Home Cytoskeletal Signaling Microtubule Associated inhibitor SSE15206

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SSE15206 Microtubule Associated inhibitor

Cat.No.S8789

SSE15206 is a tubulin polymerization inhibitor that has potent antiproliferative activities in cancer cell lines of different origins and overcomes resistance to microtubule-targeting agents.
SSE15206 Microtubule Associated inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 371.45

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Quality Control

Batch: S878901 Purity: 99.33%
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99.33

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Chemical Information, Storage & Stability

Molecular Weight 371.45 Formula

C19H21N3O3S

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 1370046-40-4 -- Storage of Stock Solutions

Synonyms N/A Smiles COC1=CC(=CC(=C1OC)OC)C2CC(=NN2C(=S)N)C3=CC=CC=C3

Mechanism of Action

Targets/IC50/Ki
tubulin polymerization
In vitro

Treatment of cells with SSE15206 causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation, a phenotype often associated with drugs that interfere with microtubule dynamics. This compound inhibits microtubule polymerization both in biochemical and cellular assays by binding to colchicine site in tubulin. Prolonged treatment of cells with this chemical results in apoptotic cell death accompanied by p53 induction.
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