Docetaxel

For research use only.

Catalog No.S1148 Synonyms: RP56976, NSC 628503

85 publications

Docetaxel Chemical Structure

CAS No. 114977-28-5

Docetaxel (RP56976, NSC 628503), an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.

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Selleck's Docetaxel has been cited by 85 publications

Purity & Quality Control

Choose Selective Microtubule Associated Inhibitors

Biological Activity

Description Docetaxel (RP56976, NSC 628503), an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.
Targets
Microtubules [1]
(Cell-free assay)
In vitro

Docetaxel is a cytotoxic agent, especially for proliferating cells, which is related to its ability to promote the formation of microtubule bundles and induce sustained mitotic arrest, followed by apoptosis of mitotically arrested cells or permanent mitotic block. Docetaxel suppresses microtubule dynamic instability as well as tread-milling, resulting in the failure of chromosomes to segregate to the daughter cells, which in turn triggers premature exit from mitosis rather than a block at this phase of the cell cycle. [2] Docetaxel inhibits the clonogenic survival of Human cancer cell Hs746T (stomach), AGS (stomach), HeLa (cervix), CaSki (cervix), BxPC3 (pancreas), Capan-1 (pancreas) with IC50 of 1 nM, 1 nM, 0.3 nM, 0.3 nM, 0.3 nM and 0.3 nM respectively. [4] Docetaxel inhibits endothelial cell migration that does not affects microtubule gross morphology or inhibit cell proliferation, although they does produce more subtle effects on microtubule dynamics. Docetaxel inhibits HUVEC migration with an observed IC50 of 1 pM. HUVEC chemotaxis stimulated by either of two angiogenic factors, thymidine phosphorylase or VEGF, is inhibited by Docetaxel with IC 50 of 10 pM and is ablated at 1 nM. [7] Docetaxel induces human monocytes, but not RAW 264.7 murine macrophages, Prostaglandin H Synthase-2m (PGHS-2) expression. [8]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HSC-3 NH30TWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Xl[WlEPTB;MD6wNFAyOzJizszN NF3ofo5USU6JRWK=
5637 M3LCVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XFd2lEPTB;MD6wNFAyPDNizszN NGnWOWZUSU6JRWK=
HT-144 M1zpcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XoR2lEPTB;MD6wNFAyPTdizszN MYXTRW5ITVJ?
NCI-H292 NVLsSGp2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nZXWlEPTB;MD6wNFAyPTlizszN NV\SPWVIW0GQR1XS
HCE-T NVv0N|h[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LBOGlEPTB;MD6wNFAyPjJizszN M1vyV3NCVkeHUh?=
ESS-1 NWXwSJdHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwMECwNVc6KM7:TR?= NYnCWXZLW0GQR1XS
D-566MG Mm\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPPS45KSzVyPUCuNFAxOTh{IN88US=> NXnmNYN5W0GQR1XS
CAL-62 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYP4W|k{UUN3ME2wMlAxODF6NTFOwG0> MkXuV2FPT0WU
GT3TKB NYPVXGllT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTBwMECwNlMzKM7:TR?= MoLVV2FPT0WU
HSC-4 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{T0bmlEPTB;MD6wNFAzOzlizszN MUTTRW5ITVJ?
KOSC-2 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LSNGlEPTB;MD6wNFAzPTVizszN Mlm0V2FPT0WU
NB14 NFnvTnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTBwMECwNlYh|ryP NWPyelhlW0GQR1XS
ES8 MofSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLsTWM2OD1yLkCwNFI3KM7:TR?= Mnr6V2FPT0WU
BFTC-905 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1:yWGlEPTB;MD6wNFAzPjhizszN M4PNXXNCVkeHUh?=
A498 NEXBSFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTBwMECwNlc5KM7:TR?= M4C4fHNCVkeHUh?=
HO-1-N-1 M3;oO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHZWY9KSzVyPUCuNFAxOjhzIN88US=> NIX5VGVUSU6JRWK=
SF539 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4r2UGlEPTB;MD6wNFA{ODJizszN MnLVV2FPT0WU
HuO-3N1 M2n0XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3kS25mUUN3ME2wMlAxODNyMjFOwG0> M1LFRXNCVkeHUh?=
NCI-H510A NFiyeVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTBwMECwN|M3KM7:TR?= M{HUNXNCVkeHUh?=
CAL-27 NYnuXFJLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTDWIJKUUN3ME2wMlAxODN|OTFOwG0> NWXDdlV2W0GQR1XS
TE-8 NGjRNWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PCXWlEPTB;MD6wNFA{PjZizszN NVPW[|hqW0GQR1XS
VA-ES-BJ M1\aOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHKxcldKSzVyPUCuNFAxOzd3IN88US=> MnrzV2FPT0WU
RH-1 MoLSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTZUZZ[UUN3ME2wMlAxODN6NjFOwG0> MoPEV2FPT0WU
COLO-800 NYPmZXExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjlTWM2OD1yLkCwNFM5QCEQvF2= M{HTT3NCVkeHUh?=
ES7 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlj2TWM2OD1yLkCwNFM5QSEQvF2= MVHTRW5ITVJ?
GAMG NU\UXHBiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2f3c2lEPTB;MD6wNFA1OTZizszN MmXkV2FPT0WU
Ca9-22 NFPocmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTtUZZsUUN3ME2wMlAxODR{MzFOwG0> M{PIVXNCVkeHUh?=
SBC-1 NXXUOolFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPlTWM2OD1yLkCwNFQ{KM7:TR?= NEjSSItUSU6JRWK=
RPMI-7951 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHuz[WNKSzVyPUCuNFAxPDR6IN88US=> NFToVWhUSU6JRWK=
SW1710 NIP3UndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUi0cXJ1UUN3ME2wMlAxODR4NjFOwG0> NHe5Z4dUSU6JRWK=
HGC-27 NXfYb5JCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\iTWM2OD1yLkCwNFQ4OSEQvF2= MljLV2FPT0WU
MC-IXC NWfKNlk5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF33b|ZKSzVyPUCuNFAxPDd7IN88US=> NVO2RZpOW0GQR1XS
FTC-133 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvYO|RKSzVyPUCuNFAxPDh7IN88US=> M{PyTnNCVkeHUh?=
HT-1080 NWrtdJd1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mon6TWM2OD1yLkCwNFUxOSEQvF2= NVP6foR{W0GQR1XS
NMC-G1 MnvoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHwc2VKSzVyPUCuNFAxPTF5IN88US=> NF3uZlNUSU6JRWK=
GI-1 MmPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTBwMECwOVI5KM7:TR?= M4fqSXNCVkeHUh?=
CGTH-W-1 NEjuZpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{G1[2lEPTB;MD6wNFA2PDJizszN NWriZldwW0GQR1XS
A2058 NFjKW3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PtPWlEPTB;MD6wNFA2PDRizszN MlzuV2FPT0WU
ETK-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHGyU4tKSzVyPUCuNFAxPTV6IN88US=> NHvtUYRUSU6JRWK=
NEC8 MmDtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnaTWM2OD1yLkCwNFU3OSEQvF2= NFjGSmtUSU6JRWK=
TE-11 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHz3bJBKSzVyPUCuNFAxPTZ7IN88US=> MnjGV2FPT0WU
NCI-H720 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4WyRmlEPTB;MD6wNFA2QCEQvF2= NYrXOoxWW0GQR1XS
PSN1 NXnSe5UyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnyTWM2OD1yLkCwNFU5OSEQvF2= MV\TRW5ITVJ?
SW780 NWi3Z5BVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTBwMECwOVg4KM7:TR?= NFTyVm1USU6JRWK=
8-MG-BA MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTQ[lR3UUN3ME2wMlAxODV6OTFOwG0> MVXTRW5ITVJ?
EC-GI-10 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;i[JlKSzVyPUCuNFAxPTl{IN88US=> Mk\zV2FPT0WU
SJSA-1 NIT1WHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPXTWM2OD1yLkCwNFYyPSEQvF2= NEPqU2ZUSU6JRWK=
639-V M1Sx[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXe2XHZHUUN3ME2wMlAxODZ2NzFOwG0> MV7TRW5ITVJ?
PFSK-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTBwMECwOlU4KM7:TR?= MYfTRW5ITVJ?
DMS-273 NVTrXlg5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\6fpRKSzVyPUCuNFAxPjd2IN88US=> NXG0fVg3W0GQR1XS
TE-9 MlXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTJTWM2OD1yLkCwNFY4PiEQvF2= MV7TRW5ITVJ?
SCC-25 MkS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwMECwOlgh|ryP NE\0fmNUSU6JRWK=
PA-1 Mn7ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jU[2lEPTB;MD6wNFA3QDdizszN M1uzUnNCVkeHUh?=
MHH-ES-1 NU[zflN1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHyTWM2OD1yLkCwNFch|ryP MnH5V2FPT0WU
Daoy MkjXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTBwMECwO{DPxE1? MVXTRW5ITVJ?
G-402 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwMECwO|A3KM7:TR?= MV\TRW5ITVJ?
YKG-1 M4XyfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TvT2lEPTB;MD6wNFA4ODdizszN Ml63V2FPT0WU
Ca-Ski NF3JT5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDVcIdUUUN3ME2wMlAxODd{ODFOwG0> NGnoT5hUSU6JRWK=
CHP-212 MnO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGP1bHZKSzVyPUCuNFAxPzNizszN NFrxZ5lUSU6JRWK=
SCC-4 M3P0VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\tdHhKSzVyPUCuNFAxPzN7IN88US=> MYnTRW5ITVJ?
EW-3 NF;oXW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vMZmlEPTB;MD6wNFA4PDVizszN NEjCW3BUSU6JRWK=
P12-ICHIKAWA NHG0OVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnjUHVKSzVyPUCuNFAxPzR3IN88US=> NEfVZmJUSU6JRWK=
HSC-2 M{PNZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDsTWM2OD1yLkCwNFc2PSEQvF2= M2XhRnNCVkeHUh?=
HN NUnveZQ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nsXWlEPTB;MD6wNFA4PThizszN NXvvU4E3W0GQR1XS
LXF-289 NVrJ[JpOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HNNWlEPTB;MD6wNFA4PThizszN NXvSbYdXW0GQR1XS
ES1 MkTVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGO5fo1KSzVyPUCuNFAxPzdizszN MWXTRW5ITVJ?
NTERA-S-cl-D1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPxTWM2OD1yLkCwNFc4OyEQvF2= M2TROnNCVkeHUh?=
K5 MlnhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1uwVmlEPTB;MD6wNFA4PzhizszN M1K1Z3NCVkeHUh?=
HOS NEXKV5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\s[mlEPTB;MD6wNFA4QDJizszN MnLlV2FPT0WU
YH-13 NUf0NFVvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LsXGlEPTB;MD6wNFA4QTFizszN NFHzOoJUSU6JRWK=
SW954 MkjlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrNTWM2OD1yLkCwNFgzOyEQvF2= MYfTRW5ITVJ?
KYSE-510 NHHtR|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fLU2lEPTB;MD6wNFA5PCEQvF2= MUPTRW5ITVJ?
8505C NYK5[lV{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXnZ|RyUUN3ME2wMlAxODh3NDFOwG0> M{DRXHNCVkeHUh?=
A549 M{fHcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3KTWM2OD1yLkCwNFg5OiEQvF2= M3zaOXNCVkeHUh?=
Detroit562 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrmepdwUUN3ME2wMlAxODlyMjFOwG0> MoL6V2FPT0WU
ES5 NYLFclN{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTBwMECwPVEh|ryP NEfFe|VUSU6JRWK=
KYSE-140 NYTWXVBQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;wTmlEPTB;MD6wNFA6OzNizszN NEixUJhUSU6JRWK=
GMS-10 M17z[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3mTWM2OD1yLkCwNFk1OSEQvF2= M3nRS3NCVkeHUh?=
D-263MG MmrlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7RVJduUUN3ME2wMlAxODl2NzFOwG0> MlnBV2FPT0WU
BCPAP M1LH[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjCTWM2OD1yLkCwNFk1PyEQvF2= MnryV2FPT0WU
CHL-1 NYLoPVRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XMfWlEPTB;MD6wNFA6PThizszN Mo[3V2FPT0WU
RKO MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTBwMECwPVg6KM7:TR?= M1HDfHNCVkeHUh?=
SW48 M12wUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTBwMECxNFEh|ryP MlPhV2FPT0WU
BPH-1 NULxe3pNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXRTJRKSzVyPUCuNFAyODJizszN MoLMV2FPT0WU
EFO-27 M3H3WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HxdWlEPTB;MD6wNFExOiEQvF2= M4TrRnNCVkeHUh?=
CAL-33 NET0NndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTFOotKSzVyPUCuNFAyODRizszN NX7KN4dqW0GQR1XS
NCI-H1792 M4jjUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF[zcnZKSzVyPUCuNFAyODRizszN MVjTRW5ITVJ?
BB30-HNC MmDmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLBOopKSzVyPUCuNFAyODVizszN NUnLXII2W0GQR1XS
VM-CUB-1 NIL2WlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVj2eY1GUUN3ME2wMlAxOTB3IN88US=> M{nzWnNCVkeHUh?=
TE-5 M1HMXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rxOmlEPTB;MD6wNFExPiEQvF2= NHe2NXVUSU6JRWK=
NB13 M4PKTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfJXVVKSzVyPUCuNFAyODdizszN M1fVS3NCVkeHUh?=
NBsusSR NV;ucZNOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPIdVQzUUN3ME2wMlAxOTFizszN M{OweXNCVkeHUh?=
LNCaP-Clone-FGC NG\NXJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\tTWM2OD1yLkCwNVEh|ryP MWjTRW5ITVJ?
EPLC-272H MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfrcJRKSzVyPUCuNFAyOTFizszN MmDrV2FPT0WU
KNS-62 MoLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFK0dWRKSzVyPUCuNFAyOTJizszN NG\3fYxUSU6JRWK=
RERF-LC-MS MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{P0[2lEPTB;MD6wNFEyOyEQvF2= MljzV2FPT0WU
LOXIMVI MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTBwMECxNVYh|ryP MlrYV2FPT0WU
KINGS-1 NVzOfYJTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzPVoVQUUN3ME2wMlAxOTF5IN88US=> MVXTRW5ITVJ?
T98G MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLufZhKSzVyPUCuNFAyOTdizszN NYjSbldvW0GQR1XS
HCC1806 MmXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwMECxNVgh|ryP MnyyV2FPT0WU
MZ1-PC MnjMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDmTWM2OD1yLkCwNVE5KM7:TR?= NXXUTHVGW0GQR1XS
RT-112 MnjOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TIV2lEPTB;MD6wNFEyQSEQvF2= NYThTlFmW0GQR1XS
LK-2 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DIPWlEPTB;MD6wNFEzOSEQvF2= MlvlV2FPT0WU
A375 M4jFZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXn0WlZjUUN3ME2wMlAxOTJzIN88US=> M1HofHNCVkeHUh?=
SF268 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mle5TWM2OD1yLkCwNVIyKM7:TR?= Mm\QV2FPT0WU
H9 NEKydW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTBwMECxNlQh|ryP NIPIO4NUSU6JRWK=
KYSE-410 NEjUPItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzjRVVZUUN3ME2wMlAxOTJ2IN88US=> MlmzV2FPT0WU
G-401 NEPuR3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHRTWM2OD1yLkCwNVI4KM7:TR?= NIX0V41USU6JRWK=
SW982 M{X1Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljlTWM2OD1yLkCwNVI4KM7:TR?= Ml;oV2FPT0WU
D-423MG M3vHVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jmXGlEPTB;MD6wNFE{KM7:TR?= NF:xToFUSU6JRWK=
CAMA-1 MnTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTBwMECxN|Eh|ryP NHjPbVNUSU6JRWK=
SCC-9 NEXXWlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjscY1qUUN3ME2wMlAxOTN{IN88US=> MnfKV2FPT0WU
SAS NHfEV|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DVbmlEPTB;MD6wNFE{PCEQvF2= NWTReG9oW0GQR1XS
KYSE-180 NU\jUJd7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1P6dGlEPTB;MD6wNFE{PSEQvF2= NXvneVE1W0GQR1XS
EW-16 NWnob2g{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\PTWM2OD1yLkCwNVM2KM7:TR?= M2O5[XNCVkeHUh?=
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LCLC-97TM1 Mn\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPC[m81UUN3ME2wMlAxOTR2IN88US=> NVf5[|B{W0GQR1XS
KS-1 NH;JfWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfQT|BZUUN3ME2wMlAxOTR2IN88US=> M4TlWHNCVkeHUh?=
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M14 Ml34S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXe1WmtRUUN3ME2wMlAxOTlzIN88US=> NHzkUVRUSU6JRWK=
NCI-H1048 Mm\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1O3cmlEPTB;MD6wNFE6OiEQvF2= M1rjN3NCVkeHUh?=
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NCI-SNU-1 M13yRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrJOWFpUUN3ME2wMlAxOTl5IN88US=> MV\TRW5ITVJ?
M059J NF3SWWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHNcHRKSzVyPUCuNFAyQThizszN MoXxV2FPT0WU
OVCAR-5 Ml7NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DLdGlEPTB;MD6wNFE6QSEQvF2= NX3DSnZzW0GQR1XS
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BB49-HNC MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLye4V1UUN3ME2wMlAxOjF{IN88US=> MljKV2FPT0WU
EFM-19 NVLhZ2tjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPKfHYxUUN3ME2wMlAxOjF3IN88US=> NEThU2tUSU6JRWK=
BHY NGHhbWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;PXY51UUN3ME2wMlAxOjF4IN88US=> M2P1b3NCVkeHUh?=
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BB65-RCC MlywS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGGxUnpKSzVyPUCuNFA{ODhizszN NU\JTYdRW0GQR1XS
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SF126 M3LVNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwMECzNlkh|ryP M{HWSHNCVkeHUh?=
UACC-62 MonNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTBwMECzN{DPxE1? Mo\vV2FPT0WU
NCI-H28 NWnMWnpzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTMOlh4UUN3ME2wMlAxOzN2IN88US=> NEHhZWhUSU6JRWK=
A2780 M1XNXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLZTWM2OD1yLkCwN|M2KM7:TR?= M{nRXHNCVkeHUh?=
CTV-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7qRXVKSzVyPUCuNFA{OzdizszN M{DvXXNCVkeHUh?=
LC-2-ad NHHtV5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPjTWM2OD1yLkCwN|Qh|ryP NYntN5ZjW0GQR1XS
NCI-H1770 MlG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPYTWM2OD1yLkCwN|QzKM7:TR?= Ml7CV2FPT0WU
HuO9 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrROJBKSzVyPUCuNFA{PDZizszN NGiyc41USU6JRWK=
U-266 NViweZE1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlqzTWM2OD1yLkCwN|Q5KM7:TR?= MXPTRW5ITVJ?
MLMA M4X4e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXKN3ZKSzVyPUCuNFA{PTVizszN M2LmZ3NCVkeHUh?=
U-87-MG MnPVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17mUWlEPTB;MD6wNFM2PSEQvF2= NInEbolUSU6JRWK=
GI-ME-N MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTBwMECzOVgh|ryP NU\5XY9SW0GQR1XS
HL-60 M2ThUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTLTWM2OD1yLkCwN|U6KM7:TR?= Mn6yV2FPT0WU
EGI-1 NWTYN4dJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfZfGxQUUN3ME2wMlAxOzZ{IN88US=> M3rHenNCVkeHUh?=
NCI-H23 NXHidFQxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;lZZBKSzVyPUCuNFA{PjRizszN MVTTRW5ITVJ?
NCI-H226 Mk\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTBwMECzOlgh|ryP NUThcWlZW0GQR1XS
NCI-H520 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEW4XWlKSzVyPUCuNFA{PzJizszN NUnTPG14W0GQR1XS
L-363 NUnpdnF4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITOcZNKSzVyPUCuNFA{PzZizszN MXjTRW5ITVJ?
CAL-12T NYrucpVST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUSwUnp2UUN3ME2wMlAxOzd4IN88US=> M3TGTHNCVkeHUh?=
BT-20 M3;DPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;veoVKSzVyPUCuNFA{PzZizszN M{LhNXNCVkeHUh?=
SNB75 M{jwRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwMECzPFEh|ryP M{G3T3NCVkeHUh?=
A4-Fuk M1XSTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\CVmlEPTB;MD6wNFM6KM7:TR?= MX7TRW5ITVJ?
BE-13 NHmxZWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDkTWM2OD1yLkCwN|k{KM7:TR?= MmTXV2FPT0WU
NCI-H1395 MmLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLxRVNZUUN3ME2wMlAxOzl4IN88US=> NIfZO5RUSU6JRWK=
SW620 NUDieVNCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXqwZWpnUUN3ME2wMlAxOzl5IN88US=> NHG3c|NUSU6JRWK=
KNS-81-FD NHHJWnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTBwMECzPVkh|ryP NIToZY9USU6JRWK=
RD M33WUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljTTWM2OD1yLkCwOEDPxE1? NFX3PFlUSU6JRWK=
HLE M4O5R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTBwMEC0NFUh|ryP M3r5eXNCVkeHUh?=
OVCAR-3 NUPEZ5ZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVyz[2RnUUN3ME2wMlAxPDB5IN88US=> MnrWV2FPT0WU
KM12 NVvldmd4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFj2R4xKSzVyPUCuNFA1ODhizszN MVfTRW5ITVJ?
HCC2998 NV3ofmhpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmSxTWM2OD1yLkCwOFA5KM7:TR?= MULTRW5ITVJ?
D-502MG NGPzU2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrMTWM2OD1yLkCwOFEh|ryP NEGyS2ZUSU6JRWK=
KNS-42 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{OxOWlEPTB;MD6wNFQyOiEQvF2= NFXWe4FUSU6JRWK=
LS-123 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vyOmlEPTB;MD6wNFQzPSEQvF2= MkjQV2FPT0WU
SiHa Mom2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfDWGRDUUN3ME2wMlAxPDNizszN M1K4T3NCVkeHUh?=
T47D NVXVcVk6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XGbmlEPTB;MD6wNFQ{OSEQvF2= MmjvV2FPT0WU
EW-24 NF;vVYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vse2lEPTB;MD6wNFQ{OyEQvF2= NXzPO3ZwW0GQR1XS
CAL-120 NXm3NmhDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHOTWM2OD1yLkCwOFM2KM7:TR?= MYjTRW5ITVJ?
JAR NFjPVYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkP0TWM2OD1yLkCwOFM4KM7:TR?= NUHMTopDW0GQR1XS
QIMR-WIL NYDB[I9WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLYfoZKSzVyPUCuNFA1OzhizszN MUnTRW5ITVJ?
OCUB-M MmL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTBwMEC0N|gh|ryP MU\TRW5ITVJ?
Calu-6 Mm[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkSzTWM2OD1yLkCwOFQ4KM7:TR?= MkfWV2FPT0WU
MDA-MB-453 NVjDV3pNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TnPWlEPTB;MD6wNFQ2OSEQvF2= NXXXWII3W0GQR1XS
MKN45 NX3QT4VTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTBwMEC0OVMh|ryP MUjTRW5ITVJ?
ECC10 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mly2TWM2OD1yLkCwOFYh|ryP NGn2WoRUSU6JRWK=
RVH-421 M13oUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlL0TWM2OD1yLkCwOFYyKM7:TR?= Ml[4V2FPT0WU
TGBC11TKB NFLiNYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fuZWlEPTB;MD6wNFQ3QSEQvF2= NEm3RoZUSU6JRWK=
MOLT-4 NVrucHQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUCybpNEUUN3ME2wMlAxPDdzIN88US=> MoLSV2FPT0WU
LN-405 MkWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUH2fYl5UUN3ME2wMlAxPDh{IN88US=> MYDTRW5ITVJ?
S-117 NHvUXYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;XTWM2OD1yLkCwOFg3KM7:TR?= NVvxeVdNW0GQR1XS
RPMI-8226 M2XMRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTBwMEC0PVch|ryP NYDuRWRmW0GQR1XS
KYSE-150 NXG4cVB6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3XTWM2OD1yLkCwOFk6KM7:TR?= NVnBeoM1W0GQR1XS
NCI-H1666 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4qwcmlEPTB;MD6wNFUxPSEQvF2= MnTOV2FPT0WU
Mewo NYX4fplpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfselZKSzVyPUCuNFA2ODVizszN NU\GVIhiW0GQR1XS
AN3-CA M362emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2[3PWlEPTB;MD6wNFUxPyEQvF2= Moe4V2FPT0WU
COLO-680N MnrGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzXTWM2OD1yLkCwOVA5KM7:TR?= NV;l[lhZW0GQR1XS
FADU NWXqNoRDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7mNWFsUUN3ME2wMlAxPTFizszN NYXHZXV{W0GQR1XS
GB-1 NIH3bIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1mybGlEPTB;MD6wNFUyOSEQvF2= MlPjV2FPT0WU
KASUMI-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonMTWM2OD1yLkCwOVEyKM7:TR?= MWTTRW5ITVJ?
NOMO-1 NIqzUIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXj6UXdYUUN3ME2wMlAxPTF|IN88US=> M2jCdXNCVkeHUh?=
BV-173 NH\nSJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYi2cGZnUUN3ME2wMlAxPTNizszN MWLTRW5ITVJ?
RO82-W-1 NVHB[IxiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTBwMEC1N|Eh|ryP NVPIbI5{W0GQR1XS
LB2241-RCC MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\3bGlEPTB;MD6wNFU{OSEQvF2= MmKzV2FPT0WU
NCI-H2170 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3YTWM2OD1yLkCwOVM2KM7:TR?= NWHkSpl5W0GQR1XS
SK-N-AS MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnSZ2hKSzVyPUCuNFA2OzVizszN MXzTRW5ITVJ?
NCI-H1651 NWPEZ4ZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PDNmlEPTB;MD6wNFU1KM7:TR?= NFXwTFZUSU6JRWK=
NCI-SNU-5 M1fRWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;HNWlEPTB;MD6wNFU1PSEQvF2= MYnTRW5ITVJ?
SN12C MlXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{KwUmlEPTB;MD6wNFU2KM7:TR?= MVXTRW5ITVJ?
KY821 NFqxfIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{S4eWlEPTB;MD6wNFU2OSEQvF2= M{n0XHNCVkeHUh?=
SW1573 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTBwMEC1OVQh|ryP Mn:0V2FPT0WU
OE19 NE\6W4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TTemlEPTB;MD6wNFU2QSEQvF2= NID6R5JUSU6JRWK=
MPP-89 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\TeZJzUUN3ME2wMlAxPTZ5IN88US=> MVTTRW5ITVJ?
HuCCT1 MlrjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLYTWM2OD1yLkCwOVY5KM7:TR?= MofNV2FPT0WU
SW1783 NVGxNFRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlm0TWM2OD1yLkCwOVch|ryP NYLyTpFCW0GQR1XS
8305C MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjRXGE1UUN3ME2wMlAxPTd4IN88US=> NEjnPGZUSU6JRWK=
OVCAR-4 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTBwMEC1PFYh|ryP MXnTRW5ITVJ?
MMAC-SF M3rXZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHOyWJhKSzVyPUCuNFA2QDZizszN M1jaTHNCVkeHUh?=
COLO-824 Mm\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXj3W2VYUUN3ME2wMlAxPTlizszN M2nN[nNCVkeHUh?=
HCC38 NI\Ld2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTBwMEC2JO69VQ>? NVfiOWlKW0GQR1XS
NCI-H1648 NXn2Not{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTJTWM2OD1yLkCwOlAyKM7:TR?= MkHYV2FPT0WU
NCI-H1573 NIHOfIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTBwMEC2NFch|ryP MVHTRW5ITVJ?
MFM-223 M3rUcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTBwMEC2NVYh|ryP MV;TRW5ITVJ?
NCI-H810 NF[xbGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3QSFc1UUN3ME2wMlAxPjJ{IN88US=> Mm\qV2FPT0WU
EM-2 M1jqSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLsWVROUUN3ME2wMlAxPjJ|IN88US=> MULTRW5ITVJ?
D-283MED NWfIbpk6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULubJRpUUN3ME2wMlAxPjJ2IN88US=> NUiwVlBsW0GQR1XS
NCI-H1755 NXrC[2E2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzMTWM2OD1yLkCwOlI1KM7:TR?= MYHTRW5ITVJ?
KYSE-70 M3\ZOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrkTWM2OD1yLkCwOlI1KM7:TR?= MXzTRW5ITVJ?
SW626 M3iweGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLnTWM2OD1yLkCwOlI1KM7:TR?= NHrkXYJUSU6JRWK=
WM-115 M3HxfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTidWxwUUN3ME2wMlAxPjJ5IN88US=> NXiydnpVW0GQR1XS
NB69 NFf1S2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwMEC2Nlkh|ryP Mk\2V2FPT0WU
DOHH-2 MnLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwMEC2N{DPxE1? MlLXV2FPT0WU
MEL-JUSO NXfPcGJLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLQTWM2OD1yLkCwOlM6KM7:TR?= NH\PW5ZUSU6JRWK=
IGR-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DBOGlEPTB;MD6wNFY1OSEQvF2= NVr4PZk5W0GQR1XS
ACN NW\tcVc4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvBXGJKSzVyPUCuNFA3PDRizszN MmDCV2FPT0WU
KARPAS-45 M1;JfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTBwMEC2OVIh|ryP MYDTRW5ITVJ?
HC-1 NULWcXdZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHf6VGFKSzVyPUCuNFA3PTZizszN NW[z[nNwW0GQR1XS
MZ2-MEL NHewVFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDEc2NLUUN3ME2wMlAxPjV6IN88US=> MkPMV2FPT0WU
NCI-H1355 NXi2fHJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTBwMEC2O|kh|ryP NHTVWXlUSU6JRWK=
HuP-T4 NXyyXGhQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIf2eYtKSzVyPUCuNFA3PzlizszN MnPsV2FPT0WU
AsPC-1 NIe0eoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\rRm1KSzVyPUCuNFA3QDNizszN NILj[5VUSU6JRWK=
SCC-15 M33nRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\sbWlEPTB;MD6wNFY5QSEQvF2= NV\EUId7W0GQR1XS
CP50-MEL-B NGr2PFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTsS5ljUUN3ME2wMlAxPjl|IN88US=> MXrTRW5ITVJ?
DMS-114 NWixfGJjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTBwMEC2PVYh|ryP MW\TRW5ITVJ?
KYSE-520 NWLXRm41T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwMEC3JO69VQ>? M4nWWnNCVkeHUh?=
NCI-H2228 NHG1WpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTBwMEC3NlUh|ryP MXLTRW5ITVJ?
COLO-829 MoDZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTBwMEC3NlUh|ryP NH;JTIVUSU6JRWK=
NCI-H2052 NWHiZow6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HCdWlEPTB;MD6wNFczPyEQvF2= NGntT|dUSU6JRWK=
HOP-92 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwMEC3N{DPxE1? NFX1WJFUSU6JRWK=
MDA-MB-231 MlHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfuTWM2OD1yLkCwO|Mh|ryP NH7HemlUSU6JRWK=
SK-MEL-30 MoPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlz3TWM2OD1yLkCwO|MzKM7:TR?= MXTTRW5ITVJ?
NCI-H2087 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLRTWM2OD1yLkCwO|Q5KM7:TR?= MkPDV2FPT0WU
SW900 MkTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDxZ3pKSzVyPUCuNFA4PTVizszN M1izbXNCVkeHUh?=
NCI-H358 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkWwTWM2OD1yLkCwO|U5KM7:TR?= NYn3SJdQW0GQR1XS
NCI-H2126 M2rXWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PlV2lEPTB;MD6wNFc4OyEQvF2= MVHTRW5ITVJ?
TGBC24TKB NVziR3hMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTBwMEC3PFEh|ryP NWjEdFhHW0GQR1XS
786-0 M1fmUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXPPYFtUUN3ME2wMlAxPzh4IN88US=> M1noPHNCVkeHUh?=
no-10 NILFeGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLm[GpKSzVyPUCuNFA4QDhizszN Mnr3V2FPT0WU
SCH M{XKUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jkSGlEPTB;MD6wNFgyQCEQvF2= NGLzZnVUSU6JRWK=
COLO-741 NXTPdGVYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPMTWM2OD1yLkCwPFIh|ryP NInORWNUSU6JRWK=
NCI-H82 MkPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3TcndQUUN3ME2wMlAxQDJ{IN88US=> MlL3V2FPT0WU
MOLT-16 M2Dmd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwMEC4Nlch|ryP M4exfnNCVkeHUh?=
IST-MES1 MoPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHjem9KSzVyPUCuNFA5PCEQvF2= NH:0d29USU6JRWK=
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COLO-684 MmWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlT5TWM2OD1yLkC0NFk2KM7:TR?= NX\Ld3FyW0GQR1XS
NCI-H1693 NYm1ZXNVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjpe5RKSzVyPUCuNFQ{ODVizszN NIricJpUSU6JRWK=
LAN-6 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHvU3FCUUN3ME2wMlA1OzN3IN88US=> Ml\0V2FPT0WU
MDA-MB-175-VII M1\vN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DXSGlEPTB;MD6wOFQyPyEQvF2= MVLTRW5ITVJ?
KMOE-2 M4TYRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;pTWM2OD1yLkC0OFY6KM7:TR?= MY\TRW5ITVJ?
DMS-79 MnPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2iwOGlEPTB;MD6wOFU4QSEQvF2= MYrTRW5ITVJ?
MHH-NB-11 M1i0PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTBwMES2NVQh|ryP NWq4U2w6W0GQR1XS
NCI-H69 NITXXphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGftbWhKSzVyPUCuNFQ5PDlizszN NFPFRndUSU6JRWK=
KE-37 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXu3blNiUUN3ME2wMlA2ODFizszN NV\2RllLW0GQR1XS
Ramos-2G6-4C10 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\wTWM2OD1yLkC1NFY4KM7:TR?= NF7ZdWRUSU6JRWK=
NCI-H1793 NE\WfYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTBwMEWwPVMh|ryP M1TzO3NCVkeHUh?=
HT-1376 M2juZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTBwMEWxPFYh|ryP NVuyNIVbW0GQR1XS
EKVX MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mor4TWM2OD1yLkC1N|g1KM7:TR?= NFrvPHBUSU6JRWK=
Capan-2 NFf5Ro9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLHTWM2OD1yLkC1N|k3KM7:TR?= MluxV2FPT0WU
DoTc2-4510 M4LMTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33iNWlEPTB;MD6wOVQ1PiEQvF2= NHPONVlUSU6JRWK=
UACC-893 M33ReWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvRTmlCUUN3ME2wMlA2PDZ{IN88US=> NWqy[G1OW0GQR1XS
SK-MEL-3 MmfHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwMEW3PFgh|ryP MnrLV2FPT0WU
SK-MEL-1 M4Hw[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTBwMEW4JO69VQ>? M{GwbXNCVkeHUh?=
SW948 M2flTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PrNGlEPTB;MD6wOVk6PiEQvF2= MUjTRW5ITVJ?
P30-OHK M2jXVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TWemlEPTB;MD6wOlE3PyEQvF2= NFvQUWZUSU6JRWK=
NH-12 NV7sXpZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\aTWM2OD1yLkC2NlQ1KM7:TR?= M3LMdHNCVkeHUh?=
KU-19-19 NHixXGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHyTWM2OD1yLkC2N|YyKM7:TR?= MnT1V2FPT0WU
A431 NUO0U2ZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTBwME[zO|Qh|ryP MlHkV2FPT0WU
NCI-H2405 NHHZVnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TxZmlEPTB;MD6wOlM5OyEQvF2= M2\MWXNCVkeHUh?=
KARPAS-299 MnrBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITmdYJKSzVyPUCuNFY2QDJizszN M3zBNnNCVkeHUh?=
BALL-1 M1frOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLuU5BKSzVyPUCuNFY3PzRizszN NUHlepljW0GQR1XS
KURAMOCHI MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\3PVhKSzVyPUCuNFcxPzNizszN NFzYRplUSU6JRWK=
LS-1034 MlvZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlv0TWM2OD1yLkC3N|Y6KM7:TR?= NEPEcndUSU6JRWK=
MFE-280 NIHxbGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Moq2TWM2OD1yLkC3OVM3KM7:TR?= NHPqO49USU6JRWK=
HOP-62 NHHkRlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTBwMEe2O|Yh|ryP NIPMWWxUSU6JRWK=
KG-1 NU\RSG1lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTBwMEe3PFch|ryP NFfrPG5USU6JRWK=
CW-2 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3yTWM2OD1yLkC3PFMzKM7:TR?= M4nS[HNCVkeHUh?=
SW837 MkW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17abmlEPTB;MD6wPFM1OiEQvF2= NVS0c4tsW0GQR1XS
MFH-ino NEjQNVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13ZTGlEPTB;MD6wPFUxOSEQvF2= MkPUV2FPT0WU
HCC1419 M1;5OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFmwdFVKSzVyPUCuNFg6QDdizszN NYT2S|ZsW0GQR1XS
HMV-II MnrPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHe5O3hKSzVyPUCuNFkxOSEQvF2= MWXTRW5ITVJ?
BEN NF:4WVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXv2Z4NMUUN3ME2wMlA6Ozh3IN88US=> MofEV2FPT0WU
SK-N-FI MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTOZldjUUN3ME2wMlA6PTV4IN88US=> NHvnZZZUSU6JRWK=
JVM-2 NGmwbXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3O5SWlEPTB;MD6wPVcyPiEQvF2= NGrOcnpUSU6JRWK=
CAL-54 Mn6wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fGbmlEPTB;MD6xNFA1KM7:TR?= M{HTcnNCVkeHUh?=
T84 MkDGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37CbWlEPTB;MD6xNFk2OiEQvF2= NVvxPFA2W0GQR1XS
SHP-77 MkfsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPVZoZKSzVyPUCuNVE3PDFizszN M3PxR3NCVkeHUh?=
G-361 M1XHNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIT2OXNKSzVyPUCuNVI{OjRizszN M2HxVHNCVkeHUh?=
Calu-3 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zWNmlEPTB;MD6xN|gyPiEQvF2= M{\6SXNCVkeHUh?=
HCC1937 MnvlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX:w[o9RUUN3ME2wMlE1QTN5IN88US=> NFSzVG5USU6JRWK=
KM-H2 Mle5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnmblF6UUN3ME2wMlE2ODFizszN MULTRW5ITVJ?
769-P NGHwUlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnriTWM2OD1yLkG1PFQ{KM7:TR?= MnHuV2FPT0WU
NCI-H1304 NVXXR4RoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTBwMU[wOlEh|ryP MlrnV2FPT0WU
D-542MG MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXnb5FKSzVyPUCuNVYzPzhizszN MlHwV2FPT0WU
ATN-1 MnHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXoTWM2OD1yLkG3OFQyKM7:TR?= MWTTRW5ITVJ?
NCI-H2029 NV7TeVJIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPU[29NUUN3ME2wMlIxOjR|IN88US=> MXfTRW5ITVJ?
ZR-75-30 M3\kS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWO5Xo5sUUN3ME2wMlIxPjR|IN88US=> NGrVb5FUSU6JRWK=
SW1116 M3;RTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1frRWlEPTB;MD6yNVEyPyEQvF2= MVjTRW5ITVJ?
CCRF-CEM M{nDc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HQOGlEPTB;MD6yO|YyPCEQvF2= NWDQSVhVW0GQR1XS
LU-135 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUX4ZmdGUUN3ME2wMlI4PzN7IN88US=> NFP5fI9USU6JRWK=
MC116 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fJS2lEPTB;MD6yPFMxQSEQvF2= MV7TRW5ITVJ?
LS-513 NE\We5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTBwMki3O|Mh|ryP MlfBV2FPT0WU
NCI-H630 MmTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTBwMkmzO|Yh|ryP NWr1V3p3W0GQR1XS
L-428 M4nLVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnyTWM2OD1yLkK5PFg{KM7:TR?= MmXXV2FPT0WU
UM-UC-3 NIDMeWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mli1TWM2OD1yLkOxNlkyKM7:TR?= Ml;2V2FPT0WU
NCI-H1838 NXK2SpB{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlmxTWM2OD1yLkOxO|g1KM7:TR?= MXLTRW5ITVJ?
HEL NV\mWmVnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTBwM{KyOEDPxE1? NUXiRWNWW0GQR1XS
OCI-AML2 NIe2cnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTBwM{KyPVgh|ryP NILj[HdUSU6JRWK=
A3-KAW M3TqdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnWTWM2OD1yLkOzOFc4KM7:TR?= M2jDXHNCVkeHUh?=
IGROV-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;nW3hZUUN3ME2wMlM{PzV3IN88US=> MWDTRW5ITVJ?
Mo-T NWCwTJRsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nQfWlEPTB;MD6zN|g2OyEQvF2= NGPJc5dUSU6JRWK=
HDLM-2 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7PSGVrUUN3ME2wMlM{QSEQvF2= NH;pRoVUSU6JRWK=
HCC1569 NWDqWXluT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFyybHNKSzVyPUCuN|Q{ODlizszN MWXTRW5ITVJ?
COLO-678 NHvYc3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjKe3JKSzVyPUCuN|cxODJizszN MYTTRW5ITVJ?
COR-L105 NV7ido45T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTBwM{e5N{DPxE1? M3\JbHNCVkeHUh?=
SK-MEL-24 M3zLTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTBwM{izPFIh|ryP MX;TRW5ITVJ?
COLO-320-HSR MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTBwNEO5O|Yh|ryP NWfnZo5VW0GQR1XS
C8166 NYHLcoZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTBwNEmwNlMh|ryP M3\EUnNCVkeHUh?=
COLO-679 NVLpV2htT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTBwNkKxO|Ih|ryP NHf6eWFUSU6JRWK=
TE-12 NHnsT2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXoTWM2OD1yLk[1N|k1KM7:TR?= NH\oSIpUSU6JRWK=
HAL-01 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoryTWM2OD1yLk[2NlIh|ryP NVTYfGpiW0GQR1XS
H-EMC-SS M1H0V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLaZ3lyUUN3ME2wMlcxPTR4IN88US=> Mkm1V2FPT0WU
SNU-449 NUjaRWFWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTMTWM2OD1yLkeyO|Q5KM7:TR?= MoKwV2FPT0WU
C32 MmD4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwN{SxNVIh|ryP MVnTRW5ITVJ?
K-562 M2XlR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTBwN{ewNlQh|ryP MYTTRW5ITVJ?
DJM-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTBwN{i3PFEh|ryP Mn2xV2FPT0WU
RCC10RGB NVfMbnVDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTBwN{mxPFMh|ryP MkXjV2FPT0WU
CAL-85-1 NGrMWIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\C[mVKSzVyPUCuPVA4KM7:TR?= MlriV2FPT0WU
NY MoPJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rIPWlEPTB;MD65N|M2OiEQvF2= MmXKV2FPT0WU
NCI-H1993 NHz0TIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HX[2lEPTB;MT6xPVI5QSEQvF2= Mn7mV2FPT0WU
SK-OV-3 NF75PWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfJbJlKSzVyPUGuNlIxQDlizszN NWrZZmYxW0GQR1XS

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
PIM1; 

PubMed: 18426800     


Cells were treated with 100 nm docetaxel for the indicated times. PIM1 and β-ACTIN proteins were analyzed by immunoblot analysis. One of three similar blots is shown. Ratio, ratio of PIM1/β-ACTIN from pooled densitometry data from three separate experimen䲧疝Ỵ疞㧀疜膉痘 瘿뾠ՂᾰƌՂĀ 㺣痖帉痖Ѐ瑖堘𢡄빢᎒ՂĀ鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ⟸෕䐺痖暼瘿⟸෕ᾰƌ

cyclin B; 

PubMed: 18426800     


Immunoblot analysis of cyclin B1 and PIM1 expression after docetaxel 10 nm (left) or 100 nm (right) treatment at various time points.

pSTAT3 / STAT3 ; 

PubMed: 18426800     


Immunoblots of RWPE-2 cells treated with 100 nm docetaxel for the indicated time.

p-p53 / p53; 

PubMed: 22996738     


C4-2 cells were treated with 5 nM docetaxel, the whole cell lysates were collected at different time points and subjected to Western blot.

18426800 22996738
Immunofluorescence
α-tubulin; 

PubMed: 27177833     


Noscapine has no effect on gross microtubule polymerization state but noscapine pre-sensitization followed by docetaxel treatment stabilizes microtubules, hence inhibits cell proliferation. TNBC cells were treated with noscapine (4 µM) or docetaxel (0.4 µ䲧疝Ỵ疞㧀疜膉痘 瘿⟸෕ᾰƌ෕Ð 㺣痖帉痖Ѐ瑖堘𢡄빢᎒෕Ð鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ뾠Ղ䐺痖暼瘿뾠Ղᾰƌ 뾠ՂÐ㺣痖뾠Ղ€𢡄뾤Ղ€䀷痗뾤Ղ౴뾤Ղ㵶痗뾤Ղ뺖᎒泌Itemセ᎒Count﫨呂뿔Ղ猴፲뾤Ղ፲씢痗猸፲髸莤䥷堙᎒セ᎒�堞ﻮ᎒፲露𢡄堚Ҕ齃礤v�堞ﻮ᎒猢Wセ᎒䨼Ą鹿齃殺獸W戀醙

cleaved PARP / cleaved caspase-3; 

PubMed: 21087597     


Immunofluorescence images of PC-3 cells treated with the docetaxel and EM011 schedule treatment. Cells were pretreated with docetaxel for 12 h before addition of EM011 and were fixed at 48 h post docetaxel treatment compared to treatment with EM011 (10 μM䲧疝Ỵ疞㧀疜膉痘 瘿⟸෕ᾰƌ෕Ð 㺣痖帉痖Ѐ瑖堘𢡄빢᎒෕Ð鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ�෋䐺痖暼瘿�෋ᾰƌ �෋à

Acetylated tubulin ; 

PubMed: 18426800     


Immunofluorescence of acetylated tubulin in cells treated with DMSO, 30 nM laulimalide and 30 nM docetaxel for 2.5 h. Tubulin shown in green and DAPI in blue, and the white arrow indicates microtubule bundling. Scale bar represents 10 μm.

SQSTM1 / LAMP1; 

PubMed: 29795139     


AGS cells were treated with docetaxel (10 nM) for 12 h. After immunostaining with SQSTM1 (Alexa Fluor 488, green) and LAMP1 (Alexa Fluor 594, red), cells were examined by fluorescence microscopy (scale bar 20 μm). The colocalization of SQSTM1and LAMP1 was䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 㺣痖帉痖Ѐ

27177833 21087597 18426800 29795139
Growth inhibition assay
Cell viability ; 

PubMed: 22996738     


Docetaxel inhibits the growth of LNCaP, C4-2, DU145, and PC3 prostate cancer cells. Cells were plated in 12-well plates and treated with different concentrations of docetaxel. The cell number was counted after 24 hr. 

22996738
In vivo Docetaxel (33 mg/kg/dose, given i.v. every 4 days for 3 injections) results in a tumor growth delay of 19.3 days in M2OL2 colon xenografts. Docetaxel also shows great antitumor activities in MX-1, SK-MEL-2, LX-1 and OVCAR-3 xenografts. Docetaxel inhibits the angiogenic response to fibroblast growth factor 2 with IC 50 of 5.4 mg/kg when injected twice weekly over a 14-day period, and angiogenesis is completely blocked in mice that receives 10 mg/kg Docetaxel. Docetaxel has selectivity for endothelial cell migration and/or microvessel formation because infiltration of inflammatory cells into the Matrigel plug is much less sensitive to inhibition by Docetaxel. [7]

Protocol

Cell Research:[5]
- Collapse
  • Cell lines: Human gastric cancer cell lines MKN-28
  • Concentrations: 6 nM
  • Incubation Time: 3 days
  • Method: 2000 cells in 180 μL of medium are seeded in a 96-well plate, and 20 μL of drug solution is simultaneously added in triplicate to each well. The plate is incubated for 3 days at 37°C in a humidified atmosphere of 5% CO2. On day 3, 25 μL of MTT reagent is added to each well. After 4 h of incubation, the medium is removed by aspiration. 0.2 mL of dimethylsulphoxide (DMSO) is added to each well and thoroughly mixed by using a mechanical plate mixer to dissolve the resulting MTT-formazan crystals. Absorbance at 540 nm (OD) is measured by a reader.
    (Only for Reference)
Animal Research:[6]
- Collapse
  • Animal Models: Human colon carcinomas xenografts CX-1
  • Dosages: 33 mg/kg
  • Administration: i.v. every 4 days for 3 injections
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (123.78 mM)
Water Insoluble
Ethanol ''53 mg/mL warmed
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 807.88
Formula

C43H53NO14

CAS No. 114977-28-5
Storage powder
in solvent
Synonyms RP56976, NSC 628503
Smiles CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04396535 Not yet recruiting Drug: Bintrafusp Alfa|Drug: Docetaxel Advanced Lung Non-Small Cell Carcinoma|Stage III Lung Cancer AJCC v8|Stage IIIA Lung Cancer AJCC v8|Stage IIIB Lung Cancer AJCC v8|Stage IIIC Lung Cancer AJCC v8|Stage IV Lung Cancer AJCC v8|Stage IVA Lung Cancer AJCC v8|Stage IVB Lung Cancer AJCC v8 Mayo Clinic|National Cancer Institute (NCI) December 1 2020 Phase 2
NCT04471675 Not yet recruiting Drug: Albumin-bound docetaxel Advanced Solid Tumors CSPC ZhongQi Pharmaceutical Technology Co. Ltd. November 15 2020 Phase 1
NCT04467801 Not yet recruiting Drug: Ipatasertib NSCLC Stage IV|NSCLC Stage IIIB University of Kansas Medical Center|University of Iowa|University of Kentucky August 2020 Phase 2
NCT04364620 Not yet recruiting Drug: AB-16B5|Drug: Docetaxel NSCLC Stage IV Alethia Biotherapeutics August 2020 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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