Docetaxel

Catalog No.S1148 Synonyms: RP56976, NSC 628503

Docetaxel Chemical Structure

Molecular Weight(MW): 807.88

Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.

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In DMSO USD 91 In stock
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Cited by 12 Publications

7 Customer Reviews

  • Immunohistochemistry and quantification of cleaved caspase 3 expression in DU145-DR tumor xenografts from (D). Scale bar, 100 mm. Data represent the mean ± SD. *p < 0.05.

    Cell, 2018, 174(5):1200-1215. Docetaxel purchased from Selleck.

    Viability of cells after exposure to 0, 10, or 10,000 nM docetaxel, assessed by calcein-AM staining (green, left panels) and ethidium homodimer-1 (red, middle panels).

    Mol Pharmaceutics, 2014, 11: 2040−50. Docetaxel purchased from Selleck.

  • J Transl Med 2013 0.6. Docetaxel purchased from Selleck.

    J Transl Med 2013 0.6. Docetaxel purchased from Selleck.

  • TNBC and non-TNBC cells were treated for 6 d with the specified concentrations of docetaxel (doc) alone, TTK inhibitor (TTKi) alone or the combinations. The survival of cells was measured using the MTS/MTA assay. ***P<0.001 comparing the combination with single agents and with non-TNBC cell lines.

    Oncogenesis, 2014, 3: e100 . Docetaxel purchased from Selleck.

    Cell cycle study of percent cell populations in various phases after treatment with vehicle, HCI-2509 in increasing concentrations and docetaxel alone and in combination with HCI-2509 using (a) PC3 cells. Student's unpaired t-tests, using GraphPad Prism software, were used to calculate two-tailed P-values for each experiment to determine statistical significance between untreated and treated samples. The statistically significant P-values are labeled in each figure with an asterisk. (Replicated two more times, representative graph shown).

    Prostate Cancer Prostatic Dis, 2016, 19(4):349-357. Docetaxel purchased from Selleck.

  • Biomed Pharmacother, 2018, 99:445-450. Docetaxel purchased from Selleck.

Purity & Quality Control

Choose Selective Microtubule Associated Inhibitors

Biological Activity

Description Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.
Targets
Microtubules [1]
(Cell-free assay)
In vitro

Docetaxel is a cytotoxic agent, especially for proliferating cells, which is related to its ability to promote the formation of microtubule bundles and induce sustained mitotic arrest, followed by apoptosis of mitotically arrested cells or permanent mitotic block. Docetaxel suppresses microtubule dynamic instability as well as tread-milling, resulting in the failure of chromosomes to segregate to the daughter cells, which in turn triggers premature exit from mitosis rather than a block at this phase of the cell cycle. [2] Docetaxel inhibits the clonogenic survival of Human cancer cell Hs746T (stomach), AGS (stomach), HeLa (cervix), CaSki (cervix), BxPC3 (pancreas), Capan-1 (pancreas) with IC50 of 1 nM, 1 nM, 0.3 nM, 0.3 nM, 0.3 nM and 0.3 nM respectively. [4] Docetaxel inhibits endothelial cell migration that does not affects microtubule gross morphology or inhibit cell proliferation, although they does produce more subtle effects on microtubule dynamics. Docetaxel inhibits HUVEC migration with an observed IC50 of 1 pM. HUVEC chemotaxis stimulated by either of two angiogenic factors, thymidine phosphorylase or VEGF, is inhibited by Docetaxel with IC 50 of 10 pM and is ablated at 1 nM. [7] Docetaxel induces human monocytes, but not RAW 264.7 murine macrophages, Prostaglandin H Synthase-2m (PGHS-2) expression. [8]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HSC-3 NHrBU|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3iWlZKSzVyPUCuNFAxOTN{IN88US=> M4\menNCVkeHUh?=
5637 MkPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrHfmxVUUN3ME2wMlAxODF2MzFOwG0> NXHTe5NGW0GQR1XS
HT-144 MmDBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPSSGZKSzVyPUCuNFAxOTV5IN88US=> MlrrV2FPT0WU
NCI-H292 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrRXJZ[UUN3ME2wMlAxODF3OTFOwG0> MWTTRW5ITVJ?
HCE-T NYLGeWFDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHKVpU4UUN3ME2wMlAxODF4MjFOwG0> M{n6RnNCVkeHUh?=
ESS-1 NIPSUolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PMdGlEPTB;MD6wNFAyPzlizszN NXjEenJKW0GQR1XS
D-566MG NHntTYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTBwMECwNVgzKM7:TR?= M361W3NCVkeHUh?=
CAL-62 MlvQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXYfHg5UUN3ME2wMlAxODF6NTFOwG0> MmrnV2FPT0WU
GT3TKB NHX6c5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvHUmNKSzVyPUCuNFAxOjN{IN88US=> MV3TRW5ITVJ?
HSC-4 M{j5O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;RS2lEPTB;MD6wNFAzOzlizszN NInlcI9USU6JRWK=
KOSC-2 NVvkSIZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHSUYNHUUN3ME2wMlAxODJ3NTFOwG0> MXjTRW5ITVJ?
NB14 NF\LWpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTBwMECwNlYh|ryP NFy3TJNUSU6JRWK=
ES8 MnHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTYTWM2OD1yLkCwNFI3KM7:TR?= MkPQV2FPT0WU
BFTC-905 Mk[3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFn0PG5KSzVyPUCuNFAxOjZ6IN88US=> M3m4dnNCVkeHUh?=
A498 M{TtR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTBwMECwNlc5KM7:TR?= NX;ibXFXW0GQR1XS
HO-1-N-1 NIPtfo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPNS21KSzVyPUCuNFAxOjhzIN88US=> M2G3TXNCVkeHUh?=
SF539 NE\M[mxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXqTWM2OD1yLkCwNFMxOiEQvF2= M17G[XNCVkeHUh?=
HuO-3N1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXQTGdNUUN3ME2wMlAxODNyMjFOwG0> MlW1V2FPT0WU
NCI-H510A NWTrT|dmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTSbY5YUUN3ME2wMlAxODN|NjFOwG0> NUjmb2J2W0GQR1XS
CAL-27 NVjIbpB5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonOTWM2OD1yLkCwNFM{QSEQvF2= MknMV2FPT0WU
TE-8 Mo\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUH5U5hoUUN3ME2wMlAxODN4NjFOwG0> NUG1eogyW0GQR1XS
VA-ES-BJ M3roNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rJbGlEPTB;MD6wNFA{PzVizszN NFP0fplUSU6JRWK=
RH-1 NHLSO5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjnNZBKSzVyPUCuNFAxOzh4IN88US=> M3;vXXNCVkeHUh?=
COLO-800 NGS2UVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7LNGNKSzVyPUCuNFAxOzh6IN88US=> MV;TRW5ITVJ?
ES7 NILFWlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\5UGZ3UUN3ME2wMlAxODN6OTFOwG0> M{jDW3NCVkeHUh?=
GAMG MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWr1RpBlUUN3ME2wMlAxODRzNjFOwG0> MVzTRW5ITVJ?
Ca9-22 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkSwTWM2OD1yLkCwNFQzOyEQvF2= NEjSU3BUSU6JRWK=
SBC-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXBTWM2OD1yLkCwNFQ{KM7:TR?= NV;GSodlW0GQR1XS
RPMI-7951 NXXCXGtpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHOfWFKSzVyPUCuNFAxPDR6IN88US=> MkDvV2FPT0WU
SW1710 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;JeWlEPTB;MD6wNFA1PjZizszN MUTTRW5ITVJ?
HGC-27 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorKTWM2OD1yLkCwNFQ4OSEQvF2= NXyxRlB1W0GQR1XS
MC-IXC MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M130XmlEPTB;MD6wNFA1PzlizszN NH;ZXI5USU6JRWK=
FTC-133 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7ITWM2OD1yLkCwNFQ5QSEQvF2= M4L0PXNCVkeHUh?=
HT-1080 M1zveWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPCTWM2OD1yLkCwNFUxOSEQvF2= MYPTRW5ITVJ?
NMC-G1 NEDp[odIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXv0NW1uUUN3ME2wMlAxODVzNzFOwG0> M1HUSHNCVkeHUh?=
GI-1 MmfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn[5TWM2OD1yLkCwNFUzQCEQvF2= M1O5THNCVkeHUh?=
CGTH-W-1 MlzIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWm4TFZjUUN3ME2wMlAxODV2MjFOwG0> MlT5V2FPT0WU
A2058 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfHb45KSzVyPUCuNFAxPTR2IN88US=> NGW4dJJUSU6JRWK=
ETK-1 M1Hwcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPITWM2OD1yLkCwNFU2QCEQvF2= NHjxO41USU6JRWK=
NEC8 MnjxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLDfm16UUN3ME2wMlAxODV4MTFOwG0> M1nyeHNCVkeHUh?=
TE-11 Mn3RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHqb5RKSzVyPUCuNFAxPTZ7IN88US=> M4DhNXNCVkeHUh?=
NCI-H720 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnQVJpKSzVyPUCuNFAxPThizszN NWW3dXQxW0GQR1XS
PSN1 M4XXVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XifmlEPTB;MD6wNFA2QDFizszN MXzTRW5ITVJ?
SW780 MmnmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2CwdmlEPTB;MD6wNFA2QDdizszN M{XacXNCVkeHUh?=
8-MG-BA MnznS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rRNGlEPTB;MD6wNFA2QDlizszN NXjIbmdkW0GQR1XS
EC-GI-10 NUX5OppFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jJNmlEPTB;MD6wNFA2QTJizszN M4H2dHNCVkeHUh?=
SJSA-1 NXiwdoR[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTBwMECwOlE2KM7:TR?= NYfGXohLW0GQR1XS
639-V NHLqWnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nCc2lEPTB;MD6wNFA3PDdizszN NH\X[3JUSU6JRWK=
PFSK-1 NHHtVYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPjTWM2OD1yLkCwNFY2PyEQvF2= NFTQbFlUSU6JRWK=
DMS-273 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULhTnFsUUN3ME2wMlAxODZ5NDFOwG0> M2TOb3NCVkeHUh?=
TE-9 MorWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzudnRnUUN3ME2wMlAxODZ5NjFOwG0> MXHTRW5ITVJ?
SCC-25 NWnDVpFrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTBwMECwOlgh|ryP NWKxdodzW0GQR1XS
PA-1 M2HKfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3jUWRjUUN3ME2wMlAxODZ6NzFOwG0> M1S1[3NCVkeHUh?=
MHH-ES-1 M{fFU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PWVGlEPTB;MD6wNFA4KM7:TR?= M4T3S3NCVkeHUh?=
Daoy NXnPUoFMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzmUI1KSzVyPUCuNFAxPyEQvF2= Ml;vV2FPT0WU
G-402 NVTIdm46T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XVc2lEPTB;MD6wNFA4ODZizszN MkW4V2FPT0WU
YKG-1 MnraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWH3eVY2UUN3ME2wMlAxODdyNzFOwG0> NWTZUmdvW0GQR1XS
Ca-Ski MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTBwMECwO|I5KM7:TR?= MWXTRW5ITVJ?
CHP-212 M3TDd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTBwMECwO|Mh|ryP NF3rd5BUSU6JRWK=
SCC-4 MorrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHToOFhKSzVyPUCuNFAxPzN7IN88US=> MWrTRW5ITVJ?
EW-3 M1;s[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTsd2VKSzVyPUCuNFAxPzR3IN88US=> NXnVbI9nW0GQR1XS
P12-ICHIKAWA NUDVeVlGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTR[XNrUUN3ME2wMlAxODd2NTFOwG0> MUTTRW5ITVJ?
HSC-2 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIm4fXJKSzVyPUCuNFAxPzV3IN88US=> MkLYV2FPT0WU
HN NIjFepdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TROWlEPTB;MD6wNFA4PThizszN Mke1V2FPT0WU
LXF-289 M1KwVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTlN|FFUUN3ME2wMlAxODd3ODFOwG0> NYH6dZNLW0GQR1XS
ES1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn21TWM2OD1yLkCwNFc4KM7:TR?= MYTTRW5ITVJ?
NTERA-S-cl-D1 NUew[3R{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTBwMECwO|c{KM7:TR?= MX;TRW5ITVJ?
K5 NV;ycWtST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzSfpN5UUN3ME2wMlAxODd5ODFOwG0> NGjXfmRUSU6JRWK=
HOS M1TLZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml21TWM2OD1yLkCwNFc5OiEQvF2= M3zwb3NCVkeHUh?=
YH-13 MlPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TwTWlEPTB;MD6wNFA4QTFizszN MX3TRW5ITVJ?
SW954 M2SwSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLqTWM2OD1yLkCwNFgzOyEQvF2= MoHGV2FPT0WU
KYSE-510 M3jEN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M36zT2lEPTB;MD6wNFA5PCEQvF2= M1nZb3NCVkeHUh?=
8505C MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2m1NWlEPTB;MD6wNFA5PTRizszN MlnZV2FPT0WU
A549 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\mT5FKSzVyPUCuNFAxQDh{IN88US=> MYfTRW5ITVJ?
Detroit562 M{\tVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTZTWM2OD1yLkCwNFkxOiEQvF2= NYPwWJFuW0GQR1XS
ES5 MmnUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7GT3hKSzVyPUCuNFAxQTFizszN MlnXV2FPT0WU
KYSE-140 MnfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTBwMECwPVM{KM7:TR?= Mm\vV2FPT0WU
GMS-10 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYL6Z5dFUUN3ME2wMlAxODl2MTFOwG0> MnrQV2FPT0WU
D-263MG Mkn5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrCc|lUUUN3ME2wMlAxODl2NzFOwG0> MWXTRW5ITVJ?
BCPAP M3KxVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPOTWM2OD1yLkCwNFk1PyEQvF2= NI[z[29USU6JRWK=
CHL-1 M{TWb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTIUYo6UUN3ME2wMlAxODl3ODFOwG0> MX;TRW5ITVJ?
RKO NV7Pd|hCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoX3TWM2OD1yLkCwNFk5QSEQvF2= NHzhOnhUSU6JRWK=
SW48 NEnRcYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4S4O2lEPTB;MD6wNFExOSEQvF2= NXX1N3lHW0GQR1XS
BPH-1 MmrxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTBwMECxNFIh|ryP M4XB[3NCVkeHUh?=
EFO-27 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorxTWM2OD1yLkCwNVAzKM7:TR?= NXjoPZliW0GQR1XS
CAL-33 M1jDXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjkbpdKSzVyPUCuNFAyODRizszN NFLnUI1USU6JRWK=
NCI-H1792 MnTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3j0OGlEPTB;MD6wNFExPCEQvF2= MlfmV2FPT0WU
BB30-HNC NV\qSll1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvK[Y9wUUN3ME2wMlAxOTB3IN88US=> NHe3XVVUSU6JRWK=
VM-CUB-1 M3O1bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTBwMECxNFUh|ryP MlG1V2FPT0WU
TE-5 NU\xfFNDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnZVJkyUUN3ME2wMlAxOTB4IN88US=> M1nuVnNCVkeHUh?=
NB13 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPzcGFWUUN3ME2wMlAxOTB5IN88US=> MoLYV2FPT0WU
NBsusSR NWPVPYN{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4K1VGlEPTB;MD6wNFEyKM7:TR?= MVHTRW5ITVJ?
LNCaP-Clone-FGC MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\tO|dwUUN3ME2wMlAxOTFizszN M4P1N3NCVkeHUh?=
EPLC-272H M1fiW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojBTWM2OD1yLkCwNVEyKM7:TR?= NF7KfHNUSU6JRWK=
KNS-62 MnO4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLEb2ZKSzVyPUCuNFAyOTJizszN NFSwPJRUSU6JRWK=
RERF-LC-MS NH60d3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjweY9KSzVyPUCuNFAyOTNizszN M4LFfnNCVkeHUh?=
LOXIMVI NFHJ[5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M32zeGlEPTB;MD6wNFEyPiEQvF2= NV\LdmRMW0GQR1XS
KINGS-1 M1v2bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTBwMECxNVch|ryP NH\VbotUSU6JRWK=
T98G MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\l[WlEPTB;MD6wNFEyPyEQvF2= NI[5UIZUSU6JRWK=
HCC1806 NIjLR|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTBwMECxNVgh|ryP M3H2ZnNCVkeHUh?=
MZ1-PC MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk[5TWM2OD1yLkCwNVE5KM7:TR?= NIi4UYlUSU6JRWK=
RT-112 NHzoU2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTtTWM2OD1yLkCwNVE6KM7:TR?= NHzXdmxUSU6JRWK=
LK-2 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwMECxNlEh|ryP MVTTRW5ITVJ?
A375 NHnYeFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnCTWM2OD1yLkCwNVIyKM7:TR?= NFjic49USU6JRWK=
SF268 MmHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwMECxNlEh|ryP NUXzS|dDW0GQR1XS
H9 NYHzSXJkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTBwMECxNlQh|ryP MofnV2FPT0WU
KYSE-410 NYTGSXNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTBwMECxNlQh|ryP MWTTRW5ITVJ?
G-401 NGHkRWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2S0fmlEPTB;MD6wNFEzPyEQvF2= M4nBRnNCVkeHUh?=
SW982 NXG3TFY6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{e0d2lEPTB;MD6wNFEzPyEQvF2= NFLXW4pUSU6JRWK=
D-423MG MlHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFriV4pKSzVyPUCuNFAyOyEQvF2= MkLvV2FPT0WU
CAMA-1 MoDWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\3TWM2OD1yLkCwNVMyKM7:TR?= M37m[XNCVkeHUh?=
SCC-9 MojVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3wTWM2OD1yLkCwNVMzKM7:TR?= MlfHV2FPT0WU
SAS NEL2OlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTBwMECxN|Qh|ryP NUniOXF7W0GQR1XS
KYSE-180 M4\SeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUW1XZllUUN3ME2wMlAxOTN3IN88US=> MV;TRW5ITVJ?
EW-16 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnDTWM2OD1yLkCwNVM2KM7:TR?= MU\TRW5ITVJ?
HD-MY-Z MojES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYribVBzUUN3ME2wMlAxOTRzIN88US=> Ml;rV2FPT0WU
KYSE-450 NYrF[HRnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHeyUZZKSzVyPUCuNFAyPDNizszN NYS2RopQW0GQR1XS
LCLC-97TM1 M4j1emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPWTWM2OD1yLkCwNVQ1KM7:TR?= M1nNb3NCVkeHUh?=
KS-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnMVW1KSzVyPUCuNFAyPDRizszN NWH4UYZbW0GQR1XS
TI-73 NWSx[FI5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vlR2lEPTB;MD6wNFE1PCEQvF2= M{DvW3NCVkeHUh?=
A427 Mo\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7CTWM2OD1yLkCwNVQ5KM7:TR?= M1nsSXNCVkeHUh?=
LB831-BLC NXm3Z|FFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnFTWM2OD1yLkCwNVQ5KM7:TR?= NFriUJJUSU6JRWK=
MG-63 NEDleJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVq2eIZGUUN3ME2wMlAxOTVzIN88US=> M1LKe3NCVkeHUh?=
PANC-03-27 NVrSW5llT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTBwMECxOVQh|ryP MmTLV2FPT0WU
23132-87 NXPQcm9PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nh[WlEPTB;MD6wNFE2PSEQvF2= MlTGV2FPT0WU
ES4 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTBwMECxOVUh|ryP NHLlN41USU6JRWK=
KP-4 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NISxVVdKSzVyPUCuNFAyPTZizszN M2nqWnNCVkeHUh?=
NCI-H1703 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLwTWM2OD1yLkCwNVU4KM7:TR?= NIqwdpZUSU6JRWK=
MCF7 M3OxcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LGOmlEPTB;MD6wNFE3OSEQvF2= M1LsPXNCVkeHUh?=
A172 Ml3CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXYdWZHUUN3ME2wMlAxOTZ|IN88US=> MX3TRW5ITVJ?
CAL-39 M3q4[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DzZ2lEPTB;MD6wNFE3OyEQvF2= M1XsXnNCVkeHUh?=
Saos-2 M1jFcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTQTWM2OD1yLkCwNVY5KM7:TR?= MVTTRW5ITVJ?
EW-11 NEnjSItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHNdIN2UUN3ME2wMlAxOTZ7IN88US=> NX7ZOYFOW0GQR1XS
D-336MG NGXCWW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvkXmVWUUN3ME2wMlAxOTZ7IN88US=> NFfpfGNUSU6JRWK=
SW13 MoLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\wb2pNUUN3ME2wMlAxOTZ7IN88US=> M2DteXNCVkeHUh?=
ME-180 Mn6xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTBwMECxOlkh|ryP NIDSRYxUSU6JRWK=
SK-MEL-2 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTBwMECxO{DPxE1? MlnIV2FPT0WU
697 M4TqZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTBwMECxO|Ih|ryP M4K4eXNCVkeHUh?=
D-247MG Mn;xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLNemxKSzVyPUCuNFAyPzNizszN MYrTRW5ITVJ?
EoL-1-cell M1[yOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LT[mlEPTB;MD6wNFE4OyEQvF2= NIDEd3ZUSU6JRWK=
MV-4-11 MmXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwMECxO|Qh|ryP M1rnUnNCVkeHUh?=
U-2-OS M{f5XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTBwMECxO|Uh|ryP MVjTRW5ITVJ?
NCI-H526 NYXmOHdST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjwUGdzUUN3ME2wMlAxOTd4IN88US=> MW\TRW5ITVJ?
SK-NEP-1 Mki1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2e1UGlEPTB;MD6wNFE4PiEQvF2= NIC3OIhUSU6JRWK=
DB MnLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfZe2JUUUN3ME2wMlAxOTd6IN88US=> NWG0WFVTW0GQR1XS
GCT MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\ueGlEPTB;MD6wNFE5KM7:TR?= MlHoV2FPT0WU
HCT-116 NXz5ZZZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTBwMECxPFEh|ryP NU\3RoM6W0GQR1XS
AU565 M{C0TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwMECxPFEh|ryP NGP3N3VUSU6JRWK=
KALS-1 Mn\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M170NWlEPTB;MD6wNFE5OSEQvF2= NHPTUFhUSU6JRWK=
C2BBe1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofWTWM2OD1yLkCwNVgzKM7:TR?= NFHZTZdUSU6JRWK=
Becker MlzLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\yUVBKSzVyPUCuNFAyQDNizszN NVnO[IZXW0GQR1XS
647-V NGHGfndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUSwcJpnUUN3ME2wMlAxOTh2IN88US=> MlzJV2FPT0WU
NCI-H2122 NFvOSo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTBwMECxPFQh|ryP MVXTRW5ITVJ?
SBC-5 NFHNUJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\6OY13UUN3ME2wMlAxOTh5IN88US=> M3vMR3NCVkeHUh?=
NB17 NGjzOXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELsd2pKSzVyPUCuNFAyQDlizszN M1nqSXNCVkeHUh?=
MHH-PREB-1 NEfFTHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\4[mlEPTB;MD6wNFE5QSEQvF2= NHrDTHpUSU6JRWK=
M14 MlXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvpTWM2OD1yLkCwNVkyKM7:TR?= MWHTRW5ITVJ?
NCI-H1048 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33lOWlEPTB;MD6wNFE6OiEQvF2= M3:xbHNCVkeHUh?=
CTB-1 Mn\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXWxc3hrUUN3ME2wMlAxOTl{IN88US=> Mn3JV2FPT0WU
SK-PN-DW Mn34S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HsOmlEPTB;MD6wNFE6PCEQvF2= NGfUblFUSU6JRWK=
H4 NEXnbIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\QTWM2OD1yLkCwNVk3KM7:TR?= M3XPbXNCVkeHUh?=
NCI-SNU-1 MmfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnzNnJxUUN3ME2wMlAxOTl5IN88US=> MlGzV2FPT0WU
M059J NFm4dGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDiTWM2OD1yLkCwNVk5KM7:TR?= M{fN[nNCVkeHUh?=
OVCAR-5 MljES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvweGRKSzVyPUCuNFAyQTlizszN MnWzV2FPT0WU
SK-MEL-28 NXfEOHFVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrDN|BKSzVyPUCuNFAzODNizszN MXzTRW5ITVJ?
PC-14 M4fDb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTBwMECyNFkh|ryP NGHvcpRUSU6JRWK=
OVCAR-8 MnLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTBwMECyNVIh|ryP MoGyV2FPT0WU
BB49-HNC MkTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DQRWlEPTB;MD6wNFIyOiEQvF2= MmjBV2FPT0WU
EFM-19 MkPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XwSmlEPTB;MD6wNFIyPSEQvF2= Mof1V2FPT0WU
BHY MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1u2[GlEPTB;MD6wNFIyPiEQvF2= NF;WSoNUSU6JRWK=
SW756 MmnRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjSTWM2OD1yLkCwNlE3KM7:TR?= MonRV2FPT0WU
TE-1 NULoTpk2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3G4UGlEPTB;MD6wNFIyPiEQvF2= MmO0V2FPT0WU
NCI-H2452 NYX4epZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYizZZhPUUN3ME2wMlAxOjF4IN88US=> MULTRW5ITVJ?
NCI-H1581 NVP2OHh[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTBwMECyNVch|ryP NUPZ[2RCW0GQR1XS
COR-L23 NFjBXo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHvTWM2OD1yLkCwNlIh|ryP Moe5V2FPT0WU
RXF393 NHLwSYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTtTWM2OD1yLkCwNlIzKM7:TR?= NVroeIhEW0GQR1XS
BFTC-909 NYjCPXQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUD5dIxVUUN3ME2wMlAxOjJ3IN88US=> NFXmZ|NUSU6JRWK=
IST-MEL1 NIrMWXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37lPGlEPTB;MD6wNFIzPSEQvF2= MYLTRW5ITVJ?
NCI-H650 NFzWcnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\2ZWlEPTB;MD6wNFIzPSEQvF2= M2jWVXNCVkeHUh?=
SK-UT-1 M{W1TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX73fm1iUUN3ME2wMlAxOjJ4IN88US=> NG\BT|ZUSU6JRWK=
GOTO NF:ySW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHf3cZJKSzVyPUCuNFAzOjdizszN MnnGV2FPT0WU
TYK-nu MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYH0XIpXUUN3ME2wMlAxOjN{IN88US=> NH\5cGZUSU6JRWK=
JVM-3 M1vBbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTBwMECyN|Mh|ryP MWXTRW5ITVJ?
SK-MES-1 NVvOfWl3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorCTWM2OD1yLkCwNlM{KM7:TR?= MVTTRW5ITVJ?
SK-HEP-1 NGjn[4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTOTWM2OD1yLkCwNlM1KM7:TR?= NVHYc21FW0GQR1XS
J-RT3-T3-5 NUi4cZpTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHhd2w5UUN3ME2wMlAxOjN3IN88US=> M2DPVHNCVkeHUh?=
A673 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPjTWM2OD1yLkCwNlM2KM7:TR?= M1fXUnNCVkeHUh?=
NCI-H446 MoDBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33vTWlEPTB;MD6wNFI1OyEQvF2= NFfzNoVUSU6JRWK=
RPMI-2650 NXuwb2hUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTBwMECyOFYh|ryP NWPGXmlIW0GQR1XS
HCE-4 Mn7MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVq4b5oyUUN3ME2wMlAxOjR5IN88US=> M1rIeHNCVkeHUh?=
KGN NEXUXVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIq0eXhKSzVyPUCuNFAzPDdizszN MUDTRW5ITVJ?
U251 NX\oNlg6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TsdWlEPTB;MD6wNFI2KM7:TR?= Mn75V2FPT0WU
BxPC-3 M{LGb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTBwMECyOVEh|ryP M{TMOHNCVkeHUh?=
VMRC-RCZ M3HjTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrUTWM2OD1yLkCwNlUzKM7:TR?= NXzxWYpVW0GQR1XS
TE-10 Mo\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTBwMECyOVQh|ryP Mo\VV2FPT0WU
OC-314 MnrHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTBwMECyOVYh|ryP MmTOV2FPT0WU
NCI-H1437 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF:0OnhKSzVyPUCuNFAzPiEQvF2= MYrTRW5ITVJ?
SNU-387 NUHUfpdmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDpTWM2OD1yLkCwNlYyKM7:TR?= Mn\VV2FPT0WU
A388 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjSS|RKSzVyPUCuNFAzPjVizszN NH\IfZFUSU6JRWK=
C-33-A NW\hNZFnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjTcXdKSzVyPUCuNFAzPjZizszN M36yXHNCVkeHUh?=
CAL-51 NFrzWlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\5cGNZUUN3ME2wMlAxOjdzIN88US=> NGLtdHpUSU6JRWK=
Hs-578-T MmnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTYZox[UUN3ME2wMlAxOjd{IN88US=> NUXMZ49tW0GQR1XS
MDA-MB-415 NXzDUVZ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzITWM2OD1yLkCwNlc1KM7:TR?= NWGwc5VWW0GQR1XS
SW1417 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\wZmlEPTB;MD6wNFI4PiEQvF2= NXTJUItTW0GQR1XS
HCC70 M1nDRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwMECyO|ch|ryP NVrDS3BIW0GQR1XS
ES3 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\FTWM2OD1yLkCwNlc4KM7:TR?= MmqxV2FPT0WU
KYSE-270 NX2xVFhzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVmxRlVsUUN3ME2wMlAxOjd6IN88US=> NEDaWZFUSU6JRWK=
HT-29 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NICye4ZKSzVyPUCuNFAzQCEQvF2= MVfTRW5ITVJ?
MDA-MB-361 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rvZmlEPTB;MD6wNFI5OSEQvF2= MXfTRW5ITVJ?
RPMI-8866 NYnGbndMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnaTWM2OD1yLkCwNlgyKM7:TR?= M1;YRXNCVkeHUh?=
JEG-3 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwMECyPFIh|ryP MmHjV2FPT0WU
HT-3 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NID3ZodKSzVyPUCuNFAzQDJizszN NXq3epJGW0GQR1XS
HTC-C3 Mn:3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjFXIlKSzVyPUCuNFAzQDVizszN NEDPVXJUSU6JRWK=
NCI-H209 MkTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\STWM2OD1yLkCwNlg3KM7:TR?= MoLRV2FPT0WU
SKG-IIIa NXLtO2dGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTBwMECyPFYh|ryP MojaV2FPT0WU
SW962 NG\FXFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFL3[mhKSzVyPUCuNFAzQTNizszN NVzoXpo3W0GQR1XS
LCLC-103H NH3TWFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTFTWM2OD1yLkCwNlk{KM7:TR?= NHzSNYlUSU6JRWK=
DOK M2r6fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnX2TWM2OD1yLkCwNlk1KM7:TR?= MU\TRW5ITVJ?
SW1088 MonPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPHeVZKSzVyPUCuNFAzQTVizszN MXLTRW5ITVJ?
GP5d M2PTTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XTOGlEPTB;MD6wNFI6PiEQvF2= NVXQcmJ5W0GQR1XS
EW-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknjTWM2OD1yLkCwNlk5KM7:TR?= MknpV2FPT0WU
CP66-MEL MnnIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTBwMECzJO69VQ>? MkDsV2FPT0WU
DEL NUK1[IpOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWf4Wo1OUUN3ME2wMlAxOzBzIN88US=> MknUV2FPT0WU
DU-4475 NHnpRnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfBU|FKSzVyPUCuNFA{ODJizszN M4fhO3NCVkeHUh?=
HEC-1 NF\OO3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVntWW9mUUN3ME2wMlAxOzB|IN88US=> NFOyWXFUSU6JRWK=
U031 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTBwMECzNFch|ryP NYTtU3BuW0GQR1XS
BB65-RCC NELzRo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXvdINKSzVyPUCuNFA{ODhizszN NEXvWXBUSU6JRWK=
NUGC-3 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\XPGlEPTB;MD6wNFMxQCEQvF2= Mm[5V2FPT0WU
IST-SL1 NVPUc2luT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHuTWM2OD1yLkCwN|EzKM7:TR?= MmPnV2FPT0WU
LS-411N NFfXfWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwMECzNVQh|ryP MorCV2FPT0WU
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HEL MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XkZ2lEPTB;MD6zNlI1KM7:TR?= M{ixNnNCVkeHUh?=
OCI-AML2 NE[2XZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnj3TWM2OD1yLkOyNlk5KM7:TR?= M1TmPXNCVkeHUh?=
A3-KAW NIrrWWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3Hn[2lEPTB;MD6zN|Q4PyEQvF2= MXLTRW5ITVJ?
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HDLM-2 MkXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vMSGlEPTB;MD6zN|kh|ryP MVLTRW5ITVJ?
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C32 M17Jb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHT3dHdKSzVyPUCuO|QyOTJizszN MWDTRW5ITVJ?
K-562 NFS3eXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHFTldKSzVyPUCuO|cxOjRizszN Mn35V2FPT0WU
DJM-1 M2DVWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnjenhMUUN3ME2wMlc5PzhzIN88US=> MnjlV2FPT0WU
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NCI-H1993 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLiW5F[UUN3ME2xMlE6Ojh7IN88US=> NXHhNZRwW0GQR1XS
SK-OV-3 NVPNUZlFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3OTWM2OD1zLkKyNFg6KM7:TR?= M4rJXHNCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo Docetaxel (33 mg/kg/dose, given i.v. every 4 days for 3 injections) results in a tumor growth delay of 19.3 days in M2OL2 colon xenografts. Docetaxel also shows great antitumor activities in MX-1, SK-MEL-2, LX-1 and OVCAR-3 xenografts. Docetaxel inhibits the angiogenic response to fibroblast growth factor 2 with IC 50 of 5.4 mg/kg when injected twice weekly over a 14-day period, and angiogenesis is completely blocked in mice that receives 10 mg/kg Docetaxel. Docetaxel has selectivity for endothelial cell migration and/or microvessel formation because infiltration of inflammatory cells into the Matrigel plug is much less sensitive to inhibition by Docetaxel. [7]

Protocol

Cell Research:[5]
+ Expand
  • Cell lines: Human gastric cancer cell lines MKN-28
  • Concentrations: 6 nM
  • Incubation Time: 3 days
  • Method: 2000 cells in 180 μL of medium are seeded in a 96-well plate, and 20 μL of drug solution is simultaneously added in triplicate to each well. The plate is incubated for 3 days at 37°C in a humidified atmosphere of 5% CO2. On day 3, 25 μL of MTT reagent is added to each well. After 4 h of incubation, the medium is removed by aspiration. 0.2 mL of dimethylsulphoxide (DMSO) is added to each well and thoroughly mixed by using a mechanical plate mixer to dissolve the resulting MTT-formazan crystals. Absorbance at 540 nm (OD) is measured by a reader.
    (Only for Reference)
Animal Research:[6]
+ Expand
  • Animal Models: Human colon carcinomas xenografts CX-1
  • Formulation: 50 mg/mL stock solution in ethanol by adding an equal volume of polysorbate 80 and diluting with 5% dextrose in water to the final volume
  • Dosages: 33 mg/kg
  • Administration: i.v. every 4 days for 3 injections
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (123.78 mM)
Ethanol 53 mg/mL warmed (65.6 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 807.88
Formula

C43H53NO14

CAS No. 114977-28-5
Storage powder
in solvent
Synonyms RP56976, NSC 628503

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03742986 Not yet recruiting Breast Cancer New York University School of Medicine April 2019 Phase 2
NCT03609047 Not yet recruiting Breast Cancer Stage II|Breast Cancer Stage III European Organisation for Research and Treatment of Cancer - EORTC|Pfizer January 7 2019 Phase 2
NCT03329378 Not yet recruiting Locally Advanced Breast Cancer Icahn School of Medicine at Mount Sinai December 2018 Phase 2
NCT03693612 Not yet recruiting Neoplasms GlaxoSmithKline|MedImmune LLC December 3 2018 Phase 2
NCT03739710 Not yet recruiting Neoplasms GlaxoSmithKline December 7 2018 Phase 2
NCT03700099 Not yet recruiting Prostate Cancer|Castration-resistant Prostate Cancer Instituto do Cancer do Estado de São Paulo|Astellas Pharma Inc December 2018 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Microtubule Associated Signaling Pathway Map

Related Microtubule Associated Products0

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID