Mertansine

Catalog No.S6773 Synonyms: DM1,Maytansinoid DM1

For research use only.

Mertansine (DM1, Maytansinoid DM1), an antibody-conjugatable maytansinoid, is a selective microtubule inhibitor that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC). Solutions are best fresh-prepared.

Mertansine Chemical Structure

CAS No. 139504-50-0

Purity & Quality Control

Choose Selective Microtubule Associated Inhibitors

Other Microtubule Associated Products

Biological Activity

Description Mertansine (DM1, Maytansinoid DM1), an antibody-conjugatable maytansinoid, is a selective microtubule inhibitor that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC). Solutions are best fresh-prepared.
Targets
Microtubule [1]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 738.29
Formula

C35H48ClN3O10S

CAS No. 139504-50-0
Storage 3 years -20°C powder
2 years -80°C in solvent

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05004129 Enrolling by invitation Drug: Tideglusib Congenital Myotonic Dystrophy AMO Pharma Limited August 23 2021 Phase 2|Phase 3
NCT04700046 Not yet recruiting Drug: Mexiletine 167 mg|Drug: Placebo Myotonic Dystrophy Type 1 and Type 2 Lupin Ltd. July 6 2021 Phase 3
NCT03692312 Recruiting Drug: Tideglusib|Drug: Placebo Congenital Myotonic Dystrophy AMO Pharma Limited March 3 2021 Phase 2|Phase 3
NCT04622319 Recruiting Drug: DS-8201a|Drug: T-DM1 HER2-Positive Primary Breast Cancer|Residual Invasive Breast Cancer Daiichi Sankyo Inc.|AstraZeneca|NSABP Foundation Inc|German Breast Group|Spanish Breast Cancer Research Group (SOLTI) December 4 2020 Phase 3

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Mertansine | Mertansine supplier | purchase Mertansine | Mertansine cost | Mertansine manufacturer | order Mertansine | Mertansine distributor