Docetaxel

Catalog No.S1148 Synonyms: RP56976, NSC 628503

Docetaxel Chemical Structure

Molecular Weight(MW): 807.88

Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.

Size Price Stock Quantity  
In DMSO USD 91 In stock
USD 70 In stock
USD 270 In stock
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6 Customer Reviews

  • Viability of cells after exposure to 0, 10, or 10,000 nM docetaxel, assessed by calcein-AM staining (green, left panels) and ethidium homodimer-1 (red, middle panels).

    Mol Pharmaceutics, 2014, 11: 2040−50. Docetaxel purchased from Selleck.

    J Transl Med 2013 0.6. Docetaxel purchased from Selleck.

  • J Transl Med 2013 0.6. Docetaxel purchased from Selleck.

    TNBC and non-TNBC cells were treated for 6 d with the specified concentrations of docetaxel (doc) alone, TTK inhibitor (TTKi) alone or the combinations. The survival of cells was measured using the MTS/MTA assay. ***P<0.001 comparing the combination with single agents and with non-TNBC cell lines.

    Oncogenesis, 2014, 3: e100 . Docetaxel purchased from Selleck.

  • Cell cycle study of percent cell populations in various phases after treatment with vehicle, HCI-2509 in increasing concentrations and docetaxel alone and in combination with HCI-2509 using (a) PC3 cells. Student's unpaired t-tests, using GraphPad Prism software, were used to calculate two-tailed P-values for each experiment to determine statistical significance between untreated and treated samples. The statistically significant P-values are labeled in each figure with an asterisk. (Replicated two more times, representative graph shown).

    Prostate Cancer Prostatic Dis, 2016, 19(4):349-357. Docetaxel purchased from Selleck.

    Biomed Pharmacother, 2018, 99:445-450. Docetaxel purchased from Selleck.

Purity & Quality Control

Choose Selective Microtubule Associated Inhibitors

Biological Activity

Description Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.
Targets
Microtubules [1]
(Cell-free assay)
In vitro

Docetaxel is a cytotoxic agent, especially for proliferating cells, which is related to its ability to promote the formation of microtubule bundles and induce sustained mitotic arrest, followed by apoptosis of mitotically arrested cells or permanent mitotic block. Docetaxel suppresses microtubule dynamic instability as well as tread-milling, resulting in the failure of chromosomes to segregate to the daughter cells, which in turn triggers premature exit from mitosis rather than a block at this phase of the cell cycle. [2] Docetaxel inhibits the clonogenic survival of Human cancer cell Hs746T (stomach), AGS (stomach), HeLa (cervix), CaSki (cervix), BxPC3 (pancreas), Capan-1 (pancreas) with IC50 of 1 nM, 1 nM, 0.3 nM, 0.3 nM, 0.3 nM and 0.3 nM respectively. [4] Docetaxel inhibits endothelial cell migration that does not affects microtubule gross morphology or inhibit cell proliferation, although they does produce more subtle effects on microtubule dynamics. Docetaxel inhibits HUVEC migration with an observed IC50 of 1 pM. HUVEC chemotaxis stimulated by either of two angiogenic factors, thymidine phosphorylase or VEGF, is inhibited by Docetaxel with IC 50 of 10 pM and is ablated at 1 nM. [7] Docetaxel induces human monocytes, but not RAW 264.7 murine macrophages, Prostaglandin H Synthase-2m (PGHS-2) expression. [8]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HSC-3 Mni3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTOZllKSzVyPUCuNFAxOTN{IN88US=> NE\HZ3dUSU6JRWK=
5637 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwMECwNVQ{KM7:TR?= NGLzeIZUSU6JRWK=
HT-144 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDwTWM2OD1yLkCwNFE2PyEQvF2= NYfDXXplW0GQR1XS
NCI-H292 M2rqRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHEVVdKSzVyPUCuNFAxOTV7IN88US=> NXjwTYNUW0GQR1XS
HCE-T MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFe5eYpKSzVyPUCuNFAxOTZ{IN88US=> NHH5SlVUSU6JRWK=
ESS-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\lcG9uUUN3ME2wMlAxODF5OTFOwG0> NU\5TnFuW0GQR1XS
D-566MG MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfjN2cyUUN3ME2wMlAxODF6MjFOwG0> NWewSVRzW0GQR1XS
CAL-62 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{iybmlEPTB;MD6wNFAyQDVizszN NGCwc5pUSU6JRWK=
GT3TKB M1jV[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfteGt[UUN3ME2wMlAxODJ|MjFOwG0> NVfLXHVGW0GQR1XS
HSC-4 NWLqZmx{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnqfoI1UUN3ME2wMlAxODJ|OTFOwG0> NYjXc25pW0GQR1XS
KOSC-2 MljSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDBTWM2OD1yLkCwNFI2PSEQvF2= M17uUHNCVkeHUh?=
NB14 NHLMfIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTBwMECwNlYh|ryP NVH6OGo4W0GQR1XS
ES8 MnPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHFTWM2OD1yLkCwNFI3KM7:TR?= MW\TRW5ITVJ?
BFTC-905 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTBwMECwNlY5KM7:TR?= MkDTV2FPT0WU
A498 MkTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTBwMECwNlc5KM7:TR?= MWfTRW5ITVJ?
HO-1-N-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;CVYtKSzVyPUCuNFAxOjhzIN88US=> NX;qSmZ4W0GQR1XS
SF539 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\jbHpyUUN3ME2wMlAxODNyMjFOwG0> M1j4NnNCVkeHUh?=
HuO-3N1 Mnz4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTBwMECwN|AzKM7:TR?= NXv5V4ViW0GQR1XS
NCI-H510A MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjKTWM2OD1yLkCwNFM{PiEQvF2= NUfJOlNtW0GQR1XS
CAL-27 MmDzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIi4PI9KSzVyPUCuNFAxOzN7IN88US=> NW\Q[XV3W0GQR1XS
TE-8 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjDb|NKSzVyPUCuNFAxOzZ4IN88US=> NELld3NUSU6JRWK=
VA-ES-BJ M{TUO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTBwMECwN|c2KM7:TR?= MUjTRW5ITVJ?
RH-1 NVvhOnJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHW3V2tKSzVyPUCuNFAxOzh4IN88US=> MknBV2FPT0WU
COLO-800 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjETWM2OD1yLkCwNFM5QCEQvF2= MWLTRW5ITVJ?
ES7 M3[5[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLpblVKSzVyPUCuNFAxOzh7IN88US=> MVHTRW5ITVJ?
GAMG M4Kzcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIewcI1KSzVyPUCuNFAxPDF4IN88US=> MUHTRW5ITVJ?
Ca9-22 MnLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPJUnRwUUN3ME2wMlAxODR{MzFOwG0> MXHTRW5ITVJ?
SBC-1 M3O4XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPUUndKSzVyPUCuNFAxPDNizszN M4nocHNCVkeHUh?=
RPMI-7951 NH\KWVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEW1PVFKSzVyPUCuNFAxPDR6IN88US=> M{fjXnNCVkeHUh?=
SW1710 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvUTHZOUUN3ME2wMlAxODR4NjFOwG0> MmLmV2FPT0WU
HGC-27 Mmn0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfkfoFKSzVyPUCuNFAxPDdzIN88US=> NFXPTm9USU6JRWK=
MC-IXC MnvlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGWy[4pKSzVyPUCuNFAxPDd7IN88US=> M{PDWHNCVkeHUh?=
FTC-133 NHvITXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTBwMECwOFg6KM7:TR?= MWDTRW5ITVJ?
HT-1080 NUHNc2tTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2i2eGlEPTB;MD6wNFA2ODFizszN NYDwW5pLW0GQR1XS
NMC-G1 Ml[3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFf0O2pKSzVyPUCuNFAxPTF5IN88US=> MUXTRW5ITVJ?
GI-1 M2\zRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\WeGlEPTB;MD6wNFA2OjhizszN NHfoVHJUSU6JRWK=
CGTH-W-1 NUOxdY9vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTBwMECwOVQzKM7:TR?= Mmi2V2FPT0WU
A2058 NUHrRW5DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXS2OZE5UUN3ME2wMlAxODV2NDFOwG0> NIK3VlhUSU6JRWK=
ETK-1 MmnzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTYTWM2OD1yLkCwNFU2QCEQvF2= NULDXXVFW0GQR1XS
NEC8 M17Pcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mki2TWM2OD1yLkCwNFU3OSEQvF2= NXXHOZZjW0GQR1XS
TE-11 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnjSZhLUUN3ME2wMlAxODV4OTFOwG0> MkjXV2FPT0WU
NCI-H720 MmLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV[z[pNsUUN3ME2wMlAxODV6IN88US=> M4nkN3NCVkeHUh?=
PSN1 MoDES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XlbmlEPTB;MD6wNFA2QDFizszN NHjlPW1USU6JRWK=
SW780 MmO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jHbWlEPTB;MD6wNFA2QDdizszN NIjR[5dUSU6JRWK=
8-MG-BA NI\tUGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYD2VJRDUUN3ME2wMlAxODV6OTFOwG0> NXriNVVlW0GQR1XS
EC-GI-10 MlvxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjZTG9bUUN3ME2wMlAxODV7MjFOwG0> MYrTRW5ITVJ?
SJSA-1 NFfTd5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7LTWM2OD1yLkCwNFYyPSEQvF2= NYfiZXpJW0GQR1XS
639-V NGT4b4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MluyTWM2OD1yLkCwNFY1PyEQvF2= NHfrVnNUSU6JRWK=
PFSK-1 NGmxS|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1y0UGlEPTB;MD6wNFA3PTdizszN NVi5fWkxW0GQR1XS
DMS-273 NGTVOItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTBwMECwOlc1KM7:TR?= M{PifnNCVkeHUh?=
TE-9 MkOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\ZbGlEPTB;MD6wNFA3PzZizszN NHz4Z5pUSU6JRWK=
SCC-25 M3rnZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfh[FVmUUN3ME2wMlAxODZ6IN88US=> M1XBcXNCVkeHUh?=
PA-1 NGraRXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzNc|F1UUN3ME2wMlAxODZ6NzFOwG0> NFrZRXFUSU6JRWK=
MHH-ES-1 NIOzTotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{K0RWlEPTB;MD6wNFA4KM7:TR?= MX;TRW5ITVJ?
Daoy NGHZd3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPNXIJKSzVyPUCuNFAxPyEQvF2= NWW0RWZ4W0GQR1XS
G-402 MoHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTBwMECwO|A3KM7:TR?= MoXZV2FPT0WU
YKG-1 MkT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XKd2lEPTB;MD6wNFA4ODdizszN M{e0TnNCVkeHUh?=
Ca-Ski NFjmfVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTBwMECwO|I5KM7:TR?= M3SyZnNCVkeHUh?=
CHP-212 NH:4N4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTBwMECwO|Mh|ryP M2P1Z3NCVkeHUh?=
SCC-4 NHf0RnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlL1TWM2OD1yLkCwNFc{QSEQvF2= M3XaWnNCVkeHUh?=
EW-3 M136WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TiOmlEPTB;MD6wNFA4PDVizszN M2jCTXNCVkeHUh?=
P12-ICHIKAWA MkfRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzoTWM2OD1yLkCwNFc1PSEQvF2= M2q0ZnNCVkeHUh?=
HSC-2 NUPpdWhTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;yfWJrUUN3ME2wMlAxODd3NTFOwG0> NHrDfnpUSU6JRWK=
HN NYjZboVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zqemlEPTB;MD6wNFA4PThizszN M{K4TnNCVkeHUh?=
LXF-289 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHtTpdOUUN3ME2wMlAxODd3ODFOwG0> NXrqSmwxW0GQR1XS
ES1 M1\LRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTBwMECwO|ch|ryP M{XOW3NCVkeHUh?=
NTERA-S-cl-D1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2riW2lEPTB;MD6wNFA4PzNizszN MYDTRW5ITVJ?
K5 NYP0RWZ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTBwMECwO|c5KM7:TR?= MXHTRW5ITVJ?
HOS MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rwd2lEPTB;MD6wNFA4QDJizszN M4KzTHNCVkeHUh?=
YH-13 NX;STlJkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\yTWM2OD1yLkCwNFc6OSEQvF2= MXnTRW5ITVJ?
SW954 NEPmNGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPLTWM2OD1yLkCwNFgzOyEQvF2= MnG3V2FPT0WU
KYSE-510 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV31TXQxUUN3ME2wMlAxODh2IN88US=> MYjTRW5ITVJ?
8505C NIj3SVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTBwMECwPFU1KM7:TR?= MnHKV2FPT0WU
A549 MkTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTBwMECwPFgzKM7:TR?= NEnuUYRUSU6JRWK=
Detroit562 Mmj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;yTWM2OD1yLkCwNFkxOiEQvF2= M2\yZnNCVkeHUh?=
ES5 NHvQVlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTBwMECwPVEh|ryP MW\TRW5ITVJ?
KYSE-140 MmDiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmftTWM2OD1yLkCwNFk{OyEQvF2= NF;JZWlUSU6JRWK=
GMS-10 M4e4W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrub2VKSzVyPUCuNFAxQTRzIN88US=> M2\JbnNCVkeHUh?=
D-263MG NWW1T|NWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPzZphjUUN3ME2wMlAxODl2NzFOwG0> MmDtV2FPT0WU
BCPAP MoTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTBwMECwPVQ4KM7:TR?= NXfRbZU{W0GQR1XS
CHL-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPLV5FlUUN3ME2wMlAxODl3ODFOwG0> NF;IWotUSU6JRWK=
RKO MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDzTWM2OD1yLkCwNFk5QSEQvF2= M1jRZXNCVkeHUh?=
SW48 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTpTWM2OD1yLkCwNVAyKM7:TR?= NYW3eoM6W0GQR1XS
BPH-1 M1rweGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnwVWdKSzVyPUCuNFAyODJizszN MYfTRW5ITVJ?
EFO-27 NVjR[pdqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjwV2VKSzVyPUCuNFAyODJizszN NXu3O2VQW0GQR1XS
CAL-33 Mo\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITHfYpKSzVyPUCuNFAyODRizszN M3XOPXNCVkeHUh?=
NCI-H1792 MnjRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{P3PGlEPTB;MD6wNFExPCEQvF2= M3Gye3NCVkeHUh?=
BB30-HNC MoDkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrzT5RKUUN3ME2wMlAxOTB3IN88US=> MXPTRW5ITVJ?
VM-CUB-1 M3rEN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jJc2lEPTB;MD6wNFExPSEQvF2= NWCw[otGW0GQR1XS
TE-5 NHG0bVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;tXWlEPTB;MD6wNFExPiEQvF2= NU\1SmRJW0GQR1XS
NB13 MnPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETOWHBKSzVyPUCuNFAyODdizszN MYHTRW5ITVJ?
NBsusSR NHjqWpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTBwMECxNUDPxE1? MkLYV2FPT0WU
LNCaP-Clone-FGC NHnacHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTBwMECxNUDPxE1? NX3tNJJZW0GQR1XS
EPLC-272H MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH36TplKSzVyPUCuNFAyOTFizszN NFOzOVZUSU6JRWK=
KNS-62 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4WxdGlEPTB;MD6wNFEyOiEQvF2= NVzKUIxEW0GQR1XS
RERF-LC-MS M3P4VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnPTWM2OD1yLkCwNVE{KM7:TR?= NH7jUYVUSU6JRWK=
LOXIMVI NY\MXWxrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWH0dIVVUUN3ME2wMlAxOTF4IN88US=> MojZV2FPT0WU
KINGS-1 Mn[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LaXmlEPTB;MD6wNFEyPyEQvF2= NVrtTnNQW0GQR1XS
T98G NYrOfm5ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTBwMECxNVch|ryP NFzXWYNUSU6JRWK=
HCC1806 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDCTG1KSzVyPUCuNFAyOThizszN MUfTRW5ITVJ?
MZ1-PC NEDYeYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXDTWM2OD1yLkCwNVE5KM7:TR?= NHLmbYtUSU6JRWK=
RT-112 NWXlRWtOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXT0bWZ5UUN3ME2wMlAxOTF7IN88US=> MULTRW5ITVJ?
LK-2 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1W1R2lEPTB;MD6wNFEzOSEQvF2= MlHBV2FPT0WU
A375 NY[2Vlg6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTsNnZIUUN3ME2wMlAxOTJzIN88US=> M4TIV3NCVkeHUh?=
SF268 NUO1W|N3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjoTWM2OD1yLkCwNVIyKM7:TR?= NIX4eHpUSU6JRWK=
H9 Mlr6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTBwMECxNlQh|ryP Ml:4V2FPT0WU
KYSE-410 NF7pT2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3UV4VnUUN3ME2wMlAxOTJ2IN88US=> MUXTRW5ITVJ?
G-401 M{fSZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzVd45KSzVyPUCuNFAyOjdizszN MVTTRW5ITVJ?
SW982 M{nFfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzpWlg2UUN3ME2wMlAxOTJ5IN88US=> MW\TRW5ITVJ?
D-423MG M3TBN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\WZ2lEPTB;MD6wNFE{KM7:TR?= MYrTRW5ITVJ?
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EW-16 M4H3Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfQfZc1UUN3ME2wMlAxOTN3IN88US=> NV3EXHUxW0GQR1XS
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LCLC-97TM1 NWnWT3c1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwMECxOFQh|ryP M3[0UnNCVkeHUh?=
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A427 M3KwbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;pTWM2OD1yLkCwNVQ5KM7:TR?= MVjTRW5ITVJ?
LB831-BLC M3fROGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\4WHJIUUN3ME2wMlAxOTR6IN88US=> M{\jVnNCVkeHUh?=
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23132-87 NHPRWFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVOzZ3VvUUN3ME2wMlAxOTV3IN88US=> NVT5XnZnW0GQR1XS
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D-336MG NF3G[oVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYruNXNYUUN3ME2wMlAxOTZ7IN88US=> M1LGU3NCVkeHUh?=
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D-247MG Mn;KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjXTWM2OD1yLkCwNVc{KM7:TR?= Mn\nV2FPT0WU
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SK-NEP-1 Mnu1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVKzXYNDUUN3ME2wMlAxOTd4IN88US=> M3:wb3NCVkeHUh?=
DB NH7Mc2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrRU5BKSzVyPUCuNFAyPzhizszN M13DWXNCVkeHUh?=
GCT NHzUTItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDQN4tKSzVyPUCuNFAyQCEQvF2= MnrTV2FPT0WU
HCT-116 NFXGUmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2WxOWlEPTB;MD6wNFE5OSEQvF2= M4POTXNCVkeHUh?=
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Becker MnPwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHqTphzUUN3ME2wMlAxOTh|IN88US=> MmPPV2FPT0WU
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NCI-H2122 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTBwMECxPFQh|ryP MlP0V2FPT0WU
SBC-5 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTBwMECxPFch|ryP NYPsTHJpW0GQR1XS
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MHH-PREB-1 NV;ZTmtWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFixcYpKSzVyPUCuNFAyQDlizszN Moi0V2FPT0WU
M14 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHBTWM2OD1yLkCwNVkyKM7:TR?= NYm2e4dMW0GQR1XS
NCI-H1048 NIfmO5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXviXG1uUUN3ME2wMlAxOTl{IN88US=> MXjTRW5ITVJ?
CTB-1 NVvWOIE3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTBwMECxPVIh|ryP NUm4TmFqW0GQR1XS
SK-PN-DW MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDqZ5BvUUN3ME2wMlAxOTl2IN88US=> NV7zdFRXW0GQR1XS
H4 M3KxdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLPT5dzUUN3ME2wMlAxOTl4IN88US=> MX\TRW5ITVJ?
NCI-SNU-1 Mny2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPOOVdKSzVyPUCuNFAyQTdizszN MWrTRW5ITVJ?
M059J MlLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETXU4lKSzVyPUCuNFAyQThizszN MljmV2FPT0WU
OVCAR-5 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4i0TWlEPTB;MD6wNFE6QSEQvF2= MoLSV2FPT0WU
SK-MEL-28 Mnn6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwMECyNFMh|ryP NFfKUoZUSU6JRWK=
PC-14 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TNcmlEPTB;MD6wNFIxQSEQvF2= NWnrRWNSW0GQR1XS
OVCAR-8 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjHem5KSzVyPUCuNFAzOTJizszN MmDmV2FPT0WU
BB49-HNC MoTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXuzd2NNUUN3ME2wMlAxOjF{IN88US=> M1T1dnNCVkeHUh?=
EFM-19 M3:3Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTBwMECyNVUh|ryP NFXqXJZUSU6JRWK=
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SW756 MnHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzCTWM2OD1yLkCwNlE3KM7:TR?= NEjJcFNUSU6JRWK=
TE-1 Mn7CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\TeplUUUN3ME2wMlAxOjF4IN88US=> Mk\EV2FPT0WU
NCI-H2452 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTBwMECyNVYh|ryP MYHTRW5ITVJ?
NCI-H1581 MlXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmqzTWM2OD1yLkCwNlE4KM7:TR?= NIe2Z4lUSU6JRWK=
COR-L23 Mm\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTkTWM2OD1yLkCwNlIh|ryP M1LCXHNCVkeHUh?=
RXF393 MnPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;HXIx7UUN3ME2wMlAxOjJ{IN88US=> NVuyXJZHW0GQR1XS
BFTC-909 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnT5TWM2OD1yLkCwNlI2KM7:TR?= NH3pT4hUSU6JRWK=
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NCI-H650 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2Lm[WlEPTB;MD6wNFIzPSEQvF2= MUnTRW5ITVJ?
SK-UT-1 NGXibnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnlfVAyUUN3ME2wMlAxOjJ4IN88US=> Mm\rV2FPT0WU
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SK-MES-1 MljZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjsSIN5UUN3ME2wMlAxOjN|IN88US=> NFj5cJhUSU6JRWK=
SK-HEP-1 MkXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn[xTWM2OD1yLkCwNlM1KM7:TR?= MYLTRW5ITVJ?
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VMRC-RCZ MmrqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTRXmdKSzVyPUCuNFAzPTJizszN M3nPO3NCVkeHUh?=
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A388 Mlq3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPB[JR[UUN3ME2wMlAxOjZ3IN88US=> NFywOlFUSU6JRWK=
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CAL-51 M2XL[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrQVWJ6UUN3ME2wMlAxOjdzIN88US=> M1vYRnNCVkeHUh?=
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RPMI-8866 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEL6bXlKSzVyPUCuNFAzQDFizszN NIXlU2pUSU6JRWK=
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HT-3 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvrZ|RRUUN3ME2wMlAxOjh{IN88US=> Ml75V2FPT0WU
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NCI-H209 MmHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3FXoVCUUN3ME2wMlAxOjh4IN88US=> NUPLXIp2W0GQR1XS
SKG-IIIa MkHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfCcJNXUUN3ME2wMlAxOjh4IN88US=> MWnTRW5ITVJ?
SW962 NUfM[ndnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\oTWM2OD1yLkCwNlk{KM7:TR?= MnziV2FPT0WU
LCLC-103H Mn2yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3TeJVKSzVyPUCuNFAzQTNizszN NULCSlVMW0GQR1XS
DOK MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vSfGlEPTB;MD6wNFI6PCEQvF2= MkKyV2FPT0WU
SW1088 MkD1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TxR2lEPTB;MD6wNFI6PSEQvF2= MYLTRW5ITVJ?
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EW-1 M1vze2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3X0SmlEPTB;MD6wNFI6QCEQvF2= NV\1TZhJW0GQR1XS
CP66-MEL NF7sPYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTBwMECzJO69VQ>? MUnTRW5ITVJ?
DEL NF3yToFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETRWG1KSzVyPUCuNFA{ODFizszN M3\PWnNCVkeHUh?=
DU-4475 M1[wfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLGco1KUUN3ME2wMlAxOzB{IN88US=> NGDJNFJUSU6JRWK=
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U031 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTBwMECzNFch|ryP MlzaV2FPT0WU
BB65-RCC M37VcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXhTWM2OD1yLkCwN|A5KM7:TR?= MYHTRW5ITVJ?
NUGC-3 NVvufYZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTBwMECzNFgh|ryP M2LWXnNCVkeHUh?=
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LS-411N Mm\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTBwMECzNVQh|ryP NYLKTXY5W0GQR1XS
22RV1 M3Pve2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPUTWM2OD1yLkCwN|E2KM7:TR?= NIXs[FNUSU6JRWK=
MKN28 NI\zXHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jWeWlEPTB;MD6wNFMyPyEQvF2= NX\KOXV5W0GQR1XS
ONS-76 M4LK[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXT2NndGUUN3ME2wMlAxOzJ{IN88US=> NVn5U2JNW0GQR1XS
SH-4 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTBwMECzNlIh|ryP NYrlWG8yW0GQR1XS
MIA-PaCa-2 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTBwMECzNlQh|ryP NU\EVnUzW0GQR1XS
CaR-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHNbnpKSzVyPUCuNFA{OjdizszN NXfYVVY4W0GQR1XS
AGS M2DyXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTJTWtKSzVyPUCuNFA{OjhizszN NVP5W5d4W0GQR1XS
SF126 Ml7tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3STWM2OD1yLkCwN|I6KM7:TR?= MVfTRW5ITVJ?
UACC-62 M1e4[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjHelVKSzVyPUCuNFA{OyEQvF2= MojyV2FPT0WU
NCI-H28 NUXGVVRGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnWdYNkUUN3ME2wMlAxOzN2IN88US=> MVnTRW5ITVJ?
A2780 NEnMfWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTBwMECzN|Uh|ryP Mn7iV2FPT0WU
CTV-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTBwMECzN|ch|ryP MVjTRW5ITVJ?
LC-2-ad NIPtNFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnVcpNKSzVyPUCuNFA{PCEQvF2= NYTXZWZ2W0GQR1XS
NCI-H1770 M1j0Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUSxS49yUUN3ME2wMlAxOzR{IN88US=> NIHzTVlUSU6JRWK=
HuO9 M4fhOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLmNpNKSzVyPUCuNFA{PDZizszN M{PlPHNCVkeHUh?=
U-266 NVrmS2JIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjRPZdKSzVyPUCuNFA{PDhizszN MXfTRW5ITVJ?
MLMA MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXZNnBKSzVyPUCuNFA{PTVizszN NU\MPGZ{W0GQR1XS
U-87-MG NF3JW3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTBwMECzOVUh|ryP MXjTRW5ITVJ?
GI-ME-N NFi2OG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTBwMECzOVgh|ryP MonCV2FPT0WU
HL-60 NY[yR5k4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTBwMECzOVkh|ryP NGrWeWZUSU6JRWK=
EGI-1 NX3tZ2VET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrvTWM2OD1yLkCwN|YzKM7:TR?= Mk\1V2FPT0WU
NCI-H23 NH6xZ4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDzO4dpUUN3ME2wMlAxOzZ2IN88US=> M3LTNXNCVkeHUh?=
NCI-H226 M1fES2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XpUGlEPTB;MD6wNFM3QCEQvF2= MmDHV2FPT0WU
NCI-H520 MnexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnOwTWM2OD1yLkCwN|czKM7:TR?= M33VNHNCVkeHUh?=
L-363 M1;GcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3PeG5VUUN3ME2wMlAxOzd4IN88US=> Mon2V2FPT0WU
CAL-12T NFq0RZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfWfFNKSzVyPUCuNFA{PzZizszN M1rvZ3NCVkeHUh?=
BT-20 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPBOJpLUUN3ME2wMlAxOzd4IN88US=> NWXkNoVpW0GQR1XS
SNB75 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTpTHdzUUN3ME2wMlAxOzhzIN88US=> NUL5ZlJZW0GQR1XS
A4-Fuk NVjBcnZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\qTWM2OD1yLkCwN|kh|ryP NEi4O4NUSU6JRWK=
BE-13 M2DDVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTBwMECzPVMh|ryP M1u3SnNCVkeHUh?=
NCI-H1395 NIOzVVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTxXVlKSzVyPUCuNFA{QTZizszN M2P5fnNCVkeHUh?=
SW620 MmHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{Xuc2lEPTB;MD6wNFM6PyEQvF2= MmfyV2FPT0WU
KNS-81-FD MoHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjaTWM2OD1yLkCwN|k6KM7:TR?= NUn1VmxZW0GQR1XS
RD NEfaWHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{GwcWlEPTB;MD6wNFQh|ryP M2LlTXNCVkeHUh?=
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OVCAR-3 NVHGN2J[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTDZ5ZKSzVyPUCuNFA1ODdizszN MVHTRW5ITVJ?
KM12 NF7odGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4r4PGlEPTB;MD6wNFQxQCEQvF2= M2m0S3NCVkeHUh?=
HCC2998 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PBTmlEPTB;MD6wNFQxQCEQvF2= MXPTRW5ITVJ?
D-502MG MnjhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLpXWJKSzVyPUCuNFA1OSEQvF2= MUTTRW5ITVJ?
KNS-42 MmXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fFWGlEPTB;MD6wNFQyOiEQvF2= M13oTHNCVkeHUh?=
LS-123 M3vUTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXyxPHBvUUN3ME2wMlAxPDJ3IN88US=> MmDQV2FPT0WU
SiHa Mke4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{joNmlEPTB;MD6wNFQ{KM7:TR?= MkPEV2FPT0WU
T47D Mmr4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DkPWlEPTB;MD6wNFQ{OSEQvF2= NVHabnBzW0GQR1XS
EW-24 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXf4V4h3UUN3ME2wMlAxPDN|IN88US=> MoHLV2FPT0WU
CAL-120 NX\P[o0zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHn2cohKSzVyPUCuNFA1OzVizszN M3nLZ3NCVkeHUh?=
JAR NUT0bmJJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTBwMEC0N|ch|ryP M4rTVHNCVkeHUh?=
QIMR-WIL MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHxTWM2OD1yLkCwOFM5KM7:TR?= NGjaVYNUSU6JRWK=
OCUB-M M4S5UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HXemlEPTB;MD6wNFQ{QCEQvF2= M1ztfnNCVkeHUh?=
Calu-6 M2ftZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTBwMEC0OFch|ryP NIjySYNUSU6JRWK=
MDA-MB-453 NWfBW3ZyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7DTWM2OD1yLkCwOFUyKM7:TR?= NV;V[GNZW0GQR1XS
MKN45 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXNTWM2OD1yLkCwOFU{KM7:TR?= Mn64V2FPT0WU
ECC10 M2i4cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTBwMEC0OkDPxE1? NYTQWnRTW0GQR1XS
RVH-421 NVTENFBDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDwTWM2OD1yLkCwOFYyKM7:TR?= NYTud4liW0GQR1XS
TGBC11TKB M1m2N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrnXmdKSzVyPUCuNFA1PjlizszN MnnQV2FPT0WU
MOLT-4 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\JVnBUUUN3ME2wMlAxPDdzIN88US=> NIjrfpZUSU6JRWK=
LN-405 MlL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfFTWM2OD1yLkCwOFgzKM7:TR?= NVvpSnZzW0GQR1XS
S-117 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDxbIZoUUN3ME2wMlAxPDh4IN88US=> MmHwV2FPT0WU
RPMI-8226 Ml\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjRVFJQUUN3ME2wMlAxPDl5IN88US=> MUfTRW5ITVJ?
KYSE-150 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXr5PHQ4UUN3ME2wMlAxPDl7IN88US=> NWTmVWl[W0GQR1XS
NCI-H1666 MorMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFX3RllKSzVyPUCuNFA2ODVizszN MnzlV2FPT0WU
Mewo NFjaR2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnLbWlUUUN3ME2wMlAxPTB3IN88US=> MWLTRW5ITVJ?
AN3-CA M4OxVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLhTWM2OD1yLkCwOVA4KM7:TR?= M2\CT3NCVkeHUh?=
COLO-680N NIXKTFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkf0TWM2OD1yLkCwOVA5KM7:TR?= MkK4V2FPT0WU
FADU NE\ZfGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LpUGlEPTB;MD6wNFUyKM7:TR?= NXG0dIVNW0GQR1XS
GB-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DVdWlEPTB;MD6wNFUyOSEQvF2= NGPmTnVUSU6JRWK=
KASUMI-1 NELs[|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7Pc4FkUUN3ME2wMlAxPTFzIN88US=> Mn\RV2FPT0WU
NOMO-1 NWLpOItUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTBwMEC1NVMh|ryP NHTjO3JUSU6JRWK=
BV-173 NXnlTYdNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3Hh[GlEPTB;MD6wNFU{KM7:TR?= MYPTRW5ITVJ?
RO82-W-1 NIrNNWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\3V2lEPTB;MD6wNFU{OSEQvF2= NWf3UnFEW0GQR1XS
LB2241-RCC NIXIWFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknxTWM2OD1yLkCwOVMyKM7:TR?= MVjTRW5ITVJ?
NCI-H2170 NGTHdmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofVTWM2OD1yLkCwOVM2KM7:TR?= MkHOV2FPT0WU
SK-N-AS NYHGb41vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHM[INzUUN3ME2wMlAxPTN3IN88US=> NVjKRWw4W0GQR1XS
NCI-H1651 MnTKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHW4T3RKSzVyPUCuNFA2PCEQvF2= MnXBV2FPT0WU
NCI-SNU-5 M1vmfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTBwMEC1OFUh|ryP MWHTRW5ITVJ?
SN12C NHLk[oZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PqUWlEPTB;MD6wNFU2KM7:TR?= M{XmSnNCVkeHUh?=
KY821 M{W5c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjQb4k6UUN3ME2wMlAxPTVzIN88US=> MV;TRW5ITVJ?
SW1573 MlnjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nuSGlEPTB;MD6wNFU2PCEQvF2= MkPNV2FPT0WU
OE19 MkWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwMEC1OVkh|ryP MVfTRW5ITVJ?
MPP-89 NFXMe3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXRSYtXUUN3ME2wMlAxPTZ5IN88US=> Mn3MV2FPT0WU
HuCCT1 M{ntRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{Di[WlEPTB;MD6wNFU3QCEQvF2= MUDTRW5ITVJ?
SW1783 M3qxVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PMVGlEPTB;MD6wNFU4KM7:TR?= MnmxV2FPT0WU
8305C MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVz4UlRkUUN3ME2wMlAxPTd4IN88US=> NFHGfWhUSU6JRWK=
OVCAR-4 NV[wN3BzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV6yZlBWUUN3ME2wMlAxPTh4IN88US=> NVfjVIl[W0GQR1XS
MMAC-SF M4HHUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXETWM2OD1yLkCwOVg3KM7:TR?= NGXvXppUSU6JRWK=
COLO-824 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7NTWM2OD1yLkCwOVkh|ryP MkjUV2FPT0WU
HCC38 Ml7JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE[3[4pKSzVyPUCuNFA3KM7:TR?= MYrTRW5ITVJ?
NCI-H1648 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfhW3hKSzVyPUCuNFA3ODFizszN NXfoSnp2W0GQR1XS
NCI-H1573 M4jMbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTBwMEC2NFch|ryP NH2zZZZUSU6JRWK=
MFM-223 Ml:4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\N[2lEPTB;MD6wNFYyPiEQvF2= MVrTRW5ITVJ?
NCI-H810 NGj4V2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHXUW9KSzVyPUCuNFA3OjJizszN M{L4WnNCVkeHUh?=
EM-2 NGfZeHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoL6TWM2OD1yLkCwOlI{KM7:TR?= NF25cJVUSU6JRWK=
D-283MED NXTnOoJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;nWWlEPTB;MD6wNFYzPCEQvF2= MXzTRW5ITVJ?
NCI-H1755 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX6wfI5nUUN3ME2wMlAxPjJ2IN88US=> Ml35V2FPT0WU
KYSE-70 NHG2WnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjzXWxbUUN3ME2wMlAxPjJ2IN88US=> MULTRW5ITVJ?
SW626 MlLSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLDWmJKSzVyPUCuNFA3OjRizszN NWPzT4g3W0GQR1XS
WM-115 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF6zbIhKSzVyPUCuNFA3OjdizszN MkfPV2FPT0WU
NB69 NW[yfoJnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTBwMEC2Nlkh|ryP MoD0V2FPT0WU
DOHH-2 NX64c5J5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwMEC2N{DPxE1? MmDtV2FPT0WU
MEL-JUSO M2X2OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nYS2lEPTB;MD6wNFY{QSEQvF2= NYGyc2o1W0GQR1XS
IGR-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTBwMEC2OFEh|ryP MX\TRW5ITVJ?
ACN MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTBwMEC2OFQh|ryP NHPUUZBUSU6JRWK=
KARPAS-45 NIrRfFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwMEC2OVIh|ryP MVPTRW5ITVJ?
HC-1 NEDhXVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwMEC2OVYh|ryP NWLQNI1XW0GQR1XS
MZ2-MEL NWD0VHl{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TJNmlEPTB;MD6wNFY2QCEQvF2= NUC4UGxHW0GQR1XS
NCI-H1355 M4LrSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrZWIl1UUN3ME2wMlAxPjd7IN88US=> MlzqV2FPT0WU
HuP-T4 NYDN[JhQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoK0TWM2OD1yLkCwOlc6KM7:TR?= MkD6V2FPT0WU
AsPC-1 NWXpPGVDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTBwMEC2PFMh|ryP NH;Ze|VUSU6JRWK=
SCC-15 NY[5WXI2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTBwMEC2PFkh|ryP M2ra[nNCVkeHUh?=
CP50-MEL-B M2\ZOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUm4b|N[UUN3ME2wMlAxPjl|IN88US=> MUPTRW5ITVJ?
DMS-114 M3;sWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEWzUGFKSzVyPUCuNFA3QTZizszN NHL0WWVUSU6JRWK=
KYSE-520 Mni2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vCO2lEPTB;MD6wNFch|ryP MmHnV2FPT0WU
NCI-H2228 NHnZ[VlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUO4OGs6UUN3ME2wMlAxPzJ3IN88US=> NFq2T|BUSU6JRWK=
COLO-829 M3TuZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTBwMEC3NlUh|ryP NIPzOVFUSU6JRWK=
NCI-H2052 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHMeY5KSzVyPUCuNFA4OjdizszN M4rUeXNCVkeHUh?=
HOP-92 MlvFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\iTWM2OD1yLkCwO|Mh|ryP NWLpb2RkW0GQR1XS
MDA-MB-231 M3TuOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDNTWM2OD1yLkCwO|Mh|ryP M1HDcHNCVkeHUh?=
SK-MEL-30 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTBwMEC3N|Ih|ryP MlG1V2FPT0WU
NCI-H2087 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XSZmlEPTB;MD6wNFc1QCEQvF2= NV7GcHBEW0GQR1XS
SW900 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnu5TWM2OD1yLkCwO|U2KM7:TR?= MXzTRW5ITVJ?
NCI-H358 NGjOTZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFG0ZY5KSzVyPUCuNFA4PThizszN MVvTRW5ITVJ?
NCI-H2126 NIPyPFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTBwMEC3O|Mh|ryP MnLjV2FPT0WU
TGBC24TKB NYKwZlJLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXYZ4RlUUN3ME2wMlAxPzhzIN88US=> NF7YSpZUSU6JRWK=
786-0 MkD5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWT1S|RrUUN3ME2wMlAxPzh4IN88US=> NYnWe3RqW0GQR1XS
no-10 NVn0bngyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDweGRnUUN3ME2wMlAxPzh6IN88US=> NXjoOFZCW0GQR1XS
SCH M1\tcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTBwMEC4NVgh|ryP MYXTRW5ITVJ?
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NCI-H82 M3fhSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvadlJjUUN3ME2wMlAxQDJ{IN88US=> NUHTfIVwW0GQR1XS
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LU-135 Mn7NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPSe2dKSzVyPUCuNlc4OzlizszN NGC2d|lUSU6JRWK=
MC116 NIXyelFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzUTWM2OD1yLkK4N|A6KM7:TR?= M{m0fnNCVkeHUh?=
LS-513 M4nYR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHhTWM2OD1yLkK4O|c{KM7:TR?= MXLTRW5ITVJ?
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NCI-H1838 NYTEcm9TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwM{G3PFQh|ryP MUHTRW5ITVJ?
HEL NITvclRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTBwM{KyOEDPxE1? M1v1cnNCVkeHUh?=
OCI-AML2 NXnVbGNZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DFT2lEPTB;MD6zNlI6QCEQvF2= NGfremhUSU6JRWK=
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C32 NYexeFdCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwN{SxNVIh|ryP M1PJZXNCVkeHUh?=
K-562 NHT2Z5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTBwN{ewNlQh|ryP MmXyV2FPT0WU
DJM-1 M17BNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH24c|VKSzVyPUCuO|g4QDFizszN NHjmSIdUSU6JRWK=
RCC10RGB NXHSW2NNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nXeGlEPTB;MD63PVE5OyEQvF2= NHjyNmlUSU6JRWK=
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NY MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTBwOUOzOVIh|ryP MW\TRW5ITVJ?
NCI-H1993 NH7GWVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmKwTWM2OD1zLkG5Nlg6KM7:TR?= NEK1[5JUSU6JRWK=
SK-OV-3 MnTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVy5eY9EUUN3ME2xMlIzODh7IN88US=> M33GNnNCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo Docetaxel (33 mg/kg/dose, given i.v. every 4 days for 3 injections) results in a tumor growth delay of 19.3 days in M2OL2 colon xenografts. Docetaxel also shows great antitumor activities in MX-1, SK-MEL-2, LX-1 and OVCAR-3 xenografts. Docetaxel inhibits the angiogenic response to fibroblast growth factor 2 with IC 50 of 5.4 mg/kg when injected twice weekly over a 14-day period, and angiogenesis is completely blocked in mice that receives 10 mg/kg Docetaxel. Docetaxel has selectivity for endothelial cell migration and/or microvessel formation because infiltration of inflammatory cells into the Matrigel plug is much less sensitive to inhibition by Docetaxel. [7]

Protocol

Cell Research:[5]
+ Expand
  • Cell lines: Human gastric cancer cell lines MKN-28
  • Concentrations: 6 nM
  • Incubation Time: 3 days
  • Method: 2000 cells in 180 μL of medium are seeded in a 96-well plate, and 20 μL of drug solution is simultaneously added in triplicate to each well. The plate is incubated for 3 days at 37°C in a humidified atmosphere of 5% CO2. On day 3, 25 μL of MTT reagent is added to each well. After 4 h of incubation, the medium is removed by aspiration. 0.2 mL of dimethylsulphoxide (DMSO) is added to each well and thoroughly mixed by using a mechanical plate mixer to dissolve the resulting MTT-formazan crystals. Absorbance at 540 nm (OD) is measured by a reader.
    (Only for Reference)
Animal Research:[6]
+ Expand
  • Animal Models: Human colon carcinomas xenografts CX-1
  • Formulation: 50 mg/mL stock solution in ethanol by adding an equal volume of polysorbate 80 and diluting with 5% dextrose in water to the final volume
  • Dosages: 33 mg/kg
  • Administration: i.v. every 4 days for 3 injections
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (123.78 mM)
Ethanol 53 mg/mL warmed (65.6 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 807.88
Formula

C43H53NO14

CAS No. 114977-28-5
Storage powder
in solvent
Synonyms RP56976, NSC 628503

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03449901 Recruiting Soft Tissue Sarcoma Washington University School of Medicine|Polaris Pharmaceuticals Inc. May 9 2018 Phase 2
NCT02485691 Recruiting Prostate Cancer Metastatic Sanofi November 9 2015 Phase 4
NCT01868022 Completed Neoplasms GlaxoSmithKline October 9 2013 Phase 1
NCT01905657 Active not recruiting Non Small Cell Lung Cancer (NSCLC) Merck Sharp & Dohme Corp. August 9 2013 Phase 2|Phase 3
NCT01695135 Completed Prostate Neoplasms Janssen Research & Development LLC August 9 2012 Phase 3
NCT03419234 Recruiting Castration Levels of Testosterone|Castration-Resistant Prostate Carcinoma|Metastatic Prostate Carcinoma in the Soft Tissue|Prostate Carcinoma Metastatic in the Bone|Stage IV Prostate Adenocarcinoma AJCC v7 ECOG-ACRIN Cancer Research Group|National Cancer Institute (NCI)|Eastern Cooperative Oncology Group February 8 2018 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Microtubule Associated Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID