Docetaxel

Catalog No.S1148 Synonyms: RP56976, NSC 628503

Docetaxel Chemical Structure

Molecular Weight(MW): 807.88

Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.

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In DMSO USD 91 In stock
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USD 270 In stock
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Cited by 41 Publications

Purity & Quality Control

Choose Selective Microtubule Associated Inhibitors

Biological Activity

Description Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.
Targets
Microtubules [1]
(Cell-free assay)
In vitro

Docetaxel is a cytotoxic agent, especially for proliferating cells, which is related to its ability to promote the formation of microtubule bundles and induce sustained mitotic arrest, followed by apoptosis of mitotically arrested cells or permanent mitotic block. Docetaxel suppresses microtubule dynamic instability as well as tread-milling, resulting in the failure of chromosomes to segregate to the daughter cells, which in turn triggers premature exit from mitosis rather than a block at this phase of the cell cycle. [2] Docetaxel inhibits the clonogenic survival of Human cancer cell Hs746T (stomach), AGS (stomach), HeLa (cervix), CaSki (cervix), BxPC3 (pancreas), Capan-1 (pancreas) with IC50 of 1 nM, 1 nM, 0.3 nM, 0.3 nM, 0.3 nM and 0.3 nM respectively. [4] Docetaxel inhibits endothelial cell migration that does not affects microtubule gross morphology or inhibit cell proliferation, although they does produce more subtle effects on microtubule dynamics. Docetaxel inhibits HUVEC migration with an observed IC50 of 1 pM. HUVEC chemotaxis stimulated by either of two angiogenic factors, thymidine phosphorylase or VEGF, is inhibited by Docetaxel with IC 50 of 10 pM and is ablated at 1 nM. [7] Docetaxel induces human monocytes, but not RAW 264.7 murine macrophages, Prostaglandin H Synthase-2m (PGHS-2) expression. [8]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HSC-3 NV30T3RxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XHVWlEPTB;MD6wNFAyOzJizszN MV\TRW5ITVJ?
5637 NHrrdYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfqTWM2OD1yLkCwNFE1OyEQvF2= NXrZUFZvW0GQR1XS
HT-144 NHHyRZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvYTWM2OD1yLkCwNFE2PyEQvF2= NWLFToQ3W0GQR1XS
NCI-H292 NEDX[2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3H0XmlEPTB;MD6wNFAyPTlizszN Mn3aV2FPT0WU
HCE-T M1rsPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3L0XmlEPTB;MD6wNFAyPjJizszN M4XPWnNCVkeHUh?=
ESS-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2Lv[WlEPTB;MD6wNFAyPzlizszN NVq5T4ZOW0GQR1XS
D-566MG M3n2[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HiTmlEPTB;MD6wNFAyQDJizszN MWDTRW5ITVJ?
CAL-62 M4K5Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfhXmVGUUN3ME2wMlAxODF6NTFOwG0> NVK3RnMyW0GQR1XS
GT3TKB MmOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGK4XJpKSzVyPUCuNFAxOjN{IN88US=> MYPTRW5ITVJ?
HSC-4 Mle3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LV[2lEPTB;MD6wNFAzOzlizszN M3LMfnNCVkeHUh?=
KOSC-2 M4TzTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTBwMECwNlU2KM7:TR?= M1vDXnNCVkeHUh?=
NB14 NWP0O2pFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLRTWM2OD1yLkCwNFI3KM7:TR?= NGjwbnFUSU6JRWK=
ES8 NHjVbI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTBwMECwNlYh|ryP NGH2SnVUSU6JRWK=
BFTC-905 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVO5dVB[UUN3ME2wMlAxODJ4ODFOwG0> M17OenNCVkeHUh?=
A498 NHnXSpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrEOZdKSzVyPUCuNFAxOjd6IN88US=> MYXTRW5ITVJ?
HO-1-N-1 M2LLV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrrW4ZlUUN3ME2wMlAxODJ6MTFOwG0> M4i4cXNCVkeHUh?=
SF539 M1vIemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLzT3dKSzVyPUCuNFAxOzB{IN88US=> NHXTR|FUSU6JRWK=
HuO-3N1 MkDHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HHb2lEPTB;MD6wNFA{ODJizszN NX\4SmpXW0GQR1XS
NCI-H510A NUXmNoU5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUf3fHVZUUN3ME2wMlAxODN|NjFOwG0> NUfifG82W0GQR1XS
CAL-27 NX:4PW5rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\yTWM2OD1yLkCwNFM{QSEQvF2= M3\1WnNCVkeHUh?=
TE-8 Ml3MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTBwMECwN|Y3KM7:TR?= NFPqZVdUSU6JRWK=
VA-ES-BJ NWHjdGRGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TtO2lEPTB;MD6wNFA{PzVizszN M{DROHNCVkeHUh?=
RH-1 M1rkZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETQVnZKSzVyPUCuNFAxOzh4IN88US=> MYLTRW5ITVJ?
COLO-800 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF22cphKSzVyPUCuNFAxOzh6IN88US=> M3TDb3NCVkeHUh?=
ES7 Mn;NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXNNIZKSzVyPUCuNFAxOzh7IN88US=> MlfBV2FPT0WU
GAMG MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDzR4VKSzVyPUCuNFAxPDF4IN88US=> NIHnW2pUSU6JRWK=
Ca9-22 MoS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\wOIVKSzVyPUCuNFAxPDJ|IN88US=> MXzTRW5ITVJ?
SBC-1 NGTWbpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHTemlKSzVyPUCuNFAxPDNizszN NEe3ZmxUSU6JRWK=
RPMI-7951 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXaTWM2OD1yLkCwNFQ1QCEQvF2= MknBV2FPT0WU
SW1710 MnjGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmj5TWM2OD1yLkCwNFQ3PiEQvF2= NIe3cYVUSU6JRWK=
HGC-27 NU[2eZkzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojUTWM2OD1yLkCwNFQ4OSEQvF2= MWrTRW5ITVJ?
MC-IXC MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvQOFVKSzVyPUCuNFAxPDd7IN88US=> NXTBTGdqW0GQR1XS
FTC-133 M3XxOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETnVIRKSzVyPUCuNFAxPDh7IN88US=> NF\RZYNUSU6JRWK=
HT-1080 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTBwMECwOVAyKM7:TR?= MVHTRW5ITVJ?
NMC-G1 M4fOZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TSfGlEPTB;MD6wNFA2OTdizszN Mn:0V2FPT0WU
GI-1 M3\0[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHHVldmUUN3ME2wMlAxODV{ODFOwG0> MYTTRW5ITVJ?
CGTH-W-1 NVnzbWROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTBwMECwOVQzKM7:TR?= MVPTRW5ITVJ?
A2058 NFvZeHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjNd|VCUUN3ME2wMlAxODV2NDFOwG0> Mn7OV2FPT0WU
ETK-1 NX7pUXdiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorkTWM2OD1yLkCwNFU2QCEQvF2= MVHTRW5ITVJ?
NEC8 NFTPTYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3MfZBKSzVyPUCuNFAxPTZzIN88US=> NV6zc3J4W0GQR1XS
TE-11 NWTObnFET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwMECwOVY6KM7:TR?= NHv5fWVUSU6JRWK=
NCI-H720 NUO0OVJ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlm3TWM2OD1yLkCwNFU5KM7:TR?= M{\qb3NCVkeHUh?=
PSN1 MojKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF24NXBKSzVyPUCuNFAxPThzIN88US=> MV7TRW5ITVJ?
SW780 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTBwMECwOVg4KM7:TR?= NVixeWhzW0GQR1XS
8-MG-BA MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrwVVRKSzVyPUCuNFAxPTh7IN88US=> MlfHV2FPT0WU
EC-GI-10 NHXGRVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYX0OHdXUUN3ME2wMlAxODV7MjFOwG0> NXfxSFhDW0GQR1XS
SJSA-1 NWHBTpMxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7XPINKSzVyPUCuNFAxPjF3IN88US=> M1G2U3NCVkeHUh?=
639-V NWXjbXl[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkiwTWM2OD1yLkCwNFY1PyEQvF2= MkHqV2FPT0WU
PFSK-1 NVzHPXFIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGC5[25KSzVyPUCuNFAxPjV5IN88US=> MoLCV2FPT0WU
DMS-273 NEnXPI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HQSmlEPTB;MD6wNFA3PzRizszN NGfvXXVUSU6JRWK=
TE-9 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTBwMECwOlc3KM7:TR?= NWKwN5RlW0GQR1XS
SCC-25 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HWWWlEPTB;MD6wNFA3QCEQvF2= Mn7uV2FPT0WU
PA-1 MmPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTBwMECwOlg4KM7:TR?= M4PBV3NCVkeHUh?=
MHH-ES-1 Mn70S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWKxbYpvUUN3ME2wMlAxODdizszN M1PiZXNCVkeHUh?=
Daoy M325NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{SzS2lEPTB;MD6wNFA4KM7:TR?= NIXy[JVUSU6JRWK=
G-402 NVL1PI14T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37kTWlEPTB;MD6wNFA4ODZizszN NIKxSFRUSU6JRWK=
YKG-1 NF23cnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHnZ3E6UUN3ME2wMlAxODdyNzFOwG0> MkjsV2FPT0WU
Ca-Ski M{f1XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlW2TWM2OD1yLkCwNFczQCEQvF2= NV\EO5VQW0GQR1XS
CHP-212 NYXlTFB2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLBTWM2OD1yLkCwNFc{KM7:TR?= M136XHNCVkeHUh?=
SCC-4 Mlj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DHUmlEPTB;MD6wNFA4OzlizszN NIW4Om1USU6JRWK=
EW-3 MonsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTBwMECwO|Q2KM7:TR?= MorlV2FPT0WU
P12-ICHIKAWA NYW4eXRlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHPb4ZWUUN3ME2wMlAxODd2NTFOwG0> NF60dmdUSU6JRWK=
HSC-2 NXfiW|I2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXYR|VKSzVyPUCuNFAxPzV3IN88US=> NX3QUlV[W0GQR1XS
HN MlnXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2OzdWlEPTB;MD6wNFA4PThizszN MX7TRW5ITVJ?
LXF-289 NHXJW4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mni0TWM2OD1yLkCwNFc2QCEQvF2= NHrBbYhUSU6JRWK=
ES1 NVnkb2g2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEO2SZlKSzVyPUCuNFAxPzdizszN MUHTRW5ITVJ?
NTERA-S-cl-D1 Mn:wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfnTWM2OD1yLkCwNFc4OyEQvF2= MXTTRW5ITVJ?
K5 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1n1VWlEPTB;MD6wNFA4PzhizszN NHGyblNUSU6JRWK=
HOS NXjWOGV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTBwMECwO|gzKM7:TR?= M3[2UXNCVkeHUh?=
YH-13 M4H3fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHwTWM2OD1yLkCwNFc6OSEQvF2= MWfTRW5ITVJ?
SW954 MnzQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2D4[2lEPTB;MD6wNFA5OjNizszN MofRV2FPT0WU
KYSE-510 NWL6WnE6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvuNnhKSzVyPUCuNFAxQDRizszN NGH6XYhUSU6JRWK=
8505C M{n5[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVX1dIxEUUN3ME2wMlAxODh3NDFOwG0> NEHBZmVUSU6JRWK=
A549 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;6TWM2OD1yLkCwNFg5OiEQvF2= NVH1b2cxW0GQR1XS
Detroit562 NHzXZXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWKxbY9OUUN3ME2wMlAxODlyMjFOwG0> NUjsb3FQW0GQR1XS
ES5 M3vnbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzXTWM2OD1yLkCwNFkyKM7:TR?= M1K4[nNCVkeHUh?=
KYSE-140 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\BSGlEPTB;MD6wNFA6OzNizszN MnzlV2FPT0WU
GMS-10 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XFcGlEPTB;MD6wNFA6PDFizszN NX;sb3dKW0GQR1XS
D-263MG MonrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTqW|JvUUN3ME2wMlAxODl2NzFOwG0> MVnTRW5ITVJ?
BCPAP MmDyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlS4TWM2OD1yLkCwNFk1PyEQvF2= MkO3V2FPT0WU
CHL-1 NV30OoNLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTBwMECwPVU5KM7:TR?= NGrWblRUSU6JRWK=
RKO NGXveIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnCc|hKSzVyPUCuNFAxQTh7IN88US=> NHjsbVRUSU6JRWK=
SW48 MnLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M121d2lEPTB;MD6wNFExOSEQvF2= MmDPV2FPT0WU
BPH-1 MoXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzQOZZKSzVyPUCuNFAyODJizszN NH3hWlNUSU6JRWK=
EFO-27 NYnuVnNmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPmSIwzUUN3ME2wMlAxOTB{IN88US=> NYLEW|lzW0GQR1XS
CAL-33 NHn2fIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnW2TWM2OD1yLkCwNVA1KM7:TR?= NHK2b|JUSU6JRWK=
NCI-H1792 NHnxWoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4X4S2lEPTB;MD6wNFExPCEQvF2= MX\TRW5ITVJ?
BB30-HNC M4rDPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPXWHc1UUN3ME2wMlAxOTB3IN88US=> M2ji[3NCVkeHUh?=
VM-CUB-1 NF\0T3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvaTWM2OD1yLkCwNVA2KM7:TR?= NXf2fZd6W0GQR1XS
TE-5 NWfuSnNsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEWxTZBKSzVyPUCuNFAyODZizszN NWTqe3A4W0GQR1XS
NB13 NU\HdG95T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjZTWM2OD1yLkCwNVA4KM7:TR?= M1PKSnNCVkeHUh?=
NBsusSR NHnFe49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTBwMECxNUDPxE1? MUnTRW5ITVJ?
LNCaP-Clone-FGC MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;uPHcyUUN3ME2wMlAxOTFizszN NHzzO3BUSU6JRWK=
EPLC-272H M1;DUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3kXZNKSzVyPUCuNFAyOTFizszN NH;yfllUSU6JRWK=
KNS-62 M1XiRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLHVnFKSzVyPUCuNFAyOTJizszN MVvTRW5ITVJ?
RERF-LC-MS NV;Jc5MxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX[ycVBvUUN3ME2wMlAxOTF|IN88US=> MWjTRW5ITVJ?
LOXIMVI MlLSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLuTWM2OD1yLkCwNVE3KM7:TR?= NUL4TmZjW0GQR1XS
KINGS-1 NGnVe3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LTVGlEPTB;MD6wNFEyPyEQvF2= M2HZNHNCVkeHUh?=
T98G M4XCTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUeydmE3UUN3ME2wMlAxOTF5IN88US=> Mn\xV2FPT0WU
HCC1806 M3zmfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33l[WlEPTB;MD6wNFEyQCEQvF2= NGTHe4JUSU6JRWK=
MZ1-PC NVjE[IhCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonXTWM2OD1yLkCwNVE5KM7:TR?= NFrUNXRUSU6JRWK=
RT-112 NYHRW3JtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwMECxNVkh|ryP NXPEUJRXW0GQR1XS
LK-2 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTBwMECxNlEh|ryP MXLTRW5ITVJ?
A375 MlnNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDIeY4{UUN3ME2wMlAxOTJzIN88US=> NWPLfnNQW0GQR1XS
SF268 MlzNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHi4UlFKSzVyPUCuNFAyOjFizszN M1\wdnNCVkeHUh?=
H9 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\uTWM2OD1yLkCwNVI1KM7:TR?= MVjTRW5ITVJ?
KYSE-410 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoL5TWM2OD1yLkCwNVI1KM7:TR?= MorzV2FPT0WU
G-401 MnrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrxcmdKSzVyPUCuNFAyOjdizszN MnLrV2FPT0WU
SW982 M3i1eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPtdINyUUN3ME2wMlAxOTJ5IN88US=> M2DGNnNCVkeHUh?=
D-423MG M2PHcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml21TWM2OD1yLkCwNVMh|ryP NEP0d2lUSU6JRWK=
CAMA-1 NVnFfmxUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zEXGlEPTB;MD6wNFE{OSEQvF2= MXPTRW5ITVJ?
SCC-9 NV;ZW|V7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvnTWM2OD1yLkCwNVMzKM7:TR?= M2LRbXNCVkeHUh?=
SAS MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjBOodKSzVyPUCuNFAyOzRizszN MVrTRW5ITVJ?
KYSE-180 NWjKN494T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofnTWM2OD1yLkCwNVM2KM7:TR?= NIfMTVBUSU6JRWK=
EW-16 NGjyU3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHOzWIdKSzVyPUCuNFAyOzVizszN MmDWV2FPT0WU
HD-MY-Z MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTBwMECxOFEh|ryP MX;TRW5ITVJ?
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LCLC-97TM1 NETJeYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rjeWlEPTB;MD6wNFE1PCEQvF2= NELrSHlUSU6JRWK=
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TI-73 Mlu4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{e2O2lEPTB;MD6wNFE1PCEQvF2= NEK5coxUSU6JRWK=
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MG-63 NEfN[mtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrFRXZJUUN3ME2wMlAxOTVzIN88US=> M2PGd3NCVkeHUh?=
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A172 MnPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TMdWlEPTB;MD6wNFE3OyEQvF2= MXHTRW5ITVJ?
CAL-39 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljVTWM2OD1yLkCwNVY{KM7:TR?= MWPTRW5ITVJ?
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D-247MG MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjo[ItnUUN3ME2wMlAxOTd|IN88US=> M3f3dHNCVkeHUh?=
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GCT M3nXOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjGTWM2OD1yLkCwNVgh|ryP MnnVV2FPT0WU
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NB17 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYW5Vlc3UUN3ME2wMlAxOTh7IN88US=> Ml:4V2FPT0WU
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M059J M3HiU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{WwWGlEPTB;MD6wNFE6QCEQvF2= NH3rSWVUSU6JRWK=
OVCAR-5 NGXjXFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlToTWM2OD1yLkCwNVk6KM7:TR?= NHz4Z|dUSU6JRWK=
SK-MEL-28 M4Lwemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWmwcXJ3UUN3ME2wMlAxOjB|IN88US=> MYfTRW5ITVJ?
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OVCAR-8 NFO1XIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\EdHZ1UUN3ME2wMlAxOjF{IN88US=> Ml\RV2FPT0WU
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RXF393 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVT5SodwUUN3ME2wMlAxOjJ{IN88US=> MXfTRW5ITVJ?
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BxPC-3 Ml:0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;LWWVJUUN3ME2wMlAxOjVzIN88US=> MXLTRW5ITVJ?
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LCLC-103H MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXRTWM2OD1yLkCwNlk{KM7:TR?= MV\TRW5ITVJ?
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MIA-PaCa-2 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTBwMECzNlQh|ryP M1nC[3NCVkeHUh?=
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AGS MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXk[JRQUUN3ME2wMlAxOzJ6IN88US=> MWfTRW5ITVJ?
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UACC-62 NITKPVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwMECzN{DPxE1? M2D5fHNCVkeHUh?=
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NCI-H23 MmntS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TZTmlEPTB;MD6wNFM3PCEQvF2= MVXTRW5ITVJ?
NCI-H226 M4PCWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3y0ZWlEPTB;MD6wNFM3QCEQvF2= NIi2OpFUSU6JRWK=
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NCI-H810 NGHBfppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjoTWM2OD1yLkCwOlIzKM7:TR?= MV7TRW5ITVJ?
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NCI-H1755 MnfHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPVNG9CUUN3ME2wMlAxPjJ2IN88US=> MVLTRW5ITVJ?
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HC-1 NVfn[Jh{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\OVXk6UUN3ME2wMlAxPjV4IN88US=> MnfWV2FPT0WU
MZ2-MEL NYTnWY1pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVm1T4VOUUN3ME2wMlAxPjV6IN88US=> NV:wNZdtW0GQR1XS
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NCI-H358 MoTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3q0VGlEPTB;MD6wNFc2QCEQvF2= NVrSdZBpW0GQR1XS
NCI-H2126 NH;j[I1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLrTWM2OD1yLkCwO|c{KM7:TR?= M1;XZ3NCVkeHUh?=
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NCI-H1623 MlHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zUOmlEPTB;MD6wNFg2PiEQvF2= Ml61V2FPT0WU
NCI-H1299 M3vteWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnuNotDUUN3ME2wMlAxQDV5IN88US=> NH3XOHJUSU6JRWK=
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MDA-MB-175-VII Mne3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlP3TWM2OD1yLkC0OFE4KM7:TR?= MXXTRW5ITVJ?
KMOE-2 NVHofo5RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTBwMES0Olkh|ryP M4T0R3NCVkeHUh?=
DMS-79 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvKUpZ5UUN3ME2wMlA1PTd7IN88US=> M1nTOHNCVkeHUh?=
MHH-NB-11 Mn7lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHZ[XhKSzVyPUCuNFQ3OTRizszN Mln3V2FPT0WU
NCI-H69 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfHTWM2OD1yLkC0PFQ6KM7:TR?= Mo[yV2FPT0WU
KE-37 M2XJ[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwMEWwNUDPxE1? MVXTRW5ITVJ?
Ramos-2G6-4C10 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvXSZhKSzVyPUCuNFUxPjdizszN M2rRWXNCVkeHUh?=
NCI-H1793 M{jFSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\WNGhKSzVyPUCuNFUxQTNizszN NVrSUJJZW0GQR1XS
HT-1376 M2j5T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTBwMEWxPFYh|ryP MXfTRW5ITVJ?
EKVX NXHCc3ppT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjPeZRDUUN3ME2wMlA2Ozh2IN88US=> MlS4V2FPT0WU
Capan-2 M{noUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrESI5MUUN3ME2wMlA2Ozl4IN88US=> Ml3PV2FPT0WU
DoTc2-4510 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTBwMEW0OFYh|ryP NH7RXZFUSU6JRWK=
UACC-893 NX;hV4dnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEK0R5dKSzVyPUCuNFU1PjJizszN NUjRbJlGW0GQR1XS
SK-MEL-3 M2r6WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfFb243UUN3ME2wMlA2Pzh6IN88US=> Mmj3V2FPT0WU
SK-MEL-1 NXO4eXo4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;VXIhKSzVyPUCuNFU5KM7:TR?= MWPTRW5ITVJ?
SW948 MkHxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XjNWlEPTB;MD6wOVk6PiEQvF2= NW\pRXRYW0GQR1XS
P30-OHK NXnSTWR[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M120[mlEPTB;MD6wOlE3PyEQvF2= M4TGWXNCVkeHUh?=
NH-12 MlzyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwME[yOFQh|ryP M{X2WnNCVkeHUh?=
KU-19-19 NFW0PFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHVZ4p2UUN3ME2wMlA3OzZzIN88US=> MWfTRW5ITVJ?
A431 NGPlU|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fQTmlEPTB;MD6wOlM4PCEQvF2= NXr1eGFwW0GQR1XS
NCI-H2405 MnnsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPxdGtJUUN3ME2wMlA3Ozh|IN88US=> Mnn6V2FPT0WU
KARPAS-299 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwME[1PFIh|ryP NFXsRmZUSU6JRWK=
BALL-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTBwME[2O|Qh|ryP NF20[25USU6JRWK=
KURAMOCHI Mlq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDGTHlKSzVyPUCuNFcxPzNizszN MVPTRW5ITVJ?
LS-1034 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;oTHZNUUN3ME2wMlA4OzZ7IN88US=> M4D2SnNCVkeHUh?=
MFE-280 M2fqW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXFbZZwUUN3ME2wMlA4PTN4IN88US=> NYLWb5h5W0GQR1XS
HOP-62 M{XWNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnWTWM2OD1yLkC3Olc3KM7:TR?= NFP3dGRUSU6JRWK=
KG-1 MoTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DEfGlEPTB;MD6wO|c5PyEQvF2= NXrkc4V6W0GQR1XS
CW-2 NGrDVYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3PVG9oUUN3ME2wMlA4QDN{IN88US=> MVjTRW5ITVJ?
SW837 NUPOTFdST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrITWM2OD1yLkC4N|QzKM7:TR?= M{XFOnNCVkeHUh?=
MFH-ino MkHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWX4bIVWUUN3ME2wMlA5PTBzIN88US=> MmPKV2FPT0WU
HCC1419 Ml[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXoTWM2OD1yLkC4PVg4KM7:TR?= MXnTRW5ITVJ?
HMV-II MlnXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTBwMEmwNUDPxE1? MV7TRW5ITVJ?
BEN NXj1eJV[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjYR3JNUUN3ME2wMlA6Ozh3IN88US=> M{\kNHNCVkeHUh?=
SK-N-FI NVTwWlk{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoP5TWM2OD1yLkC5OVU3KM7:TR?= MVHTRW5ITVJ?
JVM-2 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;vSVVKSzVyPUCuNFk4OTZizszN MUHTRW5ITVJ?
CAL-54 NIrHdnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfvSlROUUN3ME2wMlExODRizszN MYDTRW5ITVJ?
T84 MlHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnxelJiUUN3ME2wMlExQTV{IN88US=> MlXxV2FPT0WU
SHP-77 M1rkZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jhd2lEPTB;MD6xNVY1OSEQvF2= MXLTRW5ITVJ?
G-361 NFXzclhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jNfWlEPTB;MD6xNlMzPCEQvF2= M1LxUXNCVkeHUh?=
Calu-3 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwMUO4NVYh|ryP M{DxdnNCVkeHUh?=
HCC1937 NYjGNllbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTBwMUS5N|ch|ryP MVTTRW5ITVJ?
KM-H2 Mn3YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfFZ3Q2UUN3ME2wMlE2ODFizszN MYfTRW5ITVJ?
769-P NX\oS5BXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwMUW4OFMh|ryP Mmm3V2FPT0WU
NCI-H1304 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fkN2lEPTB;MD6xOlA3OSEQvF2= M2PYb3NCVkeHUh?=
D-542MG NYW4OWdTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmH2TWM2OD1yLkG2Nlc5KM7:TR?= M4\WOnNCVkeHUh?=
ATN-1 M2rLdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlj3TWM2OD1yLkG3OFQyKM7:TR?= MY\TRW5ITVJ?
NCI-H2029 Mm\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETnUoFKSzVyPUCuNlAzPDNizszN NV7QOVJCW0GQR1XS
ZR-75-30 NY\3[nZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\UfZo5UUN3ME2wMlIxPjR|IN88US=> MlX5V2FPT0WU
SW1116 M2[wW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1iyT2lEPTB;MD6yNVEyPyEQvF2= NYjobldyW0GQR1XS
CCRF-CEM NITpPXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3uz[GlEPTB;MD6yO|YyPCEQvF2= M2jyVXNCVkeHUh?=
LU-135 MkT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTBwMke3N|kh|ryP MUHTRW5ITVJ?
MC116 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTBwMkizNFkh|ryP M4nLOHNCVkeHUh?=
LS-513 NVvqW2xET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFuwWWNKSzVyPUCuNlg4PzNizszN Mnn5V2FPT0WU
NCI-H630 NXzPR2ZIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzMTWM2OD1yLkK5N|c3KM7:TR?= NYPsS2lkW0GQR1XS
L-428 MnPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTBwMkm4PFMh|ryP NYPybGhZW0GQR1XS
UM-UC-3 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTBwM{GyPVEh|ryP MUnTRW5ITVJ?
NCI-H1838 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3ETWM2OD1yLkOxO|g1KM7:TR?= MXTTRW5ITVJ?
HEL MkS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTBwM{KyOEDPxE1? NVj5NFkyW0GQR1XS
OCI-AML2 NETtSJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3UTWM2OD1yLkOyNlk5KM7:TR?= Mn;yV2FPT0WU
A3-KAW M{PidWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\v[2lEPTB;MD6zN|Q4PyEQvF2= MnHFV2FPT0WU
IGROV-1 MoTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHP4OXhKSzVyPUCuN|M4PTVizszN NXLYWpF2W0GQR1XS
Mo-T MnnDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nnW2lEPTB;MD6zN|g2OyEQvF2= NYe2dnJXW0GQR1XS
HDLM-2 Mo\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLSU3pkUUN3ME2wMlM{QSEQvF2= NGHkUFZUSU6JRWK=
HCC1569 NU\lR29DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHvemFKSzVyPUCuN|Q{ODlizszN MV;TRW5ITVJ?
COLO-678 NYniRlBoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHWxb|ZKSzVyPUCuN|cxODJizszN NWjGOXd3W0GQR1XS
COR-L105 NIO4VpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnD[2pDUUN3ME2wMlM4QTNizszN NIHY[phUSU6JRWK=
SK-MEL-24 NX7EcYFVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PkVGlEPTB;MD6zPFM5OiEQvF2= MWfTRW5ITVJ?
COLO-320-HSR NHS1fYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzpTWM2OD1yLkSzPVc3KM7:TR?= MW\TRW5ITVJ?
C8166 NXnGd4NwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTBwNEmwNlMh|ryP MXrTRW5ITVJ?
COLO-679 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PqOGlEPTB;MD62NlE4OiEQvF2= M2\GXnNCVkeHUh?=
TE-12 NYXIR4sxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\MNWlEPTB;MD62OVM6PCEQvF2= M2nm[XNCVkeHUh?=
HAL-01 M{j2dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYq1[4NSUUN3ME2wMlY3OjJizszN MoTNV2FPT0WU
H-EMC-SS MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13lU2lEPTB;MD63NFU1PiEQvF2= MXrTRW5ITVJ?
SNU-449 NY\mNlFUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTBwN{K3OFgh|ryP Mkf3V2FPT0WU
C32 NFLv[|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmSzTWM2OD1yLke0NVEzKM7:TR?= MWfTRW5ITVJ?
K-562 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUf1PVI6UUN3ME2wMlc4ODJ2IN88US=> NXfvNJpwW0GQR1XS
DJM-1 NFXPcFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfXTWM2OD1yLke4O|gyKM7:TR?= MVzTRW5ITVJ?
RCC10RGB NFjVR3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXhWmRMUUN3ME2wMlc6OTh|IN88US=> M130e3NCVkeHUh?=
CAL-85-1 M2PNRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTBwOUC3JO69VQ>? MmWxV2FPT0WU
NY NGDHe45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7PfHFDUUN3ME2wMlk{OzV{IN88US=> MnHHV2FPT0WU
NCI-H1993 MmnmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHOTWM2OD1zLkG5Nlg6KM7:TR?= NVW0PXk5W0GQR1XS
SK-OV-3 M1\MUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHQRWFKSzVyPUGuNlIxQDlizszN NIrYRo9USU6JRWK=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
PIM1; 

PubMed: 18426800     


Cells were treated with 100 nm docetaxel for the indicated times. PIM1 and β-ACTIN proteins were analyzed by immunoblot analysis. One of three similar blots is shown. Ratio, ratio of PIM1/β-ACTIN from pooled densitometry data from three separate experimen䲧疝Ỵ疞㧀疜膉痘 瘿뾠ՂᾰƌՂĀ 㺣痖帉痖Ѐ瑖堘𢡄빢᎒ՂĀ鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ⟸෕䐺痖暼瘿⟸෕ᾰƌ

cyclin B; 

PubMed: 18426800     


Immunoblot analysis of cyclin B1 and PIM1 expression after docetaxel 10 nm (left) or 100 nm (right) treatment at various time points.

pSTAT3 / STAT3 ; 

PubMed: 18426800     


Immunoblots of RWPE-2 cells treated with 100 nm docetaxel for the indicated time.

p-p53 / p53; 

PubMed: 22996738     


C4-2 cells were treated with 5 nM docetaxel, the whole cell lysates were collected at different time points and subjected to Western blot.

18426800 22996738
Immunofluorescence
α-tubulin; 

PubMed: 27177833     


Noscapine has no effect on gross microtubule polymerization state but noscapine pre-sensitization followed by docetaxel treatment stabilizes microtubules, hence inhibits cell proliferation. TNBC cells were treated with noscapine (4 µM) or docetaxel (0.4 µ䲧疝Ỵ疞㧀疜膉痘 瘿⟸෕ᾰƌ෕Ð 㺣痖帉痖Ѐ瑖堘𢡄빢᎒෕Ð鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ뾠Ղ䐺痖暼瘿뾠Ղᾰƌ 뾠ՂÐ㺣痖뾠Ղ€𢡄뾤Ղ€䀷痗뾤Ղ౴뾤Ղ㵶痗뾤Ղ뺖᎒泌Itemセ᎒Count﫨呂뿔Ղ猴፲뾤Ղ፲씢痗猸፲髸莤䥷堙᎒セ᎒�堞ﻮ᎒፲露𢡄堚Ҕ齃礤v�堞ﻮ᎒猢Wセ᎒䨼Ą鹿齃殺獸W戀醙

cleaved PARP / cleaved caspase-3; 

PubMed: 21087597     


Immunofluorescence images of PC-3 cells treated with the docetaxel and EM011 schedule treatment. Cells were pretreated with docetaxel for 12 h before addition of EM011 and were fixed at 48 h post docetaxel treatment compared to treatment with EM011 (10 μM䲧疝Ỵ疞㧀疜膉痘 瘿⟸෕ᾰƌ෕Ð 㺣痖帉痖Ѐ瑖堘𢡄빢᎒෕Ð鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ�෋䐺痖暼瘿�෋ᾰƌ �෋à

Acetylated tubulin ; 

PubMed: 18426800     


Immunofluorescence of acetylated tubulin in cells treated with DMSO, 30 nM laulimalide and 30 nM docetaxel for 2.5 h. Tubulin shown in green and DAPI in blue, and the white arrow indicates microtubule bundling. Scale bar represents 10 μm.

SQSTM1 / LAMP1; 

PubMed: 29795139     


AGS cells were treated with docetaxel (10 nM) for 12 h. After immunostaining with SQSTM1 (Alexa Fluor 488, green) and LAMP1 (Alexa Fluor 594, red), cells were examined by fluorescence microscopy (scale bar 20 μm). The colocalization of SQSTM1and LAMP1 was䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 㺣痖帉痖Ѐ

27177833 21087597 18426800 29795139
Growth inhibition assay
Cell viability ; 

PubMed: 22996738     


Docetaxel inhibits the growth of LNCaP, C4-2, DU145, and PC3 prostate cancer cells. Cells were plated in 12-well plates and treated with different concentrations of docetaxel. The cell number was counted after 24 hr. 

22996738
In vivo Docetaxel (33 mg/kg/dose, given i.v. every 4 days for 3 injections) results in a tumor growth delay of 19.3 days in M2OL2 colon xenografts. Docetaxel also shows great antitumor activities in MX-1, SK-MEL-2, LX-1 and OVCAR-3 xenografts. Docetaxel inhibits the angiogenic response to fibroblast growth factor 2 with IC 50 of 5.4 mg/kg when injected twice weekly over a 14-day period, and angiogenesis is completely blocked in mice that receives 10 mg/kg Docetaxel. Docetaxel has selectivity for endothelial cell migration and/or microvessel formation because infiltration of inflammatory cells into the Matrigel plug is much less sensitive to inhibition by Docetaxel. [7]

Protocol

Cell Research:[5]
- Collapse
  • Cell lines: Human gastric cancer cell lines MKN-28
  • Concentrations: 6 nM
  • Incubation Time: 3 days
  • Method: 2000 cells in 180 μL of medium are seeded in a 96-well plate, and 20 μL of drug solution is simultaneously added in triplicate to each well. The plate is incubated for 3 days at 37°C in a humidified atmosphere of 5% CO2. On day 3, 25 μL of MTT reagent is added to each well. After 4 h of incubation, the medium is removed by aspiration. 0.2 mL of dimethylsulphoxide (DMSO) is added to each well and thoroughly mixed by using a mechanical plate mixer to dissolve the resulting MTT-formazan crystals. Absorbance at 540 nm (OD) is measured by a reader.
    (Only for Reference)
Animal Research:[6]
- Collapse
  • Animal Models: Human colon carcinomas xenografts CX-1
  • Formulation: 50 mg/mL stock solution in ethanol by adding an equal volume of polysorbate 80 and diluting with 5% dextrose in water to the final volume
  • Dosages: 33 mg/kg
  • Administration: i.v. every 4 days for 3 injections
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (123.78 mM)
Ethanol 53 mg/mL warmed (65.6 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 807.88
Formula

C43H53NO14

CAS No. 114977-28-5
Storage powder
in solvent
Synonyms RP56976, NSC 628503

Bio Calculators

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  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04113005 Not yet recruiting Drug: Desmopressin Castrate Resistance Prostate Cancer Sunnybrook Health Sciences Centre|Sunnybrook Research Institute October 1 2019 Early Phase 1
NCT03700099 Recruiting Drug: Docetaxel|Drug: Enzalutamide Prostate Cancer|Castration-resistant Prostate Cancer Instituto do Cancer do Estado de São Paulo|Astellas Pharma Inc September 3 2019 Phase 2
NCT04067713 Recruiting -- Metastatic Prostate Cancer University College London|Epic Sciences September 20 2019 --
NCT03976375 Recruiting Biological: Pembrolizumab|Drug: Lenvatinib|Drug: Docetaxel Metastatic Non-Small Cell Lung Cancer Merck Sharp & Dohme Corp.|Eisai Inc. June 26 2019 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Microtubule Associated Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID