Home Angiogenesis HER2 inhibitor Trastuzumab-Emtansine（T-DM1）

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Trastuzumab-Emtansine（T-DM1） HER2 inhibitor

Cat.No.E2851

Trastuzumab Emtansine(T-DM1,Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1.Trastuzumab emtansine has a molecular weight of 145kDa.This product is supplied as 10mg/ml PBS solution. This product is discontinued. We recommend the replacement products: D4003
Trastuzumab-Emtansine（T-DM1） HER2 inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 145000

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Quality Control

Batch: E285101 Purity: 99.59%
99.59

Solubility

In vitro
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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 145000 Formulation 10mg/mL in PBS DAR 3.6
Antibody Trastuzumab ADC Cytotoxin DM1 Formula N/A
CAS No. 1018448-65-1 (ADC) Storage (From the date of receipt) 1 year -80°C in solvent Shipping Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Mechanism of Action

Targets/IC50/Ki
HER2
Microtubule
In vitro

Trastuzumab emtansine significantly inhibits the proliferation of epithelial ovarian cancer (EOC) cells.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05945927 Recruiting
Breast Cancer
Hoffmann-La Roche
 September 13 2023 --
NCT05388149 Recruiting
Breast Cancer|HER2-positive Breast Cancer
University Health Network Toronto
 December 6 2022 Phase 2
NCT05754502 Recruiting
Breast Cancer
Consorzio Oncotech|Roche Pharma AG
 July 27 2021 --

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Frequently Asked Questions

Question 1:
What's the solvent of this compound? And what's its concentration?

Answer:
The solvent is a PBS solution. Its concentration is 10mg/ml.

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