Docetaxel

Catalog No.S1148 Synonyms: RP56976, NSC 628503

Docetaxel Chemical Structure

Molecular Weight(MW): 807.88

Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.

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In DMSO USD 91 In stock
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USD 270 In stock
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Cited by 53 Publications

Purity & Quality Control

Choose Selective Microtubule Associated Inhibitors

Biological Activity

Description Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.
Targets
Microtubules [1]
(Cell-free assay)
In vitro

Docetaxel is a cytotoxic agent, especially for proliferating cells, which is related to its ability to promote the formation of microtubule bundles and induce sustained mitotic arrest, followed by apoptosis of mitotically arrested cells or permanent mitotic block. Docetaxel suppresses microtubule dynamic instability as well as tread-milling, resulting in the failure of chromosomes to segregate to the daughter cells, which in turn triggers premature exit from mitosis rather than a block at this phase of the cell cycle. [2] Docetaxel inhibits the clonogenic survival of Human cancer cell Hs746T (stomach), AGS (stomach), HeLa (cervix), CaSki (cervix), BxPC3 (pancreas), Capan-1 (pancreas) with IC50 of 1 nM, 1 nM, 0.3 nM, 0.3 nM, 0.3 nM and 0.3 nM respectively. [4] Docetaxel inhibits endothelial cell migration that does not affects microtubule gross morphology or inhibit cell proliferation, although they does produce more subtle effects on microtubule dynamics. Docetaxel inhibits HUVEC migration with an observed IC50 of 1 pM. HUVEC chemotaxis stimulated by either of two angiogenic factors, thymidine phosphorylase or VEGF, is inhibited by Docetaxel with IC 50 of 10 pM and is ablated at 1 nM. [7] Docetaxel induces human monocytes, but not RAW 264.7 murine macrophages, Prostaglandin H Synthase-2m (PGHS-2) expression. [8]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HSC-3 NWCyXY53T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrMTWM2OD1yLkCwNFE{OiEQvF2= NI\CfJhUSU6JRWK=
5637 M1;DN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1T6ZWlEPTB;MD6wNFAyPDNizszN NYjmdJdXW0GQR1XS
HT-144 NGjxZXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHJRndKSzVyPUCuNFAxOTV5IN88US=> MV\TRW5ITVJ?
NCI-H292 MlzlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nwVGlEPTB;MD6wNFAyPTlizszN NIn2WFJUSU6JRWK=
HCE-T MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LNV2lEPTB;MD6wNFAyPjJizszN M2LzVnNCVkeHUh?=
ESS-1 M4XmXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M336bmlEPTB;MD6wNFAyPzlizszN MlK5V2FPT0WU
D-566MG MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfTT|dsUUN3ME2wMlAxODF6MjFOwG0> MV7TRW5ITVJ?
CAL-62 M{TiRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\QTWM2OD1yLkCwNFE5PSEQvF2= MXfTRW5ITVJ?
GT3TKB M3r6[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnn2TWM2OD1yLkCwNFI{OiEQvF2= MWHTRW5ITVJ?
HSC-4 M4TzT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGS1W3ZKSzVyPUCuNFAxOjN7IN88US=> M3XWd3NCVkeHUh?=
KOSC-2 NETSXIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjvZotpUUN3ME2wMlAxODJ3NTFOwG0> MX;TRW5ITVJ?
NB14 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwMECwNlYh|ryP M1rpNXNCVkeHUh?=
ES8 NUi1c3o{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXQOGlKSzVyPUCuNFAxOjZizszN NIi5OGdUSU6JRWK=
BFTC-905 NGezbHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fGeWlEPTB;MD6wNFAzPjhizszN M4DtOnNCVkeHUh?=
A498 NFnWPWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfNVYtKSzVyPUCuNFAxOjd6IN88US=> Ml:3V2FPT0WU
HO-1-N-1 NVX1XowzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXqwOmtiUUN3ME2wMlAxODJ6MTFOwG0> NX\Nc21vW0GQR1XS
SF539 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTBwMECwN|AzKM7:TR?= MXfTRW5ITVJ?
HuO-3N1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnrNXU3UUN3ME2wMlAxODNyMjFOwG0> NXrHUnRUW0GQR1XS
NCI-H510A NIHHdnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELQVFFKSzVyPUCuNFAxOzN4IN88US=> NUTQWoJVW0GQR1XS
CAL-27 NHW2R2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHDXndKSzVyPUCuNFAxOzN7IN88US=> MVXTRW5ITVJ?
TE-8 NIKxSIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7kXXlFUUN3ME2wMlAxODN4NjFOwG0> MkjiV2FPT0WU
VA-ES-BJ M4S1dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnKTWM2OD1yLkCwNFM4PSEQvF2= NVfsWHpxW0GQR1XS
RH-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;NTWM2OD1yLkCwNFM5PiEQvF2= NFn1O3dUSU6JRWK=
COLO-800 NEXLU2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTBwMECwN|g5KM7:TR?= M3GzdnNCVkeHUh?=
ES7 NFzEZVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1noTmlEPTB;MD6wNFA{QDlizszN NFexNpdUSU6JRWK=
GAMG Ml30S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PHd2lEPTB;MD6wNFA1OTZizszN M{jvcXNCVkeHUh?=
Ca9-22 NW\NN5RZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwMECwOFI{KM7:TR?= M2\u[HNCVkeHUh?=
SBC-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTBwMECwOFMh|ryP NIXsc4ZUSU6JRWK=
RPMI-7951 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELRU5FKSzVyPUCuNFAxPDR6IN88US=> M1;6OHNCVkeHUh?=
SW1710 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILyXWpKSzVyPUCuNFAxPDZ4IN88US=> MlXqV2FPT0WU
HGC-27 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPFV|VmUUN3ME2wMlAxODR5MTFOwG0> NI\aOGRUSU6JRWK=
MC-IXC MmK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI[zS3lKSzVyPUCuNFAxPDd7IN88US=> NHHqOHhUSU6JRWK=
FTC-133 NECyPWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPpTWM2OD1yLkCwNFQ5QSEQvF2= M3zxTXNCVkeHUh?=
HT-1080 MnrDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;OTWM2OD1yLkCwNFUxOSEQvF2= MmjuV2FPT0WU
NMC-G1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzwSXdKSzVyPUCuNFAxPTF5IN88US=> M{nxeHNCVkeHUh?=
GI-1 Moq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTBwMECwOVI5KM7:TR?= MnzmV2FPT0WU
CGTH-W-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWG4Oo92UUN3ME2wMlAxODV2MjFOwG0> NHnrUplUSU6JRWK=
A2058 NVfJWG1KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HQUGlEPTB;MD6wNFA2PDRizszN NIrteXpUSU6JRWK=
ETK-1 NH7OTYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwMECwOVU5KM7:TR?= M1e2cXNCVkeHUh?=
NEC8 NXLtOXJJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fBVGlEPTB;MD6wNFA2PjFizszN Mnj6V2FPT0WU
TE-11 M1G5dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmf6TWM2OD1yLkCwNFU3QSEQvF2= NWW4XXZOW0GQR1XS
NCI-H720 MnnhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFz6SJhKSzVyPUCuNFAxPThizszN M2nzW3NCVkeHUh?=
PSN1 MoPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDPSXVLUUN3ME2wMlAxODV6MTFOwG0> M{G0NHNCVkeHUh?=
SW780 NU\pdYJsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPuR4lKSzVyPUCuNFAxPTh5IN88US=> MkDhV2FPT0WU
8-MG-BA M4n6e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HuVGlEPTB;MD6wNFA2QDlizszN NV35NVV1W0GQR1XS
EC-GI-10 NV:4fJlXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnyyTWM2OD1yLkCwNFU6OiEQvF2= NWDue4tjW0GQR1XS
SJSA-1 NGHFXmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmP1TWM2OD1yLkCwNFYyPSEQvF2= MkH6V2FPT0WU
639-V NGrofJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1y5emlEPTB;MD6wNFA3PDdizszN M1nER3NCVkeHUh?=
PFSK-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzQZmhKSzVyPUCuNFAxPjV5IN88US=> MmP1V2FPT0WU
DMS-273 MlLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HNbmlEPTB;MD6wNFA3PzRizszN MnnvV2FPT0WU
TE-9 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnoTI9KSzVyPUCuNFAxPjd4IN88US=> NYLNbWZ7W0GQR1XS
SCC-25 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTBwMECwOlgh|ryP NH3NeZFUSU6JRWK=
PA-1 NYHUOJNuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3uTWM2OD1yLkCwNFY5PyEQvF2= M4XPcXNCVkeHUh?=
MHH-ES-1 NHTB[HRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDlTWM2OD1yLkCwNFch|ryP MUPTRW5ITVJ?
Daoy MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TadWlEPTB;MD6wNFA4KM7:TR?= MljLV2FPT0WU
G-402 NYO4dG1XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHS4bnBKSzVyPUCuNFAxPzB4IN88US=> M4XIWnNCVkeHUh?=
YKG-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHUTWM2OD1yLkCwNFcxPyEQvF2= M33pXXNCVkeHUh?=
Ca-Ski NWnFZ5dHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUKwWY5LUUN3ME2wMlAxODd{ODFOwG0> NE\kN2hUSU6JRWK=
CHP-212 MnHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;TVoJ{UUN3ME2wMlAxODd|IN88US=> M1fGUnNCVkeHUh?=
SCC-4 NUX0e4xVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3K4OmlEPTB;MD6wNFA4OzlizszN NEPOSVBUSU6JRWK=
EW-3 MmjoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTBwMECwO|Q2KM7:TR?= MYDTRW5ITVJ?
P12-ICHIKAWA MnjsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nXNmlEPTB;MD6wNFA4PDVizszN MUPTRW5ITVJ?
HSC-2 M37EV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrvTWM2OD1yLkCwNFc2PSEQvF2= MmPxV2FPT0WU
HN M2Ttb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3zXW5KSzVyPUCuNFAxPzV6IN88US=> NG\6cJFUSU6JRWK=
LXF-289 M4nF[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIf5PYZKSzVyPUCuNFAxPzV6IN88US=> NEKxN3lUSU6JRWK=
ES1 NG\IdWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTBwMECwO|ch|ryP NIK2cXZUSU6JRWK=
NTERA-S-cl-D1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzwOHRKSzVyPUCuNFAxPzd|IN88US=> MnG1V2FPT0WU
K5 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonNTWM2OD1yLkCwNFc4QCEQvF2= MorDV2FPT0WU
HOS M4XWVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XnNmlEPTB;MD6wNFA4QDJizszN NHnJeZlUSU6JRWK=
YH-13 M2jqN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTBwMECwO|kyKM7:TR?= MXzTRW5ITVJ?
SW954 MlL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTBwMECwPFI{KM7:TR?= MnTWV2FPT0WU
KYSE-510 M{HQe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInHfnBKSzVyPUCuNFAxQDRizszN NVXtbWJwW0GQR1XS
8505C M3Kwfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7BTWM2OD1yLkCwNFg2PCEQvF2= MnPlV2FPT0WU
A549 NHe4XmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13EcGlEPTB;MD6wNFA5QDJizszN NHXJWGFUSU6JRWK=
Detroit562 MkHxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkKzTWM2OD1yLkCwNFkxOiEQvF2= M1H3dnNCVkeHUh?=
ES5 M{W5emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NImyNJFKSzVyPUCuNFAxQTFizszN NXrTS5VlW0GQR1XS
KYSE-140 MknxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfLTWM2OD1yLkCwNFk{OyEQvF2= MVjTRW5ITVJ?
GMS-10 NFPoe5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2r0fGlEPTB;MD6wNFA6PDFizszN MXvTRW5ITVJ?
D-263MG M{HS[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LwSWlEPTB;MD6wNFA6PDdizszN MVfTRW5ITVJ?
BCPAP MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTBwMECwPVQ4KM7:TR?= MWjTRW5ITVJ?
CHL-1 MoflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\JUmlEPTB;MD6wNFA6PThizszN M2H4eXNCVkeHUh?=
RKO MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnLTWM2OD1yLkCwNFk5QSEQvF2= NHu0UnlUSU6JRWK=
SW48 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTBwMECxNFEh|ryP MkHyV2FPT0WU
BPH-1 NE\MXYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHLTWM2OD1yLkCwNVAzKM7:TR?= NYTSc2NQW0GQR1XS
EFO-27 NYmwelV5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYm2OnFvUUN3ME2wMlAxOTB{IN88US=> MlfEV2FPT0WU
CAL-33 Ml7MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fCPWlEPTB;MD6wNFExPCEQvF2= NH;uTWlUSU6JRWK=
NCI-H1792 NEDyfIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXDN3hwUUN3ME2wMlAxOTB2IN88US=> NXOwZo1NW0GQR1XS
BB30-HNC NE\UW3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjSTWM2OD1yLkCwNVA2KM7:TR?= NF;xc25USU6JRWK=
VM-CUB-1 NH:3TJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TDOGlEPTB;MD6wNFExPSEQvF2= NFv1c3pUSU6JRWK=
TE-5 NYexUFRxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jIWGlEPTB;MD6wNFExPiEQvF2= MmHDV2FPT0WU
NB13 M4HIcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTzNYNKSzVyPUCuNFAyODdizszN NILHPZdUSU6JRWK=
NBsusSR NV76folXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjiT|NKSzVyPUCuNFAyOSEQvF2= NFXKRpVUSU6JRWK=
LNCaP-Clone-FGC M{\6[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrv[m1KSzVyPUCuNFAyOSEQvF2= Mme1V2FPT0WU
EPLC-272H M{\VeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrrUIhKSzVyPUCuNFAyOTFizszN MkC1V2FPT0WU
KNS-62 NUn2cYhjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLvdIgzUUN3ME2wMlAxOTF{IN88US=> M1rrOnNCVkeHUh?=
RERF-LC-MS MnTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoP4TWM2OD1yLkCwNVE{KM7:TR?= M4TtTXNCVkeHUh?=
LOXIMVI NGjuZ29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXFc2R4UUN3ME2wMlAxOTF4IN88US=> NEfnc|ZUSU6JRWK=
KINGS-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDsTWM2OD1yLkCwNVE4KM7:TR?= M{jaOHNCVkeHUh?=
T98G MmnnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XPOmlEPTB;MD6wNFEyPyEQvF2= MWrTRW5ITVJ?
HCC1806 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\tc2lEPTB;MD6wNFEyQCEQvF2= M3;Le3NCVkeHUh?=
MZ1-PC MoraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLwRopKSzVyPUCuNFAyOThizszN NITGeZlUSU6JRWK=
RT-112 NW\lPXZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LyWmlEPTB;MD6wNFEyQSEQvF2= M3HQSXNCVkeHUh?=
LK-2 MoPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTMTWM2OD1yLkCwNVIyKM7:TR?= MnjkV2FPT0WU
A375 M4jv[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjINVFKSzVyPUCuNFAyOjFizszN M1LFWnNCVkeHUh?=
SF268 M3q1bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PzWGlEPTB;MD6wNFEzOSEQvF2= Mn3qV2FPT0WU
H9 NH7iVnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIr1cHRKSzVyPUCuNFAyOjRizszN NH3uUHNUSU6JRWK=
KYSE-410 NWXVUmVqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTBwMECxNlQh|ryP MoLhV2FPT0WU
G-401 NUj3bJRiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTBwMECxNlch|ryP NF7wXI5USU6JRWK=
SW982 NGjVeGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLWTWM2OD1yLkCwNVI4KM7:TR?= NEWyPIJUSU6JRWK=
D-423MG NWHlW5B{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTBwMECxN{DPxE1? NF\5RWxUSU6JRWK=
CAMA-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTRUGlbUUN3ME2wMlAxOTNzIN88US=> NX7hVFVDW0GQR1XS
SCC-9 MnXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTGOmZKSzVyPUCuNFAyOzJizszN NXzWeWNnW0GQR1XS
SAS NVzsWWNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3:0ZWlEPTB;MD6wNFE{PCEQvF2= NFjMZWhUSU6JRWK=
KYSE-180 NWS0e5FoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTBwMECxN|Uh|ryP NH25XINUSU6JRWK=
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NCI-H28 NFLvOlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrEOY5mUUN3ME2wMlAxOzN2IN88US=> MlO0V2FPT0WU
A2780 NUewfYl{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnIWYNKSzVyPUCuNFA{OzVizszN MX3TRW5ITVJ?
CTV-1 M1LBfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHlTWM2OD1yLkCwN|M4KM7:TR?= NIfGeolUSU6JRWK=
LC-2-ad NIPoNm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fxdGlEPTB;MD6wNFM1KM7:TR?= MUDTRW5ITVJ?
NCI-H1770 NGi4d5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTBwMECzOFIh|ryP M3Wyd3NCVkeHUh?=
HuO9 MnzKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjXO|VUUUN3ME2wMlAxOzR4IN88US=> NV\yNXhKW0GQR1XS
U-266 M1TqT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHGeFJyUUN3ME2wMlAxOzR6IN88US=> M1rKPXNCVkeHUh?=
MLMA MlXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3yRotKSzVyPUCuNFA{PTVizszN NHrWNVBUSU6JRWK=
U-87-MG MlXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTBwMECzOVUh|ryP M136NXNCVkeHUh?=
GI-ME-N NXLTVItNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\LTnhKSzVyPUCuNFA{PThizszN NEPsNVZUSU6JRWK=
HL-60 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTBwMECzOVkh|ryP M360dHNCVkeHUh?=
EGI-1 M4O3VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHHdYN1UUN3ME2wMlAxOzZ{IN88US=> MV3TRW5ITVJ?
NCI-H23 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoniTWM2OD1yLkCwN|Y1KM7:TR?= NX\ObHM6W0GQR1XS
NCI-H226 NH7rTWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTBwMECzOlgh|ryP MnrGV2FPT0WU
NCI-H520 NXnMNW17T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nuU2lEPTB;MD6wNFM4OiEQvF2= NGLQdFJUSU6JRWK=
L-363 NIXUcWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTBwMECzO|Yh|ryP M1LJcnNCVkeHUh?=
CAL-12T M4rkfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fqWWlEPTB;MD6wNFM4PiEQvF2= NWHiN4MxW0GQR1XS
BT-20 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDWdIJKSzVyPUCuNFA{PzZizszN NF;zWIVUSU6JRWK=
SNB75 M4LCV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTBwMECzPFEh|ryP M2nVZ3NCVkeHUh?=
A4-Fuk MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LRNGlEPTB;MD6wNFM6KM7:TR?= M4W0dHNCVkeHUh?=
BE-13 NE\6T5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\uOWlEPTB;MD6wNFM6OyEQvF2= NYDJWWI4W0GQR1XS
NCI-H1395 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;HTWM2OD1yLkCwN|k3KM7:TR?= NFfK[5FUSU6JRWK=
SW620 NWPmb4ZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUH4NYVsUUN3ME2wMlAxOzl5IN88US=> NEfZeW9USU6JRWK=
KNS-81-FD NWDPcYN1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTU[oJxUUN3ME2wMlAxOzl7IN88US=> MWXTRW5ITVJ?
RD MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;TTWM2OD1yLkCwOEDPxE1? NIr2UodUSU6JRWK=
HLE M4HTNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\GfGlEPTB;MD6wNFQxPSEQvF2= NV3MW3R{W0GQR1XS
OVCAR-3 MkfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1izSWlEPTB;MD6wNFQxPyEQvF2= NUXNO4hIW0GQR1XS
KM12 NYP0d5NXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LLWGlEPTB;MD6wNFQxQCEQvF2= NWjZSVRbW0GQR1XS
HCC2998 NFnMRVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEn3S4dKSzVyPUCuNFA1ODhizszN NXq4d3NpW0GQR1XS
D-502MG M2LzV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkK5TWM2OD1yLkCwOFEh|ryP NE[1ZllUSU6JRWK=
KNS-42 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFP2TGxKSzVyPUCuNFA1OTJizszN MUDTRW5ITVJ?
LS-123 M1f2cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnnTmtKSzVyPUCuNFA1OjVizszN MnX5V2FPT0WU
SiHa M4X0bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwMEC0N{DPxE1? Mo\wV2FPT0WU
T47D MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3f0VWlEPTB;MD6wNFQ{OSEQvF2= MmrJV2FPT0WU
EW-24 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrVTWM2OD1yLkCwOFM{KM7:TR?= MlXYV2FPT0WU
CAL-120 NXzOeI1uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkL2TWM2OD1yLkCwOFM2KM7:TR?= NUS5ZWFsW0GQR1XS
JAR M2PrVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzKZZl2UUN3ME2wMlAxPDN5IN88US=> MoDzV2FPT0WU
QIMR-WIL NFfFSG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLITWM2OD1yLkCwOFM5KM7:TR?= M1\sWXNCVkeHUh?=
OCUB-M NF24OoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nkU2lEPTB;MD6wNFQ{QCEQvF2= NUP1R|Y6W0GQR1XS
Calu-6 M2ni[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHS1fZdKSzVyPUCuNFA1PDdizszN MnPTV2FPT0WU
MDA-MB-453 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml73TWM2OD1yLkCwOFUyKM7:TR?= NV31dIFCW0GQR1XS
MKN45 NIrObmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLzdFBKSzVyPUCuNFA1PTNizszN NEmyPXdUSU6JRWK=
ECC10 M3H1Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mln0TWM2OD1yLkCwOFYh|ryP MVrTRW5ITVJ?
RVH-421 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{noUmlEPTB;MD6wNFQ3OSEQvF2= NX:5SmsxW0GQR1XS
TGBC11TKB MlLXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfFTWM2OD1yLkCwOFY6KM7:TR?= Mn3rV2FPT0WU
MOLT-4 NGHnbXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHLZ5FKSzVyPUCuNFA1PzFizszN NH[2[XhUSU6JRWK=
LN-405 NGnpVVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXVWGFKSzVyPUCuNFA1QDJizszN NYrSVZJnW0GQR1XS
S-117 M{O0PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYGwWm8zUUN3ME2wMlAxPDh4IN88US=> MkTlV2FPT0WU
RPMI-8226 M3vTdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHvUHJFUUN3ME2wMlAxPDl5IN88US=> MkL6V2FPT0WU
KYSE-150 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrSOZdpUUN3ME2wMlAxPDl7IN88US=> MUnTRW5ITVJ?
NCI-H1666 MlHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXNTWM2OD1yLkCwOVA2KM7:TR?= MYjTRW5ITVJ?
Mewo NXXnfnRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M362T2lEPTB;MD6wNFUxPSEQvF2= MUPTRW5ITVJ?
AN3-CA Mn;sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfENlgxUUN3ME2wMlAxPTB5IN88US=> MWPTRW5ITVJ?
COLO-680N NYjKTI9LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTBwMEC1NFgh|ryP MnfyV2FPT0WU
FADU NYnCbZZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoraTWM2OD1yLkCwOVEh|ryP MVjTRW5ITVJ?
GB-1 MonzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHGNopKSzVyPUCuNFA2OTFizszN MX;TRW5ITVJ?
KASUMI-1 NUPDbIpXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFr0VYRKSzVyPUCuNFA2OTFizszN NGj5WG5USU6JRWK=
NOMO-1 NILRZ3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoL0TWM2OD1yLkCwOVE{KM7:TR?= NF\ab2VUSU6JRWK=
BV-173 NVOzNZY2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37qVGlEPTB;MD6wNFU{KM7:TR?= MYTTRW5ITVJ?
RO82-W-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrwb|RlUUN3ME2wMlAxPTNzIN88US=> NX;PWJFmW0GQR1XS
LB2241-RCC M3zPPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHrR5JKSzVyPUCuNFA2OzFizszN M2\4RnNCVkeHUh?=
NCI-H2170 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojITWM2OD1yLkCwOVM2KM7:TR?= NWjuXnFNW0GQR1XS
SK-N-AS MmjXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnlWJVKSzVyPUCuNFA2OzVizszN MVjTRW5ITVJ?
NCI-H1651 NEezfo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvDOWpbUUN3ME2wMlAxPTRizszN MoTqV2FPT0WU
NCI-SNU-5 MonwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXBWY9SUUN3ME2wMlAxPTR3IN88US=> MmrmV2FPT0WU
SN12C NXPn[|JrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3z3bGlEPTB;MD6wNFU2KM7:TR?= MX\TRW5ITVJ?
KY821 NIrTfo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvlO|Z{UUN3ME2wMlAxPTVzIN88US=> NEXsT2RUSU6JRWK=
SW1573 NX\6VolUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnKTWM2OD1yLkCwOVU1KM7:TR?= M4\I[HNCVkeHUh?=
OE19 MlfFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXaVFhKUUN3ME2wMlAxPTV7IN88US=> NEHtWIZUSU6JRWK=
MPP-89 NGXQZoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLLTWM2OD1yLkCwOVY4KM7:TR?= M1zmTXNCVkeHUh?=
HuCCT1 NXnRcIMxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlf2TWM2OD1yLkCwOVY5KM7:TR?= MlS2V2FPT0WU
SW1783 NIC1VW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHxTWM2OD1yLkCwOVch|ryP NELYNXFUSU6JRWK=
8305C M2jIeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTRTWM2OD1yLkCwOVc3KM7:TR?= NXuxOlF{W0GQR1XS
OVCAR-4 NGKxO41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTBwMEC1PFYh|ryP NVP0VFd3W0GQR1XS
MMAC-SF M2HNbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPhTWM2OD1yLkCwOVg3KM7:TR?= NHL3[GdUSU6JRWK=
COLO-824 M2ni[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXLNGpKSzVyPUCuNFA2QSEQvF2= MYDTRW5ITVJ?
HCC38 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHGRW1TUUN3ME2wMlAxPiEQvF2= M{PVPXNCVkeHUh?=
NCI-H1648 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTBwMEC2NFEh|ryP Mm[3V2FPT0WU
NCI-H1573 NITlbYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTBwMEC2NFch|ryP M4Oy[XNCVkeHUh?=
MFM-223 NI\0[oxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTwbFRKSzVyPUCuNFA3OTZizszN MUfTRW5ITVJ?
NCI-H810 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fQT2lEPTB;MD6wNFYzOiEQvF2= M4fIdXNCVkeHUh?=
EM-2 M2K0SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jMXGlEPTB;MD6wNFYzOyEQvF2= MY\TRW5ITVJ?
D-283MED MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHuTWM2OD1yLkCwOlI1KM7:TR?= MWfTRW5ITVJ?
NCI-H1755 NWLl[INlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M122VGlEPTB;MD6wNFYzPCEQvF2= NX31[Y9HW0GQR1XS
KYSE-70 NGj1VnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TEOGlEPTB;MD6wNFYzPCEQvF2= NYDwV2o3W0GQR1XS
SW626 MnHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGmyVohKSzVyPUCuNFA3OjRizszN NGTXPIZUSU6JRWK=
WM-115 M4L6WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PyemlEPTB;MD6wNFYzPyEQvF2= M1rvcnNCVkeHUh?=
NB69 NWDnUVFoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV33Z4JTUUN3ME2wMlAxPjJ7IN88US=> MWPTRW5ITVJ?
DOHH-2 M33TcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jTcGlEPTB;MD6wNFY{KM7:TR?= MUnTRW5ITVJ?
MEL-JUSO M{LIeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTBwMEC2N|kh|ryP MnXtV2FPT0WU
IGR-1 M1TpdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULuVYtPUUN3ME2wMlAxPjRzIN88US=> MUTTRW5ITVJ?
ACN MnfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrETWM2OD1yLkCwOlQ1KM7:TR?= NHfSRppUSU6JRWK=
KARPAS-45 NUDvSZVXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TW[GlEPTB;MD6wNFY2OiEQvF2= M4XPb3NCVkeHUh?=
HC-1 M2rxT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzN[m9PUUN3ME2wMlAxPjV4IN88US=> MYnTRW5ITVJ?
MZ2-MEL MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3KTWM2OD1yLkCwOlU5KM7:TR?= Mmi2V2FPT0WU
NCI-H1355 Mk\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\TTWM2OD1yLkCwOlc6KM7:TR?= NEO4N2lUSU6JRWK=
HuP-T4 M1XXc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fHTGlEPTB;MD6wNFY4QSEQvF2= MXHTRW5ITVJ?
AsPC-1 NVnF[IVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;xZWtMUUN3ME2wMlAxPjh|IN88US=> MWXTRW5ITVJ?
SCC-15 MmHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTBwMEC2PFkh|ryP MlLJV2FPT0WU
CP50-MEL-B NIPYSXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fzNGlEPTB;MD6wNFY6OyEQvF2= MlPsV2FPT0WU
DMS-114 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXJTWM2OD1yLkCwOlk3KM7:TR?= NW\KbWloW0GQR1XS
KYSE-520 NXfscFNkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7yWYZKSzVyPUCuNFA4KM7:TR?= Mm\wV2FPT0WU
NCI-H2228 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIqyfZVKSzVyPUCuNFA4OjVizszN NX23UVl2W0GQR1XS
COLO-829 NULWXJVwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnzTWM2OD1yLkCwO|I2KM7:TR?= MkXXV2FPT0WU
NCI-H2052 NUjXWpVLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DjVWlEPTB;MD6wNFczPyEQvF2= NVq0b|FmW0GQR1XS
HOP-92 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnm1TWM2OD1yLkCwO|Mh|ryP MkjoV2FPT0WU
MDA-MB-231 NVnxdmM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjzTWM2OD1yLkCwO|Mh|ryP MVHTRW5ITVJ?
SK-MEL-30 NHPncFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPiTWM2OD1yLkCwO|MzKM7:TR?= MXzTRW5ITVJ?
NCI-H2087 NXrzdIVwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVexW212UUN3ME2wMlAxPzR6IN88US=> NUL2XYUzW0GQR1XS
SW900 NEX4T|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXzTWM2OD1yLkCwO|U2KM7:TR?= MljPV2FPT0WU
NCI-H358 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoqyTWM2OD1yLkCwO|U5KM7:TR?= MVHTRW5ITVJ?
NCI-H2126 NFjRSFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPUOXBKSzVyPUCuNFA4PzNizszN MnTYV2FPT0WU
TGBC24TKB MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvMbIpKSzVyPUCuNFA4QDFizszN Mn3OV2FPT0WU
786-0 M2XSRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTBwMEC3PFYh|ryP NUjFUpRwW0GQR1XS
no-10 M3fiSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLHTWM2OD1yLkCwO|g5KM7:TR?= NVfnS|BmW0GQR1XS
SCH MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTQeWRKSzVyPUCuNFA5OThizszN NYS5Zo1rW0GQR1XS
COLO-741 M1fBfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXrN3dKSzVyPUCuNFA5OiEQvF2= MleyV2FPT0WU
NCI-H82 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDafGlWUUN3ME2wMlAxQDJ{IN88US=> Mo\5V2FPT0WU
MOLT-16 NUDqWJh6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DJd2lEPTB;MD6wNFgzPyEQvF2= MXTTRW5ITVJ?
IST-MES1 M3;6WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTBwMEC4OEDPxE1? M2DuNnNCVkeHUh?=
NCI-H1623 MkjQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTBwMEC4OVYh|ryP MoSxV2FPT0WU
NCI-H1299 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHq[XFKSzVyPUCuNFA5PTdizszN NFfnfVZUSU6JRWK=
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ALL-PO NGjqfFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\hN4ZKSzVyPUCuNFA5PiEQvF2= MWrTRW5ITVJ?
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KMOE-2 NWfuNYx1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXv4SIJPUUN3ME2wMlA1PDZ7IN88US=> MYnTRW5ITVJ?
DMS-79 NHzEXpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTBwMES1O|kh|ryP M{HYTXNCVkeHUh?=
MHH-NB-11 Ml7uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXIRXhKSzVyPUCuNFQ3OTRizszN M3P4S3NCVkeHUh?=
NCI-H69 MlHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mne1TWM2OD1yLkC0PFQ6KM7:TR?= NX;lR5F3W0GQR1XS
KE-37 NGizRnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\MRmlEPTB;MD6wOVAyKM7:TR?= M3jjT3NCVkeHUh?=
Ramos-2G6-4C10 NW\vXYd5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXpXHBzUUN3ME2wMlA2ODZ5IN88US=> MoHkV2FPT0WU
NCI-H1793 NIXpO2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvnepBbUUN3ME2wMlA2ODl|IN88US=> MknDV2FPT0WU
HT-1376 M3fhNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jXdWlEPTB;MD6wOVE5PiEQvF2= NHPWW4xUSU6JRWK=
EKVX NWHjU4U5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmX0TWM2OD1yLkC1N|g1KM7:TR?= MljlV2FPT0WU
Capan-2 Mmj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3X3VmlEPTB;MD6wOVM6PiEQvF2= MlLzV2FPT0WU
DoTc2-4510 NU\udlZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlK4TWM2OD1yLkC1OFQ3KM7:TR?= MXjTRW5ITVJ?
UACC-893 M{fhZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjzNFBKSzVyPUCuNFU1PjJizszN MlHsV2FPT0WU
SK-MEL-3 NU\rRm1OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPHeWlEUUN3ME2wMlA2Pzh6IN88US=> Mn3nV2FPT0WU
SK-MEL-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwMEW4JO69VQ>? NVv5N21sW0GQR1XS
SW948 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLhclFKSzVyPUCuNFU6QTZizszN M3T3UHNCVkeHUh?=
P30-OHK M4Ppc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrjbGJjUUN3ME2wMlA3OTZ5IN88US=> NFHXbGpUSU6JRWK=
NH-12 NIDqcIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHXbHB{UUN3ME2wMlA3OjR2IN88US=> MVnTRW5ITVJ?
KU-19-19 NV\Ie3JYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTBwME[zOlEh|ryP M2jUUnNCVkeHUh?=
A431 M3nJeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHIN3VnUUN3ME2wMlA3Ozd2IN88US=> MkSwV2FPT0WU
NCI-H2405 NH;NRmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LCZ2lEPTB;MD6wOlM5OyEQvF2= MXjTRW5ITVJ?
KARPAS-299 NVjMXFR4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nm[GlEPTB;MD6wOlU5OiEQvF2= MX;TRW5ITVJ?
BALL-1 M4LGcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrHc5RKSzVyPUCuNFY3PzRizszN MlzrV2FPT0WU
KURAMOCHI M{HMb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGX2SXdKSzVyPUCuNFcxPzNizszN MV\TRW5ITVJ?
LS-1034 M4DTfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTBwMEezOlkh|ryP MkjuV2FPT0WU
MFE-280 NEXsfXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HOVmlEPTB;MD6wO|U{PiEQvF2= Mk\WV2FPT0WU
HOP-62 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHYV5hKSzVyPUCuNFc3PzZizszN NFXWVFZUSU6JRWK=
KG-1 NVHGeVlCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PubWlEPTB;MD6wO|c5PyEQvF2= MljpV2FPT0WU
CW-2 NGDPfYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPUboJKUUN3ME2wMlA4QDN{IN88US=> MWjTRW5ITVJ?
SW837 M1vjfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnqTWM2OD1yLkC4N|QzKM7:TR?= MlPCV2FPT0WU
MFH-ino M1PkRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPpbnU2UUN3ME2wMlA5PTBzIN88US=> NGnxb4hUSU6JRWK=
HCC1419 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3v3XWlEPTB;MD6wPFk5PyEQvF2= NYDqUWFVW0GQR1XS
HMV-II NUDleYZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwMEmwNUDPxE1? MlK1V2FPT0WU
BEN Mn;US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWeyWJM3UUN3ME2wMlA6Ozh3IN88US=> NHvzOJlUSU6JRWK=
SK-N-FI NUP2VGkyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzLTWM2OD1yLkC5OVU3KM7:TR?= NWHwSYROW0GQR1XS
JVM-2 Mlf3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DtN2lEPTB;MD6wPVcyPiEQvF2= NXG5WpBoW0GQR1XS
CAL-54 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTBwMUCwOEDPxE1? MVHTRW5ITVJ?
T84 NYrNZ5dNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTBwMUC5OVIh|ryP M3yzfnNCVkeHUh?=
SHP-77 NWLxNmFUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHaTWM2OD1yLkGxOlQyKM7:TR?= MXfTRW5ITVJ?
G-361 NYK0UpFFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGG1RWxKSzVyPUCuNVI{OjRizszN Mnr1V2FPT0WU
Calu-3 Mm\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnSR4prUUN3ME2wMlE{QDF4IN88US=> NFvNTI9USU6JRWK=
HCC1937 MnX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwMUS5N|ch|ryP MlfmV2FPT0WU
KM-H2 NY\zVmYyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDRRYJKSzVyPUCuNVUxOSEQvF2= Mm\tV2FPT0WU
769-P NGDCS45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLETWM2OD1yLkG1PFQ{KM7:TR?= M3LtUXNCVkeHUh?=
NCI-H1304 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUf6PHRwUUN3ME2wMlE3ODZzIN88US=> NWX5OmZHW0GQR1XS
D-542MG Mn7aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NES3OYlKSzVyPUCuNVYzPzhizszN NWn3UHQxW0GQR1XS
ATN-1 NGm0eoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPUTWM2OD1yLkG3OFQyKM7:TR?= MVzTRW5ITVJ?
NCI-H2029 M1fON2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH2yZ21KSzVyPUCuNlAzPDNizszN MYfTRW5ITVJ?
ZR-75-30 NUH5NpBOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXLTWM2OD1yLkKwOlQ{KM7:TR?= NGXtXG1USU6JRWK=
SW1116 NYLISplnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLURXBoUUN3ME2wMlIyOTF5IN88US=> NIS5dmhUSU6JRWK=
CCRF-CEM M3Tkc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1qzOGlEPTB;MD6yO|YyPCEQvF2= NY[5b4hnW0GQR1XS
LU-135 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmm0TWM2OD1yLkK3O|M6KM7:TR?= NHf0VIlUSU6JRWK=
MC116 MlXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoruTWM2OD1yLkK4N|A6KM7:TR?= MWDTRW5ITVJ?
LS-513 NHTwdJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGC3OoxKSzVyPUCuNlg4PzNizszN MXnTRW5ITVJ?
NCI-H630 NHSxTW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDFTWM2OD1yLkK5N|c3KM7:TR?= MYHTRW5ITVJ?
L-428 M2Xa[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XoSmlEPTB;MD6yPVg5OyEQvF2= MX\TRW5ITVJ?
UM-UC-3 MkLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXn0V4RSUUN3ME2wMlMyOjlzIN88US=> M3rBeHNCVkeHUh?=
NCI-H1838 M{LYemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTUTWM2OD1yLkOxO|g1KM7:TR?= NHXLN2ZUSU6JRWK=
HEL MlG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTBwM{KyOEDPxE1? MXPTRW5ITVJ?
OCI-AML2 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fHe2lEPTB;MD6zNlI6QCEQvF2= NInuR|BUSU6JRWK=
A3-KAW M4D3Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF74d4xKSzVyPUCuN|M1PzdizszN MmHwV2FPT0WU
IGROV-1 M4TEOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTBwM{O3OVUh|ryP NWDSWWZSW0GQR1XS
Mo-T M4XCRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTBwM{O4OVMh|ryP NFLHS4NUSU6JRWK=
HDLM-2 MmnIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjKTWM2OD1yLkOzPUDPxE1? NIK1eoVUSU6JRWK=
HCC1569 NWf3b|RKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4m0VWlEPTB;MD6zOFMxQSEQvF2= M4HufHNCVkeHUh?=
COLO-678 NF3pZVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjmbY5KSzVyPUCuN|cxODJizszN NHX5NHFUSU6JRWK=
COR-L105 NEPmblRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTBwM{e5N{DPxE1? M{TMN3NCVkeHUh?=
SK-MEL-24 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDpTWM2OD1yLkO4N|gzKM7:TR?= M1PuXXNCVkeHUh?=
COLO-320-HSR M373ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTBwNEO5O|Yh|ryP NV;uOVI{W0GQR1XS
C8166 NEj1SYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHtXJpKSzVyPUCuOFkxOjNizszN M33vcXNCVkeHUh?=
COLO-679 MmOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmCyTWM2OD1yLk[yNVczKM7:TR?= MVPTRW5ITVJ?
TE-12 M{fQbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7DTWM2OD1yLk[1N|k1KM7:TR?= NXTrSZBHW0GQR1XS
HAL-01 M3v3emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4WzRWlEPTB;MD62OlIzKM7:TR?= NWLlbmxLW0GQR1XS
H-EMC-SS NX\lTHBuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHrTWM2OD1yLkewOVQ3KM7:TR?= M1v4V3NCVkeHUh?=
SNU-449 M1XVO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHxXJM3UUN3ME2wMlczPzR6IN88US=> NEnsNHhUSU6JRWK=
C32 M3jtVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTBwN{SxNVIh|ryP Mn70V2FPT0WU
K-562 M2jhOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEWyeJFKSzVyPUCuO|cxOjRizszN MmrwV2FPT0WU
DJM-1 NWq2SGFOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nveWlEPTB;MD63PFc5OSEQvF2= NY\1d4lMW0GQR1XS
RCC10RGB M3uxZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fVWGlEPTB;MD63PVE5OyEQvF2= M2XxVnNCVkeHUh?=
CAL-85-1 M2TJfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYj1[lZkUUN3ME2wMlkxPyEQvF2= MnrWV2FPT0WU
NY NF:xNHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTwTWM2OD1yLkmzN|UzKM7:TR?= M3y4bnNCVkeHUh?=
NCI-H1993 M3;nSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlz6TWM2OD1zLkG5Nlg6KM7:TR?= M1v6TnNCVkeHUh?=
SK-OV-3 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHINJRKSzVyPUGuNlIxQDlizszN MX7TRW5ITVJ?

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
PIM1; 

PubMed: 18426800     


Cells were treated with 100 nm docetaxel for the indicated times. PIM1 and β-ACTIN proteins were analyzed by immunoblot analysis. One of three similar blots is shown. Ratio, ratio of PIM1/β-ACTIN from pooled densitometry data from three separate experimen䲧疝Ỵ疞㧀疜膉痘 瘿뾠ՂᾰƌՂĀ 㺣痖帉痖Ѐ瑖堘𢡄빢᎒ՂĀ鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ⟸෕䐺痖暼瘿⟸෕ᾰƌ

cyclin B; 

PubMed: 18426800     


Immunoblot analysis of cyclin B1 and PIM1 expression after docetaxel 10 nm (left) or 100 nm (right) treatment at various time points.

pSTAT3 / STAT3 ; 

PubMed: 18426800     


Immunoblots of RWPE-2 cells treated with 100 nm docetaxel for the indicated time.

p-p53 / p53; 

PubMed: 22996738     


C4-2 cells were treated with 5 nM docetaxel, the whole cell lysates were collected at different time points and subjected to Western blot.

18426800 22996738
Immunofluorescence
α-tubulin; 

PubMed: 27177833     


Noscapine has no effect on gross microtubule polymerization state but noscapine pre-sensitization followed by docetaxel treatment stabilizes microtubules, hence inhibits cell proliferation. TNBC cells were treated with noscapine (4 µM) or docetaxel (0.4 µ䲧疝Ỵ疞㧀疜膉痘 瘿⟸෕ᾰƌ෕Ð 㺣痖帉痖Ѐ瑖堘𢡄빢᎒෕Ð鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ뾠Ղ䐺痖暼瘿뾠Ղᾰƌ 뾠ՂÐ㺣痖뾠Ղ€𢡄뾤Ղ€䀷痗뾤Ղ౴뾤Ղ㵶痗뾤Ղ뺖᎒泌Itemセ᎒Count﫨呂뿔Ղ猴፲뾤Ղ፲씢痗猸፲髸莤䥷堙᎒セ᎒�堞ﻮ᎒፲露𢡄堚Ҕ齃礤v�堞ﻮ᎒猢Wセ᎒䨼Ą鹿齃殺獸W戀醙

cleaved PARP / cleaved caspase-3; 

PubMed: 21087597     


Immunofluorescence images of PC-3 cells treated with the docetaxel and EM011 schedule treatment. Cells were pretreated with docetaxel for 12 h before addition of EM011 and were fixed at 48 h post docetaxel treatment compared to treatment with EM011 (10 μM䲧疝Ỵ疞㧀疜膉痘 瘿⟸෕ᾰƌ෕Ð 㺣痖帉痖Ѐ瑖堘𢡄빢᎒෕Ð鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ�෋䐺痖暼瘿�෋ᾰƌ �෋à

Acetylated tubulin ; 

PubMed: 18426800     


Immunofluorescence of acetylated tubulin in cells treated with DMSO, 30 nM laulimalide and 30 nM docetaxel for 2.5 h. Tubulin shown in green and DAPI in blue, and the white arrow indicates microtubule bundling. Scale bar represents 10 μm.

SQSTM1 / LAMP1; 

PubMed: 29795139     


AGS cells were treated with docetaxel (10 nM) for 12 h. After immunostaining with SQSTM1 (Alexa Fluor 488, green) and LAMP1 (Alexa Fluor 594, red), cells were examined by fluorescence microscopy (scale bar 20 μm). The colocalization of SQSTM1and LAMP1 was䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 㺣痖帉痖Ѐ

27177833 21087597 18426800 29795139
Growth inhibition assay
Cell viability ; 

PubMed: 22996738     


Docetaxel inhibits the growth of LNCaP, C4-2, DU145, and PC3 prostate cancer cells. Cells were plated in 12-well plates and treated with different concentrations of docetaxel. The cell number was counted after 24 hr. 

22996738
In vivo Docetaxel (33 mg/kg/dose, given i.v. every 4 days for 3 injections) results in a tumor growth delay of 19.3 days in M2OL2 colon xenografts. Docetaxel also shows great antitumor activities in MX-1, SK-MEL-2, LX-1 and OVCAR-3 xenografts. Docetaxel inhibits the angiogenic response to fibroblast growth factor 2 with IC 50 of 5.4 mg/kg when injected twice weekly over a 14-day period, and angiogenesis is completely blocked in mice that receives 10 mg/kg Docetaxel. Docetaxel has selectivity for endothelial cell migration and/or microvessel formation because infiltration of inflammatory cells into the Matrigel plug is much less sensitive to inhibition by Docetaxel. [7]

Protocol

Cell Research:[5]
- Collapse
  • Cell lines: Human gastric cancer cell lines MKN-28
  • Concentrations: 6 nM
  • Incubation Time: 3 days
  • Method: 2000 cells in 180 μL of medium are seeded in a 96-well plate, and 20 μL of drug solution is simultaneously added in triplicate to each well. The plate is incubated for 3 days at 37°C in a humidified atmosphere of 5% CO2. On day 3, 25 μL of MTT reagent is added to each well. After 4 h of incubation, the medium is removed by aspiration. 0.2 mL of dimethylsulphoxide (DMSO) is added to each well and thoroughly mixed by using a mechanical plate mixer to dissolve the resulting MTT-formazan crystals. Absorbance at 540 nm (OD) is measured by a reader.
    (Only for Reference)
Animal Research:[6]
- Collapse
  • Animal Models: Human colon carcinomas xenografts CX-1
  • Formulation: 50 mg/mL stock solution in ethanol by adding an equal volume of polysorbate 80 and diluting with 5% dextrose in water to the final volume
  • Dosages: 33 mg/kg
  • Administration: i.v. every 4 days for 3 injections
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (123.78 mM)
Ethanol 53 mg/mL warmed (65.6 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 807.88
Formula

C43H53NO14

CAS No. 114977-28-5
Storage powder
in solvent
Synonyms RP56976, NSC 628503

Bio Calculators

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04113005 Not yet recruiting Drug: Desmopressin Castrate Resistance Prostate Cancer Sunnybrook Health Sciences Centre|Sunnybrook Research Institute October 1 2019 Early Phase 1
NCT03700099 Recruiting Drug: Docetaxel|Drug: Enzalutamide Prostate Cancer|Castration-resistant Prostate Cancer Instituto do Cancer do Estado de São Paulo|Astellas Pharma Inc September 3 2019 Phase 2
NCT04067713 Recruiting -- Metastatic Prostate Cancer University College London|Epic Sciences September 20 2019 --
NCT03976375 Recruiting Biological: Pembrolizumab|Drug: Lenvatinib|Drug: Docetaxel Metastatic Non-Small Cell Lung Cancer Merck Sharp & Dohme Corp.|Eisai Inc. June 26 2019 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Microtubule Associated Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID