Docetaxel

For research use only.

Catalog No.S1148 Synonyms: RP56976, NSC 628503

77 publications

Docetaxel Chemical Structure

Molecular Weight(MW): 807.88

Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.

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Selleck's Docetaxel has been cited by 77 publications

Purity & Quality Control

Choose Selective Microtubule Associated Inhibitors

Biological Activity

Description Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.
Targets
Microtubules [1]
(Cell-free assay)
In vitro

Docetaxel is a cytotoxic agent, especially for proliferating cells, which is related to its ability to promote the formation of microtubule bundles and induce sustained mitotic arrest, followed by apoptosis of mitotically arrested cells or permanent mitotic block. Docetaxel suppresses microtubule dynamic instability as well as tread-milling, resulting in the failure of chromosomes to segregate to the daughter cells, which in turn triggers premature exit from mitosis rather than a block at this phase of the cell cycle. [2] Docetaxel inhibits the clonogenic survival of Human cancer cell Hs746T (stomach), AGS (stomach), HeLa (cervix), CaSki (cervix), BxPC3 (pancreas), Capan-1 (pancreas) with IC50 of 1 nM, 1 nM, 0.3 nM, 0.3 nM, 0.3 nM and 0.3 nM respectively. [4] Docetaxel inhibits endothelial cell migration that does not affects microtubule gross morphology or inhibit cell proliferation, although they does produce more subtle effects on microtubule dynamics. Docetaxel inhibits HUVEC migration with an observed IC50 of 1 pM. HUVEC chemotaxis stimulated by either of two angiogenic factors, thymidine phosphorylase or VEGF, is inhibited by Docetaxel with IC 50 of 10 pM and is ablated at 1 nM. [7] Docetaxel induces human monocytes, but not RAW 264.7 murine macrophages, Prostaglandin H Synthase-2m (PGHS-2) expression. [8]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HSC-3 MljnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTBwMECwNVMzKM7:TR?= Mmq2V2FPT0WU
5637 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLPTWM2OD1yLkCwNFE1OyEQvF2= NEDLU2xUSU6JRWK=
HT-144 M1L0Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTBwMECwNVU4KM7:TR?= NIHHPXhUSU6JRWK=
NCI-H292 M{\Vd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnhSFJKSzVyPUCuNFAxOTV7IN88US=> M4LtRXNCVkeHUh?=
HCE-T M2XvRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTBwMECwNVYzKM7:TR?= MlLXV2FPT0WU
ESS-1 NEnN[XZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFf3XmhKSzVyPUCuNFAxOTd7IN88US=> MmCxV2FPT0WU
D-566MG NHnkOJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTBwMECwNVgzKM7:TR?= M1HjUnNCVkeHUh?=
CAL-62 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;hPFU5UUN3ME2wMlAxODF6NTFOwG0> Mn\wV2FPT0WU
GT3TKB MnToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vweGlEPTB;MD6wNFAzOzJizszN MljBV2FPT0WU
HSC-4 NI\tOo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwMECwNlM6KM7:TR?= NUPmXpFUW0GQR1XS
KOSC-2 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPLUHVKSzVyPUCuNFAxOjV3IN88US=> M1;jVnNCVkeHUh?=
NB14 NEnTRmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;vVXUzUUN3ME2wMlAxODJ4IN88US=> MYrTRW5ITVJ?
ES8 M3G2eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfVTWM2OD1yLkCwNFI3KM7:TR?= NH\hXYxUSU6JRWK=
BFTC-905 M{HmTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWS2[3d7UUN3ME2wMlAxODJ4ODFOwG0> Mlu0V2FPT0WU
A498 NFXTWpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4G0WmlEPTB;MD6wNFAzPzhizszN MkjzV2FPT0WU
HO-1-N-1 M1L1Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTBwMECwNlgyKM7:TR?= NYLFcnp2W0GQR1XS
SF539 NHHLVZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4ix[GlEPTB;MD6wNFA{ODJizszN Mk\KV2FPT0WU
HuO-3N1 Ml\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rFZmlEPTB;MD6wNFA{ODJizszN M4TMUXNCVkeHUh?=
NCI-H510A NHHDeFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mly5TWM2OD1yLkCwNFM{PiEQvF2= NXHY[oR3W0GQR1XS
CAL-27 NGHUTJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWi1ZnJTUUN3ME2wMlAxODN|OTFOwG0> NHrYTIRUSU6JRWK=
TE-8 NULKbG1jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXXZWFKSzVyPUCuNFAxOzZ4IN88US=> NF:2dIhUSU6JRWK=
VA-ES-BJ NGDsUFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LTOmlEPTB;MD6wNFA{PzVizszN M1zVV3NCVkeHUh?=
RH-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXCPGFKSzVyPUCuNFAxOzh4IN88US=> MULTRW5ITVJ?
COLO-800 M2DBc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXuUHZKSzVyPUCuNFAxOzh6IN88US=> M2fhO3NCVkeHUh?=
ES7 NXLZXm5OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\YS2lEPTB;MD6wNFA{QDlizszN Mm\jV2FPT0WU
GAMG MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYX2Z5RxUUN3ME2wMlAxODRzNjFOwG0> MnqyV2FPT0WU
Ca9-22 MmLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTBwMECwOFI{KM7:TR?= NE[zeHdUSU6JRWK=
SBC-1 NHvSUWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWe3VnZ5UUN3ME2wMlAxODR|IN88US=> NE[4dlBUSU6JRWK=
RPMI-7951 MkjrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTBwMECwOFQ5KM7:TR?= NIrvRlNUSU6JRWK=
SW1710 NYPVeJl2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4izdGlEPTB;MD6wNFA1PjZizszN MVzTRW5ITVJ?
HGC-27 Mk\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7oTWM2OD1yLkCwNFQ4OSEQvF2= MlHNV2FPT0WU
MC-IXC MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHT4WolKSzVyPUCuNFAxPDd7IN88US=> MVTTRW5ITVJ?
FTC-133 NWTtd2w{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHMTWM2OD1yLkCwNFQ5QSEQvF2= M4jEenNCVkeHUh?=
HT-1080 NEjRcJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXOTWM2OD1yLkCwNFUxOSEQvF2= NYLxS|F{W0GQR1XS
NMC-G1 M1\BUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFz3eHVKSzVyPUCuNFAxPTF5IN88US=> M1T3RXNCVkeHUh?=
GI-1 M4Dxd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3v4WWlEPTB;MD6wNFA2OjhizszN MXvTRW5ITVJ?
CGTH-W-1 NUTzeGNmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF60[lBKSzVyPUCuNFAxPTR{IN88US=> NW\vTHJJW0GQR1XS
A2058 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUj0dYo1UUN3ME2wMlAxODV2NDFOwG0> M3PZfHNCVkeHUh?=
ETK-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\B[ZZqUUN3ME2wMlAxODV3ODFOwG0> M1\qUnNCVkeHUh?=
NEC8 NHvLbpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTFbIppUUN3ME2wMlAxODV4MTFOwG0> M3vtcnNCVkeHUh?=
TE-11 NV7sO41kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU[xSmdnUUN3ME2wMlAxODV4OTFOwG0> MV;TRW5ITVJ?
NCI-H720 NYfoOYlVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTBwMECwOVgh|ryP NXv3NFAyW0GQR1XS
PSN1 NGjpRVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknBTWM2OD1yLkCwNFU5OSEQvF2= MUnTRW5ITVJ?
SW780 M13VUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HINGlEPTB;MD6wNFA2QDdizszN M1jHWHNCVkeHUh?=
8-MG-BA M1zVR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrNdpdKSzVyPUCuNFAxPTh7IN88US=> Ml7HV2FPT0WU
EC-GI-10 NFrZbXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnvN|BwUUN3ME2wMlAxODV7MjFOwG0> NEfmR4VUSU6JRWK=
SJSA-1 M1qzPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm[xTWM2OD1yLkCwNFYyPSEQvF2= NXG3XIxyW0GQR1XS
639-V M{\2S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnVTWM2OD1yLkCwNFY1PyEQvF2= M{LXN3NCVkeHUh?=
PFSK-1 NFK1RXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjNTWM2OD1yLkCwNFY2PyEQvF2= NVH6dHF7W0GQR1XS
DMS-273 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LEOmlEPTB;MD6wNFA3PzRizszN NEKzOHpUSU6JRWK=
TE-9 NHLt[ZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jmcGlEPTB;MD6wNFA3PzZizszN MYjTRW5ITVJ?
SCC-25 NUDzR217T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zzOWlEPTB;MD6wNFA3QCEQvF2= M3;6UHNCVkeHUh?=
PA-1 Mn2zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nSTmlEPTB;MD6wNFA3QDdizszN MUPTRW5ITVJ?
MHH-ES-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnCem1OUUN3ME2wMlAxODdizszN M4PtcXNCVkeHUh?=
Daoy NIrabW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUKxO2tRUUN3ME2wMlAxODdizszN NWPYToxPW0GQR1XS
G-402 MojoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17BN2lEPTB;MD6wNFA4ODZizszN M3L4dXNCVkeHUh?=
YKG-1 NGLyUHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTBwMECwO|A4KM7:TR?= NUHq[3BqW0GQR1XS
Ca-Ski M1nuXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrkeoNSUUN3ME2wMlAxODd{ODFOwG0> NI\hSGxUSU6JRWK=
CHP-212 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DRcmlEPTB;MD6wNFA4OyEQvF2= NVPwbnF[W0GQR1XS
SCC-4 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVP3dI9{UUN3ME2wMlAxODd|OTFOwG0> M4\uRXNCVkeHUh?=
EW-3 NHfKZldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwMECwO|Q2KM7:TR?= NVmyTlRQW0GQR1XS
P12-ICHIKAWA M1Gyemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2q4c2lEPTB;MD6wNFA4PDVizszN MUHTRW5ITVJ?
HSC-2 MmrlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\YTWM2OD1yLkCwNFc2PSEQvF2= MVjTRW5ITVJ?
HN MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjMPGFKSzVyPUCuNFAxPzV6IN88US=> NFnjW5BUSU6JRWK=
LXF-289 M4jydmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXuy[ZJ{UUN3ME2wMlAxODd3ODFOwG0> NUP1OIc1W0GQR1XS
ES1 MnvkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXWTWM2OD1yLkCwNFc4KM7:TR?= MoDyV2FPT0WU
NTERA-S-cl-D1 NGjURY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUSy[WNyUUN3ME2wMlAxODd5MzFOwG0> M2WyNHNCVkeHUh?=
K5 Ml\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HIT2lEPTB;MD6wNFA4PzhizszN NUHURlF7W0GQR1XS
HOS NHXvN5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTBwMECwO|gzKM7:TR?= NGfZN5BUSU6JRWK=
YH-13 NYf4RZRqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4[1PGlEPTB;MD6wNFA4QTFizszN NWLINm1kW0GQR1XS
SW954 NXLrVlF2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HZO2lEPTB;MD6wNFA5OjNizszN M3HYd3NCVkeHUh?=
KYSE-510 M4TqdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofFTWM2OD1yLkCwNFg1KM7:TR?= MlGzV2FPT0WU
8505C NF23T21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;vTWM2OD1yLkCwNFg2PCEQvF2= MVfTRW5ITVJ?
A549 NUDNTXRnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDHRo9UUUN3ME2wMlAxODh6MjFOwG0> M1jUTHNCVkeHUh?=
Detroit562 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{OwXWlEPTB;MD6wNFA6ODJizszN Mkm5V2FPT0WU
ES5 NVLo[FQ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\TT2lEPTB;MD6wNFA6OSEQvF2= MYfTRW5ITVJ?
KYSE-140 M1TofWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkG4TWM2OD1yLkCwNFk{OyEQvF2= MlTUV2FPT0WU
GMS-10 M1H1dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTBwMECwPVQyKM7:TR?= NYPofWZHW0GQR1XS
D-263MG M4PBUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTBwMECwPVQ4KM7:TR?= MmnHV2FPT0WU
BCPAP M163cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTBwMECwPVQ4KM7:TR?= NGiyd|ZUSU6JRWK=
CHL-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjYTWM2OD1yLkCwNFk2QCEQvF2= MUnTRW5ITVJ?
RKO MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDDXpZ3UUN3ME2wMlAxODl6OTFOwG0> M3jYNnNCVkeHUh?=
SW48 NXGyVVhXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\VNXlHUUN3ME2wMlAxOTBzIN88US=> Ml7QV2FPT0WU
BPH-1 MnLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk[xTWM2OD1yLkCwNVAzKM7:TR?= MVnTRW5ITVJ?
EFO-27 M{PrNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvwTWM2OD1yLkCwNVAzKM7:TR?= MXTTRW5ITVJ?
CAL-33 NUjBTplVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWX6WGJPUUN3ME2wMlAxOTB2IN88US=> NIrEdGxUSU6JRWK=
NCI-H1792 MorKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjoSGVKSzVyPUCuNFAyODRizszN MW\TRW5ITVJ?
BB30-HNC M{DLc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4[0dGlEPTB;MD6wNFExPSEQvF2= Mo\ZV2FPT0WU
VM-CUB-1 NUnHOIZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHj0c|FKSzVyPUCuNFAyODVizszN NWrkPY9{W0GQR1XS
TE-5 M1zhbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXqUnd{UUN3ME2wMlAxOTB4IN88US=> MULTRW5ITVJ?
NB13 NH;ObXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jlbmlEPTB;MD6wNFExPyEQvF2= MX;TRW5ITVJ?
NBsusSR NYXkN5NNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPUfXNKSzVyPUCuNFAyOSEQvF2= M{nPNHNCVkeHUh?=
LNCaP-Clone-FGC MljIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfKWFNKSzVyPUCuNFAyOSEQvF2= NXjVeJJ4W0GQR1XS
EPLC-272H NXq5RmhqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTBwMECxNVEh|ryP Mn:zV2FPT0WU
KNS-62 MnzaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVP0PG9DUUN3ME2wMlAxOTF{IN88US=> M{\YNXNCVkeHUh?=
RERF-LC-MS NFvqW2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\BXGlEPTB;MD6wNFEyOyEQvF2= M2DL[XNCVkeHUh?=
LOXIMVI NIHxfWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTBwMECxNVYh|ryP M1i2UnNCVkeHUh?=
KINGS-1 MnjjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLlTWM2OD1yLkCwNVE4KM7:TR?= MnHsV2FPT0WU
T98G M1vIXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInOcolKSzVyPUCuNFAyOTdizszN MkTtV2FPT0WU
HCC1806 M4LxfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\EZo9KSzVyPUCuNFAyOThizszN M1;k[nNCVkeHUh?=
MZ1-PC NXi0U2xrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG[5bohKSzVyPUCuNFAyOThizszN MoXXV2FPT0WU
RT-112 MnLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwMECxNVkh|ryP NYXWNIN{W0GQR1XS
LK-2 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\CV2lEPTB;MD6wNFEzOSEQvF2= M1iyOHNCVkeHUh?=
A375 NFOy[WNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTlTWM2OD1yLkCwNVIyKM7:TR?= MnLJV2FPT0WU
SF268 M1TPbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXZTWM2OD1yLkCwNVIyKM7:TR?= NYTXPXl5W0GQR1XS
H9 NX;ZSlVVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvVTWM2OD1yLkCwNVI1KM7:TR?= NX71XlE6W0GQR1XS
KYSE-410 NWrx[HY2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;zVGlEPTB;MD6wNFEzPCEQvF2= M3izTnNCVkeHUh?=
G-401 NG[4dZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTBwMECxNlch|ryP Ml72V2FPT0WU
SW982 NGmyZ3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPue3JJUUN3ME2wMlAxOTJ5IN88US=> MnznV2FPT0WU
D-423MG MknpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PvUmlEPTB;MD6wNFE{KM7:TR?= NHTRTY1USU6JRWK=
CAMA-1 NVjNb41FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTBwMECxN|Eh|ryP NYW2eotGW0GQR1XS
SCC-9 NEW3SG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoS3TWM2OD1yLkCwNVMzKM7:TR?= NVTwWZdQW0GQR1XS
SAS MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;YVlFyUUN3ME2wMlAxOTN2IN88US=> MXTTRW5ITVJ?
KYSE-180 MmHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\sSmdKSzVyPUCuNFAyOzVizszN MVLTRW5ITVJ?
EW-16 NFiwZ5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGr2ZpZKSzVyPUCuNFAyOzVizszN NXvveHNpW0GQR1XS
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KS-1 M1TR[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTBwMECxOFQh|ryP M3jBVHNCVkeHUh?=
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EoL-1-cell M13qe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPOeWVQUUN3ME2wMlAxOTd|IN88US=> M1T5NXNCVkeHUh?=
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NCI-H526 NGLTdJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYG0[ld{UUN3ME2wMlAxOTd4IN88US=> MlzZV2FPT0WU
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DB NVrUV5dDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX34N5NzUUN3ME2wMlAxOTd6IN88US=> M{DDVnNCVkeHUh?=
GCT NUP1dmw{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3:3[GlEPTB;MD6wNFE5KM7:TR?= MkjzV2FPT0WU
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M14 M1\mUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjLTWM2OD1yLkCwNVkyKM7:TR?= MYnTRW5ITVJ?
NCI-H1048 NVjuPVY{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrmTWM2OD1yLkCwNVkzKM7:TR?= M1\VW3NCVkeHUh?=
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SK-PN-DW NGXRbGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTBwMECxPVQh|ryP MoPqV2FPT0WU
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NCI-SNU-1 NILkOYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXrVIFHUUN3ME2wMlAxOTl5IN88US=> MVrTRW5ITVJ?
M059J MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfuZlQxUUN3ME2wMlAxOTl6IN88US=> MVvTRW5ITVJ?
OVCAR-5 M2DF[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnBXmxkUUN3ME2wMlAxOTl7IN88US=> NEPoS3NUSU6JRWK=
SK-MEL-28 NIPxWWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTLSIdrUUN3ME2wMlAxOjB|IN88US=> M4TtZnNCVkeHUh?=
PC-14 M1q5SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTBwMECyNFkh|ryP MoTtV2FPT0WU
OVCAR-8 MnTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTBwMECyNVIh|ryP MVrTRW5ITVJ?
BB49-HNC M1fZeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHYZ2hKSzVyPUCuNFAzOTJizszN MV3TRW5ITVJ?
EFM-19 M1XpNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrMb4tCUUN3ME2wMlAxOjF3IN88US=> Mk[wV2FPT0WU
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TE-1 M1f6NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzt[2w5UUN3ME2wMlAxOjF4IN88US=> NXfXdYpXW0GQR1XS
NCI-H2452 MoPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTBwMECyNVYh|ryP NXL1b5J7W0GQR1XS
NCI-H1581 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTBwMECyNVch|ryP M3j4RXNCVkeHUh?=
COR-L23 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfQ[2pKSzVyPUCuNFAzOiEQvF2= MnjnV2FPT0WU
RXF393 Mnq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwMECyNlIh|ryP NF7McI9USU6JRWK=
BFTC-909 Mn7pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3K2fmlEPTB;MD6wNFIzPSEQvF2= NVztTHFJW0GQR1XS
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NCI-H650 M{XGUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHmwNGhKSzVyPUCuNFAzOjVizszN NGqyb4FUSU6JRWK=
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GOTO M{LH[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTBwMECyNlch|ryP MmfKV2FPT0WU
TYK-nu MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnqW4xxUUN3ME2wMlAxOjN{IN88US=> M1TWWXNCVkeHUh?=
JVM-3 M3HS[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnviTWM2OD1yLkCwNlM{KM7:TR?= NXzkb2NKW0GQR1XS
SK-MES-1 M3raVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrQdG9uUUN3ME2wMlAxOjN|IN88US=> MWjTRW5ITVJ?
SK-HEP-1 M4izc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWT1dnRIUUN3ME2wMlAxOjN2IN88US=> NFzTbY9USU6JRWK=
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NCI-H446 M{f0cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfzTWM2OD1yLkCwNlQ{KM7:TR?= MUDTRW5ITVJ?
RPMI-2650 MkDQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTBwMECyOFYh|ryP MWPTRW5ITVJ?
HCE-4 M3;uSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPhTWM2OD1yLkCwNlQ4KM7:TR?= MmjzV2FPT0WU
KGN MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XDRmlEPTB;MD6wNFI1PyEQvF2= NG\vTlRUSU6JRWK=
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OC-314 NIfafXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTLSldRUUN3ME2wMlAxOjV4IN88US=> NVPkfml3W0GQR1XS
NCI-H1437 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwMECyOkDPxE1? MkW5V2FPT0WU
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A388 MnX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljoTWM2OD1yLkCwNlY2KM7:TR?= M1\6d3NCVkeHUh?=
C-33-A MlvXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTBwMECyOlYh|ryP MnjCV2FPT0WU
CAL-51 NUT5NWpST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm[4TWM2OD1yLkCwNlcyKM7:TR?= NYK2U3FtW0GQR1XS
Hs-578-T MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLhUmczUUN3ME2wMlAxOjd{IN88US=> NWKxZY9yW0GQR1XS
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SW1417 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2P6dGlEPTB;MD6wNFI4PiEQvF2= NXS0OlU{W0GQR1XS
HCC70 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXSN|dKSzVyPUCuNFAzPzdizszN MkHtV2FPT0WU
ES3 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTBwMECyO|ch|ryP M{HLdnNCVkeHUh?=
KYSE-270 NWLz[Y1QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLKb3dEUUN3ME2wMlAxOjd6IN88US=> NYL0W|d{W0GQR1XS
HT-29 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLJTWM2OD1yLkCwNlgh|ryP NEnlbYhUSU6JRWK=
MDA-MB-361 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;5TWM2OD1yLkCwNlgyKM7:TR?= MnX3V2FPT0WU
RPMI-8866 NHXZe|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTBwMECyPFEh|ryP NWi1NpNEW0GQR1XS
JEG-3 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfOTWM2OD1yLkCwNlgzKM7:TR?= NFTYbmRUSU6JRWK=
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HTC-C3 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3KzR2lEPTB;MD6wNFI5PSEQvF2= MVzTRW5ITVJ?
NCI-H209 MlXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PmXGlEPTB;MD6wNFI5PiEQvF2= MWDTRW5ITVJ?
SKG-IIIa NI\SNFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\ZNGlEPTB;MD6wNFI5PiEQvF2= M{\rNnNCVkeHUh?=
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LCLC-103H MmfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{exfWlEPTB;MD6wNFI6OyEQvF2= NVXJWXlDW0GQR1XS
DOK MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTBwMECyPVQh|ryP MVHTRW5ITVJ?
SW1088 M3;NW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTBwMECyPVUh|ryP M{PtSnNCVkeHUh?=
GP5d NITJ[mlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVq3UXVSUUN3ME2wMlAxOjl4IN88US=> Mnz4V2FPT0WU
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CP66-MEL NVjST4lIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1v2cWlEPTB;MD6wNFMh|ryP MoXhV2FPT0WU
DEL MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUW0RoJLUUN3ME2wMlAxOzBzIN88US=> M12zPHNCVkeHUh?=
DU-4475 NYDzOIVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLae28{UUN3ME2wMlAxOzB{IN88US=> MWrTRW5ITVJ?
HEC-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDxTWM2OD1yLkCwN|A{KM7:TR?= MW\TRW5ITVJ?
U031 NWDUe|djT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTBwMECzNFch|ryP NUH6W3h4W0GQR1XS
BB65-RCC NYL0WVhLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13YTmlEPTB;MD6wNFMxQCEQvF2= M3HIOnNCVkeHUh?=
NUGC-3 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nPRmlEPTB;MD6wNFMxQCEQvF2= NXLjS5R1W0GQR1XS
IST-SL1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTBwMECzNVIh|ryP MkTjV2FPT0WU
LS-411N M4PLPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnK3TWM2OD1yLkCwN|E1KM7:TR?= M3zwWnNCVkeHUh?=
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MKN28 NE\CZ|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7le5lLUUN3ME2wMlAxOzF5IN88US=> NFHjb|dUSU6JRWK=
ONS-76 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXxeoxRUUN3ME2wMlAxOzJ{IN88US=> MYHTRW5ITVJ?
SH-4 NYjkXmU4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jXSGlEPTB;MD6wNFMzOiEQvF2= MXvTRW5ITVJ?
MIA-PaCa-2 NGGyc|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTBwMECzNlQh|ryP Ml\HV2FPT0WU
CaR-1 NVy5elJwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;2cYd7UUN3ME2wMlAxOzJ5IN88US=> NYrqfoNPW0GQR1XS
AGS MnzXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXm3bXc5UUN3ME2wMlAxOzJ6IN88US=> NXfjXmV7W0GQR1XS
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LAN-6 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHSTWM2OD1yLkC0N|M2KM7:TR?= NXLTTpJrW0GQR1XS
MDA-MB-175-VII MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrUNpZKSzVyPUCuNFQ1OTdizszN NFjv[FBUSU6JRWK=
KMOE-2 M3XDV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLEPYlKSzVyPUCuNFQ1PjlizszN MnfYV2FPT0WU
DMS-79 NEHDeHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3T5TGlEPTB;MD6wOFU4QSEQvF2= NXnHUZZbW0GQR1XS
MHH-NB-11 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTk[GJOUUN3ME2wMlA1PjF2IN88US=> M4TtbHNCVkeHUh?=
NCI-H69 Ml7JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1T2SGlEPTB;MD6wOFg1QSEQvF2= NXLFS4Y2W0GQR1XS
KE-37 M3;sV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHMN29FUUN3ME2wMlA2ODFizszN MXHTRW5ITVJ?
Ramos-2G6-4C10 M4rwcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjsNlZMUUN3ME2wMlA2ODZ5IN88US=> MWHTRW5ITVJ?
NCI-H1793 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrvTYY3UUN3ME2wMlA2ODl|IN88US=> NEfwR3ZUSU6JRWK=
HT-1376 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnriTWM2OD1yLkC1NVg3KM7:TR?= MXvTRW5ITVJ?
EKVX M161e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF23d|ZKSzVyPUCuNFU{QDRizszN MUXTRW5ITVJ?
Capan-2 NWLrVo51T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4OzVGlEPTB;MD6wOVM6PiEQvF2= Mlm3V2FPT0WU
DoTc2-4510 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTBwMEW0OFYh|ryP M1Xxe3NCVkeHUh?=
UACC-893 NWHOSm4yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TacGlEPTB;MD6wOVQ3OiEQvF2= MWTTRW5ITVJ?
SK-MEL-3 MlfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWi2SWJ1UUN3ME2wMlA2Pzh6IN88US=> M2rFNXNCVkeHUh?=
SK-MEL-1 Ml3FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwMEW4JO69VQ>? MUHTRW5ITVJ?
SW948 M4qyS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTBwMEW5PVYh|ryP MnvqV2FPT0WU
P30-OHK Mmm3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTBwME[xOlch|ryP Mn\OV2FPT0WU
NH-12 NIjSdYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnEO2NiUUN3ME2wMlA3OjR2IN88US=> NHL2fnFUSU6JRWK=
KU-19-19 Mn[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnkfFVKSzVyPUCuNFY{PjFizszN MWTTRW5ITVJ?
A431 NGXwcXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LvTWlEPTB;MD6wOlM4PCEQvF2= NHTSWmlUSU6JRWK=
NCI-H2405 NYn0NXJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfaWFZKSzVyPUCuNFY{QDNizszN M{nUNHNCVkeHUh?=
KARPAS-299 Mkj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkj1TWM2OD1yLkC2OVgzKM7:TR?= MXPTRW5ITVJ?
BALL-1 M4qxe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwME[2O|Qh|ryP M3zrOXNCVkeHUh?=
KURAMOCHI NV75VIQ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4flWmlEPTB;MD6wO|A4OyEQvF2= NXqzT|RiW0GQR1XS
LS-1034 MoW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTZTWM2OD1yLkC3N|Y6KM7:TR?= MUfTRW5ITVJ?
MFE-280 M3fDdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1mxTmlEPTB;MD6wO|U{PiEQvF2= MV;TRW5ITVJ?
HOP-62 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnadZVIUUN3ME2wMlA4Pjd4IN88US=> NEi2UnJUSU6JRWK=
KG-1 NXe3cpg5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlOxTWM2OD1yLkC3O|g4KM7:TR?= M{LoT3NCVkeHUh?=
CW-2 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PDcWlEPTB;MD6wO|g{OiEQvF2= MUDTRW5ITVJ?
SW837 NWDBSZVGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDtTWM2OD1yLkC4N|QzKM7:TR?= MXXTRW5ITVJ?
MFH-ino NVLnfnNoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTBwMEi1NFEh|ryP M1:0SnNCVkeHUh?=
HCC1419 MoXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\4NmlEPTB;MD6wPFk5PyEQvF2= NWO4[2I{W0GQR1XS
HMV-II M4[4PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPFVIdKSzVyPUCuNFkxOSEQvF2= NHHS[YRUSU6JRWK=
BEN M2fzcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTBwMEmzPFUh|ryP M3XreXNCVkeHUh?=
SK-N-FI NXnoZlB4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPncIVKSzVyPUCuNFk2PTZizszN M{PaR3NCVkeHUh?=
JVM-2 M{nDOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTBwMEm3NVYh|ryP M3vUVXNCVkeHUh?=
CAL-54 NXLzNWpVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnX1TWM2OD1yLkGwNFQh|ryP NUXr[VJWW0GQR1XS
T84 NEHWRVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnywTWM2OD1yLkGwPVUzKM7:TR?= NYC2cokzW0GQR1XS
SHP-77 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXhTWM2OD1yLkGxOlQyKM7:TR?= MYPTRW5ITVJ?
G-361 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7ZTY5VUUN3ME2wMlEzOzJ2IN88US=> NYrhSXozW0GQR1XS
Calu-3 NWG0dFBtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13ITmlEPTB;MD6xN|gyPiEQvF2= MnzjV2FPT0WU
HCC1937 NGf4UnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1S5PWlEPTB;MD6xOFk{PyEQvF2= M1\hZnNCVkeHUh?=
KM-H2 M{W0T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUixWHd5UUN3ME2wMlE2ODFizszN M{C5[nNCVkeHUh?=
769-P M{T0NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXWWIJXUUN3ME2wMlE2QDR|IN88US=> NWfRT2tTW0GQR1XS
NCI-H1304 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTBwMU[wOlEh|ryP Ml;QV2FPT0WU
D-542MG MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTBwMU[yO|gh|ryP M2\BS3NCVkeHUh?=
ATN-1 MoPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnpfoRCUUN3ME2wMlE4PDRzIN88US=> MXXTRW5ITVJ?
NCI-H2029 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTmTWM2OD1yLkKwNlQ{KM7:TR?= NGHHOmhUSU6JRWK=
ZR-75-30 NEKwS5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1Tsc2lEPTB;MD6yNFY1OyEQvF2= NI\JfYVUSU6JRWK=
SW1116 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3uwNmlEPTB;MD6yNVEyPyEQvF2= NH\vc4dUSU6JRWK=
CCRF-CEM MkPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTBwMke2NVQh|ryP MXzTRW5ITVJ?
LU-135 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGj6XGxKSzVyPUCuNlc4OzlizszN MXzTRW5ITVJ?
MC116 NYDzRoxwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjNbGRNUUN3ME2wMlI5OzB7IN88US=> NIjmd3JUSU6JRWK=
LS-513 M3LWbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHCVVVKSzVyPUCuNlg4PzNizszN NFXVVWtUSU6JRWK=
NCI-H630 NFXscGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFqzXJNKSzVyPUCuNlk{PzZizszN MVfTRW5ITVJ?
L-428 NH;lc4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDaUIFwUUN3ME2wMlI6QDh|IN88US=> NYHFRY1MW0GQR1XS
UM-UC-3 NH\zTHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\zc2xKSzVyPUCuN|EzQTFizszN MkjpV2FPT0WU
NCI-H1838 NVX0dYJxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwM{G3PFQh|ryP M{LUOXNCVkeHUh?=
HEL MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHuTWM2OD1yLkOyNlQh|ryP M2jrfXNCVkeHUh?=
OCI-AML2 NF\MWWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLVTWM2OD1yLkOyNlk5KM7:TR?= MWDTRW5ITVJ?
A3-KAW M1iyfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULHNGIzUUN3ME2wMlM{PDd5IN88US=> NVjGU|dKW0GQR1XS
IGROV-1 M1jrXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwM{O3OVUh|ryP MnrRV2FPT0WU
Mo-T NE[5[VVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfUVoxKSzVyPUCuN|M5PTNizszN NHiySmdUSU6JRWK=
HDLM-2 M{W1[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rnUWlEPTB;MD6zN|kh|ryP NGnJUmVUSU6JRWK=
HCC1569 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3uyTWlEPTB;MD6zOFMxQSEQvF2= M1npbXNCVkeHUh?=
COLO-678 NITnO|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfvTWM2OD1yLkO3NFAzKM7:TR?= NGPU[ItUSU6JRWK=
COR-L105 NIDUXlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfVTWM2OD1yLkO3PVMh|ryP NV;GeVRUW0GQR1XS
SK-MEL-24 M1H5dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\KTWM2OD1yLkO4N|gzKM7:TR?= MkPMV2FPT0WU
COLO-320-HSR Ml\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrlSGVKSzVyPUCuOFM6PzZizszN Mm\GV2FPT0WU
C8166 NU\TV3hsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTBwNEmwNlMh|ryP MUXTRW5ITVJ?
COLO-679 NYLxNodtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrTTWM2OD1yLk[yNVczKM7:TR?= MX\TRW5ITVJ?
TE-12 Mn60S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTNc|RiUUN3ME2wMlY2Ozl2IN88US=> MUfTRW5ITVJ?
HAL-01 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\FRXNKSzVyPUCuOlYzOiEQvF2= MUXTRW5ITVJ?
H-EMC-SS M3TXOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLKSmRKSzVyPUCuO|A2PDZizszN MX7TRW5ITVJ?
SNU-449 MlPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTBwN{K3OFgh|ryP NUfvXJVlW0GQR1XS
C32 NV\tT|BzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3f3PWlEPTB;MD63OFEyOiEQvF2= NYXIZopRW0GQR1XS
K-562 NWfDVoxDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHKyWmJKSzVyPUCuO|cxOjRizszN MnLEV2FPT0WU
DJM-1 M2DMbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnz3TWM2OD1yLke4O|gyKM7:TR?= NEGw[mxUSU6JRWK=
RCC10RGB M{j1emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTBwN{mxPFMh|ryP MoHnV2FPT0WU
CAL-85-1 NHTESZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zLbWlEPTB;MD65NFch|ryP MVfTRW5ITVJ?
NY M3jES2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnM[FVpUUN3ME2wMlk{OzV{IN88US=> M1z6PXNCVkeHUh?=
NCI-H1993 Ml\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjHboRKSzVyPUGuNVkzQDlizszN NFTW[oNUSU6JRWK=
SK-OV-3 NUewSnJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7GfoVKSzVyPUGuNlIxQDlizszN MnjWV2FPT0WU

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
PIM1; 

PubMed: 18426800     


Cells were treated with 100 nm docetaxel for the indicated times. PIM1 and β-ACTIN proteins were analyzed by immunoblot analysis. One of three similar blots is shown. Ratio, ratio of PIM1/β-ACTIN from pooled densitometry data from three separate experimen䲧疝Ỵ疞㧀疜膉痘 瘿뾠ՂᾰƌՂĀ 㺣痖帉痖Ѐ瑖堘𢡄빢᎒ՂĀ鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ⟸෕䐺痖暼瘿⟸෕ᾰƌ

cyclin B; 

PubMed: 18426800     


Immunoblot analysis of cyclin B1 and PIM1 expression after docetaxel 10 nm (left) or 100 nm (right) treatment at various time points.

pSTAT3 / STAT3 ; 

PubMed: 18426800     


Immunoblots of RWPE-2 cells treated with 100 nm docetaxel for the indicated time.

p-p53 / p53; 

PubMed: 22996738     


C4-2 cells were treated with 5 nM docetaxel, the whole cell lysates were collected at different time points and subjected to Western blot.

18426800 22996738
Immunofluorescence
α-tubulin; 

PubMed: 27177833     


Noscapine has no effect on gross microtubule polymerization state but noscapine pre-sensitization followed by docetaxel treatment stabilizes microtubules, hence inhibits cell proliferation. TNBC cells were treated with noscapine (4 µM) or docetaxel (0.4 µ䲧疝Ỵ疞㧀疜膉痘 瘿⟸෕ᾰƌ෕Ð 㺣痖帉痖Ѐ瑖堘𢡄빢᎒෕Ð鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ뾠Ղ䐺痖暼瘿뾠Ղᾰƌ 뾠ՂÐ㺣痖뾠Ղ€𢡄뾤Ղ€䀷痗뾤Ղ౴뾤Ղ㵶痗뾤Ղ뺖᎒泌Itemセ᎒Count﫨呂뿔Ղ猴፲뾤Ղ፲씢痗猸፲髸莤䥷堙᎒セ᎒�堞ﻮ᎒፲露𢡄堚Ҕ齃礤v�堞ﻮ᎒猢Wセ᎒䨼Ą鹿齃殺獸W戀醙

cleaved PARP / cleaved caspase-3; 

PubMed: 21087597     


Immunofluorescence images of PC-3 cells treated with the docetaxel and EM011 schedule treatment. Cells were pretreated with docetaxel for 12 h before addition of EM011 and were fixed at 48 h post docetaxel treatment compared to treatment with EM011 (10 μM䲧疝Ỵ疞㧀疜膉痘 瘿⟸෕ᾰƌ෕Ð 㺣痖帉痖Ѐ瑖堘𢡄빢᎒෕Ð鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ�෋䐺痖暼瘿�෋ᾰƌ �෋à

Acetylated tubulin ; 

PubMed: 18426800     


Immunofluorescence of acetylated tubulin in cells treated with DMSO, 30 nM laulimalide and 30 nM docetaxel for 2.5 h. Tubulin shown in green and DAPI in blue, and the white arrow indicates microtubule bundling. Scale bar represents 10 μm.

SQSTM1 / LAMP1; 

PubMed: 29795139     


AGS cells were treated with docetaxel (10 nM) for 12 h. After immunostaining with SQSTM1 (Alexa Fluor 488, green) and LAMP1 (Alexa Fluor 594, red), cells were examined by fluorescence microscopy (scale bar 20 μm). The colocalization of SQSTM1and LAMP1 was䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 㺣痖帉痖Ѐ

27177833 21087597 18426800 29795139
Growth inhibition assay
Cell viability ; 

PubMed: 22996738     


Docetaxel inhibits the growth of LNCaP, C4-2, DU145, and PC3 prostate cancer cells. Cells were plated in 12-well plates and treated with different concentrations of docetaxel. The cell number was counted after 24 hr. 

22996738
In vivo Docetaxel (33 mg/kg/dose, given i.v. every 4 days for 3 injections) results in a tumor growth delay of 19.3 days in M2OL2 colon xenografts. Docetaxel also shows great antitumor activities in MX-1, SK-MEL-2, LX-1 and OVCAR-3 xenografts. Docetaxel inhibits the angiogenic response to fibroblast growth factor 2 with IC 50 of 5.4 mg/kg when injected twice weekly over a 14-day period, and angiogenesis is completely blocked in mice that receives 10 mg/kg Docetaxel. Docetaxel has selectivity for endothelial cell migration and/or microvessel formation because infiltration of inflammatory cells into the Matrigel plug is much less sensitive to inhibition by Docetaxel. [7]

Protocol

Cell Research:[5]
- Collapse
  • Cell lines: Human gastric cancer cell lines MKN-28
  • Concentrations: 6 nM
  • Incubation Time: 3 days
  • Method: 2000 cells in 180 μL of medium are seeded in a 96-well plate, and 20 μL of drug solution is simultaneously added in triplicate to each well. The plate is incubated for 3 days at 37°C in a humidified atmosphere of 5% CO2. On day 3, 25 μL of MTT reagent is added to each well. After 4 h of incubation, the medium is removed by aspiration. 0.2 mL of dimethylsulphoxide (DMSO) is added to each well and thoroughly mixed by using a mechanical plate mixer to dissolve the resulting MTT-formazan crystals. Absorbance at 540 nm (OD) is measured by a reader.
    (Only for Reference)
Animal Research:[6]
- Collapse
  • Animal Models: Human colon carcinomas xenografts CX-1
  • Dosages: 33 mg/kg
  • Administration: i.v. every 4 days for 3 injections
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (123.78 mM)
Water Insoluble
Ethanol '53 mg/mL warmed
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 807.88
Formula

C43H53NO14

CAS No. 114977-28-5
Storage powder
in solvent
Synonyms RP56976, NSC 628503
Smiles CC(=O)OC12COC1CC(O)C3(C)C2C(OC(=O)C4=CC=CC=C4)C5(O)CC(OC(=O)C(O)C(NC(=O)OC(C)(C)C)C6=CC=CC=C6)C(=C(C(O)C3=O)C5(C)C)C

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    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04364620 Not yet recruiting Drug: AB-16B5|Drug: Docetaxel NSCLC Stage IV Alethia Biotherapeutics August 2020 Phase 2
NCT04343885 Recruiting Drug: 177Lu-PSMA-617|Drug: Docetaxel Metastatic Hormone Naive Prostate Cancer Peter MacCallum Cancer Centre Australia|Movember Foundation|Prostate Cancer Research Alliance|United States Department of Defense|Advanced Accelerator Applications|Australian Nuclear Science and Technology Organisation (ANSTO)|Australian and New Zealand Urogenital and Prostate Cancer Trials Group|Australasian Radiopharmaceutical Trials network (ARTnet)|Centre for Biostatistics and Clinical Trials (BaCT) April 21 2020 Phase 2
NCT04256707 Recruiting Drug: Selinexor|Drug: Docetaxel|Drug: Pembrolizumab Non-Small Cell Lung Carcinoma (NSCLC)|Colorectal Cancer (CRC) Karyopharm Therapeutics Inc January 14 2020 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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