Mertansine

For research use only.

Catalog No.S6773 Synonyms: DM1,Maytansinoid DM1

Mertansine Chemical Structure

CAS No. 139504-50-0

Mertansine (DM1, Maytansinoid DM1), an antibody-conjugatable maytansinoid, is a selective microtubule inhibitor that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC).

Purity & Quality Control

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Biological Activity

Description Mertansine (DM1, Maytansinoid DM1), an antibody-conjugatable maytansinoid, is a selective microtubule inhibitor that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC).
Targets
Microtubule [1]
()

Protocol

Solubility (25°C)

In vitro DMSO 50 mg/mL (67.72 mM)
Water Insoluble
Ethanol '''2 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 738.29
Formula

C35H48ClN3O10S

CAS No. 139504-50-0
Storage powder
in solvent
Synonyms DM1,Maytansinoid DM1

In vivo Formulation Calculator (Clear solution)

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Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

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  • Computed Result

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Molecular Weight Calculator

Molecular Weight Calculator

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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05004129 Enrolling by invitation Drug: Tideglusib Congenital Myotonic Dystrophy AMO Pharma Limited August 2021 Phase 2|Phase 3
NCT04700046 Not yet recruiting Drug: Mexiletine 167 mg|Drug: Placebo Myotonic Dystrophy Type 1 and Type 2 Lupin Ltd. July 6 2021 Phase 3
NCT03692312 Recruiting Drug: Tideglusib|Drug: Placebo Congenital Myotonic Dystrophy AMO Pharma Limited March 3 2021 Phase 2|Phase 3
NCT04622319 Recruiting Drug: DS-8201a|Drug: T-DM1 HER2-Positive Primary Breast Cancer|Residual Invasive Breast Cancer Daiichi Sankyo Inc.|AstraZeneca|NSABP Foundation Inc|German Breast Group|Spanish Breast Cancer Research Group (SOLTI) December 4 2020 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Microtubule Associated Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID