Docetaxel

Catalog No.S1148 Synonyms: RP56976, NSC 628503

Molecular Weight(MW): 807.88

Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.

Cited by 12 Publications

Cell, 2018, 174(5):1200-1215

PubMed: 30100187 ( click the link to review the publication )

Cancer Res, 2017, 77(12):3268-3279

PubMed: 28400477 ( click the link to review the publication )

Int J Cancer, 2015, 136(9):2065-77

PubMed: ( click the link to review the publication )

Oncogenesis, 2014, 3:e100

PubMed: 24752235 ( click the link to review the publication )

Mol Pharm, 2014, 11(7):2040-50

PubMed: 24779589 ( click the link to review the publication )

J Cell Mol Med, 2014, 18(5):811-23

PubMed: 24628949 ( click the link to review the publication )

Biochem Pharmacol, 2015, 10.1016/j.bcp.2015.05.005

PubMed: ( click the link to review the publication )

J Transl Med, 2013, 11:204

PubMed: 24004449 ( click the link to review the publication )

Prostate Cancer Prostatic Dis, 2016, 19(4):349-357

PubMed: 27349498 ( click the link to review the publication )

Prostate Cancer Prostatic Dis, 2016, 10.1038/pcan.2016.21

PubMed: 27349498 ( click the link to review the publication )

Biomed Pharmacother, 2018, 99:445-450

PubMed: 29665645 ( click the link to review the publication )

PLoS One, 2015, 10(4):e0123901

PubMed: 25875914 ( click the link to review the publication )

7 Customer Reviews

Immunohistochemistry and quantification of cleaved caspase 3 expression in DU145-DR tumor xenografts from (D). Scale bar, 100 mm. Data represent the mean ± SD. *p < 0.05.

Cell, 2018, 174(5):1200-1215. Docetaxel purchased from Selleck.

Viability of cells after exposure to 0, 10, or 10,000 nM docetaxel, assessed by calcein-AM staining (green, left panels) and ethidium homodimer-1 (red, middle panels).

Mol Pharmaceutics, 2014, 11: 2040−50. Docetaxel purchased from Selleck.
J Transl Med 2013 0.6. Docetaxel purchased from Selleck.

J Transl Med 2013 0.6. Docetaxel purchased from Selleck.
TNBC and non-TNBC cells were treated for 6 d with the specified concentrations of docetaxel (doc) alone, TTK inhibitor (TTKi) alone or the combinations. The survival of cells was measured using the MTS/MTA assay. ***P<0.001 comparing the combination with single agents and with non-TNBC cell lines.

Oncogenesis, 2014, 3: e100 . Docetaxel purchased from Selleck.

Cell cycle study of percent cell populations in various phases after treatment with vehicle, HCI-2509 in increasing concentrations and docetaxel alone and in combination with HCI-2509 using (a) PC3 cells. Student's unpaired t-tests, using GraphPad Prism software, were used to calculate two-tailed P-values for each experiment to determine statistical significance between untreated and treated samples. The statistically significant P-values are labeled in each figure with an asterisk. (Replicated two more times, representative graph shown).

Prostate Cancer Prostatic Dis, 2016, 19(4):349-357. Docetaxel purchased from Selleck.
Biomed Pharmacother, 2018, 99:445-450. Docetaxel purchased from Selleck.

Purity & Quality Control

Choose Selective Microtubule Associated Inhibitors

Biological Activity

Description

Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.

Targets

Microtubules ^[1]
(Cell-free assay)

In vitro

Docetaxel is a cytotoxic agent, especially for proliferating cells, which is related to its ability to promote the formation of microtubule bundles and induce sustained mitotic arrest, followed by apoptosis of mitotically arrested cells or permanent mitotic block. Docetaxel suppresses microtubule dynamic instability as well as tread-milling, resulting in the failure of chromosomes to segregate to the daughter cells, which in turn triggers premature exit from mitosis rather than a block at this phase of the cell cycle. ^[2] Docetaxel inhibits the clonogenic survival of Human cancer cell Hs746T (stomach), AGS (stomach), HeLa (cervix), CaSki (cervix), BxPC3 (pancreas), Capan-1 (pancreas) with IC50 of 1 nM, 1 nM, 0.3 nM, 0.3 nM, 0.3 nM and 0.3 nM respectively. ^[4] Docetaxel inhibits endothelial cell migration that does not affects microtubule gross morphology or inhibit cell proliferation, although they does produce more subtle effects on microtubule dynamics. Docetaxel inhibits HUVEC migration with an observed IC50 of 1 pM. HUVEC chemotaxis stimulated by either of two angiogenic factors, thymidine phosphorylase or VEGF, is inhibited by Docetaxel with IC 50 of 10 pM and is ablated at 1 nM. ^[7] Docetaxel induces human monocytes, but not RAW 264.7 murine macrophages, Prostaglandin H Synthase-2m (PGHS-2) expression. ^[8]

Cell Data

Cell Lines	Assay Type	Activity Description	PMID
HSC-3	NHrBU\|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NH3iWlZKSzVyPUCuNFAxOTN{IN88US=>	M4\menNCVkeHUh?=
5637	MkPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWrHfmxVUUN3ME2wMlAxODF2MzFOwG0>	NXHTe5NGW0GQR1XS
HT-144	MmDBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIPSSGZKSzVyPUCuNFAxOTV5IN88US=>	MlrrV2FPT0WU
NCI-H292	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWrRXJZ[UUN3ME2wMlAxODF3OTFOwG0>	MWTTRW5ITVJ?
HCE-T	NYLGeWFDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUHKVpU4UUN3ME2wMlAxODF4MjFOwG0>	M{n6RnNCVkeHUh?=
ESS-1	NIPSUolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3PMdGlEPTB;MD6wNFAyPzlizszN	NXjEenJKW0GQR1XS
D-566MG	NHntTYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYrJR\|UxRTBwMECwNVgzKM7:TR?=	M361W3NCVkeHUh?=
CAL-62	MlvQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYXYfHg5UUN3ME2wMlAxODF6NTFOwG0>	MmrnV2FPT0WU
GT3TKB	NHX6c5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHvHUmNKSzVyPUCuNFAxOjN{IN88US=>	MV3TRW5ITVJ?
HSC-4	M{j5O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1;RS2lEPTB;MD6wNFAzOzlizszN	NInlcI9USU6JRWK=
KOSC-2	NVvkSIZoT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYHSUYNHUUN3ME2wMlAxODJ3NTFOwG0>	MXjTRW5ITVJ?
NB14	NF\LWpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MULJR\|UxRTBwMECwNlYh\|ryP	NFy3TJNUSU6JRWK=
ES8	MnHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmTYTWM2OD1yLkCwNFI3KM7:TR?=	MkPQV2FPT0WU
BFTC-905	Mk[3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFn0PG5KSzVyPUCuNFAxOjZ6IN88US=>	M3m4dnNCVkeHUh?=
A498	M{TtR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUjJR\|UxRTBwMECwNlc5KM7:TR?=	NX;ibXFXW0GQR1XS
HO-1-N-1	NIPtfo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGPNS21KSzVyPUCuNFAxOjhzIN88US=>	M2G3TXNCVkeHUh?=
SF539	NE\M[mxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoXqTWM2OD1yLkCwNFMxOiEQvF2=	M17G[XNCVkeHUh?=
HuO-3N1	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWXQTGdNUUN3ME2wMlAxODNyMjFOwG0>	MlW1V2FPT0WU
NCI-H510A	NWTrT\|dmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXTSbY5YUUN3ME2wMlAxODN\|NjFOwG0>	NUjmb2J2W0GQR1XS
CAL-27	NVjIbpB5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MonOTWM2OD1yLkCwNFM{QSEQvF2=	MknMV2FPT0WU
TE-8	Mo\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUH5U5hoUUN3ME2wMlAxODN4NjFOwG0>	NUG1eogyW0GQR1XS
VA-ES-BJ	M3roNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3rJbGlEPTB;MD6wNFA{PzVizszN	NFP0fplUSU6JRWK=
RH-1	NHLSO5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGjnNZBKSzVyPUCuNFAxOzh4IN88US=>	M3;vXXNCVkeHUh?=
COLO-800	NGS2UVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NF7LNGNKSzVyPUCuNFAxOzh6IN88US=>	MV;TRW5ITVJ?
ES7	NILFWlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NY\5UGZ3UUN3ME2wMlAxODN6OTFOwG0>	M{jDW3NCVkeHUh?=
GAMG	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWr1RpBlUUN3ME2wMlAxODRzNjFOwG0>	MVzTRW5ITVJ?
Ca9-22	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkSwTWM2OD1yLkCwNFQzOyEQvF2=	NEjSU3BUSU6JRWK=
SBC-1	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlXBTWM2OD1yLkCwNFQ{KM7:TR?=	NV;GSodlW0GQR1XS
RPMI-7951	NXXCXGtpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEHOfWFKSzVyPUCuNFAxPDR6IN88US=>	MkDvV2FPT0WU
SW1710	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3;JeWlEPTB;MD6wNFA1PjZizszN	MUTTRW5ITVJ?
HGC-27	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MorKTWM2OD1yLkCwNFQ4OSEQvF2=	NXyxRlB1W0GQR1XS
MC-IXC	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M130XmlEPTB;MD6wNFA1PzlizszN	NH;ZXI5USU6JRWK=
FTC-133	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mn7ITWM2OD1yLkCwNFQ5QSEQvF2=	M4L0PXNCVkeHUh?=
HT-1080	M1zveWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnPCTWM2OD1yLkCwNFUxOSEQvF2=	MYPTRW5ITVJ?
NMC-G1	NEDp[odIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXv0NW1uUUN3ME2wMlAxODVzNzFOwG0>	M1HUSHNCVkeHUh?=
GI-1	MmfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mn[5TWM2OD1yLkCwNFUzQCEQvF2=	M1O5THNCVkeHUh?=
CGTH-W-1	MlzIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWm4TFZjUUN3ME2wMlAxODV2MjFOwG0>	MlT5V2FPT0WU
A2058	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHfHb45KSzVyPUCuNFAxPTR2IN88US=>	NGW4dJJUSU6JRWK=
ETK-1	M1Hwcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmPITWM2OD1yLkCwNFU2QCEQvF2=	NHjxO41USU6JRWK=
NEC8	MnjxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWLDfm16UUN3ME2wMlAxODV4MTFOwG0>	M1nyeHNCVkeHUh?=
TE-11	Mn3RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEHqb5RKSzVyPUCuNFAxPTZ7IN88US=>	M4DhNXNCVkeHUh?=
NCI-H720	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGnQVJpKSzVyPUCuNFAxPThizszN	NWW3dXQxW0GQR1XS
PSN1	M4XXVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3XifmlEPTB;MD6wNFA2QDFizszN	MXzTRW5ITVJ?
SW780	MmnmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2CwdmlEPTB;MD6wNFA2QDdizszN	M{XacXNCVkeHUh?=
8-MG-BA	MnznS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3rRNGlEPTB;MD6wNFA2QDlizszN	NXjIbmdkW0GQR1XS
EC-GI-10	NUX5OppFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1jJNmlEPTB;MD6wNFA2QTJizszN	M4H2dHNCVkeHUh?=
SJSA-1	NXiwdoR[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MU\JR\|UxRTBwMECwOlE2KM7:TR?=	NYfGXohLW0GQR1XS
639-V	NHLqWnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4nCc2lEPTB;MD6wNFA3PDdizszN	NH\X[3JUSU6JRWK=
PFSK-1	NHHtVYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkPjTWM2OD1yLkCwNFY2PyEQvF2=	NFTQbFlUSU6JRWK=
DMS-273	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NULhTnFsUUN3ME2wMlAxODZ5NDFOwG0>	M2TOb3NCVkeHUh?=
TE-9	MorWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXzudnRnUUN3ME2wMlAxODZ5NjFOwG0>	MXHTRW5ITVJ?
SCC-25	NWnDVpFrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXnJR\|UxRTBwMECwOlgh\|ryP	NWKxdodzW0GQR1XS
PA-1	M2HKfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NX3jUWRjUUN3ME2wMlAxODZ6NzFOwG0>	M1S1[3NCVkeHUh?=
MHH-ES-1	M{fFU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{PWVGlEPTB;MD6wNFA4KM7:TR?=	M4T3S3NCVkeHUh?=
Daoy	NXnPUoFMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHzmUI1KSzVyPUCuNFAxPyEQvF2=	Ml;vV2FPT0WU
G-402	NVTIdm46T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2XVc2lEPTB;MD6wNFA4ODZizszN	MkW4V2FPT0WU
YKG-1	MnraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWH3eVY2UUN3ME2wMlAxODdyNzFOwG0>	NWTZUmdvW0GQR1XS
Ca-Ski	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWPJR\|UxRTBwMECwO\|I5KM7:TR?=	MWXTRW5ITVJ?
CHP-212	M3TDd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWjJR\|UxRTBwMECwO\|Mh\|ryP	NF3rd5BUSU6JRWK=
SCC-4	MorrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHToOFhKSzVyPUCuNFAxPzN7IN88US=>	MWrTRW5ITVJ?
EW-3	M1;s[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHTsd2VKSzVyPUCuNFAxPzR3IN88US=>	NXnVbI9nW0GQR1XS
P12-ICHIKAWA	NUDVeVlGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXTR[XNrUUN3ME2wMlAxODd2NTFOwG0>	MUTTRW5ITVJ?
HSC-2	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIm4fXJKSzVyPUCuNFAxPzV3IN88US=>	MkLYV2FPT0WU
HN	NIjFepdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{TROWlEPTB;MD6wNFA4PThizszN	Mke1V2FPT0WU
LXF-289	M1KwVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUTlN\|FFUUN3ME2wMlAxODd3ODFOwG0>	NYH6dZNLW0GQR1XS
ES1	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mn21TWM2OD1yLkCwNFc4KM7:TR?=	MYTTRW5ITVJ?
NTERA-S-cl-D1	NUew[3R{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MW\JR\|UxRTBwMECwO\|c{KM7:TR?=	MX;TRW5ITVJ?
K5	NV;ycWtST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVzSfpN5UUN3ME2wMlAxODd5ODFOwG0>	NGjXfmRUSU6JRWK=
HOS	M1TLZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Ml21TWM2OD1yLkCwNFc5OiEQvF2=	M3zwb3NCVkeHUh?=
YH-13	MlPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4TwTWlEPTB;MD6wNFA4QTFizszN	MX3TRW5ITVJ?
SW954	M2SwSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnLqTWM2OD1yLkCwNFgzOyEQvF2=	MoHGV2FPT0WU
KYSE-510	M3jEN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M36zT2lEPTB;MD6wNFA5PCEQvF2=	M1nZb3NCVkeHUh?=
8505C	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2m1NWlEPTB;MD6wNFA5PTRizszN	MlnZV2FPT0WU
A549	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NH\mT5FKSzVyPUCuNFAxQDh{IN88US=>	MYfTRW5ITVJ?
Detroit562	M{\tVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmTZTWM2OD1yLkCwNFkxOiEQvF2=	NYPwWJFuW0GQR1XS
ES5	MmnUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NH7GT3hKSzVyPUCuNFAxQTFizszN	MlnXV2FPT0WU
KYSE-140	MnfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYHJR\|UxRTBwMECwPVM{KM7:TR?=	Mm\vV2FPT0WU
GMS-10	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYL6Z5dFUUN3ME2wMlAxODl2MTFOwG0>	MnrQV2FPT0WU
D-263MG	Mkn5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXrCc\|lUUUN3ME2wMlAxODl2NzFOwG0>	MWXTRW5ITVJ?
BCPAP	M3KxVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnPOTWM2OD1yLkCwNFk1PyEQvF2=	NI[z[29USU6JRWK=
CHL-1	M{TWb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYTIUYo6UUN3ME2wMlAxODl3ODFOwG0>	MX;TRW5ITVJ?
RKO	NV7Pd\|hCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MoX3TWM2OD1yLkCwNFk5QSEQvF2=	NHzhOnhUSU6JRWK=
SW48	NEnRcYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4S4O2lEPTB;MD6wNFExOSEQvF2=	NXX1N3lHW0GQR1XS
BPH-1	MmrxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWrJR\|UxRTBwMECxNFIh\|ryP	M4XB[3NCVkeHUh?=
EFO-27	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MorxTWM2OD1yLkCwNVAzKM7:TR?=	NXjoPZliW0GQR1XS
CAL-33	M1jDXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFjkbpdKSzVyPUCuNFAyODRizszN	NFLnUI1USU6JRWK=
NCI-H1792	MnTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3j0OGlEPTB;MD6wNFExPCEQvF2=	MlfmV2FPT0WU
BB30-HNC	NV\qSll1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXvK[Y9wUUN3ME2wMlAxOTB3IN88US=>	NHe3XVVUSU6JRWK=
VM-CUB-1	M3O1bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MV;JR\|UxRTBwMECxNFUh\|ryP	MlG1V2FPT0WU
TE-5	NU\xfFNDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUnZVJkyUUN3ME2wMlAxOTB4IN88US=>	M1nuVnNCVkeHUh?=
NB13	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUPzcGFWUUN3ME2wMlAxOTB5IN88US=>	MoLYV2FPT0WU
NBsusSR	NWPVPYN{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4K1VGlEPTB;MD6wNFEyKM7:TR?=	MVHTRW5ITVJ?
LNCaP-Clone-FGC	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NY\tO\|dwUUN3ME2wMlAxOTFizszN	M4P1N3NCVkeHUh?=
EPLC-272H	M1fiW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MojBTWM2OD1yLkCwNVEyKM7:TR?=	NF7KfHNUSU6JRWK=
KNS-62	MnO4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFLEb2ZKSzVyPUCuNFAyOTJizszN	NFSwPJRUSU6JRWK=
RERF-LC-MS	NH60d3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFjweY9KSzVyPUCuNFAyOTNizszN	M4LFfnNCVkeHUh?=
LOXIMVI	NFHJ[5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M32zeGlEPTB;MD6wNFEyPiEQvF2=	NV\LdmRMW0GQR1XS
KINGS-1	M1v2bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVLJR\|UxRTBwMECxNVch\|ryP	NH\VbotUSU6JRWK=
T98G	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2\l[WlEPTB;MD6wNFEyPyEQvF2=	NI[5UIZUSU6JRWK=
HCC1806	NIjLR\|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUjJR\|UxRTBwMECxNVgh\|ryP	M3H2ZnNCVkeHUh?=
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RT-112	NHzoU2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlTtTWM2OD1yLkCwNVE6KM7:TR?=	NHzXdmxUSU6JRWK=
LK-2	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MX;JR\|UxRTBwMECxNlEh\|ryP	MVTTRW5ITVJ?
A375	NHnYeFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlnCTWM2OD1yLkCwNVIyKM7:TR?=	NFjic49USU6JRWK=
SF268	MmHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWXJR\|UxRTBwMECxNlEh\|ryP	NUXzS\|dDW0GQR1XS
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KYSE-410	NYTGSXNxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXzJR\|UxRTBwMECxNlQh\|ryP	MWTTRW5ITVJ?
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CAMA-1	MoDWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Ml\3TWM2OD1yLkCwNVMyKM7:TR?=	M37m[XNCVkeHUh?=
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KYSE-180	M4\SeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUW1XZllUUN3ME2wMlAxOTN3IN88US=>	MV;TRW5ITVJ?
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HD-MY-Z	MojES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYribVBzUUN3ME2wMlAxOTRzIN88US=>	Ml;rV2FPT0WU
KYSE-450	NYrF[HRnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHeyUZZKSzVyPUCuNFAyPDNizszN	NYS2RopQW0GQR1XS
LCLC-97TM1	M4j1emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoPWTWM2OD1yLkCwNVQ1KM7:TR?=	M1nNb3NCVkeHUh?=
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TI-73	NWSx[FI5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1vlR2lEPTB;MD6wNFE1PCEQvF2=	M{DvW3NCVkeHUh?=
A427	Mo\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mn7CTWM2OD1yLkCwNVQ5KM7:TR?=	M1nsSXNCVkeHUh?=
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MG-63	NEDleJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVq2eIZGUUN3ME2wMlAxOTVzIN88US=>	M1LKe3NCVkeHUh?=
PANC-03-27	NVrSW5llT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYrJR\|UxRTBwMECxOVQh\|ryP	MmTLV2FPT0WU
23132-87	NXPQcm9PT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{nh[WlEPTB;MD6wNFE2PSEQvF2=	MlTGV2FPT0WU
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NCI-H1703	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkLwTWM2OD1yLkCwNVU4KM7:TR?=	NIqwdpZUSU6JRWK=
MCF7	M3OxcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4LGOmlEPTB;MD6wNFE3OSEQvF2=	M1LsPXNCVkeHUh?=
A172	Ml3CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVXYdWZHUUN3ME2wMlAxOTZ\|IN88US=>	MX3TRW5ITVJ?
CAL-39	M3q4[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4DzZ2lEPTB;MD6wNFE3OyEQvF2=	M1XsXnNCVkeHUh?=
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EW-11	NEnjSItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYHNdIN2UUN3ME2wMlAxOTZ7IN88US=>	NX7ZOYFOW0GQR1XS
D-336MG	NGXCWW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVvkXmVWUUN3ME2wMlAxOTZ7IN88US=>	NFfpfGNUSU6JRWK=
SW13	MoLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NY\wb2pNUUN3ME2wMlAxOTZ7IN88US=>	M2DteXNCVkeHUh?=
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EoL-1-cell	M1[yOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2LT[mlEPTB;MD6wNFE4OyEQvF2=	NIDEd3ZUSU6JRWK=
MV-4-11	MmXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWTJR\|UxRTBwMECxO\|Qh\|ryP	M1rnUnNCVkeHUh?=
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NCI-H526	NYXmOHdST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUjwUGdzUUN3ME2wMlAxOTd4IN88US=>	MW\TRW5ITVJ?
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DB	MnLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVfZe2JUUUN3ME2wMlAxOTd6IN88US=>	NWG0WFVTW0GQR1XS
GCT	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4\ueGlEPTB;MD6wNFE5KM7:TR?=	MlHoV2FPT0WU
HCT-116	NXz5ZZZHT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXnJR\|UxRTBwMECxPFEh\|ryP	NU\3RoM6W0GQR1XS
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KALS-1	Mn\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M170NWlEPTB;MD6wNFE5OSEQvF2=	NHPTUFhUSU6JRWK=
C2BBe1	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MofWTWM2OD1yLkCwNVgzKM7:TR?=	NFHZTZdUSU6JRWK=
Becker	MlzLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NH\yUVBKSzVyPUCuNFAyQDNizszN	NVnO[IZXW0GQR1XS
647-V	NGHGfndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUSwcJpnUUN3ME2wMlAxOTh2IN88US=>	MlzJV2FPT0WU
NCI-H2122	NFvOSo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYrJR\|UxRTBwMECxPFQh\|ryP	MVXTRW5ITVJ?
SBC-5	NFHNUJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NW\6OY13UUN3ME2wMlAxOTh5IN88US=>	M3vMR3NCVkeHUh?=
NB17	NGjzOXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NELsd2pKSzVyPUCuNFAyQDlizszN	M1nqSXNCVkeHUh?=
MHH-PREB-1	NEfFTHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4\4[mlEPTB;MD6wNFE5QSEQvF2=	NHrDTHpUSU6JRWK=
M14	MlXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlvpTWM2OD1yLkCwNVkyKM7:TR?=	MWHTRW5ITVJ?
NCI-H1048	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M33lOWlEPTB;MD6wNFE6OiEQvF2=	M3:xbHNCVkeHUh?=
CTB-1	Mn\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXWxc3hrUUN3ME2wMlAxOTl{IN88US=>	Mn3JV2FPT0WU
SK-PN-DW	Mn34S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2HsOmlEPTB;MD6wNFE6PCEQvF2=	NGfUblFUSU6JRWK=
H4	NEXnbIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mm\QTWM2OD1yLkCwNVk3KM7:TR?=	M3XPbXNCVkeHUh?=
NCI-SNU-1	MmfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUnzNnJxUUN3ME2wMlAxOTl5IN88US=>	MlGzV2FPT0WU
M059J	NFm4dGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmDiTWM2OD1yLkCwNVk5KM7:TR?=	M{fN[nNCVkeHUh?=
OVCAR-5	MljES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFvweGRKSzVyPUCuNFAyQTlizszN	MnWzV2FPT0WU
SK-MEL-28	NXfEOHFVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGrDN\|BKSzVyPUCuNFAzODNizszN	MXzTRW5ITVJ?
PC-14	M4fDb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXfJR\|UxRTBwMECyNFkh\|ryP	NGHvcpRUSU6JRWK=
OVCAR-8	MnLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWrJR\|UxRTBwMECyNVIh\|ryP	MoGyV2FPT0WU
BB49-HNC	MkTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4DQRWlEPTB;MD6wNFIyOiEQvF2=	MmjBV2FPT0WU
EFM-19	MkPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{XwSmlEPTB;MD6wNFIyPSEQvF2=	Mof1V2FPT0WU
BHY	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1u2[GlEPTB;MD6wNFIyPiEQvF2=	NF;WSoNUSU6JRWK=
SW756	MmnRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnjSTWM2OD1yLkCwNlE3KM7:TR?=	MonRV2FPT0WU
TE-1	NULoTpk2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3G4UGlEPTB;MD6wNFIyPiEQvF2=	MmO0V2FPT0WU
NCI-H2452	NYX4epZJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYizZZhPUUN3ME2wMlAxOjF4IN88US=>	MULTRW5ITVJ?
NCI-H1581	NVP2OHh[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWDJR\|UxRTBwMECyNVch\|ryP	NUPZ[2RCW0GQR1XS
COR-L23	NFjBXo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlHvTWM2OD1yLkCwNlIh\|ryP	Moe5V2FPT0WU
RXF393	NHLwSYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlTtTWM2OD1yLkCwNlIzKM7:TR?=	NVroeIhEW0GQR1XS
BFTC-909	NYjCPXQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUD5dIxVUUN3ME2wMlAxOjJ3IN88US=>	NFXmZ\|NUSU6JRWK=
IST-MEL1	NIrMWXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M37lPGlEPTB;MD6wNFIzPSEQvF2=	MYLTRW5ITVJ?
NCI-H650	NFzWcnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3\2ZWlEPTB;MD6wNFIzPSEQvF2=	M2jWVXNCVkeHUh?=
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GOTO	NF:ySW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHf3cZJKSzVyPUCuNFAzOjdizszN	MnnGV2FPT0WU
TYK-nu	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYH0XIpXUUN3ME2wMlAxOjN{IN88US=>	NH\5cGZUSU6JRWK=
JVM-3	M1vBbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXXJR\|UxRTBwMECyN\|Mh\|ryP	MWXTRW5ITVJ?
SK-MES-1	NVvOfWl3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MorCTWM2OD1yLkCwNlM{KM7:TR?=	MVTTRW5ITVJ?
SK-HEP-1	NGjn[4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmTOTWM2OD1yLkCwNlM1KM7:TR?=	NVHYc21FW0GQR1XS
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A673	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlPjTWM2OD1yLkCwNlM2KM7:TR?=	M1fXUnNCVkeHUh?=
NCI-H446	MoDBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M33vTWlEPTB;MD6wNFI1OyEQvF2=	NFfzNoVUSU6JRWK=
RPMI-2650	NXuwb2hUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MV\JR\|UxRTBwMECyOFYh\|ryP	NWPGXmlIW0GQR1XS
HCE-4	Mn7MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVq4b5oyUUN3ME2wMlAxOjR5IN88US=>	M1rIeHNCVkeHUh?=
KGN	NEXUXVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIq0eXhKSzVyPUCuNFAzPDdizszN	MUDTRW5ITVJ?
U251	NX\oNlg6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1TsdWlEPTB;MD6wNFI2KM7:TR?=	Mn75V2FPT0WU
BxPC-3	M{LGb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWLJR\|UxRTBwMECyOVEh\|ryP	M{TMOHNCVkeHUh?=
VMRC-RCZ	M3HjTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlrUTWM2OD1yLkCwNlUzKM7:TR?=	NXzxWYpVW0GQR1XS
TE-10	Mo\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVLJR\|UxRTBwMECyOVQh\|ryP	Mo\VV2FPT0WU
OC-314	MnrHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYDJR\|UxRTBwMECyOVYh\|ryP	MmTOV2FPT0WU
NCI-H1437	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NF:0OnhKSzVyPUCuNFAzPiEQvF2=	MYrTRW5ITVJ?
SNU-387	NUHUfpdmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MoDpTWM2OD1yLkCwNlYyKM7:TR?=	Mn\VV2FPT0WU
A388	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIjSS\|RKSzVyPUCuNFAzPjVizszN	NH\IfZFUSU6JRWK=
C-33-A	NW\hNZFnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEjTcXdKSzVyPUCuNFAzPjZizszN	M36yXHNCVkeHUh?=
CAL-51	NFrzWlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NW\5cGNZUUN3ME2wMlAxOjdzIN88US=>	NGLtdHpUSU6JRWK=
Hs-578-T	MmnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXTYZox[UUN3ME2wMlAxOjd{IN88US=>	NUXMZ49tW0GQR1XS
MDA-MB-415	NXzDUVZ4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnzITWM2OD1yLkCwNlc1KM7:TR?=	NWGwc5VWW0GQR1XS
SW1417	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{\wZmlEPTB;MD6wNFI4PiEQvF2=	NXTJUItTW0GQR1XS
HCC70	M1nDRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUPJR\|UxRTBwMECyO\|ch\|ryP	NVrDS3BIW0GQR1XS
ES3	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mn\FTWM2OD1yLkCwNlc4KM7:TR?=	MmqxV2FPT0WU
KYSE-270	NX2xVFhzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVmxRlVsUUN3ME2wMlAxOjd6IN88US=>	NEDaWZFUSU6JRWK=
HT-29	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NICye4ZKSzVyPUCuNFAzQCEQvF2=	MVfTRW5ITVJ?
MDA-MB-361	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2rvZmlEPTB;MD6wNFI5OSEQvF2=	MXfTRW5ITVJ?
RPMI-8866	NYnGbndMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmnaTWM2OD1yLkCwNlgyKM7:TR?=	M1;YRXNCVkeHUh?=
JEG-3	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MULJR\|UxRTBwMECyPFIh\|ryP	MmHjV2FPT0WU
HT-3	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NID3ZodKSzVyPUCuNFAzQDJizszN	NXq3epJGW0GQR1XS
HTC-C3	Mn:3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEjFXIlKSzVyPUCuNFAzQDVizszN	NEDPVXJUSU6JRWK=
NCI-H209	MkTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mn\STWM2OD1yLkCwNlg3KM7:TR?=	MoLRV2FPT0WU
SKG-IIIa	NXLtO2dGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXTJR\|UxRTBwMECyPFYh\|ryP	MojaV2FPT0WU
SW962	NG\FXFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFL3[mhKSzVyPUCuNFAzQTNizszN	NVzoXpo3W0GQR1XS
LCLC-103H	NH3TWFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlTFTWM2OD1yLkCwNlk{KM7:TR?=	NHzSNYlUSU6JRWK=
DOK	M2r6fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnX2TWM2OD1yLkCwNlk1KM7:TR?=	MU\TRW5ITVJ?
SW1088	MonPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEPHeVZKSzVyPUCuNFAzQTVizszN	MXLTRW5ITVJ?
GP5d	M2PTTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1XTOGlEPTB;MD6wNFI6PiEQvF2=	NVXQcmJ5W0GQR1XS
EW-1	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MknjTWM2OD1yLkCwNlk5KM7:TR?=	MknpV2FPT0WU
CP66-MEL	MnnIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWLJR\|UxRTBwMECzJO69VQ>?	MkDsV2FPT0WU
DEL	NUK1[IpOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWf4Wo1OUUN3ME2wMlAxOzBzIN88US=>	MknUV2FPT0WU
DU-4475	NHnpRnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIfBU\|FKSzVyPUCuNFA{ODJizszN	M4fhO3NCVkeHUh?=
HEC-1	NF\OO3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVntWW9mUUN3ME2wMlAxOzB\|IN88US=>	NFOyWXFUSU6JRWK=
U031	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVTJR\|UxRTBwMECzNFch\|ryP	NYTtU3BuW0GQR1XS
BB65-RCC	NELzRo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFXvdINKSzVyPUCuNFA{ODhizszN	NEXvWXBUSU6JRWK=
NUGC-3	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{\XPGlEPTB;MD6wNFMxQCEQvF2=	Mm[5V2FPT0WU
IST-SL1	NVPUc2luT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmHuTWM2OD1yLkCwN\|EzKM7:TR?=	MmPnV2FPT0WU
LS-411N	NFfXfWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUfJR\|UxRTBwMECzNVQh\|ryP	MorCV2FPT0WU
22RV1	Mm\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MljiTWM2OD1yLkCwN\|E2KM7:TR?=	NXjLU3hZW0GQR1XS
MKN28	M1XGc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnPoTWM2OD1yLkCwN\|E4KM7:TR?=	MljFV2FPT0WU
ONS-76	NGSxe\|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWjZeYxoUUN3ME2wMlAxOzJ{IN88US=>	NV:5TowzW0GQR1XS
SH-4	NYPzTWd3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVfJR\|UxRTBwMECzNlIh\|ryP	NHHkb4JUSU6JRWK=
MIA-PaCa-2	MoHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mmi4TWM2OD1yLkCwN\|I1KM7:TR?=	M371fnNCVkeHUh?=
CaR-1	MmXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWPJR\|UxRTBwMECzNlch\|ryP	NW\p[IU2W0GQR1XS
AGS	M4LXTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXXJR\|UxRTBwMECzNlgh\|ryP	MoXOV2FPT0WU
SF126	NYGxPFQ{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkixTWM2OD1yLkCwN\|I6KM7:TR?=	MV\TRW5ITVJ?
UACC-62	M4HiWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1TyemlEPTB;MD6wNFM{KM7:TR?=	MVzTRW5ITVJ?
NCI-H28	NYfURWxWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHftOFhKSzVyPUCuNFA{OzRizszN	NVHTRpZEW0GQR1XS
A2780	MkH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWTJR\|UxRTBwMECzN\|Uh\|ryP	NEjLNnJUSU6JRWK=
CTV-1	NHPJbG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4LYWmlEPTB;MD6wNFM{PyEQvF2=	M1f1e3NCVkeHUh?=
LC-2-ad	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MX\JR\|UxRTBwMECzOEDPxE1?	M2PibXNCVkeHUh?=
NCI-H1770	MkjoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmKwTWM2OD1yLkCwN\|QzKM7:TR?=	MnLMV2FPT0WU
HuO9	MnPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFnQcmtKSzVyPUCuNFA{PDZizszN	M1LRZnNCVkeHUh?=
U-266	NFnZc3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NE\xRlBKSzVyPUCuNFA{PDhizszN	MmDaV2FPT0WU
MLMA	NHzOVWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NH:4THlKSzVyPUCuNFA{PTVizszN	M4[0fHNCVkeHUh?=
U-87-MG	MlzDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmDWTWM2OD1yLkCwN\|U2KM7:TR?=	NILXb4VUSU6JRWK=
GI-ME-N	M2XoO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4\CdmlEPTB;MD6wNFM2QCEQvF2=	M2f2fXNCVkeHUh?=
HL-60	MnzQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVLJR\|UxRTBwMECzOVkh\|ryP	M{iySXNCVkeHUh?=
EGI-1	NUXMfFRDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1i5fGlEPTB;MD6wNFM3OiEQvF2=	MofTV2FPT0WU
NCI-H23	NELDb45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXj1SopKUUN3ME2wMlAxOzZ2IN88US=>	NGHSdWtUSU6JRWK=
NCI-H226	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnfvTWM2OD1yLkCwN\|Y5KM7:TR?=	MVfTRW5ITVJ?
NCI-H520	M4\zPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mlv6TWM2OD1yLkCwN\|czKM7:TR?=	MXvTRW5ITVJ?
L-363	NF7FUotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXWyc\|c1UUN3ME2wMlAxOzd4IN88US=>	MWPTRW5ITVJ?
CAL-12T	NWK5PWtnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVqxW4xVUUN3ME2wMlAxOzd4IN88US=>	MYLTRW5ITVJ?
BT-20	M2WwNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4PjUmlEPTB;MD6wNFM4PiEQvF2=	NUP4VlZFW0GQR1XS
SNB75	M2L4fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYK4S3d7UUN3ME2wMlAxOzhzIN88US=>	MXvTRW5ITVJ?
A4-Fuk	NH3ud3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUHhZlVyUUN3ME2wMlAxOzlizszN	NYrr[I5{W0GQR1XS
BE-13	MkX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmfNTWM2OD1yLkCwN\|k{KM7:TR?=	MULTRW5ITVJ?
NCI-H1395	MlXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NH:wU2NKSzVyPUCuNFA{QTZizszN	NGH1N4pUSU6JRWK=
SW620	NGPn[FNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFfNSVBKSzVyPUCuNFA{QTdizszN	MnS3V2FPT0WU
KNS-81-FD	NHLW[lFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEjTcJNKSzVyPUCuNFA{QTlizszN	NI\uRXVUSU6JRWK=
RD	NEDoe3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mnv0TWM2OD1yLkCwOEDPxE1?	MWTTRW5ITVJ?
HLE	NVP1Rmc3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVvEUFZzUUN3ME2wMlAxPDB3IN88US=>	NI\MeZFUSU6JRWK=
OVCAR-3	MkLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYfvTHY5UUN3ME2wMlAxPDB5IN88US=>	M2PLS3NCVkeHUh?=
KM12	M3zlcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWnUTlE2UUN3ME2wMlAxPDB6IN88US=>	NGXFfVlUSU6JRWK=
HCC2998	M1vPZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NU\5flZCUUN3ME2wMlAxPDB6IN88US=>	NFH6[5JUSU6JRWK=
D-502MG	NV24TIwzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVjIVpROUUN3ME2wMlAxPDFizszN	M4f1[nNCVkeHUh?=
KNS-42	MonJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVHvSoM3UUN3ME2wMlAxPDF{IN88US=>	MXjTRW5ITVJ?
LS-123	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFT5UlFKSzVyPUCuNFA1OjVizszN	MVjTRW5ITVJ?
SiHa	MojGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYnmR\|cyUUN3ME2wMlAxPDNizszN	NED0SW1USU6JRWK=
T47D	M2C2WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGHHOnJKSzVyPUCuNFA1OzFizszN	NEXicpVUSU6JRWK=
EW-24	MnnnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NH;QfmtKSzVyPUCuNFA1OzNizszN	NUTMTJl3W0GQR1XS
CAL-120	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NX73SoRwUUN3ME2wMlAxPDN3IN88US=>	NYjOTVl{W0GQR1XS
JAR	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUL0OW4zUUN3ME2wMlAxPDN5IN88US=>	MWrTRW5ITVJ?
QIMR-WIL	MkHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4DxWGlEPTB;MD6wNFQ{QCEQvF2=	NGL6dXdUSU6JRWK=
OCUB-M	M{DmNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NULBN4V4UUN3ME2wMlAxPDN6IN88US=>	MlPaV2FPT0WU
Calu-6	MmDlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlTQTWM2OD1yLkCwOFQ4KM7:TR?=	M2rkbnNCVkeHUh?=
MDA-MB-453	M136SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1jzOWlEPTB;MD6wNFQ2OSEQvF2=	M4\QVXNCVkeHUh?=
MKN45	NXXSVnM2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MonKTWM2OD1yLkCwOFU{KM7:TR?=	NYDCXnZMW0GQR1XS
ECC10	M3e5TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYTkVnBTUUN3ME2wMlAxPDZizszN	NWX2fmk4W0GQR1XS
RVH-421	M361Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mm[2TWM2OD1yLkCwOFYyKM7:TR?=	NHjhb21USU6JRWK=
TGBC11TKB	MnnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3jpXWlEPTB;MD6wNFQ3QSEQvF2=	NXPlT21lW0GQR1XS
MOLT-4	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFnGXlJKSzVyPUCuNFA1PzFizszN	MX\TRW5ITVJ?
LN-405	MnXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmDxTWM2OD1yLkCwOFgzKM7:TR?=	MYXTRW5ITVJ?
S-117	NFrZ[HpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVHJR\|UxRTBwMEC0PFYh\|ryP	M{fhXXNCVkeHUh?=
RPMI-8226	NIX5ToVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWjJR\|UxRTBwMEC0PVch\|ryP	NGe0WWNUSU6JRWK=
KYSE-150	MknLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoLVTWM2OD1yLkCwOFk6KM7:TR?=	NGLiTXFUSU6JRWK=
NCI-H1666	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFXHO2xKSzVyPUCuNFA2ODVizszN	MnjYV2FPT0WU
Mewo	MmjzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHu5XmxKSzVyPUCuNFA2ODVizszN	MX3TRW5ITVJ?
AN3-CA	M2DU[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYXJR\|UxRTBwMEC1NFch\|ryP	NFvzWmpUSU6JRWK=
COLO-680N	M{nwT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWjJR\|UxRTBwMEC1NFgh\|ryP	NWjHc\|VCW0GQR1XS
FADU	NFvQfpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoXiTWM2OD1yLkCwOVEh\|ryP	M{jCd3NCVkeHUh?=
GB-1	Mo\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkjaTWM2OD1yLkCwOVEyKM7:TR?=	NWKweHVRW0GQR1XS
KASUMI-1	NYW4bVVQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWW3c5c1UUN3ME2wMlAxPTFzIN88US=>	MVHTRW5ITVJ?
NOMO-1	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFfONI9KSzVyPUCuNFA2OTNizszN	NEHsOoZUSU6JRWK=
BV-173	NYHlTXhDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYrJR\|UxRTBwMEC1N{DPxE1?	MWHTRW5ITVJ?
RO82-W-1	M3XPPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4LueGlEPTB;MD6wNFU{OSEQvF2=	MXTTRW5ITVJ?
LB2241-RCC	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGHReGdKSzVyPUCuNFA2OzFizszN	M4\We3NCVkeHUh?=
NCI-H2170	M1v5dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXvMT5BkUUN3ME2wMlAxPTN3IN88US=>	NY\GdWg4W0GQR1XS
SK-N-AS	MnTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{PJWmlEPTB;MD6wNFU{PSEQvF2=	NVexZ3F4W0GQR1XS
NCI-H1651	NHz5T5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MX7JR\|UxRTBwMEC1OEDPxE1?	NXvlUJZwW0GQR1XS
NCI-SNU-5	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1i2XWlEPTB;MD6wNFU1PSEQvF2=	NETMRmRUSU6JRWK=
SN12C	M3;WXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{K2dWlEPTB;MD6wNFU2KM7:TR?=	NH\FVWpUSU6JRWK=
KY821	NUHtW\|NvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mn7HTWM2OD1yLkCwOVUyKM7:TR?=	MUjTRW5ITVJ?
SW1573	M1qweGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkHxTWM2OD1yLkCwOVU1KM7:TR?=	NEm4XGFUSU6JRWK=
OE19	M3HTXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Ml\NTWM2OD1yLkCwOVU6KM7:TR?=	M3\DNXNCVkeHUh?=
MPP-89	MmDGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkLTTWM2OD1yLkCwOVY4KM7:TR?=	MXzTRW5ITVJ?
HuCCT1	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MV\JR\|UxRTBwMEC1Olgh\|ryP	NVP4dYNsW0GQR1XS
SW1783	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmDUTWM2OD1yLkCwOVch\|ryP	MWjTRW5ITVJ?
8305C	MnvyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWPJR\|UxRTBwMEC1O\|Yh\|ryP	NEPQc45USU6JRWK=
OVCAR-4	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUHJR\|UxRTBwMEC1PFYh\|ryP	NGrUclZUSU6JRWK=
MMAC-SF	NXjPb3BiT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4HoS2lEPTB;MD6wNFU5PiEQvF2=	M1HwXnNCVkeHUh?=
COLO-824	NGTlZlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWjnOGtnUUN3ME2wMlAxPTlizszN	MYnTRW5ITVJ?
HCC38	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWjJR\|UxRTBwMEC2JO69VQ>?	NVuwR5hHW0GQR1XS
NCI-H1648	M4m0S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYfNb3JKUUN3ME2wMlAxPjBzIN88US=>	MVvTRW5ITVJ?
NCI-H1573	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUnzT5lRUUN3ME2wMlAxPjB5IN88US=>	NHTXNllUSU6JRWK=
MFM-223	M3HwWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEnJUINKSzVyPUCuNFA3OTZizszN	MXfTRW5ITVJ?
NCI-H810	M2HYcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3LCNWlEPTB;MD6wNFYzOiEQvF2=	MXHTRW5ITVJ?
EM-2	M3z0fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3PxO2lEPTB;MD6wNFYzOyEQvF2=	NIrIOINUSU6JRWK=
D-283MED	M17wWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXjJR\|UxRTBwMEC2NlQh\|ryP	M3myenNCVkeHUh?=
NCI-H1755	M4\1U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoS3TWM2OD1yLkCwOlI1KM7:TR?=	NXyzV\|FyW0GQR1XS
KYSE-70	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGTReXhKSzVyPUCuNFA3OjRizszN	MkLjV2FPT0WU
SW626	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHjabY9KSzVyPUCuNFA3OjRizszN	NWL1bmN3W0GQR1XS
WM-115	M3fTbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFXhU\|hKSzVyPUCuNFA3OjdizszN	NWLqbYJDW0GQR1XS
NB69	NYXqPGlNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mn;jTWM2OD1yLkCwOlI6KM7:TR?=	MomzV2FPT0WU
DOHH-2	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MoDjTWM2OD1yLkCwOlMh\|ryP	NFLHPG9USU6JRWK=
MEL-JUSO	M36xcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoXvTWM2OD1yLkCwOlM6KM7:TR?=	NUja[FhEW0GQR1XS
IGR-1	NHnyTWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NX\sc2lUUUN3ME2wMlAxPjRzIN88US=>	NUHLUJZzW0GQR1XS
ACN	NEfxWm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXrJR\|UxRTBwMEC2OFQh\|ryP	MmDXV2FPT0WU
KARPAS-45	MkPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4faZWlEPTB;MD6wNFY2OiEQvF2=	MmfQV2FPT0WU
HC-1	NHfycpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkjuTWM2OD1yLkCwOlU3KM7:TR?=	NGfGboVUSU6JRWK=
MZ2-MEL	NH\oVYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MY\JR\|UxRTBwMEC2OVgh\|ryP	NG\6OlJUSU6JRWK=
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NCI-H727	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHXVdGVKSzVyPUCuNFI1PzRizszN	M33ITHNCVkeHUh?=
NCI-H1155	NVu4bIp4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGHiNFZKSzVyPUCuNFI1PzdizszN	NHjtWGVUSU6JRWK=
GCIY	MmX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3nxV2lEPTB;MD6wNlUxOiEQvF2=	NVHsN5g3W0GQR1XS
MKN1	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{[xbWlEPTB;MD6wNlU4PiEQvF2=	M1\QZnNCVkeHUh?=
NCI-H1092	NHPXeJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MojlTWM2OD1yLkCyOlU1KM7:TR?=	NGWxfohUSU6JRWK=
RMG-I	MnrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVnJR\|UxRTBwMEK3JO69VQ>?	NWi0S5dNW0GQR1XS
NB12	NFPXXXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHzJbopKSzVyPUCuNFI4OiEQvF2=	NYC5cXVKW0GQR1XS
RCM-1	NELMSGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXXpSWo2UUN3ME2wMlAzQDF7IN88US=>	M1vvbXNCVkeHUh?=
C3A	NUHwTnBUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUD4W5Y4UUN3ME2wMlAzQDJ{IN88US=>	M3\R[3NCVkeHUh?=
NCI-H747	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MY\JR\|UxRTBwMEK4N\|ch\|ryP	MmftV2FPT0WU
LB771-HNC	NYrSe2wzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUjJR\|UxRTBwMEK4N\|ch\|ryP	MV\TRW5ITVJ?
EW-13	NX3Ie5ZPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NV7yboxPUUN3ME2wMlAzQTB2IN88US=>	M3\hWnNCVkeHUh?=
CAL-72	NITvfZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEHxUodKSzVyPUCuNFI6OThizszN	NVfaVo9KW0GQR1XS
HH	Mn;ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUi1c2h2UUN3ME2wMlAzQTl6IN88US=>	MoTpV2FPT0WU
UACC-257	NYHFc4VST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mk\UTWM2OD1yLkCzNFMh\|ryP	NFfOXm5USU6JRWK=
OAW-42	M3Twdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWnD[\|ZGUUN3ME2wMlA{ODNizszN	NYPETndmW0GQR1XS
CAPAN-1	NXrwfndtT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXXycHl6UUN3ME2wMlA{ODV{IN88US=>	MkXMV2FPT0WU
SNU-C2B	M{nZdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MULJR\|UxRTBwMEOwOlMh\|ryP	NHL2bHlUSU6JRWK=
NKM-1	MnjHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXjJR\|UxRTBwMEOxOlkh\|ryP	MVHTRW5ITVJ?
GR-ST	NW\VdWJ[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MoftTWM2OD1yLkCzNVg2KM7:TR?=	NXLXUIc{W0GQR1XS
SW1463	NUnrXGhmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWTTSmF5UUN3ME2wMlA{OzN5IN88US=>	NHrOPFdUSU6JRWK=
MEL-HO	NISwSYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NI\1VIZKSzVyPUCuNFM1OjFizszN	MVHTRW5ITVJ?
NCI-H2342	MlvES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2\QNGlEPTB;MD6wN\|Y{OyEQvF2=	MoSyV2FPT0WU
ACHN	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NF20XpdKSzVyPUCuNFM4OSEQvF2=	NIrSUYZUSU6JRWK=
RH-18	MorpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4e1WGlEPTB;MD6wN\|c3OyEQvF2=	M3q3SHNCVkeHUh?=
HCC2218	M4Dhb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnPSTWM2OD1yLkCzO\|kh\|ryP	M2PCe3NCVkeHUh?=
OS-RC-2	NYP1RZpvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYDJR\|UxRTBwMEO4Olkh\|ryP	NFLUTpVUSU6JRWK=
KP-N-YN	M2Dxemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVfSU3lxUUN3ME2wMlA{QDd4IN88US=>	MknlV2FPT0WU
COLO-668	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3Hn[WlEPTB;MD6wN\|g5PyEQvF2=	NF2xWWJUSU6JRWK=
LU-65	NULSTWllT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIrJeZRKSzVyPUCuNFM6ODRizszN	Mk\hV2FPT0WU
NB6	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4Hp[GlEPTB;MD6wN\|k2OiEQvF2=	MW\TRW5ITVJ?
HT	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUfsPXhYUUN3ME2wMlA1ODB5IN88US=>	NYm0[mlLW0GQR1XS
COLO-684	MlO4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWjrXnRFUUN3ME2wMlA1ODl3IN88US=>	M4q1[XNCVkeHUh?=
NCI-H1693	NIHQSJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NU\kbHJZUUN3ME2wMlA1OzB3IN88US=>	M3fje3NCVkeHUh?=
LAN-6	Ml7LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWDJR\|UxRTBwMESzN\|Uh\|ryP	M33ZfnNCVkeHUh?=
MDA-MB-175-VII	MkLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWPJR\|UxRTBwMES0NVch\|ryP	M{fXXXNCVkeHUh?=
KMOE-2	NHTuSnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVew[o1GUUN3ME2wMlA1PDZ7IN88US=>	MXHTRW5ITVJ?
DMS-79	MlTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIjGWYVKSzVyPUCuNFQ2PzlizszN	M3:xUHNCVkeHUh?=
MHH-NB-11	M3TzNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnnETWM2OD1yLkC0OlE1KM7:TR?=	Mk\DV2FPT0WU
NCI-H69	NV\TeYtrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIXu[ZFKSzVyPUCuNFQ5PDlizszN	MVfTRW5ITVJ?
KE-37	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3HiemlEPTB;MD6wOVAyKM7:TR?=	MoHUV2FPT0WU
Ramos-2G6-4C10	NVWxWHlyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXHJR\|UxRTBwMEWwOlch\|ryP	MXzTRW5ITVJ?
NCI-H1793	MmfFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmPmTWM2OD1yLkC1NFk{KM7:TR?=	M3exdXNCVkeHUh?=
HT-1376	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NV7acYZzUUN3ME2wMlA2OTh4IN88US=>	NX7UenZ3W0GQR1XS
EKVX	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGfjW4tKSzVyPUCuNFU{QDRizszN	NEHCRoZUSU6JRWK=
Capan-2	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlP6TWM2OD1yLkC1N\|k3KM7:TR?=	MnLyV2FPT0WU
DoTc2-4510	MmXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYTjeotZUUN3ME2wMlA2PDR4IN88US=>	NHvR[HRUSU6JRWK=
UACC-893	NH;CbYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mm[wTWM2OD1yLkC1OFYzKM7:TR?=	M{nsR3NCVkeHUh?=
SK-MEL-3	NFHtOXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXnJR\|UxRTBwMEW3PFgh\|ryP	MkXCV2FPT0WU
SK-MEL-1	M13t[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWKwb3BRUUN3ME2wMlA2QCEQvF2=	MXzTRW5ITVJ?
SW948	NVzJSGtPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmPsTWM2OD1yLkC1PVk3KM7:TR?=	NYjzepNJW0GQR1XS
P30-OHK	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYHj[ZRjUUN3ME2wMlA3OTZ5IN88US=>	NEnpWodUSU6JRWK=
NH-12	MkXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NX;oPHlsUUN3ME2wMlA3OjR2IN88US=>	MnziV2FPT0WU
KU-19-19	MljZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mlq0TWM2OD1yLkC2N\|YyKM7:TR?=	M4DU[nNCVkeHUh?=
A431	NFzRZW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUPO[GRPUUN3ME2wMlA3Ozd2IN88US=>	NWqwNXk1W0GQR1XS
NCI-H2405	M2DIVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYG4SWVjUUN3ME2wMlA3Ozh\|IN88US=>	MnrOV2FPT0WU
KARPAS-299	MoLHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYHMVXJlUUN3ME2wMlA3PTh{IN88US=>	MV3TRW5ITVJ?
BALL-1	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MX;JR\|UxRTBwME[2O\|Qh\|ryP	MWXTRW5ITVJ?
KURAMOCHI	NGXtbVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mor6TWM2OD1yLkC3NFc{KM7:TR?=	NU\xNFJEW0GQR1XS
LS-1034	NVnxUotCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVrJR\|UxRTBwMEezOlkh\|ryP	M4rmcHNCVkeHUh?=
MFE-280	NEG3XWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{PuOmlEPTB;MD6wO\|U{PiEQvF2=	MYjTRW5ITVJ?
HOP-62	NYr0bY9iT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MV3JR\|UxRTBwMEe2O\|Yh\|ryP	MmK3V2FPT0WU
KG-1	NX\uSGdlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIjwOHhKSzVyPUCuNFc4QDdizszN	NFrKUVhUSU6JRWK=
CW-2	NYrmXGVWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mme5TWM2OD1yLkC3PFMzKM7:TR?=	NI\lb\|RUSU6JRWK=
SW837	M33jUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3La[mlEPTB;MD6wPFM1OiEQvF2=	MkjxV2FPT0WU
MFH-ino	NXnMUVdiT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlXkTWM2OD1yLkC4OVAyKM7:TR?=	NWrleWMzW0GQR1XS
HCC1419	NXfae3VvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYXlSWlSUUN3ME2wMlA5QTh5IN88US=>	NVvHeVNTW0GQR1XS
HMV-II	NIDVbVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXPLcotiUUN3ME2wMlA6ODFizszN	NH;4UY1USU6JRWK=
BEN	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVnJR\|UxRTBwMEmzPFUh\|ryP	MXXTRW5ITVJ?
SK-N-FI	NIPLdZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlfSTWM2OD1yLkC5OVU3KM7:TR?=	MUPTRW5ITVJ?
JVM-2	NIrsemVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIjIXnBKSzVyPUCuNFk4OTZizszN	NF76O5VUSU6JRWK=
CAL-54	M3Xi[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXfPRY1JUUN3ME2wMlExODRizszN	NXT5T4V2W0GQR1XS
T84	MlHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2D6OGlEPTB;MD6xNFk2OiEQvF2=	NXOzW5NNW0GQR1XS
SHP-77	NFPuPIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NX;Z[4l{UUN3ME2wMlEyPjRzIN88US=>	M1HPe3NCVkeHUh?=
G-361	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlLGTWM2OD1yLkGyN\|I1KM7:TR?=	NYCzSXlZW0GQR1XS
Calu-3	M4LwVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NH7tdHZKSzVyPUCuNVM5OTZizszN	M4m5UXNCVkeHUh?=
HCC1937	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUHQXW05UUN3ME2wMlE1QTN5IN88US=>	NVTUfot1W0GQR1XS
KM-H2	M3T1Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NV;Zb253UUN3ME2wMlE2ODFizszN	NEn5SWlUSU6JRWK=
769-P	NIfSWGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHm1WVVKSzVyPUCuNVU5PDNizszN	MYLTRW5ITVJ?
NCI-H1304	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2DsfGlEPTB;MD6xOlA3OSEQvF2=	NWHMN\|F7W0GQR1XS
D-542MG	NIPXXW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1jDW2lEPTB;MD6xOlI4QCEQvF2=	MkLyV2FPT0WU
ATN-1	MnHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoXjTWM2OD1yLkG3OFQyKM7:TR?=	NVjsd\|lxW0GQR1XS
NCI-H2029	NWH6WnZiT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUDmZpd1UUN3ME2wMlIxOjR\|IN88US=>	NXfWS\|NmW0GQR1XS
ZR-75-30	MlTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NF7DTHRKSzVyPUCuNlA3PDNizszN	NGrDdGFUSU6JRWK=
SW1116	MlnsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3LHVGlEPTB;MD6yNVEyPyEQvF2=	NHrKenlUSU6JRWK=
CCRF-CEM	NWXmO21CT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmXHTWM2OD1yLkK3OlE1KM7:TR?=	NYLYO25VW0GQR1XS
LU-135	MlzPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{nqXWlEPTB;MD6yO\|c{QSEQvF2=	NHHkbIRUSU6JRWK=
MC116	M2fRZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIPhUWNKSzVyPUCuNlg{ODlizszN	NGrMfHhUSU6JRWK=
LS-513	M2L5XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoLmTWM2OD1yLkK4O\|c{KM7:TR?=	MnnhV2FPT0WU
NCI-H630	NH7IbpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3XlUmlEPTB;MD6yPVM4PiEQvF2=	NYDlOotbW0GQR1XS
L-428	NYH1dVdnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1\iTmlEPTB;MD6yPVg5OyEQvF2=	NVm3UpQ{W0GQR1XS
UM-UC-3	M{T2cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{WzO2lEPTB;MD6zNVI6OSEQvF2=	MoXzV2FPT0WU
NCI-H1838	NYjqOZpFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2T6WmlEPTB;MD6zNVc5PCEQvF2=	MmjaV2FPT0WU
HEL	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{XkZ2lEPTB;MD6zNlI1KM7:TR?=	M{ixNnNCVkeHUh?=
OCI-AML2	NE[2XZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mnj3TWM2OD1yLkOyNlk5KM7:TR?=	M1TmPXNCVkeHUh?=
A3-KAW	NIrrWWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3Hn[2lEPTB;MD6zN\|Q4PyEQvF2=	MXLTRW5ITVJ?
IGROV-1	NV;Oe5ZzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{L1NmlEPTB;MD6zN\|c2PSEQvF2=	NF;ncHJUSU6JRWK=
Mo-T	NUC3bpNST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWrJR\|UxRTBwM{O4OVMh\|ryP	NGPHfnZUSU6JRWK=
HDLM-2	MkXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1vMSGlEPTB;MD6zN\|kh\|ryP	MVLTRW5ITVJ?
HCC1569	M{PGdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4TQXmlEPTB;MD6zOFMxQSEQvF2=	NXjH[4tqW0GQR1XS
COLO-678	Mlz1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1[1TWlEPTB;MD6zO\|AxOiEQvF2=	MlK5V2FPT0WU
COR-L105	NVzU[o53T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEfZR\|JKSzVyPUCuN\|c6OyEQvF2=	NXLEdmI{W0GQR1XS
SK-MEL-24	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{TlcWlEPTB;MD6zPFM5OiEQvF2=	M4Sy[nNCVkeHUh?=
COLO-320-HSR	M4\STWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYDJR\|UxRTBwNEO5O\|Yh\|ryP	NX;kfGZNW0GQR1XS
C8166	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MoDOTWM2OD1yLkS5NFI{KM7:TR?=	NWnTflV1W0GQR1XS
COLO-679	MmTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUnOdoNsUUN3ME2wMlYzOTd{IN88US=>	MkDLV2FPT0WU
TE-12	MkLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWrJR\|UxRTBwNkWzPVQh\|ryP	NGTXVpBUSU6JRWK=
HAL-01	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NF7zT4dKSzVyPUCuOlYzOiEQvF2=	MnLZV2FPT0WU
H-EMC-SS	M2Cxfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Ml;QTWM2OD1yLkewOVQ3KM7:TR?=	M3HiSXNCVkeHUh?=
SNU-449	M3fZT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2HzT2lEPTB;MD63Nlc1QCEQvF2=	NUDtPVhvW0GQR1XS
C32	M17Jb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHT3dHdKSzVyPUCuO\|QyOTJizszN	MWDTRW5ITVJ?
K-562	NFS3eXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGHFTldKSzVyPUCuO\|cxOjRizszN	Mn35V2FPT0WU
DJM-1	M2DVWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVnjenhMUUN3ME2wMlc5PzhzIN88US=>	MnjlV2FPT0WU
RCC10RGB	NYjRRZlwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWDJR\|UxRTBwN{mxPFMh\|ryP	MULTRW5ITVJ?
CAL-85-1	M13MWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmDjTWM2OD1yLkmwO{DPxE1?	MV\TRW5ITVJ?
NY	NHvXcJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2LPVWlEPTB;MD65N\|M2OiEQvF2=	NH;qbWFUSU6JRWK=
NCI-H1993	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVLiW5F[UUN3ME2xMlE6Ojh7IN88US=>	NXHhNZRwW0GQR1XS
SK-OV-3	NVPNUZlFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Ml3OTWM2OD1zLkKyNFg6KM7:TR?=	M4rJXHNCVkeHUh?=

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In vivo

Docetaxel (33 mg/kg/dose, given i.v. every 4 days for 3 injections) results in a tumor growth delay of 19.3 days in M2OL2 colon xenografts. Docetaxel also shows great antitumor activities in MX-1, SK-MEL-2, LX-1 and OVCAR-3 xenografts. Docetaxel inhibits the angiogenic response to fibroblast growth factor 2 with IC 50 of 5.4 mg/kg when injected twice weekly over a 14-day period, and angiogenesis is completely blocked in mice that receives 10 mg/kg Docetaxel. Docetaxel has selectivity for endothelial cell migration and/or microvessel formation because infiltration of inflammatory cells into the Matrigel plug is much less sensitive to inhibition by Docetaxel. ^[7]

Protocol

Cell Research:^[5]	+ Expand Cell lines: Human gastric cancer cell lines MKN-28 Concentrations: 6 nM Incubation Time: 3 days Method: 2000 cells in 180 μL of medium are seeded in a 96-well plate, and 20 μL of drug solution is simultaneously added in triplicate to each well. The plate is incubated for 3 days at 37°C in a humidified atmosphere of 5% CO₂. On day 3, 25 μL of MTT reagent is added to each well. After 4 h of incubation, the medium is removed by aspiration. 0.2 mL of dimethylsulphoxide (DMSO) is added to each well and thoroughly mixed by using a mechanical plate mixer to dissolve the resulting MTT-formazan crystals. Absorbance at 540 nm (OD) is measured by a reader. (Only for Reference)
Animal Research:^[6]	+ Expand Animal Models: Human colon carcinomas xenografts CX-1 Formulation: 50 mg/mL stock solution in ethanol by adding an equal volume of polysorbate 80 and diluting with 5% dextrose in water to the final volume Dosages: 33 mg/kg Administration: i.v. every 4 days for 3 injections (Only for Reference)

Cell Research:^[5]

+ Expand

Cell lines: Human gastric cancer cell lines MKN-28
Concentrations: 6 nM
Incubation Time: 3 days
Method: 2000 cells in 180 μL of medium are seeded in a 96-well plate, and 20 μL of drug solution is simultaneously added in triplicate to each well. The plate is incubated for 3 days at 37°C in a humidified atmosphere of 5% CO₂. On day 3, 25 μL of MTT reagent is added to each well. After 4 h of incubation, the medium is removed by aspiration. 0.2 mL of dimethylsulphoxide (DMSO) is added to each well and thoroughly mixed by using a mechanical plate mixer to dissolve the resulting MTT-formazan crystals. Absorbance at 540 nm (OD) is measured by a reader.
(Only for Reference)

Animal Research:^[6]

+ Expand

Animal Models: Human colon carcinomas xenografts CX-1
Formulation: 50 mg/mL stock solution in ethanol by adding an equal volume of polysorbate 80 and diluting with 5% dextrose in water to the final volume
Dosages: 33 mg/kg
Administration: i.v. every 4 days for 3 injections
(Only for Reference)

References

+ Expand

Solubility (25°C)

In vitro	DMSO	100 mg/mL (123.78 mM)
	Ethanol	53 mg/mL warmed (65.6 mM)
	Water	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 5% DMSO+30% PEG 300+5% Tween 80+ddH2O For best results, use promptly after mixing.	2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download Docetaxel SDF

Molecular Weight	807.88
Formula	C₄₃H₅₃NO₁₄
CAS No.	114977-28-5
Storage	3 years -20°C powder
Storage	2 years -80°C in solvent
Synonyms	RP56976, NSC 628503

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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Computed Result

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

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Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2018-11-16)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT03742986	Not yet recruiting	Breast Cancer	New York University School of Medicine	April 2019	Phase 2
NCT03609047	Not yet recruiting	Breast Cancer Stage II\|Breast Cancer Stage III	European Organisation for Research and Treatment of Cancer - EORTC\|Pfizer	January 7 2019	Phase 2
NCT03329378	Not yet recruiting	Locally Advanced Breast Cancer	Icahn School of Medicine at Mount Sinai	December 2018	Phase 2
NCT03693612	Not yet recruiting	Neoplasms	GlaxoSmithKline\|MedImmune LLC	December 3 2018	Phase 2
NCT03739710	Not yet recruiting	Neoplasms	GlaxoSmithKline	December 7 2018	Phase 2
NCT03700099	Not yet recruiting	Prostate Cancer\|Castration-resistant Prostate Cancer	Instituto do Cancer do Estado de São Paulo\|Astellas Pharma Inc	December 2018	Phase 2

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Microtubule Associated Signaling Pathway Map

Related Microtubule Associated Products0

TAI-1 ^New

TAI-1 is a potent and specific Hec1 inhibitor, which disrupts Hec1-Nek2 protein interaction.
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Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.
Combretastatin A4 ^New

Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with K_d of 0.4 μM.Phase 3.
Paclitaxel

Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.
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Vincristine sulfate is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay.
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Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM in cell-free assays, respectively. Nocodazole improves the CRISPR-mediated HDR efficiency and has an additive effect on enhancing precise genome editing.
Vinorelbine Tartrate

Vinorelbine Tartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin.
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Cabazitaxel is a semi-synthetic derivative of a natural taxoid that kills cancer cells by inhibiting cell division and growth. Cabazitaxel exerts its effects by inhibiting microtubule growth and assembly, processes that are essential for cells to divide.

Features:A semi-synthetic derivative of a natural taxoid.
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Docetaxel

Cited by 12 Publications

7 Customer Reviews

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Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download Docetaxel SDF

Bio Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Dilution Calculator

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2018-11-16)

Tech Support

Microtubule Associated Signaling Pathway Map

Related Microtubule Associated Products0

Choose Your Country or Region

By Signaling Pathways

By product type

Docetaxel

Cited by 12 Publications

7 Customer Reviews

Purity & Quality Control

Choose Selective Microtubule Associated Inhibitors

Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download Docetaxel SDF

Bio Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Dilution Calculator

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

Instructions to calculate molar mass (molecular weight) of a chemical compound:

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2018-11-16)

Tech Support

Microtubule Associated Signaling Pathway Map

Related Microtubule Associated Products0

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)