SSE15206

Catalog No.S8789

SSE15206 Chemical Structure

Molecular Weight(MW): 371.45

SSE15206 is a tubulin polymerization inhibitor that has potent antiproliferative activities in cancer cell lines of different origins and overcomes resistance to microtubule-targeting agents.

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Biological Activity

Description SSE15206 is a tubulin polymerization inhibitor that has potent antiproliferative activities in cancer cell lines of different origins and overcomes resistance to microtubule-targeting agents.
Targets
tubulin polymerization [1]
()
In vitro

Treatment of cells with SSE15206 causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation, a phenotype often associated with drugs that interfere with microtubule dynamics. SSE15206 inhibits microtubule polymerization both in biochemical and cellular assays by binding to colchicine site in tubulin. Prolonged treatment of cells with SSE15206 results in apoptotic cell death accompanied by p53 induction[1].

Protocol

Cell Research:

[1]

+ Expand
  • Cell lines: HCT116 cells
  • Concentrations: 0.5 μM, 1 μM and 2 μM
  • Incubation Time: 4, 8, 12, 24 and 36 hours
  • Method:

    HCT116 cells are treated with 0.5 μM, 1 μM and 2 μM SSE15206 for 4 and 8 hours. Phosphorylation of histone H3 (S10) and P-MPM2 is determined by western blotting; total-histone H3 and GAPDH are used as loading controls; Or HCT116 cells are treated with 1 μM SSE15206 for 4, 8, 12, 24 and 36 hours and are analyzed through FACS following treatment.


    (Only for Reference)

Solubility (25°C)

In vitro DMSO 74 mg/mL (199.21 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 371.45
Formula

C19H21N3O3S

CAS No. 1370046-40-4
Storage powder
in solvent
Synonyms N/A

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Microtubule Associated Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID