Home Cytoskeletal Signaling Microtubule Associated inhibitor Estramustine phosphate sodium For research use only.

Estramustine phosphate sodium

Synonyms: EMP, Emcyt, Estracyt

Estramustine phosphate sodium (EMP, Emcyt, Estracyt) is an antitumour drug with a unique dual mode of action. Estrone and estradiol, products of the metabolism of estramustine phosphate sodium, have shown antigonadotrophic activity resulting in reduced testosterone levels. Estramustine(the cytotoxic metabolite produced by dephosphorylation of estramustine phosphate sodium) is an antiprostatic tumor drug with antimicrotubule effects.

Estramustine phosphate sodium Chemical Structure

Estramustine phosphate sodium Chemical Structure

CAS: 52205-73-9

Purity & Quality Control

Batch: S244101 Water] 100 mg/mL] false] DMSO] Insoluble] false] Ethanol] Insoluble] false Purity: 99.93%
99.93

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Biological Activity

Description Estramustine phosphate sodium (EMP, Emcyt, Estracyt) is an antitumour drug with a unique dual mode of action. Estrone and estradiol, products of the metabolism of estramustine phosphate sodium, have shown antigonadotrophic activity resulting in reduced testosterone levels. Estramustine(the cytotoxic metabolite produced by dephosphorylation of estramustine phosphate sodium) is an antiprostatic tumor drug with antimicrotubule effects.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05350202 Recruiting
Heart Failure
Boehringer Ingelheim
 December 15 2022 --
NCT04892797 Active not recruiting
Covid19
University of Vermont
 February 3 2021 --

Chemical Information & Solubility

Molecular Weight 564.35 Formula

C23H30Cl2NNa2O6P
CAS No. 52205-73-9 SDF --
Smiles CC12CCC3C(C1CCC2OP(=O)([O-])[O-])CCC4=C3C=CC(=C4)OC(=O)N(CCCl)CCCl.[Na+].[Na+]
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Water : 100 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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