristolochic acid A Aristolochic acid A (Aristolochic Acid I, Aristolochin, Aristolochine, TR 1736) is a carcinogenic, mutagenic, and nephrotoxic agent extracted from the flowering plant family Aristolochiaceae. This compound significantly reduces both activator protein 1 (AP-1) and nuclear factor-κB (NF-κB) activities.
Mol Ther Nucleic Acids, 2020, 6;19:1276-1289
Am J Physiol Renal Physiol, 2020, 319(6):F1003-F1014
S0855 TC-E 5003 TC-E 5003 (NSC 30176, Compound 2e) is a selective inhibitor of protein arginine methyltransferase 1 (PRMT1) with IC50 of 1.5 μM. This compound modulates the lipopolysaccharide (LPS)-induced AP-1 and NF-κB signaling pathways and can possibly be further developed as an anti-inflammatory compound.
Biol Direct, 2025, 20(1):60
Hepatol Commun, 2025, 9(4)e0647
Mol Ther, 2023, 10.1016/j.ymthe.2023.09.011
S0249 Mycro 3 Mycro 3 is a potent and selective inhibitor of c-Myc in whole cell assays. This compound also shows weak inhibitory activity against AP-1.
J Biol Chem, 2025, S0021-9258(25)00377-1