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RMC-4630 Microtubule Associated inhibitor

Name: RMC-4630
Brand: Selleck Chemicals
SKU: S9969
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S9969

Vociprotafib (RMC-4630) is a potent, selective, orally bioavailable allosteric inhibitor of SHP2 with potential anti-tumor activity. This compound targets, binds to and inhibits the activity of SHP2, thereby inhibiting the activation of the RAS-RAF-MEK-ERK signaling pathway.

Chemical Structure

Molecular Weight: 450.99

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Quality Control

Batch: S996901 DMSO]45 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.07%

Cited in Nature Medicine for its top-tier quality
COA
NMR
HPLC
SDS/MSDS
Datasheet

99.07

Related Targets	Akt Wnt/beta-catenin PKC HSP ROCK Integrin Bcr-Abl Actin FAK Kinesin
Other Microtubule Associated Inhibitors	Nocodazole Patupilone (Epothilone B) CW069 Combretastatin A4 Lexibulin (CYT997) Epothilone A ABT-751 (E7010) Cucurbitacin B TRx0237 (LMTX) mesylate DM1 (Mertansine)

Solubility

In vitro
Batch:

DMSO : 45 mg/mL (99.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	2.250mg/ml (4.99mM)	Taking the 1 mL working solution as an example, add 50 μL of 45 mg/ml clarified DMSO stock solution to 400 μL PEG300, mix evenly to clarify it; add 50 μL Tween80 to the above system, mix evenly to clarify it; then continue to add 500 μL ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	2.250mg/ml (4.99mM)	Taking the 1 mL working solution as an example, add 50 μL of 45 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	450.99	Formula	C₂₀H₂₇ClN₆O₂S	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	2172652-48-9	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Read more about storage stability stock solution CAS number

Mechanism of Action

Targets/IC₅₀/Ki	microtubule polymerization 197 nM(GI50)
References	[1] https://pubmed.ncbi.nlm.nih.gov/29459693/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2025-10-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04185883	ACTIVE_NOT_RECRUITING	Advanced Solid Tumors; Kirsten Rat Sarcoma (KRAS) pG12C Mutation	Amgen	2019-12-17	PHASE1
NCT04916236	TERMINATED	Pancreatic Cancer; Colorectal Cancer; Non-small Cell Lung Cancer; KRAS Mutation-Related Tumors	The Netherlands Cancer Institute	2022-03-31	PHASE1
NCT05054725	COMPLETED	Non-Small Cell Lung Cancer	Revolution Medicines, Inc.	2021-12-30	PHASE2
NCT03634982	UNKNOWN	Solid Tumors	Revolution Medicines, Inc.	2018-09-28	PHASE1
NCT04916236	Recruiting	Pancreatic Cancer\|Colorectal Cancer\|Non-small Cell Lung Cancer\|KRAS Mutation-Related Tumors	The Netherlands Cancer Institute\|Lustgarten Foundation	2022-03-31	Phase 1
NCT03989115	COMPLETED	Solid Tumor	Revolution Medicines, Inc.	2019-07-02	PHASE1; PHASE2

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Handling Instructions

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