Docetaxel

For research use only.

Catalog No.S1148 Synonyms: RP56976, NSC 628503

101 publications

Docetaxel Chemical Structure

CAS No. 114977-28-5

Docetaxel (RP56976, NSC 628503), an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.

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Selleck's Docetaxel has been cited by 101 publications

Purity & Quality Control

Choose Selective Microtubule Associated Inhibitors

Biological Activity

Description Docetaxel (RP56976, NSC 628503), an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.
Targets
Microtubules [1]
(Cell-free assay)
In vitro

Docetaxel is a cytotoxic agent, especially for proliferating cells, which is related to its ability to promote the formation of microtubule bundles and induce sustained mitotic arrest, followed by apoptosis of mitotically arrested cells or permanent mitotic block. Docetaxel suppresses microtubule dynamic instability as well as tread-milling, resulting in the failure of chromosomes to segregate to the daughter cells, which in turn triggers premature exit from mitosis rather than a block at this phase of the cell cycle. [2] Docetaxel inhibits the clonogenic survival of Human cancer cell Hs746T (stomach), AGS (stomach), HeLa (cervix), CaSki (cervix), BxPC3 (pancreas), Capan-1 (pancreas) with IC50 of 1 nM, 1 nM, 0.3 nM, 0.3 nM, 0.3 nM and 0.3 nM respectively. [4] Docetaxel inhibits endothelial cell migration that does not affects microtubule gross morphology or inhibit cell proliferation, although they does produce more subtle effects on microtubule dynamics. Docetaxel inhibits HUVEC migration with an observed IC50 of 1 pM. HUVEC chemotaxis stimulated by either of two angiogenic factors, thymidine phosphorylase or VEGF, is inhibited by Docetaxel with IC 50 of 10 pM and is ablated at 1 nM. [7] Docetaxel induces human monocytes, but not RAW 264.7 murine macrophages, Prostaglandin H Synthase-2m (PGHS-2) expression. [8]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HSC-3 M4HUemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPZTWM2OD1yLkCwNFE{OiEQvF2= MX\TRW5ITVJ?
5637 MkDiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nhUGlEPTB;MD6wNFAyPDNizszN NFjGfpFUSU6JRWK=
HT-144 NEf1e5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo[3TWM2OD1yLkCwNFE2PyEQvF2= NH3KR4JUSU6JRWK=
NCI-H292 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnqTWM2OD1yLkCwNFE2QSEQvF2= MlS5V2FPT0WU
HCE-T Mk\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXmU20xUUN3ME2wMlAxODF4MjFOwG0> NW\IXIlXW0GQR1XS
ESS-1 NWDvZYp1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInib5VKSzVyPUCuNFAxOTd7IN88US=> M{DZZ3NCVkeHUh?=
D-566MG M1rNOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwMECwNVgzKM7:TR?= NXjISXJPW0GQR1XS
CAL-62 Mnv2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\NTWM2OD1yLkCwNFE5PSEQvF2= NXHiRlRrW0GQR1XS
GT3TKB MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LoN2lEPTB;MD6wNFAzOzJizszN NUHnXmZkW0GQR1XS
HSC-4 M1HI[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjKZ3ZLUUN3ME2wMlAxODJ|OTFOwG0> NX3BXHNLW0GQR1XS
KOSC-2 NH\hVGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jGOGlEPTB;MD6wNFAzPTVizszN MmfoV2FPT0WU
NB14 M2PLUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTBwMECwNlYh|ryP MkC2V2FPT0WU
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BFTC-905 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF:ycVFKSzVyPUCuNFAxOjZ6IN88US=> NY\5WXVpW0GQR1XS
A498 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPWTWM2OD1yLkCwNFI4QCEQvF2= NFPDe2JUSU6JRWK=
HO-1-N-1 MmjPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTpTWM2OD1yLkCwNFI5OSEQvF2= M3q0RXNCVkeHUh?=
SF539 M2LYc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml2zTWM2OD1yLkCwNFMxOiEQvF2= NFrXSGVUSU6JRWK=
HuO-3N1 M{HVN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHq3VVZKSzVyPUCuNFAxOzB{IN88US=> M2L3cXNCVkeHUh?=
NCI-H510A M3:2R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFW0dlFKSzVyPUCuNFAxOzN4IN88US=> MkXVV2FPT0WU
CAL-27 M2G4Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLHfWRKSzVyPUCuNFAxOzN7IN88US=> MVzTRW5ITVJ?
TE-8 NIXMUGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfWTWM2OD1yLkCwNFM3PiEQvF2= M2PmV3NCVkeHUh?=
VA-ES-BJ MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwMECwN|c2KM7:TR?= M2DGcXNCVkeHUh?=
RH-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHQTWM2OD1yLkCwNFM5PiEQvF2= M2rsbXNCVkeHUh?=
COLO-800 MnfGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2WwNmlEPTB;MD6wNFA{QDhizszN NVXGelBWW0GQR1XS
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Ca9-22 NETXcmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4K1NWlEPTB;MD6wNFA1OjNizszN NUTmUVJyW0GQR1XS
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RPMI-7951 M{eyWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTIOZBKSzVyPUCuNFAxPDR6IN88US=> MWTTRW5ITVJ?
SW1710 NV;WWW5MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTBwMECwOFY3KM7:TR?= NFq5fGdUSU6JRWK=
HGC-27 NGfnUpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTBwMECwOFcyKM7:TR?= M4TFTXNCVkeHUh?=
MC-IXC NFvBRmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1ezWmlEPTB;MD6wNFA1PzlizszN M1S3eXNCVkeHUh?=
FTC-133 M1\GUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17IOGlEPTB;MD6wNFA1QDlizszN NGS1PXFUSU6JRWK=
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NMC-G1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwMECwOVE4KM7:TR?= M{Hxe3NCVkeHUh?=
GI-1 NFLJSVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rsSmlEPTB;MD6wNFA2OjhizszN M2fqWXNCVkeHUh?=
CGTH-W-1 Mlr5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXQTWM2OD1yLkCwNFU1OiEQvF2= NH3lS4xUSU6JRWK=
A2058 NEHlNGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXSb|BKSzVyPUCuNFAxPTR2IN88US=> NHq0RXZUSU6JRWK=
ETK-1 MoroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTNXIY5UUN3ME2wMlAxODV3ODFOwG0> MUPTRW5ITVJ?
NEC8 M2[zS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfjeGRKSzVyPUCuNFAxPTZzIN88US=> NEO3W21USU6JRWK=
TE-11 MlSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjITVFyUUN3ME2wMlAxODV4OTFOwG0> NHfFcHNUSU6JRWK=
NCI-H720 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvZTWM2OD1yLkCwNFU5KM7:TR?= NIXIWWVUSU6JRWK=
PSN1 NYixfZNHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M36wXWlEPTB;MD6wNFA2QDFizszN MnjYV2FPT0WU
SW780 M1H3Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTBwMECwOVg4KM7:TR?= MkfUV2FPT0WU
8-MG-BA Mne3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPWdXZKSzVyPUCuNFAxPTh7IN88US=> MYnTRW5ITVJ?
EC-GI-10 MlLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LLfWlEPTB;MD6wNFA2QTJizszN MnfqV2FPT0WU
SJSA-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jXbWlEPTB;MD6wNFA3OTVizszN M4LxdXNCVkeHUh?=
639-V MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTBwMECwOlQ4KM7:TR?= M{TE[3NCVkeHUh?=
PFSK-1 M4nSZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTBwMECwOlU4KM7:TR?= NFWwZ4hUSU6JRWK=
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SCC-25 NI[xXVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXS3cYJ{UUN3ME2wMlAxODZ6IN88US=> MoTTV2FPT0WU
PA-1 M4jNOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTBwMECwOlg4KM7:TR?= NV\6O41bW0GQR1XS
MHH-ES-1 NGfSZ4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwMECwO{DPxE1? MkTxV2FPT0WU
Daoy NXfQNmxKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3jTWM2OD1yLkCwNFch|ryP NHjZZ4VUSU6JRWK=
G-402 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnK2TWM2OD1yLkCwNFcxPiEQvF2= Ml30V2FPT0WU
YKG-1 M{HGemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFT0Om9KSzVyPUCuNFAxPzB5IN88US=> NFTOZlJUSU6JRWK=
Ca-Ski MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjofmpsUUN3ME2wMlAxODd{ODFOwG0> MmrvV2FPT0WU
CHP-212 M1jDVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH[wcGZKSzVyPUCuNFAxPzNizszN Mn7mV2FPT0WU
SCC-4 M2Xa[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVr1V3U3UUN3ME2wMlAxODd|OTFOwG0> Mkm4V2FPT0WU
EW-3 MojiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTBwMECwO|Q2KM7:TR?= NG\vXpdUSU6JRWK=
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HSC-2 M{TrXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHCT3hKSzVyPUCuNFAxPzV3IN88US=> MlPzV2FPT0WU
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LXF-289 NG\hdmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwMECwO|U5KM7:TR?= NHjNNHVUSU6JRWK=
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NTERA-S-cl-D1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXuSFZKSzVyPUCuNFAxPzd|IN88US=> NIrEVXNUSU6JRWK=
K5 MoTHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jESmlEPTB;MD6wNFA4PzhizszN MlTYV2FPT0WU
HOS NGi0WHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jtRmlEPTB;MD6wNFA4QDJizszN MYPTRW5ITVJ?
YH-13 MojMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjNTWM2OD1yLkCwNFc6OSEQvF2= MnfHV2FPT0WU
SW954 MlnkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XDRWlEPTB;MD6wNFA5OjNizszN MlW1V2FPT0WU
KYSE-510 MkXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLxTWM2OD1yLkCwNFg1KM7:TR?= NHLxXFRUSU6JRWK=
8505C MnrDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTBwMECwPFU1KM7:TR?= NWTYRnd3W0GQR1XS
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Detroit562 M17HO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NED0fZRKSzVyPUCuNFAxQTB{IN88US=> M{DZR3NCVkeHUh?=
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D-263MG MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPMWIxKSzVyPUCuNFAxQTR5IN88US=> MmG4V2FPT0WU
BCPAP NXnEfpQ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XwTmlEPTB;MD6wNFA6PDdizszN NV7WfmtGW0GQR1XS
CHL-1 NIHtd5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTBwMECwPVU5KM7:TR?= MXTTRW5ITVJ?
RKO MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfSTWM2OD1yLkCwNFk5QSEQvF2= MVzTRW5ITVJ?
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VM-CUB-1 Mlq0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwMECxNFUh|ryP M{LpUnNCVkeHUh?=
TE-5 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzLeJJbUUN3ME2wMlAxOTB4IN88US=> NELR[nRUSU6JRWK=
NB13 MlL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkX1TWM2OD1yLkCwNVA4KM7:TR?= M{jOTHNCVkeHUh?=
NBsusSR NIHpPW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlm1TWM2OD1yLkCwNVEh|ryP M{Th[3NCVkeHUh?=
LNCaP-Clone-FGC NUnDPVlmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjOdWpKSzVyPUCuNFAyOSEQvF2= M4PUdHNCVkeHUh?=
EPLC-272H M2LheWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkmzTWM2OD1yLkCwNVEyKM7:TR?= MnPyV2FPT0WU
KNS-62 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTBwMECxNVIh|ryP MYLTRW5ITVJ?
RERF-LC-MS M4S2WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXFNpJKSzVyPUCuNFAyOTNizszN NInJ[lZUSU6JRWK=
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RT-112 NXzteHdJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nsU2lEPTB;MD6wNFEyQSEQvF2= MnvWV2FPT0WU
LK-2 Mn\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlu3TWM2OD1yLkCwNVIyKM7:TR?= M3n1O3NCVkeHUh?=
A375 MnrLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfpcmdKSzVyPUCuNFAyOjFizszN NIP1b5dUSU6JRWK=
SF268 NW[we2d{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTBwMECxNlEh|ryP NGix[4VUSU6JRWK=
H9 Ml\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjPTWM2OD1yLkCwNVI1KM7:TR?= MoDyV2FPT0WU
KYSE-410 MkeyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LzR2lEPTB;MD6wNFEzPCEQvF2= MX7TRW5ITVJ?
G-401 NFnuZ2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPkNZZuUUN3ME2wMlAxOTJ5IN88US=> MVvTRW5ITVJ?
SW982 M3TufGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwMECxNlch|ryP NFzoUlhUSU6JRWK=
D-423MG MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTBwMECxN{DPxE1? NXjFdVgxW0GQR1XS
CAMA-1 NE\vfpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rDcWlEPTB;MD6wNFE{OSEQvF2= MoPVV2FPT0WU
SCC-9 MnLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fjUWlEPTB;MD6wNFE{OiEQvF2= Ml25V2FPT0WU
SAS M17RXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoH4TWM2OD1yLkCwNVM1KM7:TR?= MVfTRW5ITVJ?
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UACC-62 NFjKWplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3mTWM2OD1yLkCwN|Mh|ryP MkDSV2FPT0WU
NCI-H28 NWe2fIRrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3f5PWlEPTB;MD6wNFM{PCEQvF2= Mki4V2FPT0WU
A2780 MoLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml:xTWM2OD1yLkCwN|M2KM7:TR?= NFntVHFUSU6JRWK=
CTV-1 M3jCR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrLTWM2OD1yLkCwN|M4KM7:TR?= M1XDOHNCVkeHUh?=
LC-2-ad NGrkOW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\vWlBKSzVyPUCuNFA{PCEQvF2= NFnQ[lVUSU6JRWK=
NCI-H1770 NETLOWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7zXI9KSzVyPUCuNFA{PDJizszN MlfOV2FPT0WU
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MLMA M1nNXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXL6Wno4UUN3ME2wMlAxOzV3IN88US=> M1:ydHNCVkeHUh?=
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GI-ME-N NGfLSWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\5bW5IUUN3ME2wMlAxOzV6IN88US=> NGXlOYFUSU6JRWK=
HL-60 NUGzXm1OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXS0TYcyUUN3ME2wMlAxOzV7IN88US=> Ml\vV2FPT0WU
EGI-1 Mnm4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zqXWlEPTB;MD6wNFM3OiEQvF2= NWjjdJJDW0GQR1XS
NCI-H23 MlO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;yTWM2OD1yLkCwN|Y1KM7:TR?= M2D4T3NCVkeHUh?=
NCI-H226 M3vBb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml63TWM2OD1yLkCwN|Y5KM7:TR?= MYDTRW5ITVJ?
NCI-H520 Mn7PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXL2WGRCUUN3ME2wMlAxOzd{IN88US=> NViwfHU3W0GQR1XS
L-363 NUXUVox{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTBwMECzO|Yh|ryP M2fJe3NCVkeHUh?=
CAL-12T NYS4[mNET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmX5TWM2OD1yLkCwN|c3KM7:TR?= M136TXNCVkeHUh?=
BT-20 M1TwUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjiS2FKSzVyPUCuNFA{PzZizszN NHWzcFZUSU6JRWK=
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A4-Fuk M2PLVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTBwMECzPUDPxE1? NIm1WmlUSU6JRWK=
BE-13 MnL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7kbFJKSzVyPUCuNFA{QTNizszN MYnTRW5ITVJ?
NCI-H1395 M2H1W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTBwMECzPVYh|ryP MV3TRW5ITVJ?
SW620 NY\vZos2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPpTWM2OD1yLkCwN|k4KM7:TR?= NVnBZnVFW0GQR1XS
KNS-81-FD MnrrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHaTWM2OD1yLkCwN|k6KM7:TR?= MUjTRW5ITVJ?
RD M2DGXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFP2[WZKSzVyPUCuNFA1KM7:TR?= M4W0fnNCVkeHUh?=
HLE MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\OVGlEPTB;MD6wNFQxPSEQvF2= MmnIV2FPT0WU
OVCAR-3 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1i1fGlEPTB;MD6wNFQxPyEQvF2= NVWxdnc3W0GQR1XS
KM12 M1rB[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4Dud2lEPTB;MD6wNFQxQCEQvF2= NUjYWXJ1W0GQR1XS
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D-502MG M{TXVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTBwMEC0NUDPxE1? MXzTRW5ITVJ?
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LS-123 MnW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4L4[WlEPTB;MD6wNFQzPSEQvF2= M3fDPXNCVkeHUh?=
SiHa NXzROoZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nicGlEPTB;MD6wNFQ{KM7:TR?= M3L0THNCVkeHUh?=
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EW-24 NVXQOJhtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvxRWdKSzVyPUCuNFA1OzNizszN NIDsV3ZUSU6JRWK=
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JAR M4naUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XqUGlEPTB;MD6wNFQ{PyEQvF2= NYXEVlJrW0GQR1XS
QIMR-WIL M1rnT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTBwMEC0N|gh|ryP NGK0d|RUSU6JRWK=
OCUB-M NXnRNYM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnS5TWM2OD1yLkCwOFM5KM7:TR?= NGr1cW5USU6JRWK=
Calu-6 MlX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTBwMEC0OFch|ryP NVvkUll2W0GQR1XS
MDA-MB-453 NF3JTZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLWTWM2OD1yLkCwOFUyKM7:TR?= NH\yeplUSU6JRWK=
MKN45 NFrMTFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjOdFVwUUN3ME2wMlAxPDV|IN88US=> MVvTRW5ITVJ?
ECC10 NXvmPVh2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULu[ZJkUUN3ME2wMlAxPDZizszN MlnnV2FPT0WU
RVH-421 M1SyN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlH2TWM2OD1yLkCwOFYyKM7:TR?= MUPTRW5ITVJ?
TGBC11TKB MmSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXHTWM2OD1yLkCwOFY6KM7:TR?= MojMV2FPT0WU
MOLT-4 NFHTU4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrPbnpKSzVyPUCuNFA1PzFizszN MorqV2FPT0WU
LN-405 NHLHeWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLDTWM2OD1yLkCwOFgzKM7:TR?= NILuRXdUSU6JRWK=
S-117 NVW0Sm1IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLoTWM2OD1yLkCwOFg3KM7:TR?= NXT3NHBnW0GQR1XS
RPMI-8226 MmDpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLVTWM2OD1yLkCwOFk4KM7:TR?= M2PieXNCVkeHUh?=
KYSE-150 MoH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\ZOJdKSzVyPUCuNFA1QTlizszN NVjjdVVMW0GQR1XS
NCI-H1666 M17NT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4[wcWlEPTB;MD6wNFUxPSEQvF2= MmDwV2FPT0WU
Mewo MmjTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnNTWM2OD1yLkCwOVA2KM7:TR?= M1PwXnNCVkeHUh?=
AN3-CA NX;rfmNOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTBwMEC1NFch|ryP NF\6VXpUSU6JRWK=
COLO-680N NFrMTXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mke1TWM2OD1yLkCwOVA5KM7:TR?= MoCxV2FPT0WU
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GB-1 M17GN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;0SmlEPTB;MD6wNFUyOSEQvF2= NFfmRWRUSU6JRWK=
KASUMI-1 MoTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTBN2JuUUN3ME2wMlAxPTFzIN88US=> MVjTRW5ITVJ?
NOMO-1 M1zhfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3T5[GlEPTB;MD6wNFUyOyEQvF2= NVviWGtKW0GQR1XS
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RO82-W-1 M4TaNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHSWHp3UUN3ME2wMlAxPTNzIN88US=> NFW1ZmpUSU6JRWK=
LB2241-RCC NF[4fYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1L5WWlEPTB;MD6wNFU{OSEQvF2= NGnUSIxUSU6JRWK=
NCI-H2170 M4HkXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTYWnhKSzVyPUCuNFA2OzVizszN MmTGV2FPT0WU
SK-N-AS NV7UT4tKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3qyZmlEPTB;MD6wNFU{PSEQvF2= MXLTRW5ITVJ?
NCI-H1651 NHfXN2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mli0TWM2OD1yLkCwOVQh|ryP MneyV2FPT0WU
NCI-SNU-5 NGCxbYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7CTWM2OD1yLkCwOVQ2KM7:TR?= NIXuUVhUSU6JRWK=
SN12C M1rLdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwMEC1OUDPxE1? MmTEV2FPT0WU
KY821 NWHoXnhvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGi1XZBKSzVyPUCuNFA2PTFizszN MkTDV2FPT0WU
SW1573 NXnIPYgzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTBwMEC1OVQh|ryP Mm\zV2FPT0WU
OE19 NF3zdo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTBwMEC1OVkh|ryP M3TwXHNCVkeHUh?=
MPP-89 MlfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPMTFJKSzVyPUCuNFA2PjdizszN NXTueIM4W0GQR1XS
HuCCT1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXpTWM2OD1yLkCwOVY5KM7:TR?= NHu4ZpJUSU6JRWK=
SW1783 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3Xx[WlEPTB;MD6wNFU4KM7:TR?= MXjTRW5ITVJ?
8305C NX3qeXZIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTBwMEC1O|Yh|ryP MWTTRW5ITVJ?
OVCAR-4 MnThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7CTWM2OD1yLkCwOVg3KM7:TR?= M4G3V3NCVkeHUh?=
MMAC-SF M1TDe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjmUmJKSzVyPUCuNFA2QDZizszN NGS5PIlUSU6JRWK=
COLO-824 NV\nfWE3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrMTWM2OD1yLkCwOVkh|ryP NXfUc4VJW0GQR1XS
HCC38 MofvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwMEC2JO69VQ>? NVPIRVBoW0GQR1XS
NCI-H1648 NEHsdodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HuZ2lEPTB;MD6wNFYxOSEQvF2= M1Pz[nNCVkeHUh?=
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MFM-223 NWD3b4tET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPKeJZzUUN3ME2wMlAxPjF4IN88US=> M2jNWXNCVkeHUh?=
NCI-H810 NInUSYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\wS|kyUUN3ME2wMlAxPjJ{IN88US=> M4HFZXNCVkeHUh?=
EM-2 NUnvVlNXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2CxfGlEPTB;MD6wNFYzOyEQvF2= NXvG[opSW0GQR1XS
D-283MED Mle5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTBwMEC2NlQh|ryP MWLTRW5ITVJ?
NCI-H1755 MkDhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTBwMEC2NlQh|ryP MY\TRW5ITVJ?
KYSE-70 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHJTWM2OD1yLkCwOlI1KM7:TR?= NILvclVUSU6JRWK=
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DOHH-2 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzVdY5KSzVyPUCuNFA3OyEQvF2= NETtbIJUSU6JRWK=
MEL-JUSO MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvITWM2OD1yLkCwOlM6KM7:TR?= MWrTRW5ITVJ?
IGR-1 M{D1bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmr5TWM2OD1yLkCwOlQyKM7:TR?= MX7TRW5ITVJ?
ACN Mn\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTITWM2OD1yLkCwOlQ1KM7:TR?= NEnic3pUSU6JRWK=
KARPAS-45 NH[wS|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwMEC2OVIh|ryP NFnyfY9USU6JRWK=
HC-1 Mof2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXywXYVFUUN3ME2wMlAxPjV4IN88US=> MUDTRW5ITVJ?
MZ2-MEL MnWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWG0Sm5NUUN3ME2wMlAxPjV6IN88US=> NX74OXVyW0GQR1XS
NCI-H1355 M{HVbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTBwMEC2O|kh|ryP NVrIZmxCW0GQR1XS
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SCC-15 NELzRXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTBwMEC2PFkh|ryP M4\VfnNCVkeHUh?=
CP50-MEL-B NVvncWhWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLYTWM2OD1yLkCwOlk{KM7:TR?= MlnHV2FPT0WU
DMS-114 M2jTdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfVTWM2OD1yLkCwOlk3KM7:TR?= NWXQW21lW0GQR1XS
KYSE-520 MmnzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTBwMEC3JO69VQ>? MofiV2FPT0WU
NCI-H2228 MnrHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TmO2lEPTB;MD6wNFczPSEQvF2= MVHTRW5ITVJ?
COLO-829 MkWzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGn6RWNKSzVyPUCuNFA4OjVizszN M{PnVnNCVkeHUh?=
NCI-H2052 NF36TlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwMEC3Nlch|ryP NUfGT2Z7W0GQR1XS
HOP-92 NFjhZ2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDk[odKSzVyPUCuNFA4OyEQvF2= NYf3[XVqW0GQR1XS
MDA-MB-231 NFK0boFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzXUIJQUUN3ME2wMlAxPzNizszN MnTtV2FPT0WU
SK-MEL-30 NEPuc|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jnTGlEPTB;MD6wNFc{OiEQvF2= NV3UdVA5W0GQR1XS
NCI-H2087 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLo[lRKSzVyPUCuNFA4PDhizszN MnuxV2FPT0WU
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NCI-H358 MoLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MneyTWM2OD1yLkCwO|U5KM7:TR?= M3e2WnNCVkeHUh?=
NCI-H2126 NYGz[oVpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vGS2lEPTB;MD6wNFc4OyEQvF2= NFfNfY5USU6JRWK=
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786-0 NHPkclVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjMTWtKSzVyPUCuNFA4QDZizszN M4DQd3NCVkeHUh?=
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SCH M1S2e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULxWHJDUUN3ME2wMlAxQDF6IN88US=> NEnKdIdUSU6JRWK=
COLO-741 MkjwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDXTWM2OD1yLkCwPFIh|ryP NEjRbolUSU6JRWK=
NCI-H82 NUTMSGV4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrFbIp{UUN3ME2wMlAxQDJ{IN88US=> M3rIenNCVkeHUh?=
MOLT-16 M4nISGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTBwMEC4Nlch|ryP M3vEXXNCVkeHUh?=
IST-MES1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfHUIVKSzVyPUCuNFA5PCEQvF2= NHfnW|lUSU6JRWK=
NCI-H1623 NIjWZWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXl[lVKSzVyPUCuNFA5PTZizszN M2PJUnNCVkeHUh?=
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KMOE-2 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2H2emlEPTB;MD6wOFQ3QSEQvF2= NWf5c4x2W0GQR1XS
DMS-79 NVOwR2Y4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHTcYh1UUN3ME2wMlA1PTd7IN88US=> NIPkU3hUSU6JRWK=
MHH-NB-11 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTBwMES2NVQh|ryP NXvI[GFQW0GQR1XS
NCI-H69 NWfUTHFwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PaN2lEPTB;MD6wOFg1QSEQvF2= M2rhWHNCVkeHUh?=
KE-37 MofkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTBwMEWwNUDPxE1? M2XvWHNCVkeHUh?=
Ramos-2G6-4C10 M1vFWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fY[GlEPTB;MD6wOVA3PyEQvF2= Mk\lV2FPT0WU
NCI-H1793 M4q4bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{P5VWlEPTB;MD6wOVA6OyEQvF2= M4GwPHNCVkeHUh?=
HT-1376 NUD4WGdTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;lbmlEPTB;MD6wOVE5PiEQvF2= NWro[G9WW0GQR1XS
EKVX NITkXG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTrbFRXUUN3ME2wMlA2Ozh2IN88US=> NIrXTYRUSU6JRWK=
Capan-2 NITUb|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILteJZKSzVyPUCuNFU{QTZizszN NID2OGNUSU6JRWK=
DoTc2-4510 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\QPGRVUUN3ME2wMlA2PDR4IN88US=> MUDTRW5ITVJ?
UACC-893 M{PNdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfQSlZKSzVyPUCuNFU1PjJizszN MYPTRW5ITVJ?
SK-MEL-3 MoryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYL0OmN2UUN3ME2wMlA2Pzh6IN88US=> NF7K[3VUSU6JRWK=
SK-MEL-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmP2TWM2OD1yLkC1PEDPxE1? NVXrcoZMW0GQR1XS
SW948 NGWxTJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTBwMEW5PVYh|ryP NFLlR4xUSU6JRWK=
P30-OHK MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFKwO4pKSzVyPUCuNFYyPjdizszN MWTTRW5ITVJ?
NH-12 NH30XItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4njTWlEPTB;MD6wOlI1PCEQvF2= MkjYV2FPT0WU
KU-19-19 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFL2VJdKSzVyPUCuNFY{PjFizszN NGXF[I9USU6JRWK=
A431 NVG5ZWdWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLjZnpKSzVyPUCuNFY{PzRizszN MWrTRW5ITVJ?
NCI-H2405 Mnv1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXvc2RLUUN3ME2wMlA3Ozh|IN88US=> MXTTRW5ITVJ?
KARPAS-299 M1Hab2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI[xRYVKSzVyPUCuNFY2QDJizszN MnvOV2FPT0WU
BALL-1 MnGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;hb|lKSzVyPUCuNFY3PzRizszN NIGzWGhUSU6JRWK=
KURAMOCHI M4fFe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWG2[o5iUUN3ME2wMlA4ODd|IN88US=> MW\TRW5ITVJ?
LS-1034 NYHRfHFyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmf4TWM2OD1yLkC3N|Y6KM7:TR?= M4LzbnNCVkeHUh?=
MFE-280 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTBwMEe1N|Yh|ryP M3LXd3NCVkeHUh?=
HOP-62 M3n2UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTBwMEe2O|Yh|ryP M1eyU3NCVkeHUh?=
KG-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwMEe3PFch|ryP MWfTRW5ITVJ?
CW-2 NV\STnBjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{X5WGlEPTB;MD6wO|g{OiEQvF2= MlvFV2FPT0WU
SW837 NWjPUI8zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{e4c2lEPTB;MD6wPFM1OiEQvF2= NHHxUXhUSU6JRWK=
MFH-ino NUXKR5RxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPMTWM2OD1yLkC4OVAyKM7:TR?= NX3PboNEW0GQR1XS
HCC1419 NGTrXVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTBwMEi5PFch|ryP NEHXZ41USU6JRWK=
HMV-II NGD3OVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2[5UGlEPTB;MD6wPVAyKM7:TR?= NUS1R3ZGW0GQR1XS
BEN MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHKOphHUUN3ME2wMlA6Ozh3IN88US=> MYXTRW5ITVJ?
SK-N-FI Mm\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTBwMEm1OVYh|ryP MlfFV2FPT0WU
JVM-2 M3z0Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTBwMEm3NVYh|ryP MXHTRW5ITVJ?
CAL-54 NFrmeGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXPTWM2OD1yLkGwNFQh|ryP MknvV2FPT0WU
T84 Mk\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn[wTWM2OD1yLkGwPVUzKM7:TR?= NGnOeHFUSU6JRWK=
SHP-77 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTBwMUG2OFEh|ryP MVjTRW5ITVJ?
G-361 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTBwMUKzNlQh|ryP MWrTRW5ITVJ?
Calu-3 NEPUVWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTqU3MxUUN3ME2wMlE{QDF4IN88US=> MWfTRW5ITVJ?
HCC1937 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3PV|JoUUN3ME2wMlE1QTN5IN88US=> NVHx[2VmW0GQR1XS
KM-H2 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjWXXNKSzVyPUCuNVUxOSEQvF2= M2nYbnNCVkeHUh?=
769-P M1PoNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUn3OIdXUUN3ME2wMlE2QDR|IN88US=> NV:5[FExW0GQR1XS
NCI-H1304 Mni2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\FTWlEPTB;MD6xOlA3OSEQvF2= MlLkV2FPT0WU
D-542MG MmfsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jn[WlEPTB;MD6xOlI4QCEQvF2= MWPTRW5ITVJ?
ATN-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;2b2pFUUN3ME2wMlE4PDRzIN88US=> MmrXV2FPT0WU
NCI-H2029 M4ryN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWGyeYxlUUN3ME2wMlIxOjR|IN88US=> NIHDUXJUSU6JRWK=
ZR-75-30 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3i2O2lEPTB;MD6yNFY1OyEQvF2= MWXTRW5ITVJ?
SW1116 NFrSc5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\zNWlEPTB;MD6yNVEyPyEQvF2= M2PCTHNCVkeHUh?=
CCRF-CEM M3;6Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHr6SG9KSzVyPUCuNlc3OTRizszN M3X2UHNCVkeHUh?=
LU-135 NXm4NFE1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzjSINKSzVyPUCuNlc4OzlizszN NFXLUHlUSU6JRWK=
MC116 NXjlfHdDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDwTWM2OD1yLkK4N|A6KM7:TR?= MnnjV2FPT0WU
LS-513 NU\kVmg5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonuTWM2OD1yLkK4O|c{KM7:TR?= NEi5fJhUSU6JRWK=
NCI-H630 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTBwMkmzO|Yh|ryP NYG2WW5ZW0GQR1XS
L-428 Mmr5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\KTWM2OD1yLkK5PFg{KM7:TR?= MXjTRW5ITVJ?
UM-UC-3 NFXYN5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTNTWM2OD1yLkOxNlkyKM7:TR?= MXrTRW5ITVJ?
NCI-H1838 M4fOUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHKXG9oUUN3ME2wMlMyPzh2IN88US=> NXzYRoU6W0GQR1XS
HEL NYXiXoVjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDyTWM2OD1yLkOyNlQh|ryP NFziVZVUSU6JRWK=
OCI-AML2 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1ewZ2lEPTB;MD6zNlI6QCEQvF2= M33v[XNCVkeHUh?=
A3-KAW NYrNV41kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwM{O0O|ch|ryP NYXFZlI2W0GQR1XS
IGROV-1 NFHScIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvMfplKSzVyPUCuN|M4PTVizszN NH;QZlZUSU6JRWK=
Mo-T NGf6SGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjRXnZKUUN3ME2wMlM{QDV|IN88US=> MVjTRW5ITVJ?
HDLM-2 MkDDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33VUmlEPTB;MD6zN|kh|ryP M4PTN3NCVkeHUh?=
HCC1569 NIjQSVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDhTWM2OD1yLkO0N|A6KM7:TR?= MWLTRW5ITVJ?
COLO-678 NUTT[GppT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTBwM{ewNFIh|ryP NGniXJJUSU6JRWK=
COR-L105 M{Lyemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPiVHg1UUN3ME2wMlM4QTNizszN NX\5O|B7W0GQR1XS
SK-MEL-24 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH35V3RKSzVyPUCuN|g{QDJizszN NHTDTVVUSU6JRWK=
COLO-320-HSR MnG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTBwNEO5O|Yh|ryP NVTPPGtlW0GQR1XS
C8166 NGTyPHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTBwNEmwNlMh|ryP NIDiWnBUSU6JRWK=
COLO-679 M2LMUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XnVGlEPTB;MD62NlE4OiEQvF2= NWjoW3NpW0GQR1XS
TE-12 MnLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPpTllKSzVyPUCuOlU{QTRizszN Mni2V2FPT0WU
HAL-01 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\uTWM2OD1yLk[2NlIh|ryP MlrVV2FPT0WU
H-EMC-SS MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTBwN{C1OFYh|ryP NH7vOHhUSU6JRWK=
SNU-449 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnyeYFOUUN3ME2wMlczPzR6IN88US=> NFqwNmpUSU6JRWK=
C32 MkPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1j1SGlEPTB;MD63OFEyOiEQvF2= NHHYd5lUSU6JRWK=
K-562 M333[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPy[29WUUN3ME2wMlc4ODJ2IN88US=> MoTFV2FPT0WU
DJM-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mni4TWM2OD1yLke4O|gyKM7:TR?= Moq0V2FPT0WU
RCC10RGB NFnMTopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo[2TWM2OD1yLke5NVg{KM7:TR?= MW\TRW5ITVJ?
CAL-85-1 NXnGcHFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPldVA1UUN3ME2wMlkxPyEQvF2= NUHRdVZqW0GQR1XS
NY MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTBwOUOzOVIh|ryP M4flNnNCVkeHUh?=
NCI-H1993 NEPDWppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTFwMUmyPFkh|ryP NFXYPGxUSU6JRWK=
SK-OV-3 NFjrXoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTkW|R2UUN3ME2xMlIzODh7IN88US=> MXfTRW5ITVJ?

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
PIM1; 

PubMed: 18426800     


Cells were treated with 100 nm docetaxel for the indicated times. PIM1 and β-ACTIN proteins were analyzed by immunoblot analysis. One of three similar blots is shown. Ratio, ratio of PIM1/β-ACTIN from pooled densitometry data from three separate experimen䲧疝Ỵ疞㧀疜膉痘 瘿뾠ՂᾰƌՂĀ 㺣痖帉痖Ѐ瑖堘𢡄빢᎒ՂĀ鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ⟸෕䐺痖暼瘿⟸෕ᾰƌ

cyclin B; 

PubMed: 18426800     


Immunoblot analysis of cyclin B1 and PIM1 expression after docetaxel 10 nm (left) or 100 nm (right) treatment at various time points.

pSTAT3 / STAT3 ; 

PubMed: 18426800     


Immunoblots of RWPE-2 cells treated with 100 nm docetaxel for the indicated time.

p-p53 / p53; 

PubMed: 22996738     


C4-2 cells were treated with 5 nM docetaxel, the whole cell lysates were collected at different time points and subjected to Western blot.

18426800 22996738
Immunofluorescence
α-tubulin; 

PubMed: 27177833     


Noscapine has no effect on gross microtubule polymerization state but noscapine pre-sensitization followed by docetaxel treatment stabilizes microtubules, hence inhibits cell proliferation. TNBC cells were treated with noscapine (4 µM) or docetaxel (0.4 µ䲧疝Ỵ疞㧀疜膉痘 瘿⟸෕ᾰƌ෕Ð 㺣痖帉痖Ѐ瑖堘𢡄빢᎒෕Ð鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ뾠Ղ䐺痖暼瘿뾠Ղᾰƌ 뾠ՂÐ㺣痖뾠Ղ€𢡄뾤Ղ€䀷痗뾤Ղ౴뾤Ղ㵶痗뾤Ղ뺖᎒泌Itemセ᎒Count﫨呂뿔Ղ猴፲뾤Ղ፲씢痗猸፲髸莤䥷堙᎒セ᎒�堞ﻮ᎒፲露𢡄堚Ҕ齃礤v�堞ﻮ᎒猢Wセ᎒䨼Ą鹿齃殺獸W戀醙

cleaved PARP / cleaved caspase-3; 

PubMed: 21087597     


Immunofluorescence images of PC-3 cells treated with the docetaxel and EM011 schedule treatment. Cells were pretreated with docetaxel for 12 h before addition of EM011 and were fixed at 48 h post docetaxel treatment compared to treatment with EM011 (10 μM䲧疝Ỵ疞㧀疜膉痘 瘿⟸෕ᾰƌ෕Ð 㺣痖帉痖Ѐ瑖堘𢡄빢᎒෕Ð鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ�෋䐺痖暼瘿�෋ᾰƌ �෋à

Acetylated tubulin ; 

PubMed: 18426800     


Immunofluorescence of acetylated tubulin in cells treated with DMSO, 30 nM laulimalide and 30 nM docetaxel for 2.5 h. Tubulin shown in green and DAPI in blue, and the white arrow indicates microtubule bundling. Scale bar represents 10 μm.

SQSTM1 / LAMP1; 

PubMed: 29795139     


AGS cells were treated with docetaxel (10 nM) for 12 h. After immunostaining with SQSTM1 (Alexa Fluor 488, green) and LAMP1 (Alexa Fluor 594, red), cells were examined by fluorescence microscopy (scale bar 20 μm). The colocalization of SQSTM1and LAMP1 was䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 㺣痖帉痖Ѐ

27177833 21087597 18426800 29795139
Growth inhibition assay
Cell viability ; 

PubMed: 22996738     


Docetaxel inhibits the growth of LNCaP, C4-2, DU145, and PC3 prostate cancer cells. Cells were plated in 12-well plates and treated with different concentrations of docetaxel. The cell number was counted after 24 hr. 

22996738
In vivo Docetaxel (33 mg/kg/dose, given i.v. every 4 days for 3 injections) results in a tumor growth delay of 19.3 days in M2OL2 colon xenografts. Docetaxel also shows great antitumor activities in MX-1, SK-MEL-2, LX-1 and OVCAR-3 xenografts. Docetaxel inhibits the angiogenic response to fibroblast growth factor 2 with IC 50 of 5.4 mg/kg when injected twice weekly over a 14-day period, and angiogenesis is completely blocked in mice that receives 10 mg/kg Docetaxel. Docetaxel has selectivity for endothelial cell migration and/or microvessel formation because infiltration of inflammatory cells into the Matrigel plug is much less sensitive to inhibition by Docetaxel. [7]

Protocol

Cell Research:[5]
- Collapse
  • Cell lines: Human gastric cancer cell lines MKN-28
  • Concentrations: 6 nM
  • Incubation Time: 3 days
  • Method: 2000 cells in 180 μL of medium are seeded in a 96-well plate, and 20 μL of drug solution is simultaneously added in triplicate to each well. The plate is incubated for 3 days at 37°C in a humidified atmosphere of 5% CO2. On day 3, 25 μL of MTT reagent is added to each well. After 4 h of incubation, the medium is removed by aspiration. 0.2 mL of dimethylsulphoxide (DMSO) is added to each well and thoroughly mixed by using a mechanical plate mixer to dissolve the resulting MTT-formazan crystals. Absorbance at 540 nm (OD) is measured by a reader.
    (Only for Reference)
Animal Research:[6]
- Collapse
  • Animal Models: Human colon carcinomas xenografts CX-1
  • Dosages: 33 mg/kg
  • Administration: i.v. every 4 days for 3 injections
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (123.78 mM)
Ethanol 53 mg/mL warmed (65.6 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 807.88
Formula

C43H53NO14

CAS No. 114977-28-5
Storage powder
in solvent
Synonyms RP56976, NSC 628503
Smiles CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O

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Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04656652 Not yet recruiting Drug: DS-1062a|Drug: Docetaxel Non-small Cell Lung Cancer Daiichi Sankyo Inc.|AstraZeneca December 14 2020 Phase 3
NCT04471675 Not yet recruiting Drug: Albumin-bound docetaxel Advanced Solid Tumors CSPC ZhongQi Pharmaceutical Technology Co. Ltd. November 15 2020 Phase 1
NCT04396535 Recruiting Drug: Bintrafusp Alfa|Drug: Docetaxel Advanced Lung Non-Small Cell Carcinoma|Stage III Lung Cancer AJCC v8|Stage IIIA Lung Cancer AJCC v8|Stage IIIB Lung Cancer AJCC v8|Stage IIIC Lung Cancer AJCC v8|Stage IV Lung Cancer AJCC v8|Stage IVA Lung Cancer AJCC v8|Stage IVB Lung Cancer AJCC v8 Mayo Clinic|National Cancer Institute (NCI) October 23 2020 Phase 2
NCT04533958 Recruiting Device: HYPNO VR® device Metastatic Prostate Cancer Saint-Gregoire Private Hospital Center September 28 2020 Not Applicable

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Microtubule Associated Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID