Home Cytoskeletal Signaling Microtubule Associated inhibitor VcMMAE For research use only.

VcMMAE

Synonyms: mc-vc-PAB-MMAE

VcMMAE (mc-vc-PAB-MMAE), a MMAE derivative with valine-citrulline (Vc) linker,is an Drug-linker Conjugate for antibody-drug conjugate (ADC) with potent antitumor activity. MMAE is a synthetic antineoplastic agent and can be efficiently released from VcMMAE in vitro and exert cytotoxic activity.

VcMMAE Chemical Structure

VcMMAE Chemical Structure

CAS: 646502-53-6

Purity & Quality Control

Batch: Purity: 99.99%
99.99

VcMMAE Related Products

Signaling Pathway

Microtubule Associated Signaling Pathways

Microtubule Associated Signaling Pathway

Choose Selective Microtubule Associated Inhibitors

Biological Activity

Description VcMMAE (mc-vc-PAB-MMAE), a MMAE derivative with valine-citrulline (Vc) linker,is an Drug-linker Conjugate for antibody-drug conjugate (ADC) with potent antitumor activity. MMAE is a synthetic antineoplastic agent and can be efficiently released from VcMMAE in vitro and exert cytotoxic activity.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06181994 Recruiting
Chronic Subdural Hematoma
Montefiore Medical Center
 December 5 2023 --
NCT05514158 Recruiting
Gastric Cancer
RemeGen Co. Ltd.
 September 28 2022 Phase 1
NCT05773937 Recruiting
Advanced Malignant Solid Tumors
Mabwell (Shanghai) Bioscience Co. Ltd.
 June 21 2022 Phase 1
NCT05216965 Recruiting
Solid Tumors
Mabwell (Shanghai) Bioscience Co. Ltd.
 June 11 2022 Phase 1|Phase 2

Chemical Information & Solubility

Molecular Weight 1316.63 Formula

C68H105N11O15

 
CAS No. 646502-53-6 SDF --
Smiles CCC(C)C(C(CC(=O)N1CCCC1C(C(C)C(=O)NC(C)C(C2=CC=CC=C2)O)OC)OC)N(C)C(=O)C(C(C)C)NC(=O)C(C(C)C)N(C)C(=O)OCC3=CC=C(C=C3)NC(=O)C(CCCNC(=O)N)NC(=O)C(C(C)C)NC(=O)CCCCCN4C(=O)C=CC4=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (75.95 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble


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In vivo
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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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