Eribulin Mesylate (E7389)

Catalog No.S8912 Synonyms: B-1939 mesylate, ER-086526 mesylate,E7389 mesylate

For research use only.

Eribulin Mesylate (E7389, B-1939, ER-086526,E7389 mesylate), an analogue of the marine natural product halichondrin B, is a nontaxane completely synthetic microtubule inhibitor.

Eribulin Mesylate (E7389) Chemical Structure

CAS No. 441045-17-6

Purity & Quality Control

Choose Selective Microtubule Associated Inhibitors

Other Microtubule Associated Products

Biological Activity

Description

Eribulin Mesylate (E7389, B-1939, ER-086526,E7389 mesylate), an analogue of the marine natural product halichondrin B, is a nontaxane completely synthetic microtubule inhibitor.

Targets
microtubule [1]
In vitro

Eribulin Mesylate (1-100 nM; 72 h) inhibits cells proliferation of LM8 and Dunn cells. Eribulin Mesylate (10-50 nM; 12-72 h) increases early apoptosis significantly in LM8 cells. Eribulin Mesylate (10-50 nM; 12-72 h) induces G2/M arrest by 12 h treatment with at the dose of 50 nM, but not by long-term treatment (72 h) with 10 nM in LM8 cells. Eribulin Mesylate (1-10 nM; 16 h) induces morphological change and suppresses cell migration in a low concentration in LM8 cells.<sup><a class="sref" href="#s_ref">[2]</a></sup>

In vivo

Eribulin Mesylate reduces primary tumor growth and lung metastasis of osteosarcoma in mice.<sup><a class="sref" href="#s_ref">[2]</a></sup>

Protocol (from reference)

Cell Research:

[2]

  • Cell lines: LM8 cells, Dunn cells
  • Concentrations: 10 nM, 50 nM
  • Incubation Time: 72 h
  • Method:

    LM8 cells and  Dunn cells are incubated with 0 nM, 10 nM, or 50 nM eribulin Mesylate for 12 h, 24 h, 48 h, or 72 h. And then cell proliferation, cell cycle and apoptosis are detected by flow cytometry analysis and immunofluorescence.

Animal Research:

[2]

  • Animal Models: 4-week-old C3H/HeN mice inoculated with LM8 cells
  • Dosages: 1 mg/kg
  • Administration: I.v.

Chemical Information

Molecular Weight 826
Formula

C41H63NO14S

CAS No. 441045-17-6
Storage 3 years -20°C powder
2 years -80°C in solvent

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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