Docetaxel

For research use only.

Catalog No.S1148 Synonyms: RP56976, NSC 628503

75 publications

Docetaxel Chemical Structure

Molecular Weight(MW): 807.88

Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.

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Selleck's Docetaxel has been cited by 75 publications

Purity & Quality Control

Choose Selective Microtubule Associated Inhibitors

Biological Activity

Description Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.
Targets
Microtubules [1]
(Cell-free assay)
In vitro

Docetaxel is a cytotoxic agent, especially for proliferating cells, which is related to its ability to promote the formation of microtubule bundles and induce sustained mitotic arrest, followed by apoptosis of mitotically arrested cells or permanent mitotic block. Docetaxel suppresses microtubule dynamic instability as well as tread-milling, resulting in the failure of chromosomes to segregate to the daughter cells, which in turn triggers premature exit from mitosis rather than a block at this phase of the cell cycle. [2] Docetaxel inhibits the clonogenic survival of Human cancer cell Hs746T (stomach), AGS (stomach), HeLa (cervix), CaSki (cervix), BxPC3 (pancreas), Capan-1 (pancreas) with IC50 of 1 nM, 1 nM, 0.3 nM, 0.3 nM, 0.3 nM and 0.3 nM respectively. [4] Docetaxel inhibits endothelial cell migration that does not affects microtubule gross morphology or inhibit cell proliferation, although they does produce more subtle effects on microtubule dynamics. Docetaxel inhibits HUVEC migration with an observed IC50 of 1 pM. HUVEC chemotaxis stimulated by either of two angiogenic factors, thymidine phosphorylase or VEGF, is inhibited by Docetaxel with IC 50 of 10 pM and is ablated at 1 nM. [7] Docetaxel induces human monocytes, but not RAW 264.7 murine macrophages, Prostaglandin H Synthase-2m (PGHS-2) expression. [8]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HSC-3 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTBwMECwNVMzKM7:TR?= NGrudnJUSU6JRWK=
5637 M2XNcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DFOWlEPTB;MD6wNFAyPDNizszN NITiTYlUSU6JRWK=
HT-144 NFrJNmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTBwMECwNVU4KM7:TR?= MmS2V2FPT0WU
NCI-H292 M1zqSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUn6VXZiUUN3ME2wMlAxODF3OTFOwG0> NY[yOFh6W0GQR1XS
HCE-T M{DDc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojOTWM2OD1yLkCwNFE3OiEQvF2= Mor4V2FPT0WU
ESS-1 M2D4TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3xS4dKSzVyPUCuNFAxOTd7IN88US=> NXKyOVQzW0GQR1XS
D-566MG NVrxZWlsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M324bGlEPTB;MD6wNFAyQDJizszN NVfsbZVEW0GQR1XS
CAL-62 MmHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwMECwNVg2KM7:TR?= NV;5fpdiW0GQR1XS
GT3TKB NIDi[WRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlroTWM2OD1yLkCwNFI{OiEQvF2= MVXTRW5ITVJ?
HSC-4 NIfWTItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfjbVlKSzVyPUCuNFAxOjN7IN88US=> NUHZeVBjW0GQR1XS
KOSC-2 NIW5So9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkn5TWM2OD1yLkCwNFI2PSEQvF2= M1TJXHNCVkeHUh?=
NB14 MkPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlm5TWM2OD1yLkCwNFI3KM7:TR?= M1LoR3NCVkeHUh?=
ES8 Mn3yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4GzWGlEPTB;MD6wNFAzPiEQvF2= NHHXb2ZUSU6JRWK=
BFTC-905 NVPxSoNjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDtZ3plUUN3ME2wMlAxODJ4ODFOwG0> NVrjOWY6W0GQR1XS
A498 NF7MS3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnyyTWM2OD1yLkCwNFI4QCEQvF2= NED6XVJUSU6JRWK=
HO-1-N-1 NGPzXYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jOdWlEPTB;MD6wNFAzQDFizszN M1q5c3NCVkeHUh?=
SF539 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHDOnFXUUN3ME2wMlAxODNyMjFOwG0> NETqd|hUSU6JRWK=
HuO-3N1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzwdJF6UUN3ME2wMlAxODNyMjFOwG0> MWDTRW5ITVJ?
NCI-H510A M4XsWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TjdWlEPTB;MD6wNFA{OzZizszN MXXTRW5ITVJ?
CAL-27 MlnZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mki0TWM2OD1yLkCwNFM{QSEQvF2= NYCwSVlVW0GQR1XS
TE-8 MnfrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7iR2xuUUN3ME2wMlAxODN4NjFOwG0> NVLXOJZvW0GQR1XS
VA-ES-BJ MnfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoK1TWM2OD1yLkCwNFM4PSEQvF2= NHmzO5pUSU6JRWK=
RH-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PWT2lEPTB;MD6wNFA{QDZizszN NXLaWlFoW0GQR1XS
COLO-800 NVHo[lR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHzclNKSzVyPUCuNFAxOzh6IN88US=> M1vsd3NCVkeHUh?=
ES7 NGjPUIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTBwMECwN|g6KM7:TR?= MYPTRW5ITVJ?
GAMG M2nmcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTifYFKSzVyPUCuNFAxPDF4IN88US=> M3;rbHNCVkeHUh?=
Ca9-22 M1;m[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzRTWM2OD1yLkCwNFQzOyEQvF2= Ml2xV2FPT0WU
SBC-1 M3XRZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{n1ZmlEPTB;MD6wNFA1OyEQvF2= M{njPXNCVkeHUh?=
RPMI-7951 NGfJSXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX24WW13UUN3ME2wMlAxODR2ODFOwG0> MkH5V2FPT0WU
SW1710 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH36Vm9KSzVyPUCuNFAxPDZ4IN88US=> MnjDV2FPT0WU
HGC-27 NYLveo8yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljsTWM2OD1yLkCwNFQ4OSEQvF2= MULTRW5ITVJ?
MC-IXC MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwMECwOFc6KM7:TR?= NWHOOplJW0GQR1XS
FTC-133 NF;YeY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPKVXU6UUN3ME2wMlAxODR6OTFOwG0> NYXrOZdNW0GQR1XS
HT-1080 MkK2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTBwMECwOVAyKM7:TR?= M1rPTXNCVkeHUh?=
NMC-G1 M3PFUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fkWWlEPTB;MD6wNFA2OTdizszN MkPvV2FPT0WU
GI-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFK1NpBKSzVyPUCuNFAxPTJ6IN88US=> NVSyXnNRW0GQR1XS
CGTH-W-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVizR|FQUUN3ME2wMlAxODV2MjFOwG0> MknaV2FPT0WU
A2058 M2H2Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTBwMECwOVQ1KM7:TR?= M4e1cnNCVkeHUh?=
ETK-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HBeWlEPTB;MD6wNFA2PThizszN MkTmV2FPT0WU
NEC8 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInBdJFKSzVyPUCuNFAxPTZzIN88US=> M3zlTnNCVkeHUh?=
TE-11 Mln2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTBwMECwOVY6KM7:TR?= MnvHV2FPT0WU
NCI-H720 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33sRWlEPTB;MD6wNFA2QCEQvF2= MWrTRW5ITVJ?
PSN1 Mnf2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlq3TWM2OD1yLkCwNFU5OSEQvF2= NY\zcYJWW0GQR1XS
SW780 NUDLWodPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\VTHFKSzVyPUCuNFAxPTh5IN88US=> NXfHVmVEW0GQR1XS
8-MG-BA NHLpS|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;sXIFuUUN3ME2wMlAxODV6OTFOwG0> M37tVnNCVkeHUh?=
EC-GI-10 NX7yeZhiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTBwMECwOVkzKM7:TR?= MojZV2FPT0WU
SJSA-1 NYXLUItRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\CSmlEPTB;MD6wNFA3OTVizszN MlrnV2FPT0WU
639-V M3\OXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXVdVVPUUN3ME2wMlAxODZ2NzFOwG0> M{i3OXNCVkeHUh?=
PFSK-1 NXLjXZR2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTBwMECwOlU4KM7:TR?= NHHkdHVUSU6JRWK=
DMS-273 M1vOPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnVc4FUUUN3ME2wMlAxODZ5NDFOwG0> NYTGdpJuW0GQR1XS
TE-9 MofTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH33SYZKSzVyPUCuNFAxPjd4IN88US=> NFnCVm9USU6JRWK=
SCC-25 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fzTWlEPTB;MD6wNFA3QCEQvF2= MVTTRW5ITVJ?
PA-1 NGTvbWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HTOGlEPTB;MD6wNFA3QDdizszN MXjTRW5ITVJ?
MHH-ES-1 NHv2OodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGD5PYJKSzVyPUCuNFAxPyEQvF2= NILKfmxUSU6JRWK=
Daoy MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PMVmlEPTB;MD6wNFA4KM7:TR?= NYPMV4JtW0GQR1XS
G-402 MonmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTBwMECwO|A3KM7:TR?= MlPOV2FPT0WU
YKG-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXFPFZKSzVyPUCuNFAxPzB5IN88US=> MmroV2FPT0WU
Ca-Ski NX:3dmEzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3O1TGlEPTB;MD6wNFA4OjhizszN M3T5SXNCVkeHUh?=
CHP-212 NHzQb5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwMECwO|Mh|ryP MlXSV2FPT0WU
SCC-4 NEjM[JBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3NOoJKSzVyPUCuNFAxPzN7IN88US=> NUfF[4RZW0GQR1XS
EW-3 NVHBTFFGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTBwMECwO|Q2KM7:TR?= NIq3fFRUSU6JRWK=
P12-ICHIKAWA M{HIZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwMECwO|Q2KM7:TR?= NXzkUnJzW0GQR1XS
HSC-2 NHnOOlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;nN4tKSzVyPUCuNFAxPzV3IN88US=> MYTTRW5ITVJ?
HN NGfSb4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zYSmlEPTB;MD6wNFA4PThizszN NWPjV|dYW0GQR1XS
LXF-289 NYWzeZVjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LCbmlEPTB;MD6wNFA4PThizszN NHvEZ4pUSU6JRWK=
ES1 NIPtXohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fyOmlEPTB;MD6wNFA4PyEQvF2= MlXMV2FPT0WU
NTERA-S-cl-D1 M1\l[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDJOXpKSzVyPUCuNFAxPzd|IN88US=> MoeyV2FPT0WU
K5 NX3TSnp3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13FfWlEPTB;MD6wNFA4PzhizszN M1P3OXNCVkeHUh?=
HOS NHzhVI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFf0eWxKSzVyPUCuNFAxPzh{IN88US=> NIrOVnZUSU6JRWK=
YH-13 NGexPYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PHcmlEPTB;MD6wNFA4QTFizszN NXSxSmdvW0GQR1XS
SW954 Mn7oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwMECwPFI{KM7:TR?= MXLTRW5ITVJ?
KYSE-510 NX2yOG1UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPQTWM2OD1yLkCwNFg1KM7:TR?= M2rwcHNCVkeHUh?=
8505C MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEiyXopKSzVyPUCuNFAxQDV2IN88US=> NYHnNVQ1W0GQR1XS
A549 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnf1TWM2OD1yLkCwNFg5OiEQvF2= M1PtZ3NCVkeHUh?=
Detroit562 MlLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnLbHdKSzVyPUCuNFAxQTB{IN88US=> NXPHRW91W0GQR1XS
ES5 NI\i[5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTBwMECwPVEh|ryP NHTNd2NUSU6JRWK=
KYSE-140 NYfqdW11T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUiyc|ExUUN3ME2wMlAxODl|MzFOwG0> MYDTRW5ITVJ?
GMS-10 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfWR5Y4UUN3ME2wMlAxODl2MTFOwG0> MXvTRW5ITVJ?
D-263MG NHHPeo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTBwMECwPVQ4KM7:TR?= MlHDV2FPT0WU
BCPAP NIrFTodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{P6fmlEPTB;MD6wNFA6PDdizszN NVrpNHVtW0GQR1XS
CHL-1 MmnWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2G4SGlEPTB;MD6wNFA6PThizszN MmLtV2FPT0WU
RKO NISzWJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfxNVZCUUN3ME2wMlAxODl6OTFOwG0> NEXvWohUSU6JRWK=
SW48 NX3XbG1{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XhRWlEPTB;MD6wNFExOSEQvF2= MYrTRW5ITVJ?
BPH-1 NYDNNVA5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTBwMECxNFIh|ryP NUniOJNCW0GQR1XS
EFO-27 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXJVFNoUUN3ME2wMlAxOTB{IN88US=> MYHTRW5ITVJ?
CAL-33 NG\pTWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwMECxNFQh|ryP NWPnfJF6W0GQR1XS
NCI-H1792 Mk\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwMECxNFQh|ryP NGDnOHFUSU6JRWK=
BB30-HNC M4n2NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7UfoJKSzVyPUCuNFAyODVizszN NHu0NotUSU6JRWK=
VM-CUB-1 MlHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvnOIFlUUN3ME2wMlAxOTB3IN88US=> NF;lSGtUSU6JRWK=
TE-5 MmGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfmTWM2OD1yLkCwNVA3KM7:TR?= NGj6TmRUSU6JRWK=
NB13 NGjBNpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTBwMECxNFch|ryP MnXoV2FPT0WU
NBsusSR MorwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjH[opOUUN3ME2wMlAxOTFizszN MlrjV2FPT0WU
LNCaP-Clone-FGC MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn6zTWM2OD1yLkCwNVEh|ryP NXi3OFhmW0GQR1XS
EPLC-272H NHfzelNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTBwMECxNVEh|ryP NW\wU2tOW0GQR1XS
KNS-62 MkCyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojDTWM2OD1yLkCwNVEzKM7:TR?= MXXTRW5ITVJ?
RERF-LC-MS NX6xdGhDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;TenplUUN3ME2wMlAxOTF|IN88US=> NEjvSFVUSU6JRWK=
LOXIMVI M2P1dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXMSpZPUUN3ME2wMlAxOTF4IN88US=> M{XkWHNCVkeHUh?=
KINGS-1 M3LlZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfUTWM2OD1yLkCwNVE4KM7:TR?= Mnj6V2FPT0WU
T98G MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVr1[4tJUUN3ME2wMlAxOTF5IN88US=> M3\SbHNCVkeHUh?=
HCC1806 M2HCNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrzTWM2OD1yLkCwNVE5KM7:TR?= MlG1V2FPT0WU
MZ1-PC MnnsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\6e2lEPTB;MD6wNFEyQCEQvF2= MmCwV2FPT0WU
RT-112 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH[4SIVKSzVyPUCuNFAyOTlizszN M2XSWXNCVkeHUh?=
LK-2 M4LrVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrZXWRyUUN3ME2wMlAxOTJzIN88US=> NILx[HpUSU6JRWK=
A375 MmnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\wXFMyUUN3ME2wMlAxOTJzIN88US=> NXXFUFZFW0GQR1XS
SF268 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnYPHdKSzVyPUCuNFAyOjFizszN NEDJ[Y9USU6JRWK=
H9 NGP5d4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\sWIdTUUN3ME2wMlAxOTJ2IN88US=> M1y4XnNCVkeHUh?=
KYSE-410 NUX1bIlmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmC4TWM2OD1yLkCwNVI1KM7:TR?= NFLqd2FUSU6JRWK=
G-401 NFXq[|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvHTWM2OD1yLkCwNVI4KM7:TR?= M3XGPXNCVkeHUh?=
SW982 NEXDSI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH6yS3lKSzVyPUCuNFAyOjdizszN MWnTRW5ITVJ?
D-423MG MmryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX2xXGdjUUN3ME2wMlAxOTNizszN MmfwV2FPT0WU
CAMA-1 M3rQdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInBd3VKSzVyPUCuNFAyOzFizszN NEjkeGNUSU6JRWK=
SCC-9 NVvLcGllT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzkZ|hGUUN3ME2wMlAxOTN{IN88US=> Mln5V2FPT0WU
SAS NYrFfG1ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrqeWNKSzVyPUCuNFAyOzRizszN MYjTRW5ITVJ?
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CaR-1 MmfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nGdGlEPTB;MD6wNFMzPyEQvF2= NF;KZ5dUSU6JRWK=
AGS NW\DPXdQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7MT5JlUUN3ME2wMlAxOzJ6IN88US=> MWTTRW5ITVJ?
SF126 M4KzV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\iSYhKSzVyPUCuNFA{OjlizszN MmC4V2FPT0WU
UACC-62 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTBwMECzN{DPxE1? MkfOV2FPT0WU
NCI-H28 MkDWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;NTWM2OD1yLkCwN|M1KM7:TR?= NGrTOWZUSU6JRWK=
A2780 NYq4UVU1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\1W2lEPTB;MD6wNFM{PSEQvF2= MVPTRW5ITVJ?
CTV-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;0cmlEPTB;MD6wNFM{PyEQvF2= MlfiV2FPT0WU
LC-2-ad M4DtdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnGRVR[UUN3ME2wMlAxOzRizszN MUHTRW5ITVJ?
NCI-H1770 MmfIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX74UmxHUUN3ME2wMlAxOzR{IN88US=> M4rGfnNCVkeHUh?=
HuO9 NUG4Wm8xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTBwMECzOFYh|ryP NUH4NlVjW0GQR1XS
U-266 NEH6SGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2L0dmlEPTB;MD6wNFM1QCEQvF2= MVLTRW5ITVJ?
MLMA NV;DdGE6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7m[WZKSzVyPUCuNFA{PTVizszN NVr5dZZSW0GQR1XS
U-87-MG MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknCTWM2OD1yLkCwN|U2KM7:TR?= M2TvRXNCVkeHUh?=
GI-ME-N MkXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HXOmlEPTB;MD6wNFM2QCEQvF2= M{DkTnNCVkeHUh?=
HL-60 NYLnW5NmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\heI1lUUN3ME2wMlAxOzV7IN88US=> NUPjXGtyW0GQR1XS
EGI-1 M3HDWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrzeFlKSzVyPUCuNFA{PjJizszN NFfWS3ZUSU6JRWK=
NCI-H23 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvXZmRmUUN3ME2wMlAxOzZ2IN88US=> M3\FTnNCVkeHUh?=
NCI-H226 M1K0Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3PeIFKSzVyPUCuNFA{PjhizszN NV2xeYJNW0GQR1XS
NCI-H520 NEOxSWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTBwMECzO|Ih|ryP M1H6[3NCVkeHUh?=
L-363 NFPpPWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTBwMECzO|Yh|ryP NF;BbYFUSU6JRWK=
CAL-12T NFrT[5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHCTWM2OD1yLkCwN|c3KM7:TR?= M3H2[HNCVkeHUh?=
BT-20 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TWfGlEPTB;MD6wNFM4PiEQvF2= NHjjfIpUSU6JRWK=
SNB75 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTm[WV4UUN3ME2wMlAxOzhzIN88US=> MXLTRW5ITVJ?
A4-Fuk M4K3Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHtT2VKUUN3ME2wMlAxOzlizszN M1zGbXNCVkeHUh?=
BE-13 MkDqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfWTWM2OD1yLkCwN|k{KM7:TR?= MX7TRW5ITVJ?
NCI-H1395 NFXQXIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnSzTWM2OD1yLkCwN|k3KM7:TR?= NHzEc3JUSU6JRWK=
SW620 MkXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2O2TmlEPTB;MD6wNFM6PyEQvF2= NF;YN21USU6JRWK=
KNS-81-FD NFnDSVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlW5TWM2OD1yLkCwN|k6KM7:TR?= M4qzb3NCVkeHUh?=
RD MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTBwMEC0JO69VQ>? NWrYc5E1W0GQR1XS
HLE MmCzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXhPIJKSzVyPUCuNFA1ODVizszN MkGyV2FPT0WU
OVCAR-3 NInlNItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPlTWM2OD1yLkCwOFA4KM7:TR?= Ml7JV2FPT0WU
KM12 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{Oye2lEPTB;MD6wNFQxQCEQvF2= NELOU5ZUSU6JRWK=
HCC2998 NIH4VHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvzTWM2OD1yLkCwOFA5KM7:TR?= MoLZV2FPT0WU
D-502MG M2r0d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NESwTWpKSzVyPUCuNFA1OSEQvF2= MY\TRW5ITVJ?
KNS-42 MkT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTBwMEC0NVIh|ryP NYexOYRMW0GQR1XS
LS-123 M3zGOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTBwMEC0NlUh|ryP NHnMeIRUSU6JRWK=
SiHa MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTwbIhKSzVyPUCuNFA1OyEQvF2= M33OR3NCVkeHUh?=
T47D NVzkOIo{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTBwMEC0N|Eh|ryP M4j1U3NCVkeHUh?=
EW-24 MmX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nLTGlEPTB;MD6wNFQ{OyEQvF2= MVjTRW5ITVJ?
CAL-120 NIPhNndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PZNWlEPTB;MD6wNFQ{PSEQvF2= NGHKOnhUSU6JRWK=
JAR NYHYTGJrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHBT3B{UUN3ME2wMlAxPDN5IN88US=> MkLDV2FPT0WU
QIMR-WIL NGTQbGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPjWoNTUUN3ME2wMlAxPDN6IN88US=> M3HMbnNCVkeHUh?=
OCUB-M MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\6d3lFUUN3ME2wMlAxPDN6IN88US=> MlTxV2FPT0WU
Calu-6 M{foSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\MTWM2OD1yLkCwOFQ4KM7:TR?= M{jobnNCVkeHUh?=
MDA-MB-453 NF;2cXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELqWVNKSzVyPUCuNFA1PTFizszN M1ThZXNCVkeHUh?=
MKN45 MlXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjoTWM2OD1yLkCwOFU{KM7:TR?= MXPTRW5ITVJ?
ECC10 Mm\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\MTWM2OD1yLkCwOFYh|ryP M{LNNXNCVkeHUh?=
RVH-421 MoX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;jflJqUUN3ME2wMlAxPDZzIN88US=> NWDCb29HW0GQR1XS
TGBC11TKB MlzzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTBwMEC0Olkh|ryP NYm3W3lCW0GQR1XS
MOLT-4 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfHRm15UUN3ME2wMlAxPDdzIN88US=> MoTOV2FPT0WU
LN-405 M13COmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHRTWM2OD1yLkCwOFgzKM7:TR?= NXThdpp{W0GQR1XS
S-117 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjTRo5kUUN3ME2wMlAxPDh4IN88US=> MWrTRW5ITVJ?
RPMI-8226 NHrFdWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvCfGdFUUN3ME2wMlAxPDl5IN88US=> M37KNHNCVkeHUh?=
KYSE-150 NXP6TZBDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwMEC0PVkh|ryP NX75RY5EW0GQR1XS
NCI-H1666 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTKTWM2OD1yLkCwOVA2KM7:TR?= M4S3b3NCVkeHUh?=
Mewo MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\ROm5tUUN3ME2wMlAxPTB3IN88US=> MlPLV2FPT0WU
AN3-CA NGLRfXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXvUXNlUUN3ME2wMlAxPTB5IN88US=> MnHhV2FPT0WU
COLO-680N NY\kb2g{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwMEC1NFgh|ryP NHXobZRUSU6JRWK=
FADU MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LOTWlEPTB;MD6wNFUyKM7:TR?= NXK1Z5UyW0GQR1XS
GB-1 M2LGS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXoNGFKSzVyPUCuNFA2OTFizszN MWTTRW5ITVJ?
KASUMI-1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XTS2lEPTB;MD6wNFUyOSEQvF2= NVfoPIxvW0GQR1XS
NOMO-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3:3S2lEPTB;MD6wNFUyOyEQvF2= NXL0[FVNW0GQR1XS
BV-173 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjZe4JzUUN3ME2wMlAxPTNizszN MX3TRW5ITVJ?
RO82-W-1 NH3LNphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2mzUWlEPTB;MD6wNFU{OSEQvF2= MnLrV2FPT0WU
LB2241-RCC Mn7ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rsTWlEPTB;MD6wNFU{OSEQvF2= MWjTRW5ITVJ?
NCI-H2170 Mn75S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3L1S2lEPTB;MD6wNFU{PSEQvF2= NVPsOFlwW0GQR1XS
SK-N-AS Ml;1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXYc5Y5UUN3ME2wMlAxPTN3IN88US=> NYXIfolnW0GQR1XS
NCI-H1651 M2fzZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTBwMEC1OEDPxE1? M1LQXnNCVkeHUh?=
NCI-SNU-5 M1zZU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\mUmNbUUN3ME2wMlAxPTR3IN88US=> M3jTfnNCVkeHUh?=
SN12C M3roV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TmVGlEPTB;MD6wNFU2KM7:TR?= MmDwV2FPT0WU
KY821 Mnv1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTBwMEC1OVEh|ryP MUfTRW5ITVJ?
SW1573 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjaemZKSzVyPUCuNFA2PTRizszN NWXNXphGW0GQR1XS
OE19 NEKzeHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLheGxKUUN3ME2wMlAxPTV7IN88US=> MofmV2FPT0WU
MPP-89 MnjqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnCTWM2OD1yLkCwOVY4KM7:TR?= NX7VOlRmW0GQR1XS
HuCCT1 NHW4bI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTMfpZXUUN3ME2wMlAxPTZ6IN88US=> MkL5V2FPT0WU
SW1783 M3jxZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn34TWM2OD1yLkCwOVch|ryP NUfDVlFJW0GQR1XS
8305C M1v4Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\pOGtKSzVyPUCuNFA2PzZizszN NHnqeVhUSU6JRWK=
OVCAR-4 NWj0dIplT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTNTWM2OD1yLkCwOVg3KM7:TR?= Mn3GV2FPT0WU
MMAC-SF NYnEU|lST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXTTWM2OD1yLkCwOVg3KM7:TR?= NGPaN2VUSU6JRWK=
COLO-824 M3TMRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlq1TWM2OD1yLkCwOVkh|ryP NX7Pd5h4W0GQR1XS
HCC38 NXLlTFB2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTBwMEC2JO69VQ>? M{f0PXNCVkeHUh?=
NCI-H1648 M3;VfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjzS|luUUN3ME2wMlAxPjBzIN88US=> M{\3XnNCVkeHUh?=
NCI-H1573 MnjxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHCV2NKSzVyPUCuNFA3ODdizszN M2n5eXNCVkeHUh?=
MFM-223 M1rncGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXXTWM2OD1yLkCwOlE3KM7:TR?= NXmwSnBjW0GQR1XS
NCI-H810 M{DGV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHz2PGdKSzVyPUCuNFA3OjJizszN NX;hPZg3W0GQR1XS
EM-2 NGDxOnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojwTWM2OD1yLkCwOlI{KM7:TR?= NUnyRZdTW0GQR1XS
D-283MED MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXpOHA{UUN3ME2wMlAxPjJ2IN88US=> MlvoV2FPT0WU
NCI-H1755 MlHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLvTWM2OD1yLkCwOlI1KM7:TR?= NFLqR4NUSU6JRWK=
KYSE-70 MoTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HkbmlEPTB;MD6wNFYzPCEQvF2= MVXTRW5ITVJ?
SW626 NHTiWWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwMEC2NlQh|ryP NWS2O41RW0GQR1XS
WM-115 NXnJTFlyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTnfYViUUN3ME2wMlAxPjJ5IN88US=> M{PXT3NCVkeHUh?=
NB69 NX:1TnF6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWCzb2huUUN3ME2wMlAxPjJ7IN88US=> MlHlV2FPT0WU
DOHH-2 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTBwMEC2N{DPxE1? NGrSPIRUSU6JRWK=
MEL-JUSO M{CxS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUKyS3poUUN3ME2wMlAxPjN7IN88US=> NI[z[FFUSU6JRWK=
IGR-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jabGlEPTB;MD6wNFY1OSEQvF2= MUnTRW5ITVJ?
ACN NEfGS4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;GOI1IUUN3ME2wMlAxPjR2IN88US=> MVvTRW5ITVJ?
KARPAS-45 M4L3V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknWTWM2OD1yLkCwOlUzKM7:TR?= NEH4VndUSU6JRWK=
HC-1 NXjmcFQ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrBcYpKSzVyPUCuNFA3PTZizszN NU[wN4x[W0GQR1XS
MZ2-MEL NHvmRWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTBwMEC2OVgh|ryP MVTTRW5ITVJ?
NCI-H1355 NV3rNXJiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHmZZhOUUN3ME2wMlAxPjd7IN88US=> M4S2PHNCVkeHUh?=
HuP-T4 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rieGlEPTB;MD6wNFY4QSEQvF2= MmPvV2FPT0WU
AsPC-1 M{j4bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGf3PZpKSzVyPUCuNFA3QDNizszN NUXDbnFHW0GQR1XS
SCC-15 NHTieYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlywTWM2OD1yLkCwOlg6KM7:TR?= MmXwV2FPT0WU
CP50-MEL-B NVHMZm5sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDSXoRKSzVyPUCuNFA3QTNizszN MUnTRW5ITVJ?
DMS-114 NXvGTmZLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlO1TWM2OD1yLkCwOlk3KM7:TR?= MXHTRW5ITVJ?
KYSE-520 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjFXYdKSzVyPUCuNFA4KM7:TR?= Ml\yV2FPT0WU
NCI-H2228 NUPPZ5FLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTBwMEC3NlUh|ryP M2njNHNCVkeHUh?=
COLO-829 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrITWM2OD1yLkCwO|I2KM7:TR?= M3;VTnNCVkeHUh?=
NCI-H2052 MoPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LNRmlEPTB;MD6wNFczPyEQvF2= NG\5V5RUSU6JRWK=
HOP-92 M3zTbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwMEC3N{DPxE1? NGjjXGlUSU6JRWK=
MDA-MB-231 Mo\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M122NGlEPTB;MD6wNFc{KM7:TR?= MXXTRW5ITVJ?
SK-MEL-30 NVflco4zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWT0SFhXUUN3ME2wMlAxPzN{IN88US=> NHTlRoxUSU6JRWK=
NCI-H2087 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1mzT2lEPTB;MD6wNFc1QCEQvF2= M2rDXHNCVkeHUh?=
SW900 NXKx[oJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwMEC3OVUh|ryP NFLnZVdUSU6JRWK=
NCI-H358 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTBwMEC3OVgh|ryP NFvSNZlUSU6JRWK=
NCI-H2126 NG\PN|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfmPGFqUUN3ME2wMlAxPzd|IN88US=> NUf5eopjW0GQR1XS
TGBC24TKB Ml61S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfER4VXUUN3ME2wMlAxPzhzIN88US=> M2\hcnNCVkeHUh?=
786-0 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37sXGlEPTB;MD6wNFc5PiEQvF2= Mo\VV2FPT0WU
no-10 M2\DcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnXTWM2OD1yLkCwO|g5KM7:TR?= MYTTRW5ITVJ?
SCH M4\2fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1T5e2lEPTB;MD6wNFgyQCEQvF2= NVT5WWFQW0GQR1XS
COLO-741 MkjRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHFeYNKSzVyPUCuNFA5OiEQvF2= MmD1V2FPT0WU
NCI-H82 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\ITWM2OD1yLkCwPFIzKM7:TR?= NFz1SGxUSU6JRWK=
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NB6 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXiTWM2OD1yLkCzPVUzKM7:TR?= M36yeHNCVkeHUh?=
HT NF:yUGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\jTWlEPTB;MD6wOFAxPyEQvF2= MUHTRW5ITVJ?
COLO-684 NUCydHp[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjDSm1KSzVyPUCuNFQxQTVizszN NYDtOml2W0GQR1XS
NCI-H1693 NITwT2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmL2TWM2OD1yLkC0N|A2KM7:TR?= NFi0WmtUSU6JRWK=
LAN-6 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULlT2VTUUN3ME2wMlA1OzN3IN88US=> NFjWWmxUSU6JRWK=
MDA-MB-175-VII MlPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPUTWM2OD1yLkC0OFE4KM7:TR?= MWDTRW5ITVJ?
KMOE-2 NFPVSoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fje2lEPTB;MD6wOFQ3QSEQvF2= NH;0dWJUSU6JRWK=
DMS-79 NYficGZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXH0[40xUUN3ME2wMlA1PTd7IN88US=> M1WwNHNCVkeHUh?=
MHH-NB-11 M1nB[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvPbIRoUUN3ME2wMlA1PjF2IN88US=> MnrmV2FPT0WU
NCI-H69 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1Ph[GlEPTB;MD6wOFg1QSEQvF2= NFzv[4pUSU6JRWK=
KE-37 MmK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTBwMEWwNUDPxE1? MXvTRW5ITVJ?
Ramos-2G6-4C10 M4jzPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTBwMEWwOlch|ryP Mk[4V2FPT0WU
NCI-H1793 NVXhWnYxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTBwMEWwPVMh|ryP MmDFV2FPT0WU
HT-1376 M{jXfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlf2TWM2OD1yLkC1NVg3KM7:TR?= MlOyV2FPT0WU
EKVX MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTYTWM2OD1yLkC1N|g1KM7:TR?= Mnv2V2FPT0WU
Capan-2 NVW2SW9{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFX5bm5KSzVyPUCuNFU{QTZizszN NHLsbIFUSU6JRWK=
DoTc2-4510 NEPuS3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LuSGlEPTB;MD6wOVQ1PiEQvF2= NIfZdGJUSU6JRWK=
UACC-893 NGTXWpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;PVoo2UUN3ME2wMlA2PDZ{IN88US=> NH\Fb5FUSU6JRWK=
SK-MEL-3 MmTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTNZ4dKSzVyPUCuNFU4QDhizszN NI\ubIdUSU6JRWK=
SK-MEL-1 NIOyZ4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTBwMEW4JO69VQ>? MkW2V2FPT0WU
SW948 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTBwMEW5PVYh|ryP MUfTRW5ITVJ?
P30-OHK NUHBfZQzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPsTWM2OD1yLkC2NVY4KM7:TR?= M4njUXNCVkeHUh?=
NH-12 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TXT2lEPTB;MD6wOlI1PCEQvF2= M{H4dnNCVkeHUh?=
KU-19-19 M{XpS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPlTWM2OD1yLkC2N|YyKM7:TR?= NVPPOoJzW0GQR1XS
A431 NFT5NW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTBwME[zO|Qh|ryP M13CVXNCVkeHUh?=
NCI-H2405 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTBwME[zPFMh|ryP NFjwRmtUSU6JRWK=
KARPAS-299 NUTUXo5iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLHUmZKSzVyPUCuNFY2QDJizszN NIfrXndUSU6JRWK=
BALL-1 NXPGNYI1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTBwME[2O|Qh|ryP NEm2eFJUSU6JRWK=
KURAMOCHI MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXrR29EUUN3ME2wMlA4ODd|IN88US=> NUX6W2VoW0GQR1XS
LS-1034 Mn;HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTOTm9zUUN3ME2wMlA4OzZ7IN88US=> MWTTRW5ITVJ?
MFE-280 NEfQcphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDDTWM2OD1yLkC3OVM3KM7:TR?= NIHKUZpUSU6JRWK=
HOP-62 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTyTWM2OD1yLkC3Olc3KM7:TR?= M3THSXNCVkeHUh?=
KG-1 NETlVXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfUTWM2OD1yLkC3O|g4KM7:TR?= MUDTRW5ITVJ?
CW-2 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlOzTWM2OD1yLkC3PFMzKM7:TR?= NEPCOI9USU6JRWK=
SW837 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFS3SodKSzVyPUCuNFg{PDJizszN MYPTRW5ITVJ?
MFH-ino MmHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHMTWM2OD1yLkC4OVAyKM7:TR?= NF3uVopUSU6JRWK=
HCC1419 M4LYZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rXdGlEPTB;MD6wPFk5PyEQvF2= NVyycm5DW0GQR1XS
HMV-II NGf3b5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfWU4JKSzVyPUCuNFkxOSEQvF2= NVjmPW1RW0GQR1XS
BEN NV\TeY1rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTBwMEmzPFUh|ryP MXPTRW5ITVJ?
SK-N-FI MoLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHy2SYxKSzVyPUCuNFk2PTZizszN MUjTRW5ITVJ?
JVM-2 NXHiXW9wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PsTWlEPTB;MD6wPVcyPiEQvF2= M{LaSnNCVkeHUh?=
CAL-54 M{\VOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnMN|VKSzVyPUCuNVAxPCEQvF2= M{ewSXNCVkeHUh?=
T84 NYXWUndOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfO[3BKSzVyPUCuNVA6PTJizszN NE\5W5NUSU6JRWK=
SHP-77 MnjsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTBwMUG2OFEh|ryP NX3vXY1RW0GQR1XS
G-361 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTBwMUKzNlQh|ryP M1\1RnNCVkeHUh?=
Calu-3 NHvGfo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXviZ21ZUUN3ME2wMlE{QDF4IN88US=> NWPmOWM6W0GQR1XS
HCC1937 M3\6UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHj1eodKSzVyPUCuNVQ6OzdizszN M1zPd3NCVkeHUh?=
KM-H2 NEXPcFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLoTWM2OD1yLkG1NFEh|ryP M4DLcnNCVkeHUh?=
769-P M{jDfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlj4TWM2OD1yLkG1PFQ{KM7:TR?= MYPTRW5ITVJ?
NCI-H1304 NUja[3hQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTBwMU[wOlEh|ryP NXPQc2dnW0GQR1XS
D-542MG M4DONmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1m3TGlEPTB;MD6xOlI4QCEQvF2= MmrKV2FPT0WU
ATN-1 M2PSNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4mxTGlEPTB;MD6xO|Q1OSEQvF2= M2q4XnNCVkeHUh?=
NCI-H2029 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwMkCyOFMh|ryP NEP6ZXRUSU6JRWK=
ZR-75-30 M3HKN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHz2[|NKSzVyPUCuNlA3PDNizszN M{XlNnNCVkeHUh?=
SW1116 M1rnOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPpc21KSzVyPUCuNlEyOTdizszN NFXmZVFUSU6JRWK=
CCRF-CEM MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHKXm57UUN3ME2wMlI4PjF2IN88US=> MVLTRW5ITVJ?
LU-135 M1jzNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTBwMke3N|kh|ryP MV;TRW5ITVJ?
MC116 MmXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTBwMkizNFkh|ryP NFS4c4FUSU6JRWK=
LS-513 NHr0Ro5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTBwMki3O|Mh|ryP M2jx[XNCVkeHUh?=
NCI-H630 NHnMT3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwMkmzO|Yh|ryP MmLPV2FPT0WU
L-428 NYDDT4dxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPRTWM2OD1yLkK5PFg{KM7:TR?= Mk\SV2FPT0WU
UM-UC-3 M3LZR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrCSnFKSzVyPUCuN|EzQTFizszN NF;Wb2dUSU6JRWK=
NCI-H1838 NIm1VpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvqZpZKSzVyPUCuN|E4QDRizszN MXfTRW5ITVJ?
HEL MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGn4SIVKSzVyPUCuN|IzPCEQvF2= NIHNNnNUSU6JRWK=
OCI-AML2 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTBwM{KyPVgh|ryP NEHEd2hUSU6JRWK=
A3-KAW M{G0d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHznZYFKSzVyPUCuN|M1PzdizszN M4rkSXNCVkeHUh?=
IGROV-1 Mn\sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3sTWM2OD1yLkOzO|U2KM7:TR?= NUjld4NmW0GQR1XS
Mo-T M{DO[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;0TWM2OD1yLkOzPFU{KM7:TR?= M2rFZnNCVkeHUh?=
HDLM-2 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\IbmlEPTB;MD6zN|kh|ryP NF\2XIVUSU6JRWK=
HCC1569 Mk\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\YRnpKSzVyPUCuN|Q{ODlizszN NGi0[WdUSU6JRWK=
COLO-678 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwM{ewNFIh|ryP MnrwV2FPT0WU
COR-L105 M17q[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTkcoZtUUN3ME2wMlM4QTNizszN NGrNW4RUSU6JRWK=
SK-MEL-24 MkXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\4UY5KSzVyPUCuN|g{QDJizszN M4DmS3NCVkeHUh?=
COLO-320-HSR MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfTd3BKSzVyPUCuOFM6PzZizszN NFzwcZlUSU6JRWK=
C8166 NI\qUYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwNEmwNlMh|ryP MXHTRW5ITVJ?
COLO-679 Mm\3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwNkKxO|Ih|ryP MXfTRW5ITVJ?
TE-12 M3rmZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTnRnhKSzVyPUCuOlU{QTRizszN NHfuPWZUSU6JRWK=
HAL-01 Ml\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTBwNk[yNkDPxE1? NHv0cFdUSU6JRWK=
H-EMC-SS M17zVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTBwN{C1OFYh|ryP Mk\HV2FPT0WU
SNU-449 NHnxZ4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGL5OphKSzVyPUCuO|I4PDhizszN MWnTRW5ITVJ?
C32 NWDaT2VVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEGxUndKSzVyPUCuO|QyOTJizszN MnjBV2FPT0WU
K-562 NV7n[pE5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoW2TWM2OD1yLke3NFI1KM7:TR?= NEP2VYJUSU6JRWK=
DJM-1 NFG5WmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYj0e2dwUUN3ME2wMlc5PzhzIN88US=> MnzEV2FPT0WU
RCC10RGB MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoGyTWM2OD1yLke5NVg{KM7:TR?= MlLaV2FPT0WU
CAL-85-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXDbXpyUUN3ME2wMlkxPyEQvF2= M2HHc3NCVkeHUh?=
NY NUDBZVFNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGC3bHVKSzVyPUCuPVM{PTJizszN NGL6R21USU6JRWK=
NCI-H1993 NEXxdpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWr1eWJtUUN3ME2xMlE6Ojh7IN88US=> MYnTRW5ITVJ?
SK-OV-3 Mn3kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\qTWM2OD1zLkKyNFg6KM7:TR?= NFnybmVUSU6JRWK=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
PIM1; 

PubMed: 18426800     


Cells were treated with 100 nm docetaxel for the indicated times. PIM1 and β-ACTIN proteins were analyzed by immunoblot analysis. One of three similar blots is shown. Ratio, ratio of PIM1/β-ACTIN from pooled densitometry data from three separate experimen䲧疝Ỵ疞㧀疜膉痘 瘿뾠ՂᾰƌՂĀ 㺣痖帉痖Ѐ瑖堘𢡄빢᎒ՂĀ鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ⟸෕䐺痖暼瘿⟸෕ᾰƌ

cyclin B; 

PubMed: 18426800     


Immunoblot analysis of cyclin B1 and PIM1 expression after docetaxel 10 nm (left) or 100 nm (right) treatment at various time points.

pSTAT3 / STAT3 ; 

PubMed: 18426800     


Immunoblots of RWPE-2 cells treated with 100 nm docetaxel for the indicated time.

p-p53 / p53; 

PubMed: 22996738     


C4-2 cells were treated with 5 nM docetaxel, the whole cell lysates were collected at different time points and subjected to Western blot.

18426800 22996738
Immunofluorescence
α-tubulin; 

PubMed: 27177833     


Noscapine has no effect on gross microtubule polymerization state but noscapine pre-sensitization followed by docetaxel treatment stabilizes microtubules, hence inhibits cell proliferation. TNBC cells were treated with noscapine (4 µM) or docetaxel (0.4 µ䲧疝Ỵ疞㧀疜膉痘 瘿⟸෕ᾰƌ෕Ð 㺣痖帉痖Ѐ瑖堘𢡄빢᎒෕Ð鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ뾠Ղ䐺痖暼瘿뾠Ղᾰƌ 뾠ՂÐ㺣痖뾠Ղ€𢡄뾤Ղ€䀷痗뾤Ղ౴뾤Ղ㵶痗뾤Ղ뺖᎒泌Itemセ᎒Count﫨呂뿔Ղ猴፲뾤Ղ፲씢痗猸፲髸莤䥷堙᎒セ᎒�堞ﻮ᎒፲露𢡄堚Ҕ齃礤v�堞ﻮ᎒猢Wセ᎒䨼Ą鹿齃殺獸W戀醙

cleaved PARP / cleaved caspase-3; 

PubMed: 21087597     


Immunofluorescence images of PC-3 cells treated with the docetaxel and EM011 schedule treatment. Cells were pretreated with docetaxel for 12 h before addition of EM011 and were fixed at 48 h post docetaxel treatment compared to treatment with EM011 (10 μM䲧疝Ỵ疞㧀疜膉痘 瘿⟸෕ᾰƌ෕Ð 㺣痖帉痖Ѐ瑖堘𢡄빢᎒෕Ð鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ�෋䐺痖暼瘿�෋ᾰƌ �෋à

Acetylated tubulin ; 

PubMed: 18426800     


Immunofluorescence of acetylated tubulin in cells treated with DMSO, 30 nM laulimalide and 30 nM docetaxel for 2.5 h. Tubulin shown in green and DAPI in blue, and the white arrow indicates microtubule bundling. Scale bar represents 10 μm.

SQSTM1 / LAMP1; 

PubMed: 29795139     


AGS cells were treated with docetaxel (10 nM) for 12 h. After immunostaining with SQSTM1 (Alexa Fluor 488, green) and LAMP1 (Alexa Fluor 594, red), cells were examined by fluorescence microscopy (scale bar 20 μm). The colocalization of SQSTM1and LAMP1 was䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 㺣痖帉痖Ѐ

27177833 21087597 18426800 29795139
Growth inhibition assay
Cell viability ; 

PubMed: 22996738     


Docetaxel inhibits the growth of LNCaP, C4-2, DU145, and PC3 prostate cancer cells. Cells were plated in 12-well plates and treated with different concentrations of docetaxel. The cell number was counted after 24 hr. 

22996738
In vivo Docetaxel (33 mg/kg/dose, given i.v. every 4 days for 3 injections) results in a tumor growth delay of 19.3 days in M2OL2 colon xenografts. Docetaxel also shows great antitumor activities in MX-1, SK-MEL-2, LX-1 and OVCAR-3 xenografts. Docetaxel inhibits the angiogenic response to fibroblast growth factor 2 with IC 50 of 5.4 mg/kg when injected twice weekly over a 14-day period, and angiogenesis is completely blocked in mice that receives 10 mg/kg Docetaxel. Docetaxel has selectivity for endothelial cell migration and/or microvessel formation because infiltration of inflammatory cells into the Matrigel plug is much less sensitive to inhibition by Docetaxel. [7]

Protocol

Cell Research:[5]
- Collapse
  • Cell lines: Human gastric cancer cell lines MKN-28
  • Concentrations: 6 nM
  • Incubation Time: 3 days
  • Method: 2000 cells in 180 μL of medium are seeded in a 96-well plate, and 20 μL of drug solution is simultaneously added in triplicate to each well. The plate is incubated for 3 days at 37°C in a humidified atmosphere of 5% CO2. On day 3, 25 μL of MTT reagent is added to each well. After 4 h of incubation, the medium is removed by aspiration. 0.2 mL of dimethylsulphoxide (DMSO) is added to each well and thoroughly mixed by using a mechanical plate mixer to dissolve the resulting MTT-formazan crystals. Absorbance at 540 nm (OD) is measured by a reader.
    (Only for Reference)
Animal Research:[6]
- Collapse
  • Animal Models: Human colon carcinomas xenografts CX-1
  • Dosages: 33 mg/kg
  • Administration: i.v. every 4 days for 3 injections
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (123.78 mM)
Water Insoluble
Ethanol '53 mg/mL warmed
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 807.88
Formula

C43H53NO14

CAS No. 114977-28-5
Storage powder
in solvent
Synonyms RP56976, NSC 628503
Smiles CC(=O)OC12COC1CC(O)C3(C)C2C(OC(=O)C4=CC=CC=C4)C5(O)CC(OC(=O)C(O)C(NC(=O)OC(C)(C)C)C6=CC=CC=C6)C(=C(C(O)C3=O)C5(C)C)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation (Different batches have different solubility ratios, please contact Selleck to provide you with the correct ratio)
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04364620 Not yet recruiting Drug: AB-16B5|Drug: Docetaxel NSCLC Stage IV Alethia Biotherapeutics August 2020 Phase 2
NCT04343885 Recruiting Drug: 177Lu-PSMA-617|Drug: Docetaxel Metastatic Hormone Naive Prostate Cancer Peter MacCallum Cancer Centre Australia|Movember Foundation|Prostate Cancer Research Alliance|United States Department of Defense|Advanced Accelerator Applications|Australian Nuclear Science and Technology Organisation (ANSTO)|Australian and New Zealand Urogenital and Prostate Cancer Trials Group|Australasian Radiopharmaceutical Trials network (ARTnet)|Centre for Biostatistics and Clinical Trials (BaCT) April 21 2020 Phase 2
NCT04256707 Recruiting Drug: Selinexor|Drug: Docetaxel|Drug: Pembrolizumab Non-Small Cell Lung Carcinoma (NSCLC)|Colorectal Cancer (CRC) Karyopharm Therapeutics Inc January 14 2020 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Microtubule Associated Signaling Pathway Map

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