VcMMAE

Catalog No.S6661 Synonyms: mc-vc-PAB-MMAE

For research use only.

VcMMAE (mc-vc-PAB-MMAE), a MMAE derivative with valine-citrulline (Vc) linker,is an Drug-linker Conjugate for antibody-drug conjugate (ADC) with potent antitumor activity. MMAE is a synthetic antineoplastic agent and can be efficiently released from VcMMAE in vitro and exert cytotoxic activity.

VcMMAE Chemical Structure

CAS No. 646502-53-6

Purity & Quality Control

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Biological Activity

Description VcMMAE (mc-vc-PAB-MMAE), a MMAE derivative with valine-citrulline (Vc) linker,is an Drug-linker Conjugate for antibody-drug conjugate (ADC) with potent antitumor activity. MMAE is a synthetic antineoplastic agent and can be efficiently released from VcMMAE in vitro and exert cytotoxic activity.

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 1316.63
Formula

C68H105N11O15

 

CAS No. 646502-53-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCC(C)C(C(CC(=O)N1CCCC1C(C(C)C(=O)NC(C)C(C2=CC=CC=C2)O)OC)OC)N(C)C(=O)C(C(C)C)NC(=O)C(C(C)C)N(C)C(=O)OCC3=CC=C(C=C3)NC(=O)C(CCCNC(=O)N)NC(=O)C(C(C)C)NC(=O)CCCCCN4C(=O)C=CC4=O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05216965 Recruiting Drug: 9MW2821 Solid Tumors Mabwell (Shanghai) Bioscience Co. Ltd. June 11 2022 Phase 1|Phase 2
NCT05126719 Recruiting Drug: MRG003 Recurrent or Metastatic Nasopharyngeal Carcinoma Shanghai Miracogen Inc. August 4 2021 Phase 2
NCT05188209 Recruiting Drug: MRG003 Advanced or Metastatic Gastric Cancer|Advanced or Metastatic Gastroesophageal Junction Carcinoma Shanghai Miracogen Inc. May 24 2021 Phase 2
NCT04492488 Recruiting Drug: MRG002 Advanced Solid Tumors|Advanced or Metastatic Gastric Cancer|Advanced or Metastatic Gastroesophageal Junction Cancer Shanghai Miracogen Inc. May 24 2021 Phase 1|Phase 2
NCT04868162 Recruiting Drug: MRG003 Recurrent or Metastatic Squamous Cell Carcinoma of Head and Neck Shanghai Miracogen Inc. April 23 2021 Phase 2
NCT04617314 Recruiting Drug: RC108 Solid Tumor RemeGen Co. Ltd. March 10 2021 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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